Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.oa4857

Laura Saunders, Guilhem Collier, Ho-Fung Chan, Paul Hughes, Laurie Smith, Helen Marshall, Martin Brook, Alberto Biancardi, Madhwesha Rao, Graham Norquay, Neil Stewart, James Grist, Kher Lik Ng, Amanda Goodwin, Jonathan Brooke, Galina Pavlovskaya, Iain Stewart, Andrew Swift, Smitha Rajaram, Phil Molyneaux, Kevin Johnson, Joseph Jacob, Fergus Gleeson, Ian Hall, Thomas Meersmann, Ling-Pei Ho, A A Roger Thompson, Gisli Jenkins, Jim Wild

{"title":"Impaired xenon gas transfer observed two years after COVID-19 hospitalisation in patients with signs of interstitial lung disease","authors":"Laura Saunders, Guilhem Collier, Ho-Fung Chan, Paul Hughes, Laurie Smith, Helen Marshall, Martin Brook, Alberto Biancardi, Madhwesha Rao, Graham Norquay, Neil Stewart, James Grist, Kher Lik Ng, Amanda Goodwin, Jonathan Brooke, Galina Pavlovskaya, Iain Stewart, Andrew Swift, Smitha Rajaram, Phil Molyneaux, Kevin Johnson, Joseph Jacob, Fergus Gleeson, Ian Hall, Thomas Meersmann, Ling-Pei Ho, A A Roger Thompson, Gisli Jenkins, Jim Wild","doi":"10.1183/13993003.congress-2023.oa4857","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.oa4857","url":null,"abstract":"Introduction: Interstitial lung changes persist in some patients after COVID-19 hospitalisation. Aim: To characterise longitudinal pulmonary changes due to COVID-19 using 129Xe and 1H MRI. Methods: Patients with abnormal CT or 1H MRI underwent MRI and PFTs up to 106 weeks after hospitalisation. MRI protocol: 129Xe gas transfer (key metric: red blood cell to membrane fraction, RBC:M), 129Xe ventilation, lung perfusion and structural imaging. Longitudinal comparisons (24 vs 52 weeks) and correlations were assessed using Wilcoxon Signed Rank and Spearman9s rank. Results: 23 patients (median age: 68(range: 53-78) years, 87% male) underwent MRI at 23(6-33)(n=13), 54(42-71)(n=18) and 106(98-117)(n=7) weeks after hospital admission. Patients had decreased RBC: M compared to older controls and low transfer factor Z-score at 24, 52 and 106 weeks (median TLCOz<-2.2 at all visits). Ventilation defect percentage was <6% for all patients. There was no longitudinal change (n=8) in 129Xe gas transfer or TLCOz between 24 and 52 weeks. There was a significant decrease in FEV1/FVC Z-score and an increase in FVC Z-score (p=0.018; p=0.043). At 24 and 52 weeks, RBC:M correlated with TLCOz (r=0.661, p=0.038; r=0.709, p=0.015). Conclusion: Xenon gas transfer remains impaired two years post hospitalisation in this cohort. Fig 1: RBC:M alongside healthy control data (57(41-68)years, 67% male).","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136201024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of HRCT and SPECT in the estimation of emphysema heterogeneity for endoscopic lung volume reduction HRCT与SPECT在内镜下肺减容诊断肺气肿异质性中的比较

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa4002

Tim Jonas Hallenberger, Meropi Karakioulaki, Desiree Schumann, Michael Tamm, Daiana Stolz, Eleni Papakonstantinou

