Journal of Advances in Pharmacy Practices最新文献

{"title":"Peritoneal Carcinomatosis and Situs Inversus Totalis: A Rare Case Report","authors":"Gautham Krishna, Nihal Muhammed, Drishya L., Shaiju S. Dharan","doi":"10.46610/japp.2023.v05i02.003","DOIUrl":"https://doi.org/10.46610/japp.2023.v05i02.003","url":null,"abstract":"Gastric cancer remains one of the foremost important cancers around the world because it positions as the fifth most common cancer and the fourth driving cause of cancer passing all-inclusive. Situs inversus totalis (SIT) alludes to a turned-around area of the stomach and thoracic organs. The heart is found on the correct side of the chest (dextrocardia) with a total inversion of the heart chambers. The ordinary pulmonary anatomy is additionally turned around, so the cleared-out lung has three flaps and the proper lung has two flaps. In addition, the liver and gallbladder are found on the cleared-out side of the guts, though the spleen and stomach are found on the proper side. The remaining internal structures are moreover a reflected picture of the typical. This natural irregularity is outstandingly remarkable with a pace of one case in 10,000 births. SIT might be a phenomenal intrinsic irregularity that stances unique difficulties amid careful organization. Preoperative organizing, counting imaging and the mindful idea of careful techniques, are fundamental for powerful outcomes in SIT patients with gastric disease. The use of laparoscopic and automated procedures has seemed, by all accounts, to be secure and practical in this calm people. Advanced research is expected to push ahead the comprehension of the aetiology and optimal organization of SIT patients with gastric disease. SIT could be a remarkable innate eccentricity that stances unique difficulties during careful organization. Preoperative orchestrating, counting imaging and the wary idea of surgeries, are crucial for productive outcomes in SIT patients with gastric disease. Advanced careful fitness is expected to play out a definite lymphadenectomy in calm with SIT by envisioning the exact reflected image of the existing frameworks during the activity. The diligent had an ordinary intra-and postoperative course and was taken after up at the short-term division with no demonstration of rehash. All in all, medical procedures in comprehension with peritoneal disease and SIT can be safely performed by paying thought to the improved anatomic designs amid the activity.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Clinical Presentation and Diagnostic Challenges in Metachromatic Leukodystrophy-A Narrative Review","authors":"R. H., Vikashini Subramani, S. J, M. Ali S., Baharul Islam","doi":"10.46610/japp.2024.v06i01.001","DOIUrl":"https://doi.org/10.46610/japp.2024.v06i01.001","url":null,"abstract":"Metachromatic leukodystrophy is a lysosomal storage disorder characterized by the deterioration of the myelin sheath that covers the majority of nerve fibers in both the central and peripheral nervous systems. The condition arises from a deficiency of the lysosomal enzyme arylsulfatase A (ARSA) or its associated sphingolipid activator protein B (SapB), resulting in a progressive decline in both motor and cognitive functions. Mutations in the ARSA and PSAP genes lead to the deficiency of ARSA and SapB proteins, respectively, with the clinical severity of metachromatic leukodystrophy depending on the residual ARSA activity, which varies based on the mutation type. Unfortunately, effective treatments for this disease are currently lacking. While there have been clinical reports of bone marrow or cord blood transplants, their therapeutic efficacy remains insufficient to prevent the worsening of neurological disorders. Encouraging results have been achieved through gene therapy, involving the introduction of the wild-type ARSA gene using vectors based on different adeno-associated virus serotypes. Additionally, mesenchymal stem cells and combined gene-cell therapies have shown promise in the treatment of this condition. This review examines therapeutic approaches for addressing metachromatic leukodystrophy, alongside diagnostic techniques and animal models that help evaluate the effectiveness of new treatments.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oral Microbiome: What it means for Gum Disease and Periodontal Disease","authors":"A. Patil","doi":"10.46610/japp.2023.v05i02.002","DOIUrl":"https://doi.org/10.46610/japp.2023.v05i02.002","url":null,"abstract":"Modulating the oral microbiome for therapeutic purposes has become a potential way to avoid and treat diseases of the mouth. Oral health depends on the oral microbiome, which is a complex community of bacteria that live in the mouth. Dysbiosis is an imbalance in the mouth bacteria community. Mouth diseases start and get worse because of dysbiosis. This abstract talk about different ways to change the mouth microbiome to restore a healthy mix of microorganisms and improve oral health. Probiotics, prebiotics, and antimicrobial drugs are used to introduce good microorganisms, specifically boost the growth of good bacteria, and get rid of bad microorganisms. Probiotics can fight harmful bacteria, increase the range of good bacteria, and boost the immune responses of the host. Prebiotics provide food for the good bacteria in your mouth, which helps them grow and slows the spread of pathogens. Antimicrobial drugs target and kill only harmful microorganisms, lowering the number of bacteria and stopping biofilms from forming. Another new approach is phage treatment, which uses bacteriophages to kill only harmful bacteria while keeping the good bacteria in the environment. Phages can be used instead of standard antibiotics, especially as bacteria become more resistant to antibiotics. In the end, changing the oral microbiome for medicinal purposes could help avoid and treat oral illnesses. Probiotics, prebiotics, antimicrobial drugs, phage treatment, and host immune modulation techniques are all ways to restore a healthy balance of microorganisms in the oral area. More study and development in this area could change the way people take care of their teeth and make it easier to treat oral illnesses.