Medicina Universitaria最新文献_第6页

Disintegrins obtained from snake venom and their pharmacological potential 从蛇毒中提取的崩解素及其药理潜力

Medicina Universitaria Pub Date : 2017-01-01 DOI: 10.1016/j.rmu.2017.02.004

E.A. Rivas-Mercado, L. Garza-Ocañas

引用次数: 15

The importance of scientific research in higher education 科学研究在高等教育中的重要性

Medicina Universitaria Pub Date : 2017-01-01 DOI: 10.1016/j.rmu.2016.11.002

Y.A. Castellanos Castellanos , C.M. Rios-González

引用次数: 4

Lineage switch from acute lymphoblastic leukemia to myeloid leukemia 谱系从急性淋巴细胞白血病切换到髓性白血病

Medicina Universitaria Pub Date : 2017-01-01 DOI: 10.1016/j.rmu.2017.02.001

G.J. Ruiz-Delgado , A.K. Nuñez-Cortez , J.C. Olivares-Gazca , Y.C. Fortiz , A. Ruiz-Argüelles , G.J. Ruiz-Argüelles

{"title":"Lineage switch from acute lymphoblastic leukemia to myeloid leukemia","authors":"G.J. Ruiz-Delgado , A.K. Nuñez-Cortez , J.C. Olivares-Gazca , Y.C. Fortiz , A. Ruiz-Argüelles , G.J. Ruiz-Argüelles","doi":"10.1016/j.rmu.2017.02.001","DOIUrl":"10.1016/j.rmu.2017.02.001","url":null,"abstract":"<div><h3>Objective and background</h3><p>Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, representing 25% of childhood cancers, with a peak prevalence between 2 and 9 years. Conversions of the leukemic cell lineage throughout the duration of the disease is a rare manifestation, accounting for 6–9% of relapsed cases and being more frequently observed in pediatric patients. We present a case of a patient with a lineage switch from lymphoblastic leukemia to myeloid leukemia.</p></div><div><h3>Case presentation</h3><p>A 60-year-old male was seen due to pancytopenia, weight loss and weakness. Initial laboratory work-up was performed. Bone and marrow aspirate flow cytometric analysis disclosed pre-B lymphoblastic acute leukemia BCR ABL (−), 46 XY, hyperdiploid, CD20(−), CD 10 (−), CD19 (+), CD33 (−), CD34 (+), CD38 (+), CD79a (+), TdT (+), IgS(−), CD45 (+/−), HLA-DR (+), MLL (−), FLT3 (−), TEL AML (−). He was treated with a pediatric-inspired TOTAL XI schedule. Sixty days afterward, induction blasts appeared in the peripheral blood, but immunophenotyping was not conclusive for MRD+ status. One week later, he presented blasts in the peripheral blood compatible with acute myeloid leukemia. CD7 (+−), CD13 (+), CD14 (−), CD15(−), CD33(+), CD34(+), CD38(+), CD45(+−), CD64(−), CD117(+), HLA-DR heterogenous. BCR-ABL, PML-RAR alfa, and FLT-3 were repeated in peripheral blood when AML developed and was negative. The patient started subcutaneous cytarabine and was alive 90 days after initial diagnosis with active AML leukemia.</p></div><div><h3>Conclusion</h3><p>There is a small number of reports of lineage conversion in the literature, probably because immunophenotyping is performed at diagnosis without a follow up.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"19 74","pages":"Pages 27-31"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2017.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82571452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Thyroid and obesity 甲状腺和肥胖

Medicina Universitaria Pub Date : 2017-01-01 DOI: 10.1016/j.rmu.2017.01.001

Ó.J. Garza-Ovalle, J.F. Ovalle-Berumen

引用次数: 0

Antibiotic self-medication in university students from Trujillo, Peru 秘鲁特鲁希略大学生的抗生素自我用药

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2016.10.003

M. Núñez , M. Tresierra-Ayala , F. Gil-Olivares

{"title":"Antibiotic self-medication in university students from Trujillo, Peru","authors":"M. Núñez , M. Tresierra-Ayala , F. Gil-Olivares","doi":"10.1016/j.rmu.2016.10.003","DOIUrl":"10.1016/j.rmu.2016.10.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Antibiotic self-medication is a kind of indiscriminate use of antibiotics. This practice has been growing worldwide, and has been identified as a risk factor for bacterial resistance (according to the WHO, it is one of the most difficult public health problems to combat in the XXI century). This activity has also been observed in the university population, and there is some literature reporting factors among young people that could increase it.</p></div><div><h3>Objectives</h3><p>To describe risk factors associated with antibiotic self-medication among university students from Trujillo, Peru.</p></div><div><h3>Materials and methods</h3><p>An observational, analytical, retrospective study was performed using a questionnaire. It was applied to 1000 college students selected by proportional allocation from three universities in Trujillo.</p></div><div><h3>Results</h3><p>Seventy percent self-medicated two or more times during the last year. The drug most often used for self-medication was amoxicillin, by 133 students (20.33%). An association was found between antibiotic self-medication and the female gender. No association was found between antibiotic self-medication and age (<em>p</em>  =0.83), knowledge level (<em>p</em>  =0.14) and college year (<em>p</em>  <!-->0.15).</p></div><div><h3>Conclusions</h3><p>A high use of antibiotic self-medication was reported and a probable link to females. However, we could not establish an association between antibiotic self-medication and age, income, prior knowledge about antibiotics, school programs or college years.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 73","pages":"Pages 205-209"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87460143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Impact of air pollution in respiratory allergic diseases 空气污染对呼吸道过敏性疾病的影响