{"title":"Comparison of HRCT and SPECT in the estimation of emphysema heterogeneity for endoscopic lung volume reduction","authors":"Tim Jonas Hallenberger, Meropi Karakioulaki, Desiree Schumann, Michael Tamm, Daiana Stolz, Eleni Papakonstantinou","doi":"10.1183/13993003.congress-2023.pa4002","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa4002","url":null,"abstract":"Introduction: Lung volume reduction (LVR) is a therapeutic option for patients with advanced heterogeneous lung emphysema in COPD. We compared the extent of emphysema as assessed by two current standard methods: high-resolution computed tomography (HRCT) analysed by StratX® software and single photon emission computed tomography (SPECT).   Method: Patients evaluated for LVR were considered for inclusion. The primary endpoint was the qualitative and quantitative discordance on the extent of tissue destruction per lobe as assessed by perfusion (SPECT) and voxel density (StratX®). Secondary outcomes were the evaluation of fissure completeness by StratX® and an improvement in lung function test (LFT) after LVR. Results: We included 164 patients in this study. Qualitative discordance occurred in 29.3% patients, mainly in the RUL and was more severely rated by SPECT. Quantitative discordance was highest in the RUL (20.16±35.49%). The highest fissure completeness was measured between the LUL and LLL (91.61±12.46%). After LVR, there was a significant improvement in RV, TLC and FEV1 (all p<0.001) and in 50% of patients there was a significant improvement in at least one LFT parameter. However, seven patients showed no improvement in any LFT parameter.   Conclusion: In this study we demonstrated that there is a discordance regarding the estimation of emphysema extent in at least one lobe in one third of patients evaluated for LVR with SPECT and HRCT/StratX®. Our results warrant direct comparison of SPECT and StratX® in terms of preoperative evaluation in a randomized controlled trial.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136201532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in lung volumes during bronchoalveolar lavage according to bedside position. Case Series 支气管肺泡灌洗时肺容量随床位的变化。案例系列

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa3540

Ignacio Fernández Ceballos, Julieta Gonzalez Anaya, Juan Martín Nuñez Silveira, Emilio Steinberg, Leiniker Navarro Rey, Gabriel Elias Vega, Ivan Huespe, Indalecio Carboni Bisso, Marcos Las Heras, Rodriogo Cornejo

{"title":"Changes in lung volumes during bronchoalveolar lavage according to bedside position. Case Series","authors":"Ignacio Fernández Ceballos, Julieta Gonzalez Anaya, Juan Martín Nuñez Silveira, Emilio Steinberg, Leiniker Navarro Rey, Gabriel Elias Vega, Ivan Huespe, Indalecio Carboni Bisso, Marcos Las Heras, Rodriogo Cornejo","doi":"10.1183/13993003.congress-2023.pa3540","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3540","url":null,"abstract":"Introduction: Bronchoalveolar lavage (BAL) is used in the diagnosis of pneumonia in patients with Mechanical Ventilation. Its performance involves the instillation of saline solution, which is associated with lung collapse and worsening hypoxemia. Positioning the patient9s head at 0° could increase the loss of lung volume and oxygenation. A therapeutic option to mitigate this effect could be to perform this procedure with head elevation at 30°. Aims and Objectives: The study aimed to assess changes in lung volumes in relation to the position of the patient9s head. Methods: Case series of 3 patients. End-expiratory Lung Impedance (EELI) measurements were performed (Pulmovista V500) in the following situations: Head at 30° before BAL, 0° before BAL, 0° post-BAL and 30° post-BAL. Results: In patients 1 and 2, the change of headrest from 30° to 0° before BAL resulted in an overall decrease in EELI (83.1% - 20.2%). Performing BAL increased the drop in EELI, with greater expression in the regions where BAL was performed. After BAL was completed, in both patients, the repositioning of the headrest to 30° produced an increase in global EELI without reaching the values obtained with the headrest at 30° before BAL (Patient 1 80.5% - Patiente 2 52.9%). In patient 3, the change of head position from 30° to 0° after BAL showed a 12.5% decrease in EELI. Performing BAL deepened the drop in overall EELI (-44.4%), as did repositioning the headrest to 30° (-70%) post-BAL. Conclusion: Changes in bedside positioning before BAL resulted in a reduction in EELI in all 3 patients. The repositioning of the head after BAL had a heterogeneous behavior increasing the EELI in patients 1 and 2, and decreasing it in patient 3","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumonectomy in the surgery of pulmonary Hydatid cysts: A therapeutic option that is sometimes unavoidable 肺包虫囊肿手术中的全肺切除术:有时是不可避免的治疗选择

