Medicina Universitaria最新文献_第9页

How do we approach an adult patient with suspected acute appendicitis? 我们如何处理疑似急性阑尾炎的成年患者?

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.05.001

A.E. De la Torre-Quiroga , F.J. Bosques-Padilla , L.A. Morales-Garza

引用次数: 0

Triple negative breast cancer: Deciphering the biology and heterogeneity 三阴性乳腺癌:解读生物学和异质性

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.05.007

G.I. Uscanga-Perales , S.K. Santuario-Facio , R. Ortiz-López

{"title":"Triple negative breast cancer: Deciphering the biology and heterogeneity","authors":"G.I. Uscanga-Perales , S.K. Santuario-Facio , R. Ortiz-López","doi":"10.1016/j.rmu.2016.05.007","DOIUrl":"10.1016/j.rmu.2016.05.007","url":null,"abstract":"<div><p>Triple negative breast cancer (TNBC) is a subtype of breast cancer (BC) with a heterogeneous nature that stains negatively for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor 2 (HER2) during immunohistochemistry. Approximately 15–20% of all cases of breast cancer are triple negative phenotypes. Compared to patients with hormone receptor-positive cancer, TNBC patients are typically younger (<50 years), African American, and have a high incidence of mutations in BRCA1/2 genes. To date, not a single targeted therapy has been approved for TNBC treatment, and cytotoxic chemotherapy remains as the standard systemic treatment, meaning that TNBC is an aggressive subtype of breast cancer with a poor prognosis. In this review, the literature search was done up to date on which gene expression profile of TNBC has been analyzed in order to identify the consensus on molecular mechanisms involved in carcinogenesis and/or the prognostic markers of the disease. In conclusion, these studies have reported that TNBC is composed of several clusters or genomic signatures as basal keratins. They have also reported on their proliferation, luminal/basal apocrine, regulatory interferon, immune cells/immunoglobulin related to stem cells, epithelial-mesenchymal, androgen receptor and angiogenesis. However, not all research groups have reported reproducible results. This confirms the heterogeneous nature of TNBC and the need for research on uniform selection criteria. However, these discoveries have led to the proposal of new treatments, such as the addition of platinum salts, new combinations of therapeutic agents, some targeted therapies such as PARP inhibitors, and PI3K and androgen antagonists. There is no doubt that a better understanding of the nature of TNBC will allow individualized and more effective therapies.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 71","pages":"Pages 105-114"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.05.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82486326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Bases and foundations of the treatment of peritoneal carcinomatosis: Review article 腹膜癌治疗的基础和基础:综述文章

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.06.001

J.F. Castro-Mesta , J.F. González-Guerrero , P. Barrios-Sánchez , G. Villarreal-Cavazos

{"title":"Bases and foundations of the treatment of peritoneal carcinomatosis: Review article","authors":"J.F. Castro-Mesta , J.F. González-Guerrero , P. Barrios-Sánchez , G. Villarreal-Cavazos","doi":"10.1016/j.rmu.2016.06.001","DOIUrl":"10.1016/j.rmu.2016.06.001","url":null,"abstract":"<div><p>Peritoneal carcinomatosis refers to a shedding or tumor that spreads to the peritoneal serosa and structures of the abdominal cavity. It is an entity with a poor prognosis. Several conditions can cause this, the most common being colon, rectum, ovary, stomach or appendix cancers, including peritoneal pseudomyxoma, among others. The abdominal cavity invasion is considered a clinical stage IV. For a long time life expectancy of this entity was very short. With the advent of meticulous techniques in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) the prognosis of patients has changed. In some conditions, these procedures are standard treatments. CRS is a very important prognostic factor; leaving a less residual disease in the patient, the evolution will be better. The HIPEC starts immediately after the surgical event. The hyperthermia increases the cytotoxic effect of antineoplastic drugs. Numerous studies have appeared in medical literature wherein the clear improvement in survival of the affected population is demonstrated. It is essential that a multidisciplinary team participates in the decision for the best treatment option and the maximum clinical benefit of the patients.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 71","pages":"Pages 98-104"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80449328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Changing the rules of engagement: Perspective of Zika virus 改变交战规则:寨卡病毒的视角

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.04.002

L. Palau-Dávila, A. Camacho-Ortiz

引用次数: 0

Knowledge about Dengue, Zika and Chikungunya in Latin American students, 2016 2016年拉丁美洲学生对登革热、寨卡和基孔肯雅热的了解

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.04.004

C.M. Rios-González , C. Díaz-Vélez

引用次数: 3

Management of firearm facial fractures at the “Dr. José Eleuterio González”: University Hospital Case Report 在“jos<s:1> Eleuterio博士González”治疗火器性面部骨折:大学医院病例报告