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129546823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meconium Aspiration Syndrome: Analysis of Case Report","authors":"M. Akram Ali S., R. H., R. S., T. Mf, Porkodi M., V. S","doi":"10.46610/japp.2023.v05i01.004","DOIUrl":"https://doi.org/10.46610/japp.2023.v05i01.004","url":null,"abstract":"Introduction: The first stool of a newborn child is meconium. Meconium is a sticky material composed of denuded intestinal epithelium cells, bile acid, amniotic fluid, swallowed lanugo hair, digestive enzymes, water and mucus. Post-term infants are more likely to have meconium-stained amniotic fluid (MSAF). Meconium aspiration syndrome, a leading cause of severe illness and death in newborns, occurs in about 5 per cent to 10 per cent of births. Case study: A newborn male baby was admitted to the Neonatal Care Unit with the chief complaints of Term, vacuum extraction and thick MSAF and Respiratory Distress skin colour was found to be dark green in the chest and dorsal limb of the body. Breath sound was found to be abnormal with grunting sounds on examination with a stethoscope. The patient’s Clinical symptoms include the appearance of skin colour, and breath sound and Chest radiography shows the diagnosis of Meconium Aspiration Syndrome (MAS). The patient was treated with O2 through nasal continuous positive airway pressure, fluid management was based on daily body weight and antibiotics like ampicillin and gentamicin was administered at the time of admission. The Patients caretaker was advised to Kangaroo mother care and direct breastfeeding. Conclusion: Over the years, medication and care for newborns with meconium aspiration have evolved and changed. Prophylactic antibiotic therapy in MAS does not change the prognosis of patients. In newborns with extreme and recurrent hypoxemia caused by MAS, extracorporeal membrane oxygenation (ECMO) has been utilised as a last-resort therapy. Nevertheless, there are still several techniques for preventing and treating meconium aspiration syndrome; therefore research should continue to diminish illness and death caused by Meconium aspiration syndrome.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"257 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114696707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Growth Test in Male Rabbits (Oryctolagus cuniculus) With Variations in The Concentration of Ethanol Extract Terentang (Campnosperma brevipetiolatum Volkens) Stem Barks","authors":"E. Gunawan, Danielda Fransiska Mochta Mano, Krisna Dewi, R. Pratiwi","doi":"10.46610/japp.2022.v04i02.005","DOIUrl":"https://doi.org/10.46610/japp.2022.v04i02.005","url":null,"abstract":"Terentang (Campnosperma brevipetiolatum Volkens) stem bark contains alkaloids, saponins, tannins, and flavonoids that can nourish hair and blacken and clean hair. This study aimed to determine male rabbits' hair growth activity from terentang stem bark extract and the most effective concentration in hair growth. This study used 6 treatments, namely: no treatment, negative control (aqua dest), positive control (Regrou), and terentang stem bark extract with a concentration of 0.5%, 1%, and 5%. Treatment was carried out every day with an application volume of 1 ml for 21 days. Hair length measurements were carried out on the 7th, 14th, and 21st days. Hair weight measurements were carried out on the 22nd day. Data obtained were processed statistically with the one-way ANOVA method. The results of one-way ANOVA statistical analysis showed significant differences in hair growth activity in each treatment with a value of P=<0.00 (P<0.05). Based on the results, it can be concluded that terentang stem bark extract with a concentration of 5% was the most effective concentration in growing hair of male rabbits.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"29 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116349052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piper Betel Leaf Phytochemical Study and Antimicrobial Effect against Clinical Bacterial Isolates","authors":"Reshma Das, P. Pandey, Mahendra Chandravanshi, W. Raja","doi":"10.46610/japp.2022.v04i02.002","DOIUrl":"https://doi.org/10.46610/japp.2022.v04i02.002","url":null,"abstract":"Herbal resources are useful for traditional medicine, folk medicine, modern medicine, nutraceuticals, dietary supplements, pharmaceutical intermediates, and chemical precursors for synthetic drugs. The antibacterial qualities of the leaves of piper betel, also known as paan, have long been employed in Indian traditional medicine. A methanol extract of Piper betel leaves was examined for its ability to inhibit the growth of Bacillus subtilis, Bacillus cereus, Bacillus frimicutes, Escherichia coli, Entrobacter, Klebsiella, and other bacteria (both gram-positive and gram-negative bacteria).The extract of Piper betel leaves also contained proteins, glycosides, alkaloids, flavonoids, terpenoids, tannins, fixed oil, and lipids. The antibacterial activity was evaluated using the agar disc diffusion method. The outcomes shown that the antibacterial properties of Piper betel Linn's limit the growth of microorganisms in a dose-dependent manner. The outcomes demonstrate that the extract from Piper betel possesses antibacterial activity in the tested system. Secondary metabolites are thought to be produced by this plant. The results also imply that favorable results can emerge from habitually using herbs with historical efficacy claims in scientific study.