Hepatitis B Annual最新文献

Non-invasive markers of hepatic fibrosis in chronic Hepatitis B: A review 慢性乙型肝炎肝纤维化的非侵入性标志物:综述

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.45090

M. Al‐Mahtab, S. Rahman, Mobin Khan

引用次数: 2

Study on awareness about hepatitis B viral infection in coastal Eastern India. 印度东部沿海地区乙型肝炎病毒感染意识调查

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.76902

Bijay Misra, C. Panda, H. Das, Kinshuk C. Nayak, S. Singh

{"title":"Study on awareness about hepatitis B viral infection in coastal Eastern India.","authors":"Bijay Misra, C. Panda, H. Das, Kinshuk C. Nayak, S. Singh","doi":"10.4103/0972-9747.76902","DOIUrl":"https://doi.org/10.4103/0972-9747.76902","url":null,"abstract":"Background: Hepatitis B is a major health problem in India. To prevent transmission and progression of the disease in the community, proper community awareness about the disease, including prevention, is necessary. Our objective was to study the awareness amongst the general population about hepatitis B virus, including knowledge regarding vaccine. Materials and Methods: The study was conducted in Department of Gastroenterology of SCB Medical College. The patients attending the OPD and their attendants were subjected to a questionnaire about different aspects of hepatitis B. Binary logistic regression analysis (SPSS 16) was employed to assess the statistical importance of the observations. Results: In all, 682 individuals (65% patients, 35% non-patients) were studied; 78% were males while 22% were females. Majority were in the age group of 31-40 years. 65% hailed from rural area; 65% were poor. About half of the subjects attended state run medical centers for medical attention; only 17% preferred medical colleges. Awareness about the disease and the vaccine among the subjects was 38% and 32%, respectively. 50% of those who were aware had no knowledge about route of transmission, infectivity, or importance of vaccination. Educated individuals were more aware about hepatitis B vaccine (P Conclusions: Only about one-third of the population in coastal Eastern India are aware about hepatitis B and its vaccine. Less than a third of the population are vaccinated for hepatitis B. The educated, especially those who read newspapers and listened to radio, were more aware about the disease/vaccine. The government health agencies and physicians should work together to educate the masses about hepatitis B and its vaccine.","PeriodicalId":345516,"journal":{"name":"Hepatitis B Annual","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128433603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Perinatal transmission of Hepatitis B 乙型肝炎的围产期传播

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.76906

S. Chowdhury, C. Eapen

引用次数: 5

Flares on and off therapy during chronic HBV infection: Pathogenesis, significance and management 慢性HBV感染治疗前后的耀斑:发病机制、意义和管理

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.58803

D. Amarapurkar

{"title":"Flares on and off therapy during chronic HBV infection: Pathogenesis, significance and management","authors":"D. Amarapurkar","doi":"10.4103/0972-9747.58803","DOIUrl":"https://doi.org/10.4103/0972-9747.58803","url":null,"abstract":"Approximately 400 million people worldwide are chronically infected with the hepatitis B virus (HBV). Chronic infection with HBV can lead to progressive liver diseases including cirrhosis, liver failure, and hepatocellular carcinoma. During treatment of chronic hepatitis B (CHB) patients, flares of inflammatory activity are a well known phenomenon. Flares can be life threatening but have also been associated with virological response. While, interferon induced flares have been attributed to the stimulatory effect of IFN, and may precede HBeAg seroconversion, Lamivudine related flares are seen during treatment and after withdrawal of lamivudine, which are probably caused by reoccurrence of HBV replication, and have been associated with decompensation of liver disease. These flares play an important role in the treatment with Peg-IFN α-2b alone or in combination with lamivudine, and patients with pre-existing cirrhosis are at greater risk for experiencing a flare. Furthermore, host induced flares but not virus induced flares may herald a response to therapy. For optimisation of treatment, it is necessary to understand the virological and immunological mechanisms which induce the specific flare patterns. This article reviews the pathogenesis, significance and management of flares encountered during and after cessation of treatment of patients with chronic HBV infection.","PeriodicalId":345516,"journal":{"name":"Hepatitis B Annual","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127753567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comparison of different hepatitis B guidelines. 不同乙肝指南的比较。

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.76905

P. Sethy, M. Goenka

引用次数: 3

Efficacy and safety of telbivudine during pregnancy in a patient with HBeAg-Negative chronic Hepatitis B 替比夫定在慢性乙型肝炎hbeag阴性患者妊娠期的疗效和安全性

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.76912

Arumugam Mohan, M. Hariharan

引用次数: 3

Hepatitis B viral infection: Emerging issues 乙肝病毒感染:新出现的问题

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.45085

S. Singh, Y. Chawla

引用次数: 0

Screening for chronic hepatitis B. 筛查慢性乙型肝炎。

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.162105

K. Shenoy

引用次数: 0

Interferon for HBV infection: Plain or Pegylated? Alone or in combination? Concurrent or sequential? 干扰素治疗HBV感染:普通还是聚乙二醇化?单独还是联合使用?并发还是顺序?

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.190081

A. Sood, V. Midha

{"title":"Interferon for HBV infection: Plain or Pegylated? Alone or in combination? Concurrent or sequential?","authors":"A. Sood, V. Midha","doi":"10.4103/0972-9747.190081","DOIUrl":"https://doi.org/10.4103/0972-9747.190081","url":null,"abstract":"Hepatitis B Virus (HBV) infection is a significant global public health problem. Treatment options that have evolved rapidly over the last two decades have proven to be effective, but clear recommendations regarding the choice of first-line therapy are lacking. With the emergence of pegylated interferon (PEG IFN), conventional interferon has been relegated into the background and has a very limited role in the treatment of chronic Hepatitis B. Pegylated interferon α2a / 2b treatment has been documented to successfully achieve normalization of alanine aminotransferase (ALT) and viral suppression in nearly half of the patients. However, HBsAg loss can be achieved only rarely. Combination therapy, comprising of pegylated interferon plus nucleos(t)ide analogs theoretically appear attractive because of the synergistic anti-viral and immunomodulatory actions, but the available present literature does not provide sufficient evidence to recommend the combination therapy. Patient selection is important for tailoring the therapy for patients with chronic hepatitis B. Pegylated interferon seems suitable for young patients with raised ALTs, moderately high viral load, and having Genotype A / B; the advantage being finite duration of therapy and no risk of emergence of drug resistance.","PeriodicalId":345516,"journal":{"name":"Hepatitis B Annual","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127088763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidentally detected asymptomatic HBsAg positive subjects 偶然发现无症状的HBsAg阳性受试者

Hepatitis B Annual Pub Date : 1900-01-01 DOI: 10.4103/0972-9747.58808

V. Dixit, S. Jena

引用次数: 3