Trends in Oncology最新文献

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Tumor-associated Macrophages (TAMs) is an Available Biotarget for Therapeutic of Hepatocellular Carcinoma 肿瘤相关巨噬细胞(TAMs)是治疗肝细胞癌的有效生物靶点
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0301-6
M. Zhang, Xue Shan, Haifeng Lin, Mingyue Zhu, Mengsen Li
{"title":"Tumor-associated Macrophages (TAMs) is an Available Biotarget for Therapeutic of Hepatocellular Carcinoma","authors":"M. Zhang, Xue Shan, Haifeng Lin, Mingyue Zhu, Mengsen Li","doi":"10.37155/2717-5278-0301-6","DOIUrl":"https://doi.org/10.37155/2717-5278-0301-6","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128724884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Paradigm of T Cells in Shaping Tumor Microenvironment T细胞在塑造肿瘤微环境中的范式
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0202-2
Dia Roy, S. Bose, S. Dutta, G. Sa
{"title":"The Paradigm of T Cells in Shaping Tumor Microenvironment","authors":"Dia Roy, S. Bose, S. Dutta, G. Sa","doi":"10.37155/2717-5278-0202-2","DOIUrl":"https://doi.org/10.37155/2717-5278-0202-2","url":null,"abstract":"The infiltration of immune cells in the tumor micro-environment is well-documented in cancer patients and the resultant complex interactions are determinants of disease prognosis. Consequently, a proper understanding of this interplay is essential for the development and advancement of therapeutic strategies as well as novel prognostic markers. The co-existence of immune cells with the tumor is often accompanied by an impaired immune response that creates a tumor-promoting micro-environment. T-cell mediated immunity forms the major branch of the immune system that is required to mount an effective response against nascent tumors. Major research in the last few decades indicates that a potent source of immunosuppressive cellular and molecular networks prevailing at the site of tumor is mediated by dysfunctional and defective responses mediated by T cell thereby redirecting and reshaping the destiny of T cell and promoting tumor progression. In this review, we aim to summarize the breakthrough advances in recent years that help us gain a better understanding of the immunosuppressive networks resulting from T-cell anergy, exhaustion, senescence and presence of Treg cells in the tumor micro-environment. We also focus on recent discoveries regarding advance in the Th17 balance, polyfunctionality of T cells as well as T cell stemness that improve our perception of the tumor-immunity interactions. We try to emphasize how such information has an impact on therapeutic development and the clinical outcome of the patients.","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131885003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Biomarkers in Patients with Renal Cell Carcinoma: Where are We Going from Here? 肾细胞癌患者的预后生物标志物:我们将从这里走向何方?
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0301-1
G. Aurilio, M. Santoni, A. Cimadamore, E. Verri, R. Montironi
{"title":"Prognostic Biomarkers in Patients with Renal Cell Carcinoma: Where are We Going from Here?","authors":"G. Aurilio, M. Santoni, A. Cimadamore, E. Verri, R. Montironi","doi":"10.37155/2717-5278-0301-1","DOIUrl":"https://doi.org/10.37155/2717-5278-0301-1","url":null,"abstract":"Treatment algorithm in metastatic renal cell carcinoma (RCC) patients has rapidly evolved during the last decade, and determining the prognosis of these patients has become a priority step for correctly planning the treatment. In the present article, we firstly address the most currently used prognostic models and how they have changed the treatment algorithm in routine clinical care; then we assess whether patient selection may be improved in the firstline treatment and the usefulness of a prognostic model following first-line failure; ultimately we culminate in new clinical and molecular prognostic factors under investigation. For this last issue, biomarkers for immunotherapy and angiogenesis inhibitors, as well as biomarkers for liquid analysis and for clinical obesity are presented.","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125147554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Microbiota: The Servant of Human Being and the Accessary of Tumorigenesis 肠道微生物群:人类的仆人和肿瘤发生的助手
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0301-5
Pan Gu, Di Li, Gang Xu, Yingnan Sun, Minghua Wu
{"title":"Gut Microbiota: The Servant of Human Being and the Accessary of Tumorigenesis","authors":"Pan Gu, Di Li, Gang Xu, Yingnan Sun, Minghua Wu","doi":"10.37155/2717-5278-0301-5","DOIUrl":"https://doi.org/10.37155/2717-5278-0301-5","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122631498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Analysis of Areola Small Incision Surgery for Benign Breast Tumors 乳晕小切口手术治疗乳腺良性肿瘤的临床分析
