International Journal of Dermatology and Venerology最新文献_第8页

Research Progress of Genomic Variation in Psoriasis 银屑病基因组变异研究进展

International Journal of Dermatology and Venerology Pub Date : 2022-12-01 DOI: 10.1097/jd9.0000000000000276

Liang Sun

引用次数: 0

Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study 中国西北地区广泛性脓疱性银屑病特征的单中心回顾性研究

International Journal of Dermatology and Venerology Pub Date : 2022-12-01 DOI: 10.1097/JD9.0000000000000275

Xiao-Na Li, B. Peng, S. Geng

{"title":"Characterization of Generalized Pustular Psoriasis in Northwest China: A Single-Center Retrospective Study","authors":"Xiao-Na Li, B. Peng, S. Geng","doi":"10.1097/JD9.0000000000000275","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000275","url":null,"abstract":"Objective: This study was performed to investigate the clinical characteristics of patients with generalized pustular psoriasis (GPP) in Northwest China. Methods: The clinical data of patients with GPP were retrospectively collected in the Second Affiliated Hospital of Xi’an Jiaotong University from January 1, 2017, to December 31, 2021 and analyzed using the chi-square test and Mann-Whitney U test. Results: In total, 179 hospitalized patients were included. The male:female ratio was 1.16:1.00, and the mean age at onset was 35.05 ± 19.11 years. Psoriasis vulgaris was also present in 76.0% of patients, and a family history of psoriasis was present in 15.6%. The mean duration of hospitalization was 10.67 ± 4.31 days, and the mean duration of flares was 29.58 ± 24.32 days. Infections and suspected drugs were predisposing factors. A fever developed in 54.7% of patients, and pruritus developed in 70.9%. Some patients had involvement of the nails (38.0%), scalp (46.9%), and tongue (4.5%). Cardiovascular disease, hypertension, and gallbladder-related disease were common comorbidities. The efficacy of acitretin was 84.7%, that of methotrexate was 66.7%, and that of cyclosporine was 100%. Fifteen patients were treated with secukinumab or adalimumab and responded well. The mean response time was 6.34 ± 2.91 days based on the combination treatments. The mean duration of the treatment regimen was 111.35 ± 94.25 days, and approximately 46.6% (n = 131) of patients developed recurrence. Conclusion: Our retrospective study showed that most cases of GPP were accompanied by psoriasis vulgaris and associated with fever or pruritus. Acitretin had good therapeutic efficacy, but recurrence should be noted. Biologics are increasingly becoming effective treatments, but their superiority and safety need further research.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"5 1","pages":"191 - 198"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46731284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Pathogenesis of Generalized Pustular Psoriasis Based on Molecular Genetics and Immunopathology 基于分子遗传学和免疫病理学的广泛性脓疱性银屑病发病机制研究

International Journal of Dermatology and Venerology Pub Date : 2022-12-01 DOI: 10.1097/JD9.0000000000000277

A. Zhao, Ming Li

{"title":"Understanding the Pathogenesis of Generalized Pustular Psoriasis Based on Molecular Genetics and Immunopathology","authors":"A. Zhao, Ming Li","doi":"10.1097/JD9.0000000000000277","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000277","url":null,"abstract":"Generalized pustular psoriasis (GPP) is a rare and life-threatening autoinflammatory skin disease characterized by recurrent and sudden episodes of widespread rashes with scattered sterile pustules. Clinical and genetic evidence indicates that the pathogenesis of GPP both overlaps and is separate from psoriasis vulgaris (PV). Interleukin (IL)-23/IL-17 immune pathway is well known to play a critical role in the immunopathogenesis of PV, while the inflammation of GPP is more inclined to involve the innate immune response via the IL-1/IL-36–chemokine pathway. Mutations in IL36RN, CARD13, AP1S3, MPO, TNIP1, SERPINA3, and SERPINA1 have been shown to be associated with GPP, among which loss-of-function mutation in IL36RN is the dominant mutation with the highest prevalence. Recent studies have shown that interaction of the IL-36 pathway and the IL-23/IL-17 axis underlies the immunological disturbances of GPP, indicating that innate and adaptive immune responses intertwine in the pathogenesis of GPP. With this deeper understanding of the pathogenesis of GPP, treatment by biologics targeting the IL-1/IL-36 pathway appears to be promising. IL-1 inhibitors, anakinra, canakinumab, and gevokizumab have reportedly been effective in some cases. Spesolimab and imsidolimab, which are antibodies to the IL-36 receptor, are undergoing investigation in a phase II trial and showing promising results. In the present review, we illustrate the current understanding of the pathogenesis of GPP based on recent updates on the molecular genetics and immunopathology of GPP and review recent clinical trials and case reports of novel biologics in the treatment of GPP.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"5 1","pages":"199 - 206"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43990361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Female Gender Was Associated With Increased Odds of Sleep Disturbance in Adult Chinese With Moderate-to-Severe Psoriasis: A Cross-Sectional Study 女性与中重度银屑病成年患者睡眠障碍几率增加相关：一项横断面研究

