The Journal of rheumatology. Supplement最新文献_第3页

Impact of Axial Spondyloarthritis on Quality of Life: Results From the European Map of Axial Spondyloarthritis (EMAS) Study in France 中轴性脊柱炎对生活质量的影响:来自法国中轴性脊柱炎欧洲地图(EMAS)研究的结果

The Journal of rheumatology. Supplement Pub Date : 2022-05-15 DOI: 10.3899/jrheum.210864

J. Kędra, P. Claudepierre, R. Flipo, M. Garrido-Cumbrera, F. Alliot-Launois, E. Desfleurs, L. Grange, L. Gossec

引用次数: 0

Vasculitis: What Have We Learned in the Last 50 Years? 血管炎:过去50年我们学到了什么?

The Journal of rheumatology. Supplement Pub Date : 2022-05-15 DOI: 10.3899/jrheum.220207

S. Carette

引用次数: 0

Management of Calcinosis Cutis in Rheumatic Diseases 风湿病患者皮肤钙质沉着症的治疗

The Journal of rheumatology. Supplement Pub Date : 2022-05-15 DOI: 10.3899/jrheum.211393

Hadiya Elahmar, B. Feldman, S. Johnson

引用次数: 9

Dr. Griffiths et al reply Griffiths博士等人回答

The Journal of rheumatology. Supplement Pub Date : 2022-05-15 DOI: 10.3899/jrheum.220120

J. Leadbetter, H. Griffiths

引用次数: 0

Association of M2 Macrophages, Th2, and B Cells With Pathomechanism in Microscopic Polyangiitis Complicated by Interstitial Lung Disease M2巨噬细胞、Th2和B细胞与显微多血管炎合并间质性肺疾病的病理机制的关联

The Journal of rheumatology. Supplement Pub Date : 2022-05-02 DOI: 10.3899/jrheum.220123

S. Matsuda, T. Kotani, H. Kuwabara, Takayasu Suzuka, Takao Kiboshi, Y. Wada, T. Ishida, Youhei Fujiki, Hideyuki Shiba, K. Hata, T. Shoda, Y. Hirose, T. Takeuchi

{"title":"Association of M2 Macrophages, Th2, and B Cells With Pathomechanism in Microscopic Polyangiitis Complicated by Interstitial Lung Disease","authors":"S. Matsuda, T. Kotani, H. Kuwabara, Takayasu Suzuka, Takao Kiboshi, Y. Wada, T. Ishida, Youhei Fujiki, Hideyuki Shiba, K. Hata, T. Shoda, Y. Hirose, T. Takeuchi","doi":"10.3899/jrheum.220123","DOIUrl":"https://doi.org/10.3899/jrheum.220123","url":null,"abstract":"Objective To address the pathomechanism of microscopic polyangiitis (MPA) complicated by interstitial lung disease (ILD) using serum biomarker profile and pulmonary histopathology. Methods Serum biomarkers from patients with MPA-ILD (n = 32), MPA without ILD (n = 17), and healthy controls (n = 10) were examined. Based on the biomarker profiles, principal component analysis (PCA) and cluster analysis were performed to classify patients with MPA-ILD into subgroups. Clinical characteristics and prognosis were assessed for each subgroup. Two lung biopsies were examined following H&E staining and immunostaining. Results T cell and macrophage polarization was skewed toward the T helper (Th) 2 cells and M2 macrophages in the MPA-ILD group relative to that in MPA without ILD group. The PCA allowed classification of the 19 biomarker profiles into 3 groups: (1) B cell– and neutrophil-related cytokines, vascular angiogenesis-related factors, extracellular matrix-producing factors; (2) Th1-driven cytokines, M1 macrophage-driven cytokines, and Th2-driven cytokines; and (3) M2 macrophage-induced and driven cytokines. The cluster analysis stratified the patients with MPA-ILD into clinically fibrotic-dominant (CFD) and clinically inflammatory-dominant (CID) groups. Notably, severe infections were significantly higher in the CFD group than in the CID group. Immunohistochemical staining demonstrated intense CXC motif chemokine ligand 13 staining in B cells and Th2 cells in the interstitium of the lungs of patients with MPA-ILD. Conclusion. The activation of M2 macrophages, Th2 cells, and B cells plays a key role in the pathomechanism of MPA-ILD. Classification of MPA-ILD based on serum biomarker profile would be useful in predicting the disease activity and the complications of severe infection in MPA-ILD.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":"51 1","pages":"913 - 921"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90691548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia 纤维肌痛患者心理症状和疼痛的神经炎症的显微结构证据

The Journal of rheumatology. Supplement Pub Date : 2022-05-02 DOI: 10.3899/jrheum.211170

