Journal of Psychedelic Studies最新文献

{"title":"A pilot study of the effect of group-administered psilocybin on psychological flexibility and outcomes","authors":"Brian Pilecki, Jason Luoma, Kati M. Lear","doi":"10.1556/2054.2024.00295","DOIUrl":"https://doi.org/10.1556/2054.2024.00295","url":null,"abstract":"Psychological flexibility has been proposed as a core process of change when psychedelics are used for therapeutic purposes, but to date empirical outcomes have only documented changes on the Acceptance and Action Questionnaire (AAQ-II), a very general measure of psychological flexibility. This pilot study measured outcomes from psilocybin administered in a retreat setting across a range of measures assessing aspects of psychological flexibility. Nine participants attended a 7-day psilocybin retreat and completed measures at baseline, 2-, and 6-month follow up. Participants demonstrated significant improvements in cognitive defusion (Cognitive Fusion Questionnaire), valued living (Valuing Questionnaire), and Self-Compassion (Self-Compassion Scale), as well as a trend towards increased overall psychological flexibility (AAQ). Other outcome and process measures included measures related to acute effects of the psilocybin, belief in oneness, social safeness, mental health, burnout and emotion expressivity. These results offer preliminary evidence that therapeutic benefits obtained from psilocybin experiences may be linked to changes in psychological flexibility.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultivation, chemistry, and genome of Psilocybe zapotecorum","authors":"D. Miller, J. Jacobs, Alan Rockefeller, Harte Singer, Ian M. Bollinger, James Conway, Jason C. Slot, David E. Cliffel","doi":"10.1556/2054.2023.00332","DOIUrl":"https://doi.org/10.1556/2054.2023.00332","url":null,"abstract":"Psilocybe zapotecorum is a strongly blue-bruising psilocybin mushroom used by indigenous groups in southeastern Mexico and beyond. While this species has a rich history of ceremonial use, research into its chemistry and genetics has been limited. Herein, we report on mushroom morphology, cultivation parameters, chemical profile, and the full genome sequence of P. zapotecorum. First, we detail growth and cloning methods that are simple, and reproducible. In combination with high resolution microscopic analysis, the strain was identified by DNA barcoding, confirming the field identification. Full genome sequencing reveals the architecture of the psilocybin gene cluster in P. zapotecorum, and can serve as a reference genome for Psilocybe clade I. Characterization of the tryptamine profile revealed a psilocybin concentration of 17.9 ± 1.7 mg/g, with a range of 10.6–25.7 mg/g (n = 7), and similar tryptamines (psilocin, baeocystin, norbaeocystin, norpsilocin, aeruginascin, and 4-HO-tryptamine) in lesser concentrations for a combined tryptamine concentration of 22.5 ± 3.2 mg/g. These results show P. zapotecorum to be a potent and chemically variable Psilocybe mushroom. Chemical profiling, genetic analysis, and cultivation assist in demystifying these mushrooms. As clinical studies with psilocybin gain traction, understanding the diversity of Psilocybe expands the conversation beyond the molecule.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gayze through the looking glass: The curious absence of queer narratives in psychedelia","authors":"Stefanie Desrochers","doi":"10.1556/2054.2024.00316","DOIUrl":"https://doi.org/10.1556/2054.2024.00316","url":null,"abstract":"Despite increasing public acceptance of the LGBTQ+ community and psychedelic medicines, published accounts of queer psychedelia are limited. Specifically, the queer nature of psychedelics and the parallels between narratives of being queer and of psychedelic experiences, are lacking. This report brings queer experiences of psychedelia out of the metaphorical closet and argues for the development of Queer Affirming models of Psychedelic Assisted Psychotherapy (QA-PAP).This knowledge report examines the extant psychedelic literature as it relates to queerness, and positions it against reports of rising anti-2SLGBTQ+ sentiments, and legislation aimed at dismantling civil liberties.Specifically in Canada, the United States of America, and the United Kingdom, the current socio-political climate fosters increasingly positive attitudes towards psychedelic medicine, while recently won 2SLGBTQ+ civil rights are under attack. The convergence of these trends means the psychedelic community must guard against repetition of mistakes made during the first wave of psychedelic research.Including queer narratives within psychedelic research is integral to the equitable, safe, effective and accessible implementation of emerging modalities of psychedelic-assisted psychotherapies (PAP), and to ensure that ethical standards protect patients from sexual and gender based violence.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are first responders interested in psychedelics? Assessing previous use, interest, and willingness to participate in psychedelic-assisted therapy","authors":"Sonia M. Brodie, Chelsea Stunden, Jay A. Olson, Despina Z. Artenie, Venugopal Karapareddy, Ryan C.N. D'Arcy","doi":"10.1556/2054.2024.00318","DOIUrl":"https://doi.org/10.1556/2054.2024.00318","url":null,"abstract":"First responders such as firefighters and police officers often experience traumatic events as part of their work. As a result, they are more likely to have mental health issues such as post-traumatic stress disorder, depression, and anxiety compared to the general population. Psychedelic-assisted therapy has emerged as a promising avenue to alleviate these issues, but little is currently known about first responders' interest in, and barriers to, these treatments. Here, we aimed to document first responders' attitudes towards LSD-assisted therapy and previous use of psychoactive drugs.We recruited 102 participants through mailing lists of first responders' unions. Respondents were typically male firefighters in western Canada; others were police officers, paramedics, and military personnel across Canada and the United States. They were asked about their attitudes towards LSD- and marijuana-assisted therapies, previous psychiatric diagnoses, psychosocial impairments, and substance use.Respondents showed higher rates of distress and illicit drug use compared to the general population. Of those who sought professional treatment, a minority reported that the treatment had helped them. The respondents were generally interested in taking part in therapy or research involving LSD or marijuana. The setting (e.g., at home vs. a clinic), therapist presence, and drug dose were commonly reported to influence this participation.First responders may particularly benefit from psychedelic therapy given their high interest in psychedelic drugs and high rates of treatment-relevant disorders. Better understanding the needs of this population will help inform future clinical trials and psychedelic therapies.