International Journal of Dermatology and Venerology Pub Date : 2022-11-11 DOI: 10.1097/JD9.0000000000000274

M. Tan, Yan-Hua Luo, Jingjing Hu, Qiaolin Wang, Li-Cong Xu, Kun Hu, Xing-yu Li, Jing Yang, Jun-Chen Chen, Y. Kuang, Wu Zhu

{"title":"Female Gender Was Associated With Increased Odds of Sleep Disturbance in Adult Chinese With Moderate-to-Severe Psoriasis: A Cross-Sectional Study","authors":"M. Tan, Yan-Hua Luo, Jingjing Hu, Qiaolin Wang, Li-Cong Xu, Kun Hu, Xing-yu Li, Jing Yang, Jun-Chen Chen, Y. Kuang, Wu Zhu","doi":"10.1097/JD9.0000000000000274","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000274","url":null,"abstract":"Objective: Up to 85.3% of patients with psoriasis experience sleep disturbance (SD). However, SD has not been characterized in Chinese patients with psoriasis, and the factors that affect SD among adult patients with psoriasis remain unclear. This study was performed to examine the risk of SD in patients with psoriasis compared with a control group of healthy individuals and to identify factors contributing to SD in patients with psoriasis. Methods: This was a cross-sectional, questionnaire-based, case-control study involving 142 adult participants with psoriasis and 142 healthy controls. The Pittsburgh Sleep Quality Index (PSQI) was administered to assess SD. Mild psoriasis was defined by Psoriasis Area and Severity Index and body surface area cut-offs of <10, and mild to severe psoriasis was determined by Psoriasis Area and Severity Index and body surface area cut-offs of ≥10. Logistic regression was performed to investigate the associations. Results: The prevalence of SD (PSQI score of ≥6) was 47.9% in adult patients with psoriasis. The mean PSQI score in patients with psoriasis was 6.1 ± 3.7, which was higher than that in the control group (4.9 ± 2.5, P < 0.001). The risk of SD in the psoriasis group was 1.669 times higher (95% confidence interval, 1.008–2.761; P = 0.046) than that in the healthy group. Female sex (adjusted odds ratio, 4.130; 95% confidence interval, 1.306–13.058; P = 0.016) was significantly associated with an increased risk of SD in patients with moderate to severe psoriasis, whereas there were no significant factors affecting the risk of SD in patients with mild psoriasis. Conclusion: Patients with psoriasis were more likely than healthy controls to develop SD. In patients with moderate to severe psoriasis, but not in those with mild psoriasis, female sex was associated with a higher likelihood of SD.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"6 1","pages":"67 - 71"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47870412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudoainhum Associated With Lepromatous Leprosy: A Very Rare Association in Modern World 伪麻风病与麻风病：现代世界罕见的关联

International Journal of Dermatology and Venerology Pub Date : 2022-11-09 DOI: 10.1097/JD9.0000000000000273

A. A. N. Nishad, M. Pathman, Seyed Ahamed Uwyse, A. Mendis, Prabath Kularathne Abeysundara, A. de Silva

{"title":"Pseudoainhum Associated With Lepromatous Leprosy: A Very Rare Association in Modern World","authors":"A. A. N. Nishad, M. Pathman, Seyed Ahamed Uwyse, A. Mendis, Prabath Kularathne Abeysundara, A. de Silva","doi":"10.1097/JD9.0000000000000273","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000273","url":null,"abstract":"Introduction: Pseudoainhum (dactylolysis spontanea) is characterized by the development of a fibrous band around the digit that gradually leads to autoamputation. Digital pain associated with Pseudoainhum may not be evident in patients with neuropathic conditions. Here, we present a rare case of pseudoainhum patient, which describes a very rare association of pseudoainhum with leprosy. Case presentation: A 48 year old male with lepromatous leprosy, with resorption of digits, charcot joints and tropical ulcers was seen in the clinic. The forth digit of the left hand had a narrowing due to a fibrous band at the 2nd inter phalangeal joint with shiny tethering distal phalanx. He could not recall the duration of the ainhum. He was not suffering from any pain. Discussion: The current report describes a very rare association of pseudoainhum with leprosy. The case involved a 48-year-old man in the dermatology ward with lepromatous leprosy presenting with a pseudoainhum. Conclusion: This case highlights the possibility of delayed presentation of patients with pseudoainhum to physicians when the patients have underlying neuropathic conditions that prevent feeling finger pain and cause abnormal appearance of the digits, especially in leprosy.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"6 1","pages":"110 - 111"},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41779572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major Clinical Features and Epidemic Characteristics of Erosive Vulvar Lichen Planus: A Retrospective Analysis of 40 Patients 40例糜烂性外阴扁平苔藓的主要临床特征及流行病学特征回顾性分析