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa3538

Kaouther Ben Amara, Imen Bouassida, wifek SAIDANI, Sarra Zairi, Hazem Zribi, Mehdi Abdennadher, Imen Sahnoun, Adel Marghli, Sarra Zairi

{"title":"Pneumonectomy in the surgery of pulmonary Hydatid cysts: A therapeutic option that is sometimes unavoidable","authors":"Kaouther Ben Amara, Imen Bouassida, wifek SAIDANI, Sarra Zairi, Hazem Zribi, Mehdi Abdennadher, Imen Sahnoun, Adel Marghli, Sarra Zairi","doi":"10.1183/13993003.congress-2023.pa3538","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3538","url":null,"abstract":"Introduction: A parenchyma-saving operation is the rule in the treatment of pulmonary hidatid cyst (PHC). However, pneumonectomy can be necessary in some situations. Material : Retrospective study over a period of 20 years including 5 patients who underwent pneumonectomy for pulmonary hydatidosis. Results: The average age was 45 years old with a female predominance of 80%. Three patients had a history of complicated PHC treated by cystectomy (1 case) and liver hydatid cyst operated on (2 cases). Two patients presented a pulmonary hydatid embolism treated medically (1 case) and surgically (1 case). The main symptoms were chest pain (5 cases), dry cough (5 cases). Chest computed tomography, performed in all patients, revealed voluminous fluid tone masses, homogeneous well limited, occupying one lobe (1 cases), two lobes (2 cases) and three lobes (2 cases) with pulmonary hydatid embolism in two cases. Four patients had pneumonectomy for a destroyed hepatized lung and one patient a totalisation pneumonectomy, through a posterolateral thoracotomy in all cases. The mean duration of postoperative drainage was 3 days. The histological study confirmed the diagnosis. The postoperative course was simple for 3 patients. Two postoperative complications were reported: Cardiac arrythmia and postoperative pneumonia. Conclusion : In pulmonary hydatidosis surgery, lung tissue should be preserved and resection should be avoided whenever it is possible. However, Pulmonary resection becomes unavoidable if irreversible changes have occurred throughout the lung and a large amount of parenchyma is attached to the cyst. This highlights the importance of rigourous prophylaxis and early diagnosis.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"368 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observer agreement in the diagnosis of interstitial lung diseases 间质性肺疾病诊断的观察者一致

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa4012

Rebecca Saray Marchesini Stival, Bruno Pedrazzani, Ariele Haagsma, Cristina Pellegrino Baena

{"title":"Observer agreement in the diagnosis of interstitial lung diseases","authors":"Rebecca Saray Marchesini Stival, Bruno Pedrazzani, Ariele Haagsma, Cristina Pellegrino Baena","doi":"10.1183/13993003.congress-2023.pa4012","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa4012","url":null,"abstract":"Introduction: The density of radiologists per inhabitant is 7.5/100 thousand in the United Kingdom; in Brazil, it is 6.2, and in some areas, 1.5. Thoracic Radiologists are even scarcer. Pulmonologists frequently diagnose features associated with pulmonary fibrosis. Objective: To determine the interobserver agreement in diagnosing features associated with interstitial lung diseases. Methods: 63 chest CTs of covid-19 outpatients discharged from public hospitals of Curitiba/PR/Brazil from June 2020 to December 2021 were evaluated by an experienced pulmonologist and a thoracic radiologist. Each chest CT was assessed for the following characteristics: presence or absence of traction bronchiectasis and parenchymal bands in any lung lobe, independent of the severity, and qualitative visual evaluation was used to determine the extension of GGO, characterized: mild (1%–24%), moderate (25%–49%), severe (50–74%); very severe (≥ 75%). In addition, interobserver agreement for two observers in overall image quality or CT features was determined for a nonparametric Cohen´s Kappa test. Results: Traction bronchiectasis was identified for the thoracic radiologist in 14 (22.2%) and parenchymal bands in 38 (60.3%) CT, for the pulmonologist in 9 (14.3%), 32 (50.8%), respectively. The kappa agreement of traction bronchiectasis between professionals was 0,632 (p=<0.001), interpreted as substantial, for parenchymal bands was k=0.49 (p<0.001), with a moderate agreement. On the Other hand, extension GGO had no agreement (k=0.221; p= 0.001). Conclusions: Interobserver agreement in the diagnosis of traction bronchiectasis, the main feature associated with pulmonary fibrosis, was substantial.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic modeling in idiopathic pulmonary fibrosis using deep learning 基于深度学习的特发性肺纤维化预后建模