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121146943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Activity Test of Tegari Plant (Dianella Nemorosa Lam.) Root","authors":"Imam Nursyahroni, E. Simaremare, R. Pratiwi, Nur Fadilah Bakri","doi":"10.46610/japp.2022.v04i02.001","DOIUrl":"https://doi.org/10.46610/japp.2022.v04i02.001","url":null,"abstract":"Tegari plants (Dianella nemorosa Lam) from the Liliaceae family are used in several areas as a medicine traditional at the Tepin community in Sorong and Tablanusu in the Depapre Jayapura District, Papua. This plant is used by the community to cure various diseases such as pneumonia, cancer, internal and external wound healing, also antiseptic to asthma. This objective of this work is to estimate the antioxidant potential and IC50 level of the root extract and fraction. Sampling was carried out in the Dormena Village, Depapre District, Jayapura Regency. A yield of 16.28 percent was achieved from the extraction utilizing the maceration process and a solvent of 96 percent ethanol. Additionally, n-hexane, ethyl acetate, and ethanol were used as solvents for fractionation, and the extracts and fractions were then subjected to preliminary phytochemical. Using the DPPH assay (1.1-diphenyl-2-picryl-hydrazil), test concentrations of 5, 10, 15, 20, and 25 ppm were used to determine each fraction's antioxidant activity. Vitamin C was the positive control that was employed. The Tegari root included flavonoids, alkaloids, saponins, tannins, and terpenoids according to the results of the phytochemical screening. The Tegari plant exhibited a very high potential for antioxidant properties, according the findings of the antioxidant activity test.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115143876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of Nootropic Drugs with Neurotransmitter Enzyme Acetylcholinesterase: An Insilico Approach: A Review","authors":"Kashif Abbas","doi":"10.46610/japp.2021.v03i02.005","DOIUrl":"https://doi.org/10.46610/japp.2021.v03i02.005","url":null,"abstract":"Nootropic drugs are the class of drugs or supplements that are claimed to enhance cognitive functions, specifically executive functions, memory and creativity in healthy individual. They are sometime referred as cognitive enhancers or smart drugs as they are associated with memory improvement functioning. Some of them are well known drugs and clinically approved by the Food and Drug Administration (FDA). All metabolic reactions are purely dependent on enzymatic actions as they play a very important role in regulating and maintaining most of the biological responses and various processes. An enzyme Acetylcholinesterase (AChE) seems to play an essential role in the conduction of cholinergic brain synapses and neuromuscular junctions. There have been different nootropic drugs identified and approved for curing neurodegenerative disorders such as Alzheimer, Parkinson and Huntington's disease. Their binding efficiency and energy have been well studied an established by using the in-silico docking tools. There are different docking tools available today for analysis of molecules such as PyRx, Auto dock and schrodinger suite. The advent of these tools is being widely used by the pharmaceutical industries for the virtual screening of the formulated drugs against the desired target molecule. It has made the drug formulation process more time efficient and cost effective. Thus, an in-silico approach has been widely accepted for drug discovery and its design.","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133892217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review Article on Pharmacologic Evaluation, Botanical report and Calming uses of Dioscorea bulbifera Linn. and Dioscorea pentaphylla Linn.","authors":"Suhan Moholkar, Shubham Suryawanshi, A. Raut","doi":"10.46610/JAPP.2021.V03I02.001","DOIUrl":"https://doi.org/10.46610/JAPP.2021.V03I02.001","url":null,"abstract":"The present-day investigation focuses on the Pharmacologic revision of the climbers of D. bulbifera L &. D. pentaphylla L. (Dioscoreaceae). Climbers have been deliberate from diverse angles of morphological and, residue scrutiny, and extractive standards. Morphological analysis discovered nature, dimensions, aroma and flavour of tubers. The genus Dioscorea have its place to the family Dioscoreaceae, universally recognized as yam, consist of nearly 600 sps. Scattered all over the earth realm, but customarily in steamy section. Most sps. encompass steroid saponins and correspondingly sapogenins, such as diosgenin, which is preparatory quantifiable for blend of various steroidal hormones castoff as anti-inflammatory, androgenic estrogenic and contraceptive drugs. Associates of the genre Dioscorea are one of ancient tuber crop cultured or garnered from uninhabited in steamy constituency all over earth realm and set up one of the key food element for various indigenous groups. Genus is reflected to be amid the most primeval angiosperms and was recognized to occur and broaden the horizons nearly 75 M. Yrs. past in segments of southern celestial-sphere at the termination of the cretaceous period","PeriodicalId":351381,"journal":{"name":"Journal of Advances in Pharmacy Practices","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128856305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}