发布求助
文献互助 智能选刊 最新文献

PHARMACOMES: Cause-and-Effect Models linking Drugs, Targets and Disease Mechanisms最新文献

筛选
英文 中文
PHARMACOMES: Cause-and-Effect Models linking Drugs, Targets and Disease Mechanisms 药物组:连接药物、靶点和疾病机制的因果模型
PHARMACOMES: Cause-and-Effect Models linking Drugs, Targets and Disease Mechanisms Pub Date : 2022-08-25 DOI: 10.14293/s2199-rexpo22006.v1
M. Hofmann-Apitius
{"title":"PHARMACOMES: Cause-and-Effect Models linking Drugs, Targets and Disease Mechanisms","authors":"M. Hofmann-Apitius","doi":"10.14293/s2199-rexpo22006.v1","DOIUrl":"https://doi.org/10.14293/s2199-rexpo22006.v1","url":null,"abstract":"Cause-and-Effect models are knowledge assemblies representing essential causal and correlative relationships in a pre-defined disease context. Unlike “pathways”, Cause-and-Effect models can span across scales and readily integrate clinical readouts and endpoints. In my talk, I will guide through some of our work on generating Cause-and-Effect models in the field of neurodegenerative diseases (Alzheimer; Parkinsonism) and will demonstrate, how we generate those using advanced, AI-based “text-2-graph” workflows. The enrichment of Cause-and-Effect models with drug-target information allows us to generate “disease-specific PHARMACOMES”. PHARMACOMES link drug-target information to specific pathophysiology mechanisms and are ideally suited for rational approaches towards modulation of pathophysiology mechanisms. Examples for productive usage of this novel approach in drug repurposing experiments will cover the COVID-19 PHARMACOME and the Human Brain PHARMACOME","PeriodicalId":346256,"journal":{"name":"PHARMACOMES: Cause-and-Effect Models linking Drugs, Targets and Disease Mechanisms","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127191540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信