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.oa4851

Neha Anegondi, Yixuan Zou, Xuefeng Hou, Mohammadreza Negahdar, Dorothy Cheung, Paula Belloni, Alex De Crespigny, Alexandre Fernandez Coimbra

{"title":"Prognostic modeling in idiopathic pulmonary fibrosis using deep learning","authors":"Neha Anegondi, Yixuan Zou, Xuefeng Hou, Mohammadreza Negahdar, Dorothy Cheung, Paula Belloni, Alex De Crespigny, Alexandre Fernandez Coimbra","doi":"10.1183/13993003.congress-2023.oa4851","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.oa4851","url":null,"abstract":"Introduction: Idiopathic pulmonary fibrosis (IPF) results in lung function decline. Prognostic models that accurately predict IPF progression could inform research studies and clinical care. Objectives: To develop deep learning (DL) models to predict IPF progression using baseline high-resolution computed tomography (HRCT). Methods: Retrospective analysis was performed on IPF patients enrolled in clinical trials (NCT01872689, NCT00287729, NCT01366209). Only baseline visit HRCT (non-contrast, supine position, full inspiration) were included in the analysis. The image dataset was split into training (n = 274) and holdout (n = 117). The training dataset was then split into 5 folds for cross-validation (CV). Two multi-task DL models [HRCT-only and multi-modal (HRCT and baseline clinical features)] were trained to simultaneously predict 3 endpoints: FVC at 1 year (mL), FVC change at 1 year (mL) and FVC slope (mL/year). The performance of the DL models were benchmarked with a linear model using baseline clinical features and evaluated using squared Pearson correlation coefficient (r2). Results: The multi-modal model had the best CV performance on training set with mean r2 of 0.87, 0.13, and 0.14 for FVC at 1 year, FVC change at 1 year, and FVC slope. On the holdout set, the same model showed r2 of 0.88, 0.11, and 0.12. In comparison, the benchmark model had a mean r2 of 0.85, 0.05, and 0.05 on the training set and 0.89, 0.04, and 0.04 on the holdout set, respectively, for the 3 endpoints. Conclusion: HRCT scans add marginal value to baseline clinical features in predicting IPF progression. Further work is required to improve the performance of the current models for potential use in research studies and clinical care.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comparison of quantitative CT features of COPD and pre-COPD: results from a real-life study COPD与COPD前期的定量CT特征比较:来自现实生活研究的结果

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa2282

Selin Ercan, Aylin Ozgen Alpaydin, Ali Canturk, Emre Ruhat Avci, Saliha Selin Ozuygur Ermis, Gozde Tokatli, Gökçen Ömeroglu Simsek, Pinar Balci, Naciye Sinem Gezer

