Sibirskij medicinskij vestnik最新文献

{"title":"NEOADJUVANT CHEMOTHERAPY FOR HER2-POSITIVE BREAST CANCER USING TRASTUZUMAB AND PERTUZUMAB","authors":"A.A. Chapanov, A.E. Kоzyakov, V.E. Voytsytskiy, O. A. Tkachuk","doi":"10.31549/2541-8289-2022-6-1-64-70","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-1-64-70","url":null,"abstract":"Breast cancer is the most common malignant tumor in women. HER2-positive (HER2+) breast cancer is a molecular subtype characterized by an aggressive course, a tendency for tumor cells to spread rapidly, and resistance to standard cytostatic regimens. A number of large randomized trials have shown that the use of neoadjuvant chemotherapy provides the same overall survival rates as adjuvant regimens. In addition, the use of neoadjuvant chemotherapy makes it possible to achieve therapeutic pathomorphosis. The discovery of new chemotherapeutic drugs has made it possible to use a dual blockade of HER2 receptors due to interaction with different subdomains of this protein. In particular, chemotherapy using Trastuzumab, Pertuzumab, and Docetaxel has proven to be an effective regimen to achieve high rates of therapeutic pathomorphosis and survival. The paper analyzes the mechanism of action and effectiveness of the combined use of Trastuzumab and Pertuzumab, presents two clinical cases of practical treatment using dual targeted blockade.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131812855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF MORTALITY IN 2020 OF THE ALTAI TERRITORY RESIDENTS WHO SUFFERED FROM RADIATION EXPOSURE","authors":"I. Kolyado, Environmental Problems, S. Plugin","doi":"10.31549/2541-8289-2021-2-48-52","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-2-48-52","url":null,"abstract":"In the Altai Territory, the Altai Medical Dosimetric Register is functioning, containing information on the health status of the inhabitants of the Territory exposed to radiation. The most numerous contingents are persons exposed to radiation as a result of nuclear tests at the Semipalatinsk testing area. The aim of the study is to obtain up-to-actual data on the health status of persons listed in the register. This research analyzed mortality rates for 2019 and 2020. Preliminary data for 2020 showed significant reductions in overall mortality and mortality from specific causes for the majority of the largest populations in the register.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133317709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE STUDY OF THE PSYCHO-EMOTIONAL STATUS LEVEL IN PATIENTS WITH ACUTE CEREBROVASCULAR ACCIDENT","authors":"M.A. Zhivotova, A. Sultanova, D. Ioanidi, A. Stankevich","doi":"10.31549/2541-8289-2021-3-67-72","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-3-67-72","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116787371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT OF A RISK ASSESSMENT SYSTEM FOR GYNECOLOGICAL DISEASES","authors":"D.S. Denisov, N. Kondakova, A. V. Usova, Т.М. Sokolova","doi":"10.31549/2541-8289-2021-4-72-77","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-4-72-77","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116404141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIASTOLIC DYSFUNCTION OF THE LEFT VENTRICLE AS A «TIME BOMB» IN THE PERIOPERATIVE PERIOD","authors":"E. Vereshchagin, I. V. Peshkova, G. Vereshchagina, T. N. Rеider, V. Valeeva, M. Kozina","doi":"10.31549/2541-8289-2021-1-3-10","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-1-3-10","url":null,"abstract":"Despite of the growing number of patients, the understanding of diastolic dysfunction (DD) and heart failure with preserved ejection fraction (HFpEF) is still not sufficient. The pathophysiological mechanisms of HFpEF are not fully investigated. The mortality rate among patients suffering from heart failure with preserved ejection fraction is the same as among patients with heart failure and reduced ejection fraction. At the moment, the diagnosis and treatment of patients with HFpEF has not been optimized despite these alarming trends. Echocardiography is the main diagnostic tool. The identification of clinically significant echocardiographic changes, even without an evident clinical picture, can contribute to a change in the patient's treatment plan or a revision of surgical tactics and anesthetic management.