Dubai Diabetes and Endocrinology Journal最新文献

{"title":"Real-World Assessment of Efficacy and Safety Parameters for Dapagliflozin in Management of Type 2 Diabetes Mellitus: REWARD Study","authors":"A. Hassoun, Denish Kumar Dhanwal, Jalal Nafach, Yasmin Ajaz, Asif Majid Khan, Abdullah Ben Nakhi, M. Alarouj, Khadija Hafidh, Majdi AlNajjar, Ahmed Reyas, Sana Qamar, Mohamed Alsayed, Ahmad Bdair","doi":"10.1159/000519871","DOIUrl":"https://doi.org/10.1159/000519871","url":null,"abstract":"Introduction: While ample evidence on improved glycemic control, weight reduction, and lowered blood pressure (BP) with sodium-glucose cotransporter type 2 inhibitors (SGLT2is) exists, real-world data on the potential benefit of SGLT2i on the diabetic population in the Middle East are lacking. The aim of our study was to describe the glycemic control, changes in body weight, body mass index (BMI), lipid profile, and BPs in patients receiving dapagliflozin with other antidiabetic medication. Methods: The REWARD study was a multicenter, post-authorization, prospective, open-label, noninterventional, real-world, cohort study. We enrolled 511 adult, type 2 diabetes mellitus patients on antidiabetic medications. These patients were started on dapagliflozin and followed up for 1 year to assess changes in their clinical and laboratory outcomes. Results: The mean HbA1c decreased significantly from 8.5 ± 1.6% at baseline to 7.6 ± 1.3% after 12 months (p value <0.001), with an absolute change of 0.9%. Of the study population, 41.6% of patients reached an HbA1c level less than 7% (53 mmol/mol). The systolic pressure improved (mean change = −1.9 mm Hg, p value = 0.003), yet no change in the diastolic pressure was observed. Both body weight and BMI significantly decreased by 0.7 kg and 0.2 kg/m2, respectively (p value <0.001). About 84.5% of patients were on antidyslipidemic agents, while 57.4% were on antihypertensives. Approximately 83.6% of adverse events were mild. A total of 90 hypoglycemic episodes were reported; none were severe. Conclusion: In a real-world setting, dapagliflozin in combination with other antidiabetic medications exhibited significant improvement in glycemic control, weight, BMI, and systolic BP. Additionally, it demonstrated a well-tolerated safety profile.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"425 1","pages":"25 - 34"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79625500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the 11th Emirates Diabetes and Endocrine (Virtual) Congress, March 4–6, 2021","authors":"S. Beshyah, Fauzia Rashid, Elamin Ibrahim Abdelgadir","doi":"10.1159/000520783","DOIUrl":"https://doi.org/10.1159/000520783","url":null,"abstract":"Backgrounds: The Eleventh Diabetes and Endocrine Virtual Congress (EDEC 2021) was held on March 4–6, 2021, due to the COVID pandemic. Objectives: We aimed to present highlights of the congress proceedings. Materials and Methods: The journal appointed 3 rapporteurs to prepare this congress report. They prepared assigned sections and reviewed the rest of the manuscript, and approved its final version. Results: The conference contents over 3 days included a wide range of lectures by world-class experts and key opinion leaders on various topical subjects, endocrinology, diabetes care, and metabolism, in addition to original data from submitted abstracts. The clinical approach to managing a pituitary mass, contemporary management of acromegaly, and the relationship between growth hormone and neoplasia were discussed. The virtual EDEC 2021 provided a comprehensive review of topical issues concerning clinical practice and research in diabetes, endocrinology, and metabolism. Predictably, the thyroid took the scene’s center, spanning many subjects from hypothyroidism, pregnancy care, thyroid nodules, and cancer management. Rational approaches to pituitary disease and acromegaly were valuable for practicing endocrinologists. Recent advances in adrenal disease were valuable, practical, and futuristic. The reviews on bone metabolism and calcium homeostasis at large and during the COVID-19 pandemic were fascinating. On the diabetes side, emphasis on the cardiovascular outcomes, the use of newer agents when compelling indications exist, and the role of technology were precious contributions. Some of the classical questions were addressed and revisited, such as endocrinology of thalassemia, precocious puberty, and testosterone replacement. The newer and future lipid-modifying therapies were stimulating, mainly when high-risk patients are considered. Imaging, immunology, and molecular biology took their share in various presentations. Conclusions: The virtual EDEC 2021 provided a comprehensive review of topical issues concerning clinical practice and research in diabetes, endocrinology, and metabolism. Many new concepts were introduced in diabetes care and endocrinology, bringing the audience to the forefront of research and world-class clinical practice.