{"title":"The comparison of quantitative CT features of COPD and pre-COPD: results from a real-life study","authors":"Selin Ercan, Aylin Ozgen Alpaydin, Ali Canturk, Emre Ruhat Avci, Saliha Selin Ozuygur Ermis, Gozde Tokatli, Gökçen Ömeroglu Simsek, Pinar Balci, Naciye Sinem Gezer","doi":"10.1183/13993003.congress-2023.pa2282","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2282","url":null,"abstract":"Background: Although fixed airway obstruction on spirometry is crucial for COPD diagnosis, it might be insufficient to identify subjects with pre-COPD. Quantitative computerized tomography (CT) measurements might be helpful to distinguish the subjects with pre-COPD. Thus, we aimed to compare quantitative CT findings of subjects with pre-COPD and COPD. Methods: Subjects who were admitted to our clinic with chronic respiratory symptoms and were evaluated for COPD as a pre-diagnosis were included in the study. Subjects were categorized as COPD and pre-COPD groups according to the FEV1/FVC ratio. Thorax CT voxel-based attenuation analysis was performed by Myrian® Expert software(Intrasense SA-1231, Montpellier, France). Attenuation values lower than -950 Hounsfield Units (HU) were defined as emphysema. Results: Of 163, 106 COPD and 57 pre-COPD cases were included. COPD group had significantly higher lung volume (5683 ml vs 4921 ml, p=0.001) and lower mean attenuation value (-830.0 HU vs -808.2 HU, p<0.001) than the pre-COPD group. Moreover, the COPD group had a higher emphysema percentage than the pre-COPD group (3.87% vs 0.28%, p<0.001). Conclusion: Quantitative CT of pre-COPD demonstrated radiologic findings that might help to corroborate COPD diagnosis, which was also associated with the severity of the airflow obstruction and be an alternative method for COPD diagnosis when it is difficult to reach spirometry.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased volume of pulmonary veins on CT associates independently with higher mortality in smokers with and without COPD CT上肺静脉体积增大与有或无COPD的吸烟者较高的死亡率独立相关

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa2280

Tjeerd van der Veer, Anastasia Kimberley Ay-Lan Kwee, Leticia Gallardo Estrella, Elrozy R. Andrinopoulou, Jean Paul Charbonnier, Stephen M. Humphries, Pim A. De Jong, David A. Lynch, Harm A. W. M. Tiddens, Esther Pompe

{"title":"Increased volume of pulmonary veins on CT associates independently with higher mortality in smokers with and without COPD","authors":"Tjeerd van der Veer, Anastasia Kimberley Ay-Lan Kwee, Leticia Gallardo Estrella, Elrozy R. Andrinopoulou, Jean Paul Charbonnier, Stephen M. Humphries, Pim A. De Jong, David A. Lynch, Harm A. W. M. Tiddens, Esther Pompe","doi":"10.1183/13993003.congress-2023.pa2280","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2280","url":null,"abstract":"Aims: Subclinical heart failure may lead to congestion in the pulmonary veins and increased mortality. Aim: To determine the association of pulmonary vein volume with all-cause mortality in smokers with and without COPD. Methods: The artery-vein phenotyping analysis (AVX) was performed using the AI-based lung quantification platform LungQ (Thirona, The Netherlands). AVX quantified total volume of small (diameter <2mm; AVXSV) and large (≥2mm; AVXLV) pulmonary veins on CT in 7903 participants of the COPDGene study, normalized for body height. Cox regression analysis was used to analyze associations between AVXSV and AVXLV scores and mortality. Corrections were made for age, sex, BMI, FEV1%predicted, mMRC, 6MWT, smoking status, emphysema, airway wall thickness, coronary artery calcium score, severe exacerbations, and scanner model. Results: Mean age was 60.1±9.0 years; 3594 (45.5%) subjects had COPD. AVXSV was 82.3±13.3 mm3/cm; AVXLV 178.2±53.1 mm3/cm. Higher AVXSV and AVXLV were both associated with higher mortality, HR 1.57 (CI 1.31-1.88) and HR 1.07 (CI 1.01-1.13) per 50 mm3/cm, respectively. Conclusions: Increased pulmonary venous volume is associated with a higher mortality in smokers with and without COPD, independent of emphysema and coronary artery calcium score, and may be a marker of volume redistribution as a result of heart failure.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136195207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioradiomic SPECT-CT quantification of active lung inflammation is influenced by heterogeneity of lung tissue 活动性肺炎症的生物放射学SPECT-CT定量受肺组织异质性的影响