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121991401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF REMISSION IN BIPOLAR DISORDER ASSOCIATED WITH PLANT CANNABINOID ADDICTION SYNDROME (AMONG PATIENTS WHO STARTED THE USE OF CANNABINOIDS DUE TO BIPOLAR DISORDER, AND MORE THAN FIVE-YEAR DISEASE DURATION)","authors":"I. Klimova, A. Ovchinnikov, Yu.S. Volnaya","doi":"10.31549/2541-8289-2022-6-3-43-49","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-3-43-49","url":null,"abstract":"Bipolar disorder (BD) is a severe mental illness characterized by recurrent episodes of mania, depression, or mixed states. The lifetime prevalence of bipolar disorder across the spectrum is estimated at 2–4% in the general population and is the sixth leading cause of disability worldwide. Cannabis is the most commonly used substance after alcohol and tobacco. Its use increased from 4 to 9.5% between 2020 and 2022, and the prevalence of cannabis use disorders rose from 1.5 to 2.9% over the same period. Among patients with mental disorders, the most common reason for using cannabinoids is to try to alleviate their underlying illness, which is probably achieved in the initial stages of using this type of psychoactive substsance. However, its influence on the course and prognosis of the disease in the long term remains insufficiently studied, which requires a detailed investigation of this problem. For our study, in the period from 2020 to 2022, we selected 104 patients with a diagnosis of bipolar disorder (F31) with a plant cannabinoid addiction syndrome (F12) with a disease duration of more than five years, and the onset of cannabinoid use was noted already amid an established diagnosis of bipolar disorder. The average age in the group was 39 ± 3 years, the distribution by sex was 47% (p < 0.005) — men, 53% (p < 0.005) — women. The study showed that the beginning of the use of plant cannabinoids in a context of BD generally worsens the mental state of patients and, in terms of prognosis, is unfavorable for the course of the disease. This conclusion is confirmed by the complete absence of remission in 2% of patients with an interval of 6 months from the beginning of the study of these patients, the severity of the condition in general, rapid change in the phases of bipolar disorder, and the need to prescribe higher doses of a pharmacological drug. A change in the labor activity of patients was noted — in the primary study we did not register non-working patients; in the study spaced 6 months apart, there were 5% of them; the level of qualification of the work performed in the group as a whole also decreased (employed in highly skilled labor in the primary study — 31%, in the study of this group of patients, this figure decreased to 25%. The motive for using plant cannabinoids was an attempt to alleviate their mental state (73%), 20% of patients noted the motive as “an attempt to experience pleasure”, 7% of patients could not explain the reason for starting cannabinoid use.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117194528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SCREENING PATHOANATOMICAL EXAMINATION OF THE PLACENTA AS A RESERVE FOR REDUCING PERINATAL MORTALITY","authors":"A. P. Nadeev, M. A. Karpov, K.A. Nizovtsev","doi":"10.31549/2541-8289-2022-6-3-9-15","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-3-9-15","url":null,"abstract":"Introduction. The continuity of the morphofunctional system \"mother-placenta-fetus\" allows for the histological examination of the placenta to reveal risk groups for the newborn, pregnant women, puerperas, and to take out preventive measures. Aim of the research. To study the structure and localization of pathological changes in the placenta and the significance of mass pathomorphological studies as a reserve for reducing infant and perinatal mortality. Materials and methods. The afterbirths were examined according to the algorithm proposed by A.P. Milovanov (1999). Histological examination assessed the maturity of the placenta, the severity of compensatory-adaptive reactions and involutive-dystrophic changes, noted the presence and severity of inflammatory changes both in the placenta (placentitis, intervillusitis, villusitis) and extraplacental membranes (choriodeciduiitis, chorioamnionitis). Results. In a large-scale pathoanatomical examination of placentas, the proportion of normal mature placentas without pathological findings was up to 20%. The main pathological process in the placenta is an acute and chronic inflammation, often combined with chronic placental insufficiency (up to 77%). Among the forms of chronic placental insufficiency, the variant of pathological immaturity predominates – immature intermediate villi. For severe inflammation, the most common localization was noted in the fetal membranes, which reflects the ascending route of intrauterine infection. For chronic inflammation, the most common localization was basal deciduitis and parietal choriodeciduitis, which is associated with a high incidence of latent infectious foci in women. Conclusion. A large-scale pathoanatomical examination of placentas , with the identification of risk groups for newborns, along with other factors, can serve as a reserve for reducing perinatal and early neonatal mortality.