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-2021-03-02-3
Stephan Ohlinger
{"title":"Clinical Analysis of Areola Small Incision Surgery for Benign Breast Tumors","authors":"Stephan Ohlinger","doi":"10.37155/2717-5278-2021-03-02-3","DOIUrl":"https://doi.org/10.37155/2717-5278-2021-03-02-3","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126430750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Hp Infection with Clinicopathological Features, Tumor Markers, Oncogene Expression in Patients with Gastric Cancer Hp感染与胃癌患者临床病理特征、肿瘤标志物、癌基因表达的关系
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-2021-03-02-5
Jonathan Yeoh
{"title":"Correlation between Hp Infection with Clinicopathological Features, Tumor Markers, Oncogene Expression in Patients with Gastric Cancer","authors":"Jonathan Yeoh","doi":"10.37155/2717-5278-2021-03-02-5","DOIUrl":"https://doi.org/10.37155/2717-5278-2021-03-02-5","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122699141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Balanced Analgesia with Sufentanil and Flurbiprofen Axetil in Patients with Cervical Cancer after Open Surgery 舒芬太尼与氟比洛芬酯平衡镇痛在宫颈癌开放手术后的疗效观察
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-2021-03-02-4
Tian Dong
{"title":"The Effect of Balanced Analgesia with Sufentanil and Flurbiprofen Axetil in Patients with Cervical Cancer after Open Surgery","authors":"Tian Dong","doi":"10.37155/2717-5278-2021-03-02-4","DOIUrl":"https://doi.org/10.37155/2717-5278-2021-03-02-4","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124874623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Cetuximab Re-introduction and Re-challenge in Later Lines of Treatment in Metastatic Colorectal Cancer: A Case Series 西妥昔单抗在转移性结直肠癌后期治疗中的作用:一个病例系列
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0202-4
A. Shaaban, A. Mohanty, Yousef Abo Eseud, J. Albarrak
{"title":"Role of Cetuximab Re-introduction and Re-challenge in Later Lines of Treatment in Metastatic Colorectal Cancer: A Case Series","authors":"A. Shaaban, A. Mohanty, Yousef Abo Eseud, J. Albarrak","doi":"10.37155/2717-5278-0202-4","DOIUrl":"https://doi.org/10.37155/2717-5278-0202-4","url":null,"abstract":"Colorectal cancer (CRC) is the third-largest cancer in the world and has the second-highest mortality rate, characterized by poor prognosis and high metastasis. The early symptoms of CRC are mostly inconspicuous and it is usually diagnosed in the advanced stages. Nearly half of the patients diagnosed with metastatic colorectal cancer (mCRC) are inoperable and have high chances of recurrence and metastasis. Combination therapy with cetuximab and chemotherapy is considered the first-line treatment for mCRC. In patients with Kirsten RAt Sarcoma wild-type mCRC, re-challenge and maintenance therapy with cetuximab was found to be beneficial. However, the disease progression is inevitable. This paper discusses three different cases of metastatic adenocarcinoma in the colon and rectum treated with the re-introduction and re-challenge of cetuximab in combination with chemotherapy. The treatment was found to be effective in treating mCRC in later lines of therapy where treatment options are scarce.","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"83 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131010841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Use or not to Use Anticoagulation in Patients with Advanced Malignancies? – This is the Question 晚期恶性肿瘤患者使用或不使用抗凝?-这就是问题所在
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0202-3
K. Rygiel
{"title":"To Use or not to Use Anticoagulation in Patients with Advanced Malignancies? – This is the Question","authors":"K. Rygiel","doi":"10.37155/2717-5278-0202-3","DOIUrl":"https://doi.org/10.37155/2717-5278-0202-3","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128112899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Approaches for T Cell Immunomodulation T细胞免疫调节的新途径
Trends in Oncology Pub Date : 1900-01-01 DOI: 10.37155/2717-5278-0301-3
E. Bahattab, Khalid Shah, M. Fallatah
{"title":"New Approaches for T Cell Immunomodulation","authors":"E. Bahattab, Khalid Shah, M. Fallatah","doi":"10.37155/2717-5278-0301-3","DOIUrl":"https://doi.org/10.37155/2717-5278-0301-3","url":null,"abstract":"","PeriodicalId":348972,"journal":{"name":"Trends in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114786140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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