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"27 1","pages":"1 - 19"},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83486483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers","authors":"Saira Abbas, Nemat Abdulrahman Abduljabbar, V. Aeri, B. Afandi, Al Ain, P. Ahmad, Hafez Abdel Fattah, Ahmed, Muhaisnah, Shehla Ahmed, Salim Marzouk, S. Beshyah, Abu Dhabi, J. S. Bhatti, N. Elbarbary, Mohamed Ali Eltom, M. Farooqi, N. Ghouri, Khadija Hafidh, M. Jallo, Archana B. Kadam, M. Sankhla, M. A. Siddiqui, Marwan Zidan","doi":"10.1159/000521535","DOIUrl":"https://doi.org/10.1159/000521535","url":null,"abstract":"© 2021 The Author(s) Published by S. Karger AG, Basel karger@karger.com www.karger.com/dde Saira Abbas, Dubai ElAmin Abdelgader, Dubai Nemat Abdulrahman Abduljabbar, Dubai Vidhu Aeri, New Delhi Bachar Afandi, Al Ain Peerzada Ovais Ahmad, Srinagar Hafez Abdel Fattah Ahmed, Muhaisnah Shehla Ahmed, Barrie, ON Ishma Aijazi, Dubai Budoor Al Emadi, Dubai Salim Marzouk Al Ibrahimi, Al-Manathira Khaled Aldahmani, Al Ain Dalal Almehmadi, Jeddah Nasr Anaizi, Benghazi AlaaEldin M.K. Bashier, Dubai Alaaeldin Bashier, Dubai Salem A. Beshyah, Abu Dhabi Jasvinder Singh Bhatti, Bathinda Dowen Birhked, Malmö Lawrence Cheskin, Baltimore, MD Nancy Samir Elbarbary, Cairo Targ Elgzyri, Malmo Ahmed Elhassan, Dubai Mohamed Ali Eltom, Omdurman Polycarp Erivwo, St. Johns Muhammad Hamed Farooqi, Dubai Nazim Ghouri, Glasgow Maria Luz Gunturiz, Bogotá Khadija Hafidh, Dubai Issam M. Hajjaji, Tripoli Hathama Razooki Hasan, Baghdad. Mohamed Hassanein, Dubai Mir Mosarraf Hossain, Dhaka Mahir Khalil Jallo, Ajman Manoj Kumar Jena, Phagwara Mathew John, Trivandrum Archana Kadam, Navi Mumbai Shankar Kanumakala, Brighton Wilfried Karmaus, Memphis, TN Tawfik Ahmed Khoja, Riyadh Abdulfattah A. Lakhdar, London Ajay Mahajan, Oviedo, FL Abbas Ali Mansour, Basrah Sarabjit Singh Mastana, Loughborough Zayd Merza, Barnsley Gideon Gabriel Mlawa, London Bashair Mussa, Sharjah Huda Mustafa, Abu Dhabi Sushil Patel, Vadodara Prateek Rajkarnikar, Kathmandu Vinod Rao, Mumbai Tamar Saeed, Dudley Sumanta Saha, Kolkata Manisha Sankhla, Jaipur Shahjada Selim, Dhaka I.O. Sherif, Mansoura Mohammad Asim Siddiqui, New Delhi Wilma Delphine Silvia CR, Bangalore Nabil Sulaiman, Sharjah Mohamed Suliman, Al Ain Ahmad Hamad Suliman, Arar Puja Thadani, Coventry Zalak Madhav Upadhyay, Rajkot Madhava Vijayakumar, Manjeri Taiba Wahidi, Makkah Marwan Zidan, Dubai Karger Publishers and the editors of the Dubai Diabetes and Endocrinology Journal would like to thank the reviewers for their support in reviewing manuscripts for the journal. We sincerely thank all contributing reviewers who have volunteered their time, effort, and expertise to improve the quality of the manuscripts in 2021. Individual reviewers can also claim their personal ‘Certificate of Review’ via the Journal’s manuscript submission system.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"1 1","pages":"165 - 165"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79886184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumour-Not So Sweet, Tumour-Induced Hypoglycemia: A Rare Case of Refractory Hypoglycemia in a Toddler","authors":"Jayati Joshipura, Vani H.N., Nabanita Kora","doi":"10.1159/000520177","DOIUrl":"https://doi.org/10.1159/000520177","url":null,"abstract":"Tumour-induced hypoglycaemia is a rare complication/condition mainly seen in adults. It is caused due to increased production of insulin or insulin-like growth factor (IGF) 2 tumour cells. We present a 3-year-old paediatric patient with non-islet cell tumour induced hypoglycaemia (NICTH) secondary to rhabdomyosarcoma. She presented with abdominal mass and refractory hypoglycaemia, requiring high glucose infusion and steroids. Critical sample analysis during hypoglycaemia showed suppression of insulin, IGF-1, C-peptide, growth hormone, and ketones, with a high cortisol level. CT scan of abdomen and pelvis showed a huge retroperitoneal mass, later diagnosed as rhabdomyosarcoma. In a resource-limited setting, where IGF-2 is not possible, low serum insulin and IGF-1 levels during hypoglycaemia aids in diagnosis of NICTH. This is one of the first few reported paediatric cases with NICTH from India, and we believe that reporting this case would add more information to the existing literature. Thus, NICTH should be suspected in all malignancies presenting with intractable hypoglycaemia irrespective of their age.