Clinical Trials in Orthopedic Disorders最新文献

{"title":"Poncet′s disease (tubercular rheumatism): a narrative review","authors":"G. Dharmshaktu","doi":"10.4103/2542-4157.305396","DOIUrl":"https://doi.org/10.4103/2542-4157.305396","url":null,"abstract":"Poncet′s disease or tubercular rheumatism is uncommon, and there are not many related studies. No consensus has been achieved with respect to its etiopathogenesis. The low prevalence of this Poncet′s disease even in endemic regions suggests hidden mechanisms that require further research to fully comprehend this enigmatic disorder. Careful identification of primary focus of tubercular infection, clinical suspicion and knowledge of this disorder is crucial for prompt identification and treatment. This article aims to provide an overview of the recently published articles about Poncet′s disease. The article attempts to highlight key features of the disease for better understanding of this peculiar disorder.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"96 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125984786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and prognosis of transforaminal endoscopy in the treatment of lumbar disc herniation in patients infected with human immunodeficiency virus: a nonrandomized, controlled, 2-year follow-up clinical study","authors":"Ming Lu, Chun-hong Wang, Min Li, T. Luo, Yong-Sui Lin, Weili Zhou, Bao Sha, Ming-xin Wang, Deqiang Meng, Zhenpu Gao, Guangling Yang, Xing-Cheng Zhao, Qiu Chen","doi":"10.4103/2542-4157.298830","DOIUrl":"https://doi.org/10.4103/2542-4157.298830","url":null,"abstract":"Background and objective: Transforaminal endoscopy has certain advantages over traditional surgeries (e.g., intervertebral disc fusion) in the treatment of lumbar disc herniation, as it is associated with minimal trauma, clear surgical vision, and lower degree of bleeding. However, the therapeutic effects of transforaminal endoscopy on lumbar disc herniation in human immunodeficiency virus (HIV)-infected patients are poorly understood. The purposes of this study are to indicate the efficacy of transforaminal endoscopy in the treatment of lumber disc herniation in HIV-infected patients and compare the efficacy between transforaminal endoscopy and conventional lumbar disc fusion based on 2-year follow-up and prognosis turnover. Subjects and Methods: This is a prospective, single-center, non-randomized, controlled, 2-year follow-up clinical study. Sixty HIV-infected patients with lumbar disc herniation who will receive treatment in the Shanghai Public Health Clinical Center will be included in this study. These patients will be divided into two groups according to the surgical treatment. Patients in the experimental group (n = 30) will undergo nucleus pulposus enucleation under an intervertebral foramen endoscope, while patients in the control group (n = 30) will undergo intervertebral disc fusion. All patients will be followed up postoperatively at 6, 12, and 24 months. This study was approved by the Institutional Ethics Committee of Shanghai Public Health Clinical Center of China (approval No. [2020]2020-S122-02) on July 28, 2020. All participants will be informed about the study protocol and will be asked to provide written informed consent. This study was designed on November 30, 2018. Patient recruitment will be performed in the period between October 30, 2020 and April 30, 2021. The study outcomes will be analyzed between May 1, 2023 and May 30, 2023. The study will be terminated on June 30, 2023. The primary outcome measure of this study is the change in the symptom improvement rate evaluated by the Japanese Orthopedic Association score at 24 months after the surgery. The secondary outcome measures include the changes in the symptom improvement rate evaluated by the Japanese Orthopedic Association score at 6 and 12 months after the surgery; pain improvement rate evaluated by the Visual Analogue Scale, and improvement in the quality of life evaluated by 36-Item Short Form Health Survey (SF-36) at 6, 12, and 24 months, as well as the recurrence rate of lumbar disc herniation and the incidence of postoperative adverse reactions at 6, 12, and 24 months after the surgery. Results: In our preliminary study ongoing between January 2016 and January 2018, 86 patients were included and divided into two groups, i.e., the experimental group (n = 48; nucleus pulposus enucleation under intervertebral foramen endoscope) and the control group (n = 38; intervertebral disc fusion). Six-month follow-up results revealed that the mortality of the experimental and","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133075094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating periodontal intrabony defects using guided