Y. Lo, Tang Jun Tiffany Li, Ting-Chun Lin, You-Yin Chen, Jiunn-Horng Kang

{"title":"Microstructural Evidence of Neuroinflammation for Psychological Symptoms and Pain in Patients With Fibromyalgia","authors":"Y. Lo, Tang Jun Tiffany Li, Ting-Chun Lin, You-Yin Chen, Jiunn-Horng Kang","doi":"10.3899/jrheum.211170","DOIUrl":"https://doi.org/10.3899/jrheum.211170","url":null,"abstract":"Objective In patients with fibromyalgia (FM), the brain shows altered structure and functional connectivity, but the mechanisms underlying these changes remain unclear. This study investigated the associated changes in brain microstructures and neuroinflammation of patients with FM. Methods We recruited 14 patients with FM and 14 healthy controls (HCs). Visual analog scale (VAS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II) were used for assessing their pain, anxiety, and depression levels, respectively. Diffusion kurtosis imaging (DKI) was used to visualize microstructural alterations associated with neuroinflammation in specific brain regions. The biomarkers for neuron damage, including serum tau and amyloid β protein fragment 1-42 (Aβ1-42) levels, were assessed. Spearman correlation of DKI parameters with VAS, BAI, and BDI-II scores as well as tau and Aβ1-42 levels were assessed. Results The patients with FM had significantly higher levels of Aβ1-42 levels than HCs. Compared with HCs, the patients with FM showed significantly lower DKI parameters in the bilateral dorsolateral prefrontal cortex and orbitofrontal cortex. Patients with FM showed a significant correlation between the axial kurtosis values of the amygdala and VAS scores (left: ρ = −0.60, P = 0.02; right: ρ = −7.04, P = 0.005). Conclusion To the best of our knowledge, this is the first study to use DKI to examine the brains of patients with FM. We noted significant DKI changes associated with neuroinflammation at specific areas in patients with FM. Our results provide valuable information on brain neuroinflammation and pathophysiological changes in patients with FM.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":"7 1","pages":"942 - 947"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84974069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Male Sex Predicts a Favorable Outcome in Early ACPA-Negative Rheumatoid Arthritis: Data From an Observational Study 男性预测早期acpa阴性类风湿性关节炎的有利结果:来自一项观察性研究的数据

The Journal of rheumatology. Supplement Pub Date : 2022-05-02 DOI: 10.3899/jrheum.211199

G. Cagnotto, L. Jacobsson, E. Rydell, A. Eberhard, M. Compagno, C. Turesson

{"title":"Male Sex Predicts a Favorable Outcome in Early ACPA-Negative Rheumatoid Arthritis: Data From an Observational Study","authors":"G. Cagnotto, L. Jacobsson, E. Rydell, A. Eberhard, M. Compagno, C. Turesson","doi":"10.3899/jrheum.211199","DOIUrl":"https://doi.org/10.3899/jrheum.211199","url":null,"abstract":"Objective The aim of the present study was to investigate whether the relationship between sex and clinical outcomes in early rheumatoid arthritis (RA) varies by autoantibody status. Methods Two inception cohorts of consecutive patients with early RA (ie, symptom duration ≤ 12 months) in the southern region of Sweden were investigated. Patients were stratified by anticitrullinated peptide antibody (ACPA) status. The primary outcome was remission (Disease Activity Score in 28 joints [DAS28] < 2.6) at 12 months. Secondary outcomes were remission at 6 months and European Alliance of Associations for Rheumatology good response at 6 and 12 months compared to baseline. In logistic regression models, which were adjusted for age, DAS28 values, and Health Assessment Questionnaire values at baseline, the relationship between sex and clinical outcomes, stratified by ACPA status, was investigated. Results In total, 426 patients with early RA were included: 160 patients were ACPA negative and 266 patients were ACPA positive. At 12 months, 27.1% (38/140) of females and 24.1% (13/54) of males with ACPA-positive RA achieved DAS28 remission. In ACPA-negative RA, 16.0% (13/81) of females and 48.6% (18/37) of males achieved DAS28 remission at 12 months. Males had higher odds of reaching remission at 12 months in the ACPA-negative patient group (pooled adjusted odds ratio [OR] 4.79, 95% CI 1.97-11.6), but not in the ACPA-positive group (pooled adjusted OR 1.06, 95% CI 0.49-2.30). Conclusion Male sex was associated with better clinical outcomes in ACPA-negative early RA, but not in ACPA-positive early RA. The poor outcomes in females with early seronegative RA suggest that this represents a difficult-to-treat patient group.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":"41 ","pages":"990 - 997"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72495682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rho Kinase Expression in Giant Cell Arteritis: Validating Phosphorylated Ezrin/Radixin/Moesin Intensity Score to Increase Sensitivity of Temporal Artery Biopsy Rho激酶在巨细胞动脉炎中的表达:验证磷酸化Ezrin/Radixin/Moesin强度评分以增加颞动脉活检的敏感性

The Journal of rheumatology. Supplement Pub Date : 2022-04-15 DOI: 10.3899/jrheum.220012