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"19 1","pages":"162 - 164"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72725729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Study of the Association of Serum Parathyroid Hormone Level with Obesity in Patients Admitted to a Tertiary Care Center in Basrah","authors":"Mohammed Khazaal Jumaahm, A. Alhamza, A. Mansour","doi":"10.1159/000520660","DOIUrl":"https://doi.org/10.1159/000520660","url":null,"abstract":"Background: Parathyroid hormone (PTH) has been reported to have a positive correlation with insulin resistance and the development of the metabolic syndrome. This study aims to evaluate if there is an association between obesity and serum PTH levels. Methods: This case-control study was conducted at the Faiha Specialized Diabetes Endocrine and Metabolism Center in Basrah (Southern Iraq) from September 2018 to July 2019. A total of 230 patients were recruited for this study (103 male and 127 female), divided into 2 groups according to the BMI: <30 kg/m2 were considered as the control group (83 persons) and ≥30 kg/m2 were considered as obese persons (147 persons). The study groups were also subdivided into 3 groups according to the serum level of PTH: <40 pg/mL, 40–65 pg/mL, and >65 pg/mL. Results: The mean age of the obese and control groups was 44.39 ± 10.64 and 30.12 ± 8.95 years, respectively. About 46.25% of obese were men and 53.75% were women, while 42% of the control group were men and 58% were women. Serum PTH level was significantly higher (p < 0.001) among obese persons with a mean level of 53.21 ± 19.58 pg/mL for obese and 37.63 ± 21.8 pg/mL for control. Vitamin D deficiency was seen in 84.4% of the obese group while in 71.1% of the control group (p value 0.04). Females turned to have higher PTH levels than males in both the obese and the control group (p value <0.001). However, age and the presence of diabetes mellitus were not associated with higher PTH levels (p value 0.155 and 0.6, respectively). Conclusion: Obesity was associated with a higher serum PTH level related to the severity of vitamin D deficiency.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"12 1","pages":"143 - 149"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79550029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Knowledge, Attitudes, and Practices of Individuals with Diabetes Mellitus in the Sultanate of Oman","authors":"Noora Al Shihi, Abdulhakeem Al Rawahi, Raya Al Jahdhami, Rayyan Al Riyami, Abdulaziz Al Murazza, Noor Al Busaidi, Fatma Al Riyami, S. Al Salti","doi":"10.1159/000529684","DOIUrl":"https://doi.org/10.1159/000529684","url":null,"abstract":"Introduction: Diabetes mellitus is a chronic disease with an increasing global prevalence. The condition has several oral health implications, with oral health in turn affecting diabetes control. People with diabetes are at higher risk of oral health problems, including periodontal disease, dental caries, and candidiasis; in particular, there appears to be a two-way relationship between periodontitis and blood glucose control. While previous research has indicated that diabetics have poor awareness of oral health, there is a gap in the literature from the Sultanate of Oman. This study aimed to determine oral health knowledge, attitudes, and practices among Omani diabetics. Materials and Methods: A cross-sectional study was conducted using a convenience sample of 400 adult Omani diabetics who attended the outpatient clinic of the National Diabetes and Endocrine Center, Oman, in the period between May 2019 and May 2020. A self-administered, Arabic language questionnaire to assess oral health knowledge, attitudes, and practices was developed and validated. Mean scores were calculated to determine overall levels of oral health knowledge, attitudes, and practice. Ethical approval was obtained from the Center of Studies and Research of the national Ministry of Health. Results: A total of 136 (34.0%) male and 264 (66.0%) female Omani adult diabetics participated in the study. The majority of participants (76.8%) demonstrated poor knowledge of oral health, especially with regards to complications like gingivitis (32.4%), dental caries (27.3%), halitosis (27.1%), and gingival abscesses (21.5%). Moreover, most (76.6%) were unaware that oral diseases affected glycated hemoglobin levels. In terms of practices, more than half (54.74.8%) routinely brushed their