International Journal of Dermatology and Venerology Pub Date : 2022-10-24 DOI: 10.1097/jd9.0000000000000272

Ya-Kun Shao, K. Sun, Min Yang, Wan Liu, Yu Fu, Jianmin Chang

引用次数: 0

Correlation of Whole Blood Zinc Levels, CD4 Cell Count, Disease Stage, and Dermatologic Manifestations Among HIV Patients: A Single Center Experience in Philippines 全血锌水平、CD4细胞计数、疾病分期和HIV患者皮肤病表现的相关性:菲律宾单一中心经验

International Journal of Dermatology and Venerology Pub Date : 2022-10-24 DOI: 10.1097/JD9.0000000000000271

Riza I. Sarne, M. T. Gabriel, E. G. Vista, Maria Jenina P. Aguado, Cynthia Angela Karim

{"title":"Correlation of Whole Blood Zinc Levels, CD4 Cell Count, Disease Stage, and Dermatologic Manifestations Among HIV Patients: A Single Center Experience in Philippines","authors":"Riza I. Sarne, M. T. Gabriel, E. G. Vista, Maria Jenina P. Aguado, Cynthia Angela Karim","doi":"10.1097/JD9.0000000000000271","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000271","url":null,"abstract":"Objective: Zinc deficiency is the most common micronutrient abnormality seen in human immunodeficiency virus (HIV) infection. Depletion of CD4 cells is a hallmark of HIV infection. The study aims to determine the association between whole blood zinc levels and CD4 cell count and stage of HIV infection among patients in a tertiary hospital in the Philippines. Methods: Sixty-five newly diagnosed HIV-positive patients of the institution were recruited. Demographic profile, whole blood zinc levels, CD4 cell count level, HIV disease stage, and presence of any dermatologic manifestations were noted. Prevalence of zinc deficiency and correlation between whole blood zinc levels and CD4 cell count were determined. The data were analyzed by chi-square and pearson correlation analysis. Results: Among the 65 patients, overall zinc deficiency was noted at 33.8%. Low CD4 count and HIV disease stage IV participants had the highest percentage of zinc deficiency at 54.6% and 50%, respectively. A correlation coefficient at r = 0.3364 was noted between whole blood zinc levels and CD4 cell count (P = 0.006). Twenty-nine patients presented with dermatologic manifestations, with 10 patients being zinc deficient. Conclusion: A weak positive correlation was seen between zinc levels and CD4 count. There is an increasing frequency of zinc level deficiency with a higher HIV disease stage. Dermatologic manifestations of HIV may be present in both patients with normal and deficient zinc levels.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":"6 1","pages":"25 - 28"},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Creeping hair: A case report 爬毛:一份病例报告

International Journal of Dermatology and Venerology Pub Date : 2022-10-12 DOI: 10.1097/jd9.0000000000000255

Shan Cao, Xiangdong Lu, Baoxing Yang

引用次数: 0

Recalcitrant pediatric pyoderma gangrenosum controlled with adalimumab 顽固性小儿坏疽性脓皮病用阿达木单抗控制

International Journal of Dermatology and Venerology Pub Date : 2022-10-12 DOI: 10.1097/jd9.0000000000000258

Z. Wu, Qianyue Xu, Z. Yao

引用次数: 0

Mechanism, impact, and effectiveness of herpes zoster vaccines: A comprehensive review 带状疱疹疫苗的作用机制、影响和有效性：综述

International Journal of Dermatology and Venerology Pub Date : 2022-10-12 DOI: 10.1097/jd9.0000000000000256

Yaser Mansoor Almutawa, Emma Bhattarai, Jing-jun Zhao

引用次数: 0