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine and epigenetic processes in depression, intersection between serotonergic and glutamatergic pathways","authors":"Arghavan Nepton, Hesam Farahani, Monnica T. Williams, Linda Booij, Sonya C. Faber","doi":"10.1556/2054.2024.00343","DOIUrl":"https://doi.org/10.1556/2054.2024.00343","url":null,"abstract":"Hypotheses surrounding the etiology of depressive disorders encompass a wide range of biological changes that can occur in a depressed individual, from gene variations to epigenetic modifications and not only serotonergic mechanisms. Once again, the therapy response of the patient to antidepressants is connected to modifications in the epigenetic regulation of genes within the serotonergic system. The persistence of depressive symptoms points to the possibility that stable molecular adaptations in the brain, particularly at the epigenetic level, may be involved.Narrative review to first, discuss the historical evidence behind how serotonin (5-hydroxytryptamine, 5-HT) signaling and its associated actors are involved in various biological processes and second, examine the role of ketamine as one of the newer treatments for depression.There is increasing evidence that responses to psychotherapy for mood disorders are correlated with epigenetic alterations. Although therapy response appears to be associated with epigenetic changes in genes regulating the serotonergic system, there are multiple lines of research that provide additional data implicating epigenetic alterations in the glutamatergic system. Also, the epigenetic regulation of target genes along the HPA axis are becoming more intriguing in linking mood disorders with environmental stressors, and warrant a closer look. Recent research suggests that ketamine's antidepressant effects may be linked to epigenetic alterations. Considering the multiple studies linking BDNF with depression, further exploration of its relation with ketamine in the context of epigenetic signaling is warranted.Understanding how and to what extent epigenetic mechanisms change gene expression and how these changes are influenced by environmental stressors may eventually allow mental health professionals to better understand the biological basis of depression as well as to gauge the efficacy, onset, durability and duration of therapies to treat mood disorders. Moreover, understanding the relation between serotonergic neurotransmission and epigenetic mechanisms of how these may be modified by ketamine should lead us to a greater knowledge of their therapeutic potential.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking through the doors of perception, consciousness, and existence: to what extent does psychedelic phenomenology ontologically depend on external factors?","authors":"Denis Fradkin","doi":"10.1556/2054.2022.00168","DOIUrl":"https://doi.org/10.1556/2054.2022.00168","url":null,"abstract":"As reliable facilitators of characteristically unique altered states of consciousness that are notoriously difficult to comprehend, psychedelics naturally attract a multidisciplinary scope for their research, with direct relevance to neuroscience, pharmacology, psychology, as well as philosophy of mind, metaphysics, and epistemology — disciplines united by the common inquiry into the nature of conscious experience. Accordingly, the central focus of this paper concerns the metaphysical debate between internalism and externalism about whether psychedelic phenomenology — in particular, its ‘breakthrough’ level — could be said to directly ontologically depend on external factors, as well as the interpretive implications arising from each of those positions. The main contributions of the author of this paper include the provision of a coherent account of the essential phenomenal characteristics of psychedelic experiences, the integration of relatively fragmented philosophical debates on psychedelic phenomenology into the traditional internalist-externalist framework in metaphysics, as well as the exploration of the extent to which the externalist position on psychedelic phenomenology — traditionally associated with non-naturalism — is compatible with naturalistic explanatory frameworks. In Part 1, psychedelic phenomenology will be outlined first, after which the central inquiries of this paper will be contextualised and qualified. In Part 2, the internalist position on psychedelic phenomenology — both its strong and weak versions — will be discussed. In Part 3, the externalist position will be explored, which will be followed by a final evalutation between the three positions presented in this paper. The paper will conclude in favour of the weak internalist position, and that whilst the externalist position remains significantly more speculative than both the strong and the weak internalist positions, the externalist position cannot be rejected altogether until further progress in consciousness research is made.