teeth twice a day. However, only 14.6% and 12.6% regularly flossed and used mouthwash, respectively. With regards to attitudes, 0.5%, 23.8%, and 75.8% of the participants demonstrated poor, moderate, and good attitudes toward oral health, respectively. Smokers more frequently demonstrated poor attitudes compared to nonsmokers (6.3% vs. 1.6%). Conclusion: Omani adults with diabetes mellitus demonstrated poor to moderate levels of oral health knowledge. Various studies conducted elsewhere around the world have similarly shown that diabetics have limited knowledge and awareness of oral health. Oral self-care behaviors are imperative to minimize the risk of oral health complications associated with diabetes. Previous researchers have shown that education is an effective method of reducing the incidence and burden of diabetes-related oral health complications. Thus, additional multidisciplinary initiatives are needed to raise awareness of good oral hygiene practices among diabetics in Oman.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"76 1","pages":"33 - 41"},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80657868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Patients for Healthy Nutrition, Physical Activity, and Self-Care Using the Diabetes Score Questionnaire","authors":"M. J. Hashim, H. Mustafa","doi":"10.1159/000519225","DOIUrl":"https://doi.org/10.1159/000519225","url":null,"abstract":"Objectives: Lifestyle factors such as nutrition and physical activity play an important role in the management of diabetes mellitus. Unfortunately, adherence to lifestyle change remains low among patients with diabetes. The aim of this study was to evaluate the effectiveness of the Diabetes Score questionnaire in a clinical setting. Methods: The Diabetes Score is a 10-item shared decision-making tool designed to empower lifestyle change in individuals with diabetes. It yields an intuitive score from 0 to 100 based on a patient’s adherence to lifestyle recommendations. An observational study was conducted at an ambulatory health care center. After obtaining written informed consent, adult patients with type 2 diabetes mellitus were interviewed by a trained researcher using the Diabetes Score questionnaire. Patients’ Diabetes Score values were analyzed in reference to their glycemic control and other clinical and demographic factors. Results: A total of 60 individuals with type 2 diabetes participated in the study. The mean age was 56 years (minimum 43 years, maximum 70 years) with 60% being males. Higher Diabetes Scores correlated with better glycemic control (hemoglobin A1C; r = −0.23, p = 0.044) indicating the effect of lifestyle factors such as healthy nutrition, smaller portion sizes, active lifestyle, and aerobic exercise. The questionnaire showed internal consistency (alpha 0.66), construct validity, and high patient satisfaction (98%). Conclusion: Diabetes Score, a behavioral lifestyle questionnaire, correlates with glycemic control in type 2 diabetes. Diabetes Score can be used in clinical settings for measuring, discussing, and setting targets for lifestyle change among patients with diabetes.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"20 1","pages":"131 - 136"},"PeriodicalIF":0.0,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81546707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Bariatric Surgery in Terms of Weight Loss and Diabetes Remission in the Indian Population","authors":"M. Khaitan, Riddhish Gadani, K. Pokharel","doi":"10.1159/000518856","DOIUrl":"https://doi.org/10.1159/000518856","url":null,"abstract":"Objectives: The growing prevalence of obesity rates worldwide is associated with an upsurge in its comorbidities, particularly type 2 diabetes mellitus (T2DM). Bariatric surgery is a proven treatment modality for producing sustained weight loss and resolution of associated T2DM providing marked improvement in quality of life with rapid recovery. This study aims to investigate the effects of laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB), and mini-gastric bypass (MGB) on obese patients suffering from T2DM in the Indian population and their long-term association with regard to diabetes remission, resolution of comorbidities, and percentage EWL. Methods: Retrospective data of obese patients with T2DM (preoperative BMI 45.37 ± 8.1) who underwent bariatric surgery (RYGB, LSG, and MGB) were analyzed in this study over a period of 9 years. The mean follow-up period was 2.2 years. Following surgery, the clinical outcome on BMI, resolution of percentage weight loss, and T2DM were studied. The predictive factors