tissue regeneration and Bio-Oss® with platelet-rich fibrin: study protocol for a self-controlled trial","authors":"Kaining Liu, Zhen Huang, Zhi-bin Chen, B. Han, X. Ouyang","doi":"10.4103/2542-4157.289237","DOIUrl":"https://doi.org/10.4103/2542-4157.289237","url":null,"abstract":"Background and objective: Guided tissue regeneration (GTR) has been widely used for periodontal regeneration after intrabony defects, and Bio-Oss® can be used together with GTR for the stability of the space under the GTR membrane. Platelet-rich fibrin (PRF), as a kind of platelet concentrate with rich autologous biologic agent, has been also used to treat periodontal intrabony defects for periodontal regeneration. However, whether PRF can enhance the regenerative effect of GTR and Bio-Oss® is not reported. Subjects and methods: This is a randomized self-controlled trial. Fourteen patients with periodontal intrabony defects who will receive treatment in the Department of Periodontology, Peking University School and Hospital of Stomatology, China will be included in this study. The left or right intrabony defects of each patient will be randomly randomized to a test group and a control group. In the test group, GTR, Bio-Oss® and PRF will be used for the treatment of periodontal intrabony defects. In the control group, GTR and Bio-Oss® will be used for the treatment of periodontal intrabony defects. PRF used in the trial will be liquid PRF, which can form Bio-Oss®-PRF mixture with Bio-Oss®, making the use of PRF easier in periodontal surgery. This study was approved by the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-201629066) on November 4, 2016. Outcome measures: The primary outcome is clinical attachment level, which will be measured at baseline, as well as 6, 12 and 24 months after surgery. The secondary outcomes include (1) depth of intrabony defect, (2) vertical bone loss, (3) probing depth, (4) bleeding index and (5) time of bone graft filling in the surgery. Radiographic evaluation will be accomplished at baseline and at 12 and 24 months after surgery. Probing depth and bleeding index assessments will be performed at baseline, and at 6, 12 and 24 months after surgery. Discussion: If the regenerative effects of GTR, Bio-Oss®, and PRF in combination are superior to those of GTR combined with Bio-Oss®, then the trial results will provide clinical evidence for the treatment of periodontal intrabony defects. Trial registration: Chinese Clinical Trial Registry, ID: ChiCTR1900027581. Registered on November 19, 2019.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131824540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for authors - Clinical Trials in Orthopedic Disorders (CTOD)","authors":"","doi":"10.4103/2542-4157.281594","DOIUrl":"https://doi.org/10.4103/2542-4157.281594","url":null,"abstract":"","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115083322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of three-dimensional printing in spinal surgery","authors":"","doi":"10.4103/2542-4157.281593","DOIUrl":"https://doi.org/10.4103/2542-4157.281593","url":null,"abstract":"Objective: To perform bibliometric analysis of studies on the developing trend of three-dimensional (3D) printing in spinal surgery using the Science Citation Index Expanded via the Web of Science. Methods: The key words were “3D printing, spine.” Web of Science data were retrieved for relevant studies published from 2010 to 2020. A total of 4181 studies were collected for visual analysis. Results and conclusion: From 2010 to 2020, 4181 studies concerning the application of 3D printing in spinal surgery were listed in the Web of Science database. The United States had the largest number of publications (1249 studies), accounting for 29.8% of the total. The institutions with many publications included University of California, University of Montreal, Harvard University, and Johns Hopkins University. The journals publishing the included studies were mainly devoted to spinal surgery. European Spine Journal had the largest number of articles (202), accounting for 4.8% of the total. In the past 10 years, the number of studies regarding the application of 3D printing to spinal surgery worldwide has risen at a slow rate. The studies on the application of 3D printing to spinal surgery have received generous funding, with the United States Department of Health and Human Services as the major source of funding.