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123983336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF THE MEDICAL INFORMATION SYSTEM OF THE NOVOSIBIRSK REGION IN THE DOCUMENT FLOW OPTIMIZATION AND FORMATION OF PATIENT'S INTEGRATED ELECTRONIC MEDICAL CARD DURING LIFETIME PATHOANATOMICAL DIAGNOSTICS OF BIOLOGICAL MATERIAL","authors":"Y. Bravve, N. N. Velichkina, I. V. Odarchenko, A. P. Nadeev, S.V. Sokolov, E.A. Kvashnina, O.E. Isupova","doi":"10.31549/2541-8289-2022-6-2-4-10","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-2-4-10","url":null,"abstract":"Early diagnosis of malignant neoplasms is ensured by the quality, accessibility and continuity between medical institutions in the organization of the lifetime pathoanatomical diagnostics of biological material. Improving medical information systems with the involvement of the lifetime pathoanatomical diagnostics in the process of informatization of regional health care, developing mechanisms for documenting, storing and electronic exchange of personal medical information between medical institutions in the Novosibirsk region, is the main task of the system for organizing this type of diagnostics. The urgency of solving this problem is due to the shortage of personnel in the pathoanatomical services, the distance barriers between medical specialists and pathologist; need to ensure the formation of a created system for the exchange of medical documentation. The article presents the experience of using the functionality of the components of the Medical Information System of the Novosibirsk Region (MIS NR) in a regional state budgetary healthcare institution to form a unified information environment, integrate approved accounting forms and ensure efficient workflow in the course of lifetime pathoanatomical diagnostics. The aim of this research is to study the possibilities of additional functionality of the components of the MIS NR, implemented by the employees of the Center for Informatization of Medical Information Analytical Center, to identify the advantages of using the developed functions in optimizing the workflow during the lifetime pathoanatomical diagnostics of biopsy (operative) material, in the formation of a regional Integrated electronic medical record.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126892595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSTCOITAL CYSTITIS: RESULTS OF SURGICAL TREATMENT","authors":"I. V. Feofilov, М.М. Boboev, S. S. Shkuratov, А.К. Pochivalov, P. S. Plugin","doi":"10.31549/2541-8289-2021-3-19-23","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-3-19-23","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125824004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN CHANGES IN THE VAGINAL MICROBIOCENOSIS THROUGH THE EXAMPLE OF WOMEN OF THE REPRODUCTIVE AGE IN NOVOSIBIRSK","authors":"U. Piletskaya, K. Makarov, T. M. Sokolova","doi":"10.31549/2541-8289-2023-7-2-48-53","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-2-48-53","url":null,"abstract":"Introduction. Bacterial vaginosis is associated with a large number of pregnancy complications as well as pelvic inflammatory diseases. However, it is necessary to take into account the species composition of pathogens before starting empirical therapy. Aim of the research. Study of the species composition of vaginal discharge in women of reproductive age in the city of Novosibirsk. Materials and methods. To assess the species composition of the vaginal microflora in women with complaints of pathological discharge from the genital tract, 485 women of the reproductive period of the Central District of Novosibirsk were selected who applied to the antenatal clinic and were diagnosed with bacterial vaginosis. All women underwent a bacteriological examination of the discharge from the genital tract, and 240 women with complaints of pathological discharge from the genital tract were assessed for microbiocenosis using the real-time PCR method. Results. According to the bacteriological examination, the majority of patients did not reveal opportunistic pathogens (75.05%). Representatives of the genus Candida sp. predominated among the identified microorganisms (11.55%), Enterococcus sp. – 9.07%. Representatives of the genus Proteus were detected least often during bacteriological examination – 0.21%. According to the RT-PCR study, representatives of Gardnerella vaginalis + Prevotella bivia + Porphyromonas (89.17%), Eubacterium spp. (68.33%), Megasphaera spp. + Veillonella spp. + Dialister spp. (37.5%) and Atopobium vaginae (30.83%) predominated. Staphylococcus spp., Mycoplasma ho-minis – 2.83% and Enterobacterium spp. were detected less frequently – 4.17%. Conclusion. Since in more than 50% of cases it is not possible to isolate an infectious agent in the presence of pathological discharge from the genital tract of women by the bacteriological method of research, while the real-time PCR method is not always available, an understanding of the microbial landscape of the vagina in women with pathological discharge from the genital tract will allow to prescribe an effective empiric therapy.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"123 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116576483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}