L. Lally, N. Narula, N. Goodfellow, R. Luqmani, D. Pisapia, R. Spiera

{"title":"Rho Kinase Expression in Giant Cell Arteritis: Validating Phosphorylated Ezrin/Radixin/Moesin Intensity Score to Increase Sensitivity of Temporal Artery Biopsy","authors":"L. Lally, N. Narula, N. Goodfellow, R. Luqmani, D. Pisapia, R. Spiera","doi":"10.3899/jrheum.220012","DOIUrl":"https://doi.org/10.3899/jrheum.220012","url":null,"abstract":"Objective Aberrant Rho-associated protein kinase (ROCK) activity is implicated in several vascular and immunologic disorders. We previously demonstrated increased ROCK activity in histopathologically negative temporal artery biopsies (TABs) in subjects with clinical giant cell arteritis (GCA) compared to those without GCA. This current study aimed to examine ROCK activity in a larger cohort of biopsy-negative GCA subjects and to validate the prior findings. Methods. Based on clinical data 6 months after TAB, subjects were categorized into 2 groups: biopsy-negative GCA and controls without GCA. Paraffin-embedded TABs were stained for phosphorylated ezrin/radixin/ moesin (pERM), a surrogate of ROCK activity, and scored by 2 pathologists blinded to clinical diagnosis using a previously derived scoring system measuring staining intensity in 3 areas of the vessel. Results. Thirty-six subjects with biopsy-negative GCA and 43 controls were analyzed. The mean (SD) pERM intensity score in non-GCA subjects was 3.9 (1.4), compared to 5.0 (1.4) in those with GCA (P = 0.002). Using the predetermined cut-off of 4 to define high pERM intensity, subjects with GCA were significantly more likely to have a high pERM intensity score compared to non-GCA (odds ratio 3.67, 95% CI 1.19-11.36; P = 0.02. The sensitivity of high pERM intensity score for diagnosis of GCA in histologically negative TABs was 86% (95% CI 70-95). Conclusion. In this well-characterized cohort, those with biopsy-negative GCA had significantly higher pERM intensity scores compared to subjects without GCA. pERM staining has diagnostic significance in enhancing the sensitivity of TAB and may help to define the clinically important group of biopsy-negative GCA.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":"2 1","pages":"908 - 912"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85094319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2021 GRAPPA Meet the Experts Session: A Summary of Presentations. 2021年GRAPPA专家会议:报告总结。

The Journal of rheumatology. Supplement Pub Date : 2022-04-15 DOI: 10.3899/jrheum.211326

A. Armstrong, Rasika M Reddy, O. FitzGerald, K. Callis Duffin, P. Helliwell, P. Mease, A. Kavanaugh, J. Merola, William Tillet, M. D. de Wit

引用次数: 0

Potential Impact of Sex and BMI on Response to Therapy in Psoriatic Arthritis: Post Hoc Analysis of Results From the SEAM-PsA Trial 性别和BMI对银屑病关节炎治疗反应的潜在影响:SEAM-PsA试验结果的事后分析

The Journal of rheumatology. Supplement Pub Date : 2022-04-15 DOI: 10.3899/jrheum.211037

P. Mease, D. Gladman, J. Merola, A. Deodhar, A. Ogdie, D. Collier, L. Liu, A. Kavanaugh

{"title":"Potential Impact of Sex and BMI on Response to Therapy in Psoriatic Arthritis: Post Hoc Analysis of Results From the SEAM-PsA Trial","authors":"P. Mease, D. Gladman, J. Merola, A. Deodhar, A. Ogdie, D. Collier, L. Liu, A. Kavanaugh","doi":"10.3899/jrheum.211037","DOIUrl":"https://doi.org/10.3899/jrheum.211037","url":null,"abstract":"Objective In this post hoc analysis, we examined the potential impact of sex and BMI on response in the Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis (SEAM-PsA) trial (NCT02376790), a 48-week, phase III, randomized controlled trial that compared outcomes with methotrexate (MTX) monotherapy, etanercept (ETN) monotherapy, and MTX+ETN combination therapy in patients with psoriatic arthritis (PsA) who were naïve to MTX and biologics. Methods We evaluated key outcomes at week 24 stratified by sex (male vs female) and BMI (kg/m2; ≤ 30 vs > 30), including the American College of Rheumatology 20 (ACR20) criteria, minimal disease activity (MDA), very low disease activity (VLDA), and Psoriatic Arthritis Disease Activity Score (PASDAS). We analyzed data using descriptive statistics, normal approximation, logistic model, and analysis of covariance. Results A total of 851 patients completed the SEAM-PsA trial. Higher proportions of men than women who received MTX+ETN combination therapy achieved ACR20 (71.5% vs 58.3%; P = 0.02), MDA (45.8% vs 25.2%; P = 0.0003), and VLDA (19.1% vs 9.5%; P = 0.03), and men achieved better PASDAS (-3.0 vs -2.3; P = 0.0004). Patients with BMI ≤ 30 generally had better outcomes than those with BMI > 30 in some treatment arms for ACR20, MDA, VLDA, and PASDAS; however, there was no consistent pattern regarding the treatment arm in which the difference occurred. Conclusion Improved outcomes were observed more in men than in women for MDA and PASDAS with MTX+ETN combination therapy. Patients with BMI ≤ 30 had better outcomes than those with BMI > 30, with no clear pattern regarding treatment received. These findings suggest that contextual factors such as sex and BMI may affect response to PsA therapy.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":"54 1","pages":"885 - 893"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88414060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9