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133865723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous atraumatic bilateral Achilles tendon tear: surgical reconstruction of flexor hallucis longus graft","authors":"M. Mruthyunjaya, Supreeth Nekkanti, Punith Nanjesh","doi":"10.4103/2542-4157.272835","DOIUrl":"https://doi.org/10.4103/2542-4157.272835","url":null,"abstract":"Background and objective: Spontaneous atraumatic bilateral Achilles tendon tears are very rare. The most common risk factors for sudden bilateral Achilles tendon tears have been attributed to prolonged corticosteroid use. This study aimed to present the efficiency of surgical reconstruction of bilateral flexor hallucis longus graft on spontaneous atraumatic bilateral Achilles tendon tear. Subject and methods: This study reported a 25-year-old male who suffered from spontaneous atraumatic bilateral Achilles tendon tear. The patient was surgically managed by surgical reconstruction of bilateral flexor hallucis longus graft and immobilised with above knee cast in plantarflexion for six weeks. The patient was then subjected to physiotherapy at 6 weeks after surgery. This study was approved by the Institutional Review Board of Jagadguru Sri Shivarathreeshwara Hospital, India. Results: Flexor strength at the time of removal of the cast was 3/5. After graded physiotherapy targeted at calf strengthening, flexor strength improved to 4/5. At the end of one-year follow-up, foot function recovered well. The Leppilahti score was recorded to be 78 for the right calf and 76 for the left calf at the last follow-up. Conclusion: Idiopathic spontaneous bilateral Achilles tendon tear was successfully managed by surgical reconstruction of flexor hallucis longus graft.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123782142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated medial subtalar dislocation: the importance of early mobilization","authors":"Supreeth Nekkanti, A. Siddartha, P. Tushar","doi":"10.4103/2542-4157.272834","DOIUrl":"https://doi.org/10.4103/2542-4157.272834","url":null,"abstract":"Background and objective: Isolated subtalar dislocations are rare injuries. Current studies have reported that it requires 5 or 6 weeks immobilization after the injury. The purpose of this study was to understand the effect of 4-week immobilization on the recovery of foot function after isolated medial subtalar dislocation. Subject and methods: We reported a rare case of an isolated medial subtalar dislocation in a male who was immobilized for only 4 weeks after closed reduction under anesthesia. The patient underwent early mobilization of the feet and ankles. This report has been submitted after due approval from the Institutional Review Board of Jagadguru Sri Shivarathreeshwara Hospital, India. Results: The patient was successfully managed by closed reduction under anesthesia. The foot function of the patient recovered well at 6 months of follow-up. The results of 1-year follow-up showed that the foot function was basically normal. Conclusion: Early closed reduction and early mobilization of the foot and ankle ensured the good functional outcome.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116184464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of different inclination angles on middle deltoid muscle activity in stroke patients with shoulder subluxation: protocol for a cross-sectional study","authors":"Navjyoti Gupta, S. Chatterjee","doi":"10.4103/2542-4157.265974","DOIUrl":"https://doi.org/10.4103/2542-4157.265974","url":null,"abstract":"Background and objective: Glenohumeral subluxation is a common complication that is a palpable gap between the acromion and humeral head and causes mechanical integrity change in the joint. Electromyography is a method used to assess and capture skeletal muscle electrical activity and assess the strength of muscle that controls motor neurons. The objective of this study is to investigate whether different inclination angles influence middle deltoid muscle activity in patients with glenohumeral subluxation. Subjects and methods: It is a cross-sectional study in which 30 stroke patients with shoulder subluxation were included. Recruitment started from September, 2018. The study was completed in July 2019. Uncooperative patients or those who develop reflex sympathetic dystrophy or have psychological problems were excluded from this study. Purposeful sampling was used to collect samples. Glenohumeral subluxation will be assessed. Electromyography surface electrodes will be used to capture the middle deltoid muscle activity. The study is conducted in the Neurophysiology Unit of Neurophysiotherapy Research Lab of the Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation (India). Ethical approval was obtained from Institutional Ethical Committee (IEC) of Maharishi Markandeshwar University (IEC/MMU 2018/1114) on March 24, 2018. Outcome measures: Primary outcome measure is electromyography motor unit action potential parameter. Secondary outcome measures are amplitude, duration, and rise time. Discussion: Results from