ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology最新文献

{"title":"Use of CRISPR/Cas9 with Homology-Directed Repair (HDR) to Gene-Edit Topoisomerase IIβ in Human Leukemia K562 Cells: Generation of a Resistance Phenotype","authors":"Jessika Carvajal-Moreno, Xinyi Wang, Victor A. Hernandez, J. Yalowich, T. Elton","doi":"10.1124/jpet.122.181860","DOIUrl":"https://doi.org/10.1124/jpet.122.181860","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124448242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Free Targeted Therapy for T-cell Acute Lymphoblastic Leukemia","authors":"J. Neethling, Kostandin V. Pajcini","doi":"10.1124/jpet.122.210240","DOIUrl":"https://doi.org/10.1124/jpet.122.210240","url":null,"abstract":"Abstract","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125048773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Cell Cycle Checkpoints CHK1 and CHK2 is a Novel Therapeutic Approach for Pediatric Neuroblastoma","authors":"B. Morrison, Rameswari Chilamakuri, Saurabh Agarwal","doi":"10.1124/jpet.122.230730","DOIUrl":"https://doi.org/10.1124/jpet.122.230730","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126116481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent and Selective Anti-Tumor Activity","authors":"D. Richardson, M. Dharmasivam, B. Kaya","doi":"10.1124/jpet.122.173810","DOIUrl":"https://doi.org/10.1124/jpet.122.173810","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"11 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116440812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine Disrupting Chemicals as \"structural cues\" for the development of drugs for the treatment of Prostate Cancer (Castration Resistant Prostate Cancer) and PCOS","authors":"Katyayani Sharma, Angelo Lanzilotto, Søren Therkelsen, Therina du Toit, F. Jørgensen, Amit Pandey","doi":"10.1124/jpet.122.163500","DOIUrl":"https://doi.org/10.1124/jpet.122.163500","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114800277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Alleviates Chemotherapy-Induced Toxicities in Non-Diabetic Breast Cancer Patients: A Randomized Controlled Study","authors":"M. El-Mas, Amira B. Kassem, Noha A. El-Bassiouny, M. Helmy, Y. El-Kerm, Manar A Serageldin","doi":"10.1124/jpet.122.159900","DOIUrl":"https://doi.org/10.1124/jpet.122.159900","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116225011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Analysis of DNA Methylation Status of T-Cell Inflamed Signature Reveals a Therapeutic Strategy to Improve Immune Checkpoint Inhibitors Efficacy in Wilms Tumor","authors":"Sarah A. Albasha, Manar Z. Almotawa, Abdulmonem A. Alsaleh, Noura N. Alibrahim, Zaheda H. Radwan, Y. Alhashem, Jenan A Almatouq, Mariam K. Alamoudi","doi":"10.1124/jpet.122.534470","DOIUrl":"https://doi.org/10.1124/jpet.122.534470","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127173967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Paracrine Action of Mutant P53 In Breast Cancer","authors":"Abie Williams-Villalobo, Yun Zhang, Bin Liu, S. Xiong, G. Chau, G. Lozano","doi":"10.1124/jpet.122.562150","DOIUrl":"https://doi.org/10.1124/jpet.122.562150","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128612955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphotericin A21 reduces cell proliferation and modulates anti- and pro-apoptotic proteins in MCF-7 cells.","authors":"L. Rodríguez-Fragoso, Rubi Escobar‐Reséndiz, I. Ortega‐Blake, A. Galván‐Hernández","doi":"10.1124/jpet.122.170830","DOIUrl":"https://doi.org/10.1124/jpet.122.170830","url":null,"abstract":"","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115309099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Role of OGT-mediated Novel NF-κB O-GlcNAcylation in Pancreatic Cancer","authors":"Aishat Motolani, Mat Martin, Benlian Wang, Guanglong Jiang, Yunlong Liu, T. Lu","doi":"10.1124/jpet.122.139650","DOIUrl":"https://doi.org/10.1124/jpet.122.139650","url":null,"abstract":"\u0000 Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortalities of all malignancies, with a mere 5-year survival of ~10%. However, the current first-line treatments have poor patient outcomes, highlighting the urgent need for innovative therapeutics. The nuclear factor κB (NF-κB) is a crucial transcription factor frequently activated constitutively in PDAC. It mediates the transcription of oncogenic and inflammatory genes that facilitate multiple PDAC phenotypes. Thus, a better understanding of the mechanistic underpinnings of NF-κB activation holds substantial promise in PDAC diagnosis and new therapeutics. The purpose of this study is to identify novel regulation of NF-κB, with the aim of providing new diagnostic and therapeutic strategies for PDAC. Here, we report protein O-GlcNAc transferase (OGT) - mediated NF-κB activation through novel serine O-GlcNAcylation of its p65 subunit. We show that overexpression of serine-to-alanine (S-A) mutant at the O-GlcNAcylation site impaired NF-κB nuclear translocation and transcriptional activity in PDAC cells. Moreover, these S-A p65 mutants downregulate NF-κB-target genes important to major cancer hallmarks and inhibit cellular proliferation, migration, and anchorage-independent growth of PDAC cells compared to WT-p65. Interestingly, this modification happens downstream of the inhibitor of NF-κB (IκBα) degradation. Collectively, we have identified OGT-mediated serine O-GlcNAcylation of NF-κB and determined its mechanistic and cellular function in driving PDAC phenotypes. Thus, our study holds great significance as it uncovers a brand-new strategy for PDAC diagnosis and effective therapeutics development.\u0000 Citation Format: Aishat Motolani, Matthew Martin, Benlian Wang, Guanglong Jiang, Yunlong Liu, Tao Lu. Critical role of OGT-mediated novel NF-κB o-glcNAcylation in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1482.","PeriodicalId":344837,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125490543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}