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An examination of internal family systems interventions for trauma with implications for ethical psychedelic-assisted treatment","authors":"Mitch Earleywine, Alyssa Oliva, J. D. De Leo, Robyn Banks","doi":"10.1556/2054.2024.00265","DOIUrl":"https://doi.org/10.1556/2054.2024.00265","url":null,"abstract":"Though several treatments effectively address the pervasive impact of trauma, they do not achieve complete symptom resolution for all clients, inspiring the search for alternatives. Internal Family Systems (IFS) therapy has grown popular, especially in informal psychedelic-assisted treatments (PAT). Compared to stereotypes of empirically validated, exposure-based treatments, IFS has novel facets with widespread appeal. The model encourages improved quality of interactions among multiple, naturally arising “parts” or subpersonalities potentially generated by traumatic experience. The body of IFS literature is extensive, enthusiastic, and thought-provoking. Outcome data for applying the model to Post-Traumatic Stress Disorder are limited. Attempts to operationalize and falsify the theory's assumptions and proposed mechanisms will likely prove challenging. Nevertheless, the model's popularity underscores a problem with perceptions of the empirically-supported treatments. Contemplating ethical ways to present the IFS approach given the state of relevant research, we note strategies that would apply to recommendations for PAT of any type. These strategies include detailed psychoeducation about empirically-supported treatments, candid description of the experimental nature of alternatives, frequent assessments of improvement, and detailed monitoring of potential iatrogenic effects. Drawing on facets of IFS to improve perceptions of the empirically validated treatments might provide an efficient way to appeal to more clients, decrease drop out, and increase gains as we await results of empirical investigations of IFS-influenced PAT. These steps can allow clients to choose an approach consistent with their own impressions of a credible intervention, potentially leading to better outcomes.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140265075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived attachment history predicts psychedelic experiences: A naturalistic study","authors":"Aaron D. Cherniak, Mario Mikulincer, Joel Gruneau Brulin, P. Granqvist","doi":"10.1556/2054.2024.00330","DOIUrl":"https://doi.org/10.1556/2054.2024.00330","url":null,"abstract":"Emerging research indicates that psychedelics may have therapeutic potential by fostering meaningful experiences that act as “inflection points” in people's narratives of personal development. However, psychedelic research has largely failed to address pertinent developmental considerations. We investigated whether attachment-related variables were associated with psychedelic experiences and whether psychedelic experiences moderated expected links between perceived attachment history and current adult attachment orientations.We administered an online survey to an international Jewish sample (N = 185) with psychedelic experience. The survey included measures about recollection of attachment interactions with parents (perceived attachment history), adult attachment orientations (anxiety, avoidance), and psychedelic phenomenology (mystical experiences, challenging experiences, emotional breakthrough, ego dissolution, sensed presence) associated with respondents' most memorable psychedelic experiences.Perceptions of an insecure attachment history were positively linked to all measures of psychedelic phenomenology (r's = 0.19–32, p's mostly < 0.01). In contrast, adult attachment orientations were unrelated to psychedelic phenomenology. Also, psychedelic phenomenology mostly did not moderate the links observed between perceptions of an insecure attachment history and adult attachment orientations.Our findings suggest that perceptions of early attachment experiences may be relevant to psychedelic phenomenology. However, subjective experiences associated with naturalistic psychedelic use do not typically attenuate links between a perceived insecure attachment history and attachment insecurity at present.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychonauts: Drugs and the making of the modern mind","authors":"Ido Hartogsohn","doi":"10.1556/2054.2024.00361","DOIUrl":"https://doi.org/10.1556/2054.2024.00361","url":null,"abstract":"","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140432013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indigenous psilocybin mushroom practices: An annotated bibliography","authors":"Nicholas Spiers, B. Labate, Anna O. Ermakova, Patrick Farrell, Osiris Sinuhé González Romero, Ibrahim Gabriell, Nidia Olvera","doi":"10.1556/2054.2023.00297","DOIUrl":"https://doi.org/10.1556/2054.2023.00297","url":null,"abstract":"This annotated bibliography comprises 49 texts concerning psilocybin mushroom practices developed by Indigenous peoples. The books and articles have been selected for their academic rigor, relevance, and historical significance, and to foreground overlooked research and subject matter. This includes research on a plurality of contemporary practices and evidence of historical uses, from cultural traditions in Mexico and other regions of the world. The curated texts are sourced from various disciplines, including anthropology, history, archaeology, ethnolinguistics, and ethnomycology. Employing diverse methodological and analytical frameworks, the texts explore the diversity of ways Indigenous cultures have related with, utilized, and conceptualized psilocybin mushrooms and the effects occasioned by their consumption. The annotations include brief summaries of the texts, contextualization of the research, and more critical appraisals. The aim of this annotated bibliography is to offer the reader a diverse overview of the research to date and provide an accessible resource for further exploration of historical and contemporary Indigenous psilocybin practices. The team of psychedelic researchers behind this annotated bibliography hope it will contribute to more nuanced dialogue around Indigenous people and practices in the context of the so-called psychedelic renaissance.","PeriodicalId":34732,"journal":{"name":"Journal of Psychedelic Studies","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140459706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}