this study will provide evidence whether patient exercise performance without changing patient position but only adjusting bed/couch angles can improve the motor function of stroke patients. The study findings may help therapists and patients to prescribe exercise in what particular degree to get good results from the therapy. Trial registration: The study was registered with Clinical Trials Registry-India on September 17, 2018 (registration No. CTRI/2018/09/015732).","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129749140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is arthroscopic surgery adequate to treat pigmented villonodular synovitis of the knee joint?","authors":"V. Chandru, Supreeth Nekkanti, R. Madhukesh, Sumit Sudan, M. Rishikesh","doi":"10.4103/2542-4157.265976","DOIUrl":"https://doi.org/10.4103/2542-4157.265976","url":null,"abstract":"Background and objective: Pigmented villonodular synovitis (PVNS) is characterized by inflammation and deposition of hemosiderin in the synovium. There is no clear consensus on the exact treatment protocol of PVNS. This study aimed to understand the effectiveness of arthroscopic surgery for PVNS of the knee joint. Subject and methods: We reported a case of 21-year-old male who presented with a progressive painful diffuse swelling of the knee joint. Radiographic imaging revealed PVNS of the knee which was confirmed by arthroscopy. The patient underwent radiotherapy after arthroscopic surgery for 8 weeks. This study has been submitted after due approval from the institutional review board of Jagadguru Sri Shivarathreeshwara Hospital, India. Results: Patient was followed up for 1 year with no evidence of recurrence. Conclusion: Arthroscopy coupled with postoperative radiotherapy is useful in inhibiting PVNS and preventing its recurrence.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"33 1-2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134483147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors for development of postoperative heterotopic ossification in a high-volume hip arthroscopy practice: A case series","authors":"Thomas W. Smith, A. Ravipati, I. Wong","doi":"10.4103/2542-4157.265973","DOIUrl":"https://doi.org/10.4103/2542-4157.265973","url":null,"abstract":"Background and objective: Heterotopic ossification (HO) is a known complication of hip arthroscopy and may significantly affect the outcomes of patients undergoing hip arthroscopy. Its incidence in the literature varies from 0–44% following hip arthroscopy without prophylaxis. Our primary goal was to find the local rate of HO after hip arthroscopy as determined by the Brooker Classification. Secondary outcomes included determining risk factors for development of HO by sex, age, body mass index, hip pathology and effects on outcome scores. Subjects and methods: Patients who underwent hip arthroscopy by a local high-volume surgeon from July 2012 to June 2015 were reviewed for the presence of pre- and postoperative HO retrospectively. Patients required at least 12 months of postoperative radiographic follow-up with anteroposterior pelvis radiographs. Patients were excluded if they had any other procedure performed at the time of hip arthroscopy or if medical records were not accessible. Radiographs were reviewed for HO according to the Brooker Classification. Demographic data including sex, age, body mass index, presence of labral tear and repair and outcome score were obtained. The incidence of HO and demographic averages were calculated and compared. This study received approval from the Nova Scotia Health Authority (NSHA) Research Ethics Board (REB) (approval No. 1021503) on August 8, 2016. Results: A total of 307 hips met inclusion criteria, 152 females and 155 males. The overall incidence of HO was 23.45% (72 hips). Fifty-six hips (78%) had Brooker class I HO, 13 (18%) hips had Brooker class II HO, and 3 (4%) hips had Brooker class III HO. No specific demographic variables or the pathology were seen to be associated significantly with development of HO. Outcome score differences were not significantly different between the HO and non-HO groups (P = 0.94). Conclusion: The incidence of HO in our series matched the range found in other studies of HO incidence in the literature. The incidence of HO dose not appear to be influenced by demographic variables including sex, age, and body mass index in our study. This data will add to the developing base of literature on HO incidence in hip arthroscopy and will serve as a comparison and benchmark for future study on HO prophylaxis.","PeriodicalId":348394,"journal":{"name":"Clinical Trials in Orthopedic Disorders","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130599193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}