Thrombosis Update最新文献

{"title":"Revisiting hemodynamic definition: Incidence of chronic thromboembolic pulmonary hypertension following acute intermediate-high and high-risk pulmonary embolism","authors":"Bárbara Lacerda Teixeira,&nbsp;André Grazina,&nbsp;Ricardo Carvalheiro,&nbsp;Tiago Mendonça,&nbsp;Tiago Pereira da Silva,&nbsp;António Fiarresga,&nbsp;Ruben Ramos,&nbsp;Duarte Cacela,&nbsp;João Reis,&nbsp;Ana Galrinho,&nbsp;Luís Almeida Morais,&nbsp;Rui Cruz Ferreira","doi":"10.1016/j.tru.2024.100194","DOIUrl":"10.1016/j.tru.2024.100194","url":null,"abstract":"<div><h3>Background</h3><div>The hemodynamic definition of pulmonary hypertension (PH) was updated, lowering the mean pulmonary arterial pressure (PAP) threshold to 20 mmHg and the pulmonary vascular resistance (PVR) to 2 Wood units. The impact of these revised criteria on the number of patients reclassified as PH has not been extensively studied, namely in chronic thromboembolic pulmonary hypertension (CTEPH) population. Since the true incidence of CTEPH after acute pulmonary embolism (PE) is debatable, we aimed to analyze the incidence of CTEPH after high-risk forms of acute PE according to the new 2022 ESC/ERS hemodynamic criteria.</div></div><div><h3>Methods</h3><div>A prospective registry of consecutive intermediate-high- and high-risk PE patients submitted to catheter directed therapies (CDT) in a tertiary center was used. Clinical, echocardiographic, computed tomography angiography (CTA), right heart catheterization (RHC) and digital subtraction pulmonary angiogram (DSPA) data were collected at admission and at 3 months.</div></div><div><h3>Results</h3><div>Among 25 patients, RHC revealed that 36 % of patients met the criteria for PH per the new guidelines, compared to 16 % under the previous definition (p = 0.010), resulting in 20 % being reclassified. Mean PAP and PVR differed significantly according to both definitions. Under the new definition, additional parameters of RHC also showed significant differences (p &lt; 0.05). Perfusion defects were noted in 33 % of PH patients on DSPA but not on CTA, while the remained displayed them on both modalities. Among patients without PH, 31.3 % exhibited perfusion defects.</div></div><div><h3>Conclusion</h3><div>According to the new updated criteria for PH, 36 % of intermediate-high- and high-risk PE patients met the criteria of CTEPH at 3 months of follow-up. With a possible rising incidence of CTEPH, special monitoring and management is crucial.</div></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival and cerebrovascular events after carotid artery stenting in patients with chronic kidney disease","authors":"Qiaoming Jiang ,&nbsp;Jiangkai Yu ,&nbsp;Yutao Zhao ,&nbsp;Bichao Wang ,&nbsp;Xixiang Gao ,&nbsp;Yingchun Xiao","doi":"10.1016/j.tru.2024.100193","DOIUrl":"10.1016/j.tru.2024.100193","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic kidney disease (CKD) is associated with cerebrovascular diseases (CVDs) due to chronic systemic inflammation. This study aimed to estimate perioperative and long-term outcomes in Chinese patients undergoing carotid artery stenting (CAS) who had different stages of CKD.</div></div><div><h3>Method</h3><div>This retrospective study enrolled 888 patients undergoing CAS for carotid artery stenosis. Patients were classified into normal, mild, moderate, and severe CKD and dialysis groups based on their renal function. The primary endpoint was long-term survival from a major adverse event (MAE), which was predefined as the development of a stroke, myocardial infarction (MI), or death during a 10-year long-term follow-up.</div></div><div><h3>Results</h3><div>Perioperative rates for MAE were 1.5 %, 1.8 %, 3.0 %, 10.3 %, and 9.1 % for the five categories (<em>p</em> &lt; 0.001). There was no death within the perioperative 30 days. The estimated 5-year death-free survival rates decreased with worsening renal function (92.2 % vs. 82.7 % vs. 76.9 % vs. 61.4 % vs. 58.6 %, <em>p</em> &lt; 0.001). The long-term MAE-free survival was 94.7 % vs. 91.0 % vs. 80.2 % vs. 63.7 % vs. 52.2 % for the groups, with the differences being significant between normal to moderate CKD and severe CKD and hemodialysis-dependent cases. Cox regression analysis revealed that dialysis (HR = 3.216 (95%CI: 1.662, 6.223), <em>p</em> = 0.001), severe CKD (HR = 4.592 (95%CI: 2.348, 8.982), <em>p</em> &lt; 0.001), hypertension (HR = 1.977 (95%CI: 1.292, 3.024), <em>p</em> = 0.002), coronary artery disease (HR = 1.509 (95%CI: 1.037, 2.196), <em>p</em> = 0.032) and diabetes mellitus (HR = 2.459 (95%CI: 1.482, 4.079), <em>p</em> &lt; 0.001) were predictors of long-term MAE after CAS.