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa2294

Benjamin Welham, Michael Bennett, Kristoffer Ostridge, Matthew Guy, Clint Zvavamwe, Francis Sundram, Tom Wilkinson

{"title":"Bioradiomic SPECT-CT quantification of active lung inflammation is influenced by heterogeneity of lung tissue","authors":"Benjamin Welham, Michael Bennett, Kristoffer Ostridge, Matthew Guy, Clint Zvavamwe, Francis Sundram, Tom Wilkinson","doi":"10.1183/13993003.congress-2023.pa2294","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2294","url":null,"abstract":"Introduction: COPD is a heterogenous disease. Molecular imaging of inflammation could define endotypes, but heterogeneity of lung structure complicates this process. We aimed to develop methods to quantify inflammatory cytokines in heterogenous lung tissue as potential targets for therapy. Methods: Using SPECT-CT imaging, we developed techniques to quantify cytokine activity. Five patients with COPD and 5 healthy volunteers were recruited under ethically approved informed consent. They underwent SPECT-CT of the lungs at 6 (+/- 1) and 24 (+/- 4) hours after infusion of 99mTc-anti-TNF-α to quantify TNF-α activity in the lungs. Quantification was normalised to aortic arch signal to account for biological clearance. Results: Median normalised SPECT counts (CN) were higher in the healthy group at both time points. Strong correlations were seen between CN and both blood vessel density and emphysema quantification (figure 1). A regression model to correct for emphysema revealed higher CN at both time points in the COPD group, but differences were not statistically significant. Conclusions: Molecular imaging of inflammatory cytokines is affected by key confounding factors, and analysis techniques should account for structural heterogeneity.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136200706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of FDG uptake in nodes of IPF patients undergoing PET imaging 经PET显像的IPF患者淋巴结FDG摄取的意义

Imaging Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa4008

Jagdeep Sahota, Balaji Ganeshan, Thida Win, Francesco Fraioli, Raymondo Endozo, Robert Shortman, Ashley M Groves, Joanna C Porter

{"title":"Significance of FDG uptake in nodes of IPF patients undergoing PET imaging","authors":"Jagdeep Sahota, Balaji Ganeshan, Thida Win, Francesco Fraioli, Raymondo Endozo, Robert Shortman, Ashley M Groves, Joanna C Porter","doi":"10.1183/13993003.congress-2023.pa4008","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa4008","url":null,"abstract":"Introduction: Mediastinal lymphadenopathy is a common feature in patients with IPF. We investigated the relationship between node avidity and survival. Aim: To assess the significance of FDG uptake in nodes of IPF patients undergoing PET imaging. Materials and Methods: 92 IPF patients were recruited prospectively. Mediastinal nodal FDG uptake was measured as SUVmax, SUVmin, and TBR (SUVmax/SUVmin). Kaplan Meier survival analysis was used to investigate overall survival between avid and non-avid node cohorts. Correlation between nodal uptake and Neutrophil lymphocyte ratio (NLR) was assessed using Pearson non-parametric Spearman’s rank correlation. Results: Of 92 IPF patients, 83 had enlarged lymph nodes and 65 were avid. Patients with avid lymphadenopathy had poorer survival compared to the rest at 50 months (p=0.454). Using a median value as a cut-off, TBR ≥1.72 was significantly associated with poorer outcome (p=0.05). Using an optimal value as a cut-off, SUVmax ≥3.68 were significantly associated with poorer outcome (p=0.033). FDG avidity (SUVmax and TBR) in the nodes correlated with NLR (p=0.033 and 0.041 respectively). Conclusion: Increased FDG avidity in the mediastinal nodes of IPF patients is associated with poorer outcome. Nodal activity correlated with NLR.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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