Medicina Universitaria Pub Date : 2016-04-01 DOI: 10.1016/j.rmu.2016.03.005

I.Z. González-Vargas, M. García-Pérez, Y. Castro-Govea, C.E. Franco-Vazquez, A. Juárez-López de Nava, J.I. Fonseca-Sada

引用次数: 1

A new form of fraud in scientific publishing: Supplanting or hacking the scientific review process 科学出版中的一种新形式的欺诈:取代或入侵科学审查过程

Medicina Universitaria Pub Date : 2016-01-01 DOI: 10.1016/j.rmu.2016.01.002

F.J. Bosques-Padilla , D. Gómez-Almaguer

引用次数: 0

Sensitivity of histological chorioaminionitis and premature rupture of membranes for neonatal sepsis and its risk factors 组织学绒毛膜炎和胎膜早破对新生儿败血症的敏感性及其危险因素

Medicina Universitaria Pub Date : 2016-01-01 DOI: 10.1016/j.rmu.2016.01.001

I. Rodríguez-Balderrama, M.E. de la O-Cavazos, A. Martínez-Rios, I.M. Cadena-López, K.A. Flores-Treviño

{"title":"Sensitivity of histological chorioaminionitis and premature rupture of membranes for neonatal sepsis and its risk factors","authors":"I. Rodríguez-Balderrama, M.E. de la O-Cavazos, A. Martínez-Rios, I.M. Cadena-López, K.A. Flores-Treviño","doi":"10.1016/j.rmu.2016.01.001","DOIUrl":"10.1016/j.rmu.2016.01.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Set the sensitivity of the histopathological diagnosis of chorioamnionitis (CAMH) for early diagnosis of neonatal sepsis and the relationship between histological chorioamnionitis and premature rupture of membranes and neonatal sepsis.</p></div><div><h3>Materials and methods</h3><p>Prospective, observational study and diagnostic test performed in the Neonatology Service of the “Dr. José Eleuterio González” University Hospital. Epidemiological variables were collected from mothers and newborns. The relationship between histological chorioamnionitis with premature rupture of membranes and early neonatal sepsis was established.</p></div><div><h3>Results</h3><p>We recorded 3694 births. Of these, 122 patients were studied as potentially infected, of whom 37 patients were excluded (2 by transfer to another hospital and 35 by not finding a histopathological study of the placenta). The study included 85 newborns. Of these, 43 (50.5%) developed clinical and laboratory data of early neonatal sepsis, the rest (<em>n</em>   <0.001), weight <1500g (<0.001), gestational age <28 weeks (<0.05), APGAR score <6 in 5min (<em>p</em>   <!-->h has an 81% sensitivity for neonatal sepsis. A newborn with histological chorioamnionitis has a 51% sensitivity for neonatal sepsis.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 70","pages":"Pages 10-15"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74166536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

It's the academia, dummy! or when quantity supersedes quality 这是学术界，笨蛋!或者当数量取代质量

Medicina Universitaria Pub Date : 2016-01-01 DOI: 10.1016/j.rmu.2015.12.003

H.A. Barrera-Saldaña

引用次数: 0

Self-inflicted wound with a nail in the heart: Case report 心脏被钉子钉伤:个案报告

Medicina Universitaria Pub Date : 2016-01-01 DOI: 10.1016/j.rmu.2016.03.002

F. Reyna-Sepúlveda , R. Cueto-Ramos , F. Vásquez-Fernández , M. Hernández-Guedea , A. Guevara-Charles , G.E. Muñoz-Maldonado

{"title":"Self-inflicted wound with a nail in the heart: Case report","authors":"F. Reyna-Sepúlveda , R. Cueto-Ramos , F. Vásquez-Fernández , M. Hernández-Guedea , A. Guevara-Charles , G.E. Muñoz-Maldonado","doi":"10.1016/j.rmu.2016.03.002","DOIUrl":"10.1016/j.rmu.2016.03.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Adequate diagnosis and treatment of penetrating cardiac injury (PCI) represents a great challenge for the surgeon in the emergency department (ED) because of its high mortality. It is estimated that more than 90% of mortality happens before the patient reaches the hospital and only 15–50% of those will receive appropriate medical treatment.</p></div><div><h3>Case report</h3><p>A 42-year-old hemodynamically stable male is brought to the ED with a protruding nail in his thorax. He is taken to the operating room (OR) where a medial sternotomy is performed and an injury is found in the left ventricle. Cardiac muscle repair is performed with pericardial patch.</p></div><div><h3>Discussion</h3><p>PCI from a suicide attempt secondary to a nail hammered into the chest is very rare and no previous reports were found by the author.</p></div><div><h3>Conclusion</h3><p>The objects that penetrate cardiac structures must be removed in a proper OR with capable personnel and the resources available to perform procedures like an urgent thoracotomy or sternotomy.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 70","pages":"Pages 20-22"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73866134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0