</div></div><div><h3>Conclusion</h3><div>Risk of perioperative and long-term MAE increased with CKD severity. Patients with normal to moderate CKD benefited from MAE-free survival after CAS. However, preventive CAS appeared to be inappropriate in severe CKD or hemodialysis cases with asymptomatic carotid stenosis, particularly in those with a number of comorbidities.</div></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving management of catheter related thrombosis (CRT) in cancer patients by incorporating real world data. The value of cancer VTE registries","authors":"Dr Emmanouil S. Papadakis MD, MSc,&nbsp;Dr Lucy A. Norris PhD","doi":"10.1016/j.tru.2024.100195","DOIUrl":"10.1016/j.tru.2024.100195","url":null,"abstract":"","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue factor (F3) gene variants and thrombotic risk among middle-aged and older adults: A population-based cohort study","authors":"Eric Manderstedt ,&nbsp;Christina Lind-Halldén ,&nbsp;Christer Halldén ,&nbsp;Johan Elf ,&nbsp;Peter J. Svensson ,&nbsp;Gunnar Engström ,&nbsp;Olle Melander ,&nbsp;Aris Baras ,&nbsp;Luca A. Lotta ,&nbsp;Bengt Zöller ,&nbsp;for the Regeneron Genetics Center","doi":"10.1016/j.tru.2024.100190","DOIUrl":"10.1016/j.tru.2024.100190","url":null,"abstract":"<div><h3>Background</h3><div>Tissue factor (TF), encoded by the <em>F3</em> gene, is the main initiator of blood coagulation. The molecular epidemiology of the <em>F3</em> gene and the relation to venous thromboembolism (VTE) remains to be determined.</div></div><div><h3>Objectives</h3><div>The aim was to determine the molecular epidemiology and the importance of <em>F3</em> variants for incident VTE by analysis of the population-based MDC study (Malmö Diet and Cancer), consisting of unselected middle-aged and older individuals.</div></div><div><h3>Methods</h3><div>The exons of <em>F3</em> were analyzed in a total of 28,794 individuals from the MDC cohort, and of these, 2584 (9 %) were affected by VTE during follow‐up (1991–2018). Qualifying variants used in gene-collapsing analysis were defined as loss-of-function or non-benign (PolyPhen-2) missense variants with minor allele frequency less than 0.1 %.</div></div><div><h3>Results</h3><div>Exon sequencing of the <em>F3</em> gene identified 61 different variants, 3′ UTR variants (n = 5), 5′ UTR variants (n = 9) synonymous (n = 10), in frame insertion (n = 1), splice region variants (n = 2), missense (n = 33) or loss-of-function variants (n = 1). No associations between common <em>F3</em> gene variants and incident VTE were found. Seventeen rare variants were classified as qualifying and included in collapsing analysis (16 non-benign missense and 1 loss-of-function variants). The prevalence of <em>F3</em> qualifying variants was 0.14 %. Seven individuals with <em>F3</em> qualifying variants had VTE, while 34 individuals had no VTE. The adjusted VTE model was significant (hazard ratio = 2.1 [95 % confidence interval, 1.02–4.48], <em>P-value</em> = 0.045).</div></div><div><h3>Conclusions</h3><div>Qualifying <em>F3</em> gene variants are very rare, indicating a constrained gene. Rare but not common variation in the <em>F3</em> gene may be involved in VTE.</div></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter – related thrombosis in cancer patients: Data from the registry of thrombosis and nEoplasia of SEOM (TESEO)","authors":"Francisco José Pelegrín Mateo ,&nbsp;Teresa Quintanar Verdúguez ,&nbsp;Dialina Brilhante ,&nbsp;Asia Ferrández Arias ,&nbsp;Alejandra Romano Cardozo ,&nbsp;Eva Martínez de Castro ,&nbsp;José Muñoz Langa ,&nbsp;Elena Brozos Vázquez ,&nbsp;María Vallamayor Delgado ,&nbsp;Berta Obispo Portero ,&nbsp;Enrique Gallardo ,&nbsp;José Rubio Pérez ,&nbsp;Isaura Fernández Pérez ,&nbsp;Ignacio García Escobar ,&nbsp;Silvia García Adrián ,&nbsp;José Antonio Santiago Crespo ,&nbsp;Lola Rodríguez-Nogueira ,&nbsp;Gretel Benítez López ,&nbsp;Paula Jimenez-Fonseca ,&nbsp;Andrés Muñoz Martín","doi":"10.1016/j.tru.2024.100191","DOIUrl":"10.1016/j.tru.2024.100191","url":null,"abstract":"<div><h3>Background</h3><div>Catheter related thrombosis (CRT) is the most frequent non-infectious complication associated with central venous access devices (CVAD), with a reported incidence between 13 % and 66 % in symptomatic and asymptomatic patients, respectively, with several factors influencing its development.