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2016.10.006

S.N. González-Díaz, A. Arias-Cruz, C. Macouzet-Sánchez, A.B. Partida-Ortega

{"title":"Impact of air pollution in respiratory allergic diseases","authors":"S.N. González-Díaz, A. Arias-Cruz, C. Macouzet-Sánchez, A.B. Partida-Ortega","doi":"10.1016/j.rmu.2016.10.006","DOIUrl":"10.1016/j.rmu.2016.10.006","url":null,"abstract":"<div><p>Allergic respiratory disease, which includes allergic rhinoconjunctivitis and asthma, is one of the most common diseases, with a major impact on a patient's quality of life. Air pollution is one of the main factors associated with the development of allergic respiratory disease, it has been shown to impair lung development in children and adolescents. The origins of particulate matter produced from various sources, including those issued by traffic and the burning of fuels such as coal, gasoline and diesel. Diesel emissions represent the majority of the particulate matter in urban air pollution. It has been found that the co-exposure of diesel emissions and airborne allergens increases allergen-specific IgE levels, severity of asthma, inflammation and airway hyper-responsiveness. <em>In vivo</em> and <em>in vitro</em> studies have reported the activation of anti-transcription and pro-inflammatory mediators. Polycyclic aromatic hydrocarbons, metal components or metabolites may increase due to the formation of oxygen reactive species that interact with DNA, producing different types of damage as oxidative damage.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 73","pages":"Pages 212-215"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73623659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The College Adjustment Scales (CAS) test and recent students’ school performance upon entry into a medical school 大学适应量表(CAS)测试和近期学生进入医学院后的学习成绩

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2016.10.005

J.L. Iglesias-Benavides , E. Blum-Valenzuela , A.V. López-Tovar , A.M. Espinosa-Galindo , A.M. Rivas-Estilla

{"title":"The College Adjustment Scales (CAS) test and recent students’ school performance upon entry into a medical school","authors":"J.L. Iglesias-Benavides , E. Blum-Valenzuela , A.V. López-Tovar , A.M. Espinosa-Galindo , A.M. Rivas-Estilla","doi":"10.1016/j.rmu.2016.10.005","DOIUrl":"10.1016/j.rmu.2016.10.005","url":null,"abstract":"<div><p>Admission to a degree program represents a challenge for new students, which those that show greater emotional stability and ability to face school adjustment will best solve. The Draw a Person test and Anton and Reed's College Adjustment Scales (CAS) questionnaire was applied to 2364 first year students of a Medical School in northeastern México admitted during the years 2013 and 2014. One or more abnormal scales were documented in 674 students (28.4%). A correlation study between 1000 students with normal scales and the 674 students with abnormal scales was performed. The group with normal tests had a greater number of student approval (64% vs 46.9%) <em>p</em>  =0.005), academic problems (<em>p</em>  =0.004) and suicidal ideation (<em>p</em>  <!-->0.043). We concluded that the evidence of depression, academic problems, substance abuse and suicidal ideation were associated statistically with low academic performance in the study population.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 73","pages":"Pages 201-204"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76298601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Laparoscopic training by use of a physical simulator and its application in the general surgery residency 物理模拟器的腹腔镜训练及其在普通外科住院医师中的应用

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2016.10.002

A.J. Guerrero-Hernández, J.T. Palacios-Zertuche, F.J. Reyna-Sepúlveda, G.E. Muñoz-Maldonado

{"title":"Laparoscopic training by use of a physical simulator and its application in the general surgery residency","authors":"A.J. Guerrero-Hernández, J.T. Palacios-Zertuche, F.J. Reyna-Sepúlveda, G.E. Muñoz-Maldonado","doi":"10.1016/j.rmu.2016.10.002","DOIUrl":"10.1016/j.rmu.2016.10.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Minimally invasive techniques have become the gold standard for a number of surgical procedures. The benefits include a decrease in morbidity, reducing the length of hospital stay and a faster return to daily activities.</p></div><div><h3>Material and methods</h3><p>An experimental, longitudinal, comparative, prospective, non-blinded study. A training program of 4 weeks’ duration was carried out with an experimental group of first and second year General Surgery residents and social service medical interns (group A); at the end of the training there was a test, where a series of exercises compared the residents who took the training program with a control group (group B) composed of residents from the fourth and fifth year who did not take this training.</p></div><div><h3>Results</h3><p>Upon analyzing the two groups, we observed a decrease in the average time by group A compared to group B. Overall, the 7 exercises show a difference in average time, with group A completing them in 5min compared to group B's 12min (<em>p</em>  <!-->0.05).</p></div><div><h3>Discussion</h3><p>This study shows that training in a physical simulator for laparoscopic surgery, for at least two hours a week for a month, is sufficient to improve laparoscopic surgical skills, reducing turnaround times by more than half compared to those who did not undergo this training.</p></div>","PeriodicalId":34640,"journal":{"name":"Medicina Universitaria","volume":"18 73","pages":"Pages 189-193"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rmu.2016.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73865009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The complete blood count in the early diagnosis of acute leukemia in children 全血细胞计数在儿童急性白血病早期诊断中的价值

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2016.07.006

O. González Llano

引用次数: 2

Glucose tolerance test as a tool in the diagnosis of diabetes mellitus 糖耐量试验在糖尿病诊断中的应用

Medicina Universitaria Pub Date : 2016-10-01 DOI: 10.1016/j.rmu.2017.05.001

J.F. Ovalle Berumen

引用次数: 0