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Michael Lazarou: Building a body of research Michael Lazarou:建立一个研究体系
The Journal of Cell Biology Pub Date : 2019-11-19 DOI: 10.1083/jcb.201911052
M. A. O'Donnell
{"title":"Michael Lazarou: Building a body of research","authors":"M. A. O'Donnell","doi":"10.1083/jcb.201911052","DOIUrl":"https://doi.org/10.1083/jcb.201911052","url":null,"abstract":"Lazarou investigates the relationship between mitochondria and autophagy.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134105208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ciliary force-responsive striated fibers promote basal body connections and cortical interactions 睫状体力响应纹状纤维促进基底体连接和皮层相互作用
The Journal of Cell Biology Pub Date : 2019-11-18 DOI: 10.1083/jcb.201904091
Adam W. J. Soh, Teunis J. P. van Dam, Alexander J. Stemm-Wolf, Andrew T. Pham, G. Morgan, E. O'Toole, C. Pearson
{"title":"Ciliary force-responsive striated fibers promote basal body connections and cortical interactions","authors":"Adam W. J. Soh, Teunis J. P. van Dam, Alexander J. Stemm-Wolf, Andrew T. Pham, G. Morgan, E. O'Toole, C. Pearson","doi":"10.1083/jcb.201904091","DOIUrl":"https://doi.org/10.1083/jcb.201904091","url":null,"abstract":"Soh et al. study the organization of Tetrahymena ciliary arrays. Basal body–associated striated fibers organize motile cilia by promoting basal body orientation, reorientation, and resistance to ciliary forces. To do so, striated fiber length is modulated to ensure connections between neighboring basal bodies and to the cell cortex.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131798960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
NuMA1 promotes axon initial segment assembly through inhibition of endocytosis NuMA1通过抑制内吞作用促进轴突初始片段组装
The Journal of Cell Biology Pub Date : 2019-11-14 DOI: 10.1083/jcb.201907048
Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband
{"title":"NuMA1 promotes axon initial segment assembly through inhibition of endocytosis","authors":"Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband","doi":"10.1083/jcb.201907048","DOIUrl":"https://doi.org/10.1083/jcb.201907048","url":null,"abstract":"Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116936445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Getting under the skin: Cuticle damage elicits systemic autophagy response in C. elegans 进入皮肤下:角质层损伤引起秀丽隐杆线虫的全身自噬反应
The Journal of Cell Biology Pub Date : 2019-11-13 DOI: 10.1083/jcb.201911020
Caroline Kumsta, M. Hansen
{"title":"Getting under the skin: Cuticle damage elicits systemic autophagy response in C. elegans","authors":"Caroline Kumsta, M. Hansen","doi":"10.1083/jcb.201911020","DOIUrl":"https://doi.org/10.1083/jcb.201911020","url":null,"abstract":"Kumsta and Hansen highlight new findings from Zhang and Zhang exploring how local cellular stress triggers autophagy in distant tissues.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"40 7-8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120897815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes fg -核孔蛋白的液态模拟了核孔复合物的渗透屏障特性
The Journal of Cell Biology Pub Date : 2019-11-13 DOI: 10.1083/jcb.201907157
G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke
{"title":"The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes","authors":"G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke","doi":"10.1083/jcb.201907157","DOIUrl":"https://doi.org/10.1083/jcb.201907157","url":null,"abstract":"Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation. Freshly formed liquid nucleoporin droplets mimic permeability barrier properties of NPCs.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129263892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 82
CD2AP links actin to PI3 kinase activity to extend epithelial cell height and constrain cell area CD2AP连接肌动蛋白与PI3激酶活性，延长上皮细胞高度并限制细胞面积
The Journal of Cell Biology Pub Date : 2019-11-13 DOI: 10.1083/jcb.201812087
Y. Wang, W. Brieher
{"title":"CD2AP links actin to PI3 kinase activity to extend epithelial cell height and constrain cell area","authors":"Y. Wang, W. Brieher","doi":"10.1083/jcb.201812087","DOIUrl":"https://doi.org/10.1083/jcb.201812087","url":null,"abstract":"Epithelial cells are categorized as cuboidal versus squamous based on the height of the lateral membrane. Wang and Brieher show that CD2AP links PI3K activity to actin assembly to extend the height of the lateral membrane.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125393560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover 将APEX标记与单个细胞器成像质谱相结合，揭示了溶酶体蛋白周转的异质性
The Journal of Cell Biology Pub Date : 2019-11-12 DOI: 10.1083/jcb.201901097
Derek P. Narendra, C. Guillermier, F. Gyngard, Xiaoping Huang, Michael E. Ward, M. Steinhauser
{"title":"Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover","authors":"Derek P. Narendra, C. Guillermier, F. Gyngard, Xiaoping Huang, Michael E. Ward, M. Steinhauser","doi":"10.1083/jcb.201901097","DOIUrl":"https://doi.org/10.1083/jcb.201901097","url":null,"abstract":"Narendra et al. demonstrate that APEX can be used as the first genetically encoded reporter for isotope ratio imaging mass spectrometry. Bulk protein turnover is measured in individual lysosomes demonstrating unanticipated heterogeneity among lysosomes within a single cell.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122253226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases 拓扑异构酶II summoylation通过Haspin和Aurora B激酶激活中期检查点
The Journal of Cell Biology Pub Date : 2019-11-11 DOI: 10.1083/jcb.201807189
Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke
{"title":"Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases","authors":"Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke","doi":"10.1083/jcb.201807189","DOIUrl":"https://doi.org/10.1083/jcb.201807189","url":null,"abstract":"To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122847408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
DNA replication and mitotic entry: A brake model for cell cycle progression DNA复制和有丝分裂进入:细胞周期进程的刹车模型
The Journal of Cell Biology Pub Date : 2019-11-11 DOI: 10.1083/jcb.201909032
B. Lemmens, A. Lindqvist
{"title":"DNA replication and mitotic entry: A brake model for cell cycle progression","authors":"B. Lemmens, A. Lindqvist","doi":"10.1083/jcb.201909032","DOIUrl":"https://doi.org/10.1083/jcb.201909032","url":null,"abstract":"Lemmens and Lindqvist discuss how DNA replication and mitosis are coordinated and propose a cell cycle model controlled by brakes.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"38 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120994584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Regulation of MT dynamics via direct binding of an Abl family kinase 通过Abl家族激酶的直接结合调控MT动力学
The Journal of Cell Biology Pub Date : 2019-11-07 DOI: 10.1083/jcb.201812144
Yuhan Hu, Wanqing Lyu, L. A. Lowery, A. Koleske
{"title":"Regulation of MT dynamics via direct binding of an Abl family kinase","authors":"Yuhan Hu, Wanqing Lyu, L. A. Lowery, A. Koleske","doi":"10.1083/jcb.201812144","DOIUrl":"https://doi.org/10.1083/jcb.201812144","url":null,"abstract":"Genetic studies revealed that Abl family kinases interact functionally with microtubules, but the mechanism by which Abl kinases regulate microtubules remains unclear. Hu et al. provide the first evidence that the Abl family kinase Abl2 directly binds microtubules to regulate microtubule dynamics.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130727306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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