</div></div><div><h3>Methods</h3><div>CRT events recorded in TESEO, an international, multicentric, and prospective cancer-associated thrombosis registry were assessed. Descriptive analyses were conducted.</div></div><div><h3>Results</h3><div>Between July 2018 and December 2023, 2,567 patients were included in TESEO. Of these, 245 patients developed CRT and were included in this analysis. Mean age was 60.5 years (SD 12.3). Peripherally inserted central catheters (PICC) were present in 42.1%, totally implanted ports (PORT) in 40.9% while 17% had missing data. The most common reported comorbidities were arterial hypertension (28.6%) and dyslipidemia (28.2%). Other thromboembolism associated risk factors were present in ≤10% of patients.</div><div>Venous thromboembolism (VTE) related symptoms occurred in 70.2% of cases at presentation. Pulmonary embolism (PE) was present in 6.5%, being clinically suspected in 56.2% of cases. The diagnosis was mainly unilateral (81.3%) and 50% were central. Arterial and venous rethrombosis was present in 0.8% and 4.9% of cases respectively. Minor bleeding episodes occurred in 2.5% of cases, while major/clinically relevant episodes were present in 3.6%.</div></div><div><h3>Conclusions</h3><div>Usual VTE associated risk factors were infrequent in the TESEO registry population. CRT was symptomatic in most cases, with reduced complication rates after treatment.</div></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usability study of the qLabs® FIB: A new point-of-care system for functional fibrinogen testing","authors":"Maxence Hureau ,&nbsp;Anne-Sophie Bouthors ,&nbsp;Lucie Deroo ,&nbsp;Anne-Sophie Baptiste ,&nbsp;Agnès Le Gouez ,&nbsp;Mathias Rossignol ,&nbsp;Frederic J. Mercier ,&nbsp;Agnès Rigouzzo","doi":"10.1016/j.tru.2024.100192","DOIUrl":"10.1016/j.tru.2024.100192","url":null,"abstract":"<div><h3>Background</h3><div>Identification of hypofibrinogenemia is particularly important in obstetrics since this predicts progression to severe Post-Partum Haemorrhage (PPH).</div></div><div><h3>Objectives</h3><div>To evaluate the usability of qLabs® FIB at the bedside of patients with PPH.</div></div><div><h3>Methods</h3><div>The qLabs® FIB test was performed using a drop of whole blood from a citrated laboratory tube sampled from each parturient with PPH &gt;1 L by a trained user. A usability survey was completed by each clinician performing the test.</div></div><div><h3>Results</h3><div>During the evaluation, 101 qLabs® FIB tests were performed. One hundred completed surveys and 58 free comments were collected. Satisfaction was achieved in 84 % of tests. Usability in emergency setting, timeliness of results, and the results display were considered positive. The qLabs® FIB results were obtained in &lt;3 min for concentrations below 3 g/L whilst the median time to paired laboratory results was 60 (20–120) minutes. The lower a patient's fibrinogen level, the faster the qLabs® FIB result.</div></div><div><h3>Conclusion</h3><div>The usability study was the first step in the validation process of the qLabs® FIB point of care device in obstetric settings.</div></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"17 ","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrous oxide and VTE – no laughing matter","authors":"Lucy A. Norris,&nbsp;Emmanouil S. Papadakis","doi":"10.1016/j.tru.2024.100188","DOIUrl":"10.1016/j.tru.2024.100188","url":null,"abstract":"","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"16 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666572724000300/pdfft?md5=cca7db39af55ba8c3355b4e96dc70579&pid=1-s2.0-S2666572724000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical model for implementation of cancer-associated thrombosis prevention in the outpatient setting","authors":"João Gramaça ,&nbsp;Ana Robalo Lopes,&nbsp;Marta Ganhão,&nbsp;Joana Gonçalves,&nbsp;Rita Gameiro,&nbsp;Isabel Fernandes,&nbsp;Adriano Baptista,&nbsp;Luísa Barbosa,&nbsp;Idília Pina","doi":"10.1016/j.tru.2024.100187","DOIUrl":"10.1016/j.tru.2024.100187","url":null,"abstract":"","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"16 