of diabetic remission after surgery were determined. Student’s t test and ANOVA and McNemar’s test were applied. Results: Out of a total of 274 patients, complete remission of T2DM was achieved in 52.9% (n = 145) with mean fasting blood glucose and glycated hemoglobin values being 6.1 ± 0.769 (p = 0.00) at 1 year after surgery. The independent predictive factors of remission were age, gender, BMI, preoperative comorbidities, and % EWL. Gender had no correlation with the chance of achieving disease remission. Conclusion: Based on our results, bariatric surgery proves to be a successful treatment option resulting in sustained weight loss in obese patients suffering from T2DM. It is found to be beneficial for the long-term resolution of T2DM and improving comorbidities such as hypertension and dyslipidemia. The outcome of the different surgical methods is found to be similar for all patients irrespective of the independent predictors of complete remission.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"56 1","pages":"119 - 125"},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89557177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Macroprolactinemia in Patients with Hyperprolactinemia Using Roche Elecsys Platform in a Large Tertiary Referral Center in UAE","authors":"Abdulla H. Al Nuaimi, R. Almazrouei, Y. Othman, S. Beshyah, Khaled M. Aldahmani","doi":"10.1159/000519094","DOIUrl":"https://doi.org/10.1159/000519094","url":null,"abstract":"Objectives: Macroprolactin (macroPRL) excess is an important cause of hyperprolactinemia. Several prolactin assays have high reactivity to macroPRL. However, macroPRL screening is not routinely performed in many labs. This study aimed to evaluate the prevalence of macroprolactinemia (MP) in patients with elevated prolactin using the Roche Elecsys assay in a large tertiary center in UAE. Materials and Methods: Consecutive samples of patients with elevated prolactin presenting to Tawam Hospital from June to August 2018 were evaluated for MP. Polyethylene glycol (PEG) was used to precipitate macroPRL. Monomeric prolactin recovery cutoff ≤50% was used to determine the prevalence of MP. Results: A total of 180 patients with elevated prolactin were included in the study with a mean age of 33.1 ± 11.9 years. The majority were women (87.2%), and about 77.8% were newly diagnosed patients with hyperprolactinemia. The main indications for prolactin testing were menstrual irregularity (n = 121), infertility (n = 11), galactorrhea (n = 11), and sellar masses (n = 12). MP was present in 8.3% of the patients. The median (IQR) of total prolactin level was 740.5 (579–1,085) IU/m before PEG precipitation and was not significantly different between MP and true hyperprolactinemia cases. Three patients with MP had pituitary MRI evaluation, which was normal. Eight patients with MP were treated with cabergoline. Conclusion: One in 12 patients with hyperprolactinemia had MP on the Roche Elecsys assay defined as the cutoff recovery of ≤50% post-PEG precipitation. Physicians should be aware of the prolactin assay used in their labs, and we recommend routine macroPRL assessment in mild hyperprolactinemia samples in labs using the Roche Elecsys platform.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"123 1","pages":"126 - 130"},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85684811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year Course of Olanzapine-Induced Diabetic Ketoacidosis: A Case Report","authors":"Mohammed Zain Ulabedin Adhoni, R. Assadi, Saira Abbas","doi":"10.1159/000519726","DOIUrl":"https://doi.org/10.1159/000519726","url":null,"abstract":"Second-generation antipsychotics, despite being highly effective, are among the drugs known to cause insulin resistance and metabolic syndrome, eventually leading to diabetes mellitus and less commonly diabetic ketoacidosis (DKA). Here, we present the case of a 21-year-old male, who was not previously known to have any comorbid factors but presented with DKA 1 year and 9 months after beginning treatment with olanzapine for an unspecified psychotic disorder requiring hospital admission and the resolution of the same following discontinuation of the drug. Our case report emphasizes the need for regular screening of patients requiring diabetogenic drugs, so that early identification of possible side effects can be noted and averted.","PeriodicalId":34679,"journal":{"name":"Dubai Diabetes and Endocrinology Journal","volume":"54 1","pages":"158 - 161"},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86592772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}