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666572724000294/pdfft?md5=8ceba687e678dd8c5260c022af9b9069&pid=1-s2.0-S2666572724000294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombotic complications after hematopoietic stem cell transplantation and other cellular therapies","authors":"Paschalis Evangelidis ,&nbsp;Eleni Gavriilaki ,&nbsp;Dimitrios A. Tsakiris","doi":"10.1016/j.tru.2024.100186","DOIUrl":"10.1016/j.tru.2024.100186","url":null,"abstract":"<div><p>Hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) immunotherapy are widely used for the management of hematological malignancies. HSCT can be complicated by endothelial injury syndromes, such as HSCT-thrombotic microangiopathy (HSCT-TMA) and sinusoidal obstructive syndrome/veno-occlusive disease (SOS/VOD), which are life-threatening. Moreover, venous thromboembolic events (VTEs) are common in HSCT recipients due to endothelial injury, use of central venous catheters, prolonged hospitalization, and the development of a procoagulant state. VTEs have also been reported post-CAR-T infusion. The management of thrombotic events in these patients is challenging, due to the high risk of bleeding that is present. CAR-T immunotherapy might be followed by toxicities, such as cytokine release syndrome (CRS) and immune effector cell-associated neuro-toxicity syndrome (ICANS). Endothelial dysfunction is implicated in the pathogenesis of these syndromes. Early recognition and management of the above complications are crucial for better patient outcomes.</p></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"16 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666572724000282/pdfft?md5=81a6ec543fa848b1f54eee965017eeb7&pid=1-s2.0-S2666572724000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of heparin-induced thrombocytopenia with factor xa inhibitors: A systematic review","authors":"Colton Jones ,&nbsp;Abiodun Idowu ,&nbsp;Elvis Obomanu ,&nbsp;Raymond Smith ,&nbsp;Karecia Byfield ,&nbsp;Avinash Ramkissoon ,&nbsp;Kevin Bryan Lo ,&nbsp;Ryan Mayo","doi":"10.1016/j.tru.2024.100185","DOIUrl":"10.1016/j.tru.2024.100185","url":null,"abstract":"<div><p>Heparin-induced thrombocytopenia (HIT) is a rare but severe prothrombotic disorder that develops in patients exposed to heparin products. Diagnosis is associated with significant morbidity and mortality. The mainstay of treatment for HIT involves discontinuing all heparin products and administering non-heparin anticoagulants. Since the publication of the American Society of Hematology (ASH) guidelines in 2018, factor Xa inhibitors have become an attractive alternative. We systematically reviewed the literature to determine the efficacy and safety of factor Xa inhibitors in managing HIT. We included any case series, retrospective, or prospective study that evaluated the efficacy of factor Xa inhibitors. We searched PubMed, Ovid, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar from inception to September 2023. Three reviewers independently reviewed titles, abstracts, and full-text articles to determine eligibility using prespecified inclusion and exclusion criteria. Disagreements were resolved by discussion and consensus. Nine hundred sixty-four articles were screened against title and abstract, and 75 studies were selected for full-text review. Fifteen studies eventually met the inclusion criteria. Two hundred eighty-five patients across 15 studies were treated with factor Xa inhibitor. Across all study arms combined, HIT thrombosis-associated mortality was 0 % (n = 0), recurrent thrombosis was 4.56 % (n = 13), and major bleeding was 2.80 % (n = 8). Factor Xa inhibitors showed positive outcomes in HIT in terms of both safety and efficacy. Major limitation of this review is that the studies included are primarily retrospective and, thus, are subject to inherent limitations of observational study design. More randomized controlled trials (RCT) or prospective studies examining non-inferiority or superiority of transitioning to direct oral anticoagulant (DOAC) vs primary treatment with DOAC are needed.</p></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":"16 ","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666572724000270/pdfft?md5=237ceb7c77231c44b9e5334492078af2&pid=1-s2.0-S2666572724000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}