Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII最新文献_第2页

Multispectral endoscopy for early detection of dysplasia in Barrett’s oesophagus (MuSE): a pilot study (Conference Presentation) 多光谱内窥镜早期检测Barrett食管发育不良(MuSE):一项初步研究(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2507009

D. Waterhouse, Siri Luthman, M. Pietro, W. Januszewicz, R. Fitzgerald, S. Bohndiek

{"title":"Multispectral endoscopy for early detection of dysplasia in Barrett’s oesophagus (MuSE): a pilot study (Conference Presentation)","authors":"D. Waterhouse, Siri Luthman, M. Pietro, W. Januszewicz, R. Fitzgerald, S. Bohndiek","doi":"10.1117/12.2507009","DOIUrl":"https://doi.org/10.1117/12.2507009","url":null,"abstract":"Barrett’s oesophagus is an acquired condition that predisposes patients to the development of oesophageal adenocarcinoma through intermediate stages of dysplasia. Early detection of dysplasia allows curative endoscopic therapy, but current standard of care surveillance achieves only around 40% sensitivity for dysplasia.\u0000\u0000Multispectral imaging (MSI) allows simultaneous collection of morphological (spatial) and biochemical (spectral) information from tissue, which can help to more effectively delineate disease. This motivated the design and construction of a compact, clinically translatable multispectral endoscope (MuSE) that can be introduced through the accessory channel of a standard gastroscope to collect multispectral images in vivo.\u0000\u0000MuSE is based around a spectrally resolved detector array (SRDA) with 9 spectral filters (8 narrow bands; average FWHM 30nm, center wavelengths 553, 587, 629, 665, 714, 749, 791, 829nm; 1 broadband; 500–850nm). The SRDA was coupled to a clinically approved 10,000-fibre endoscope (PolyScope) for imaging. Illumination was provided by sequentially by a broadband (400–750nm) and narrowband (400–480nm) source for reflectance and autofluorescence imaging respectively. \u0000\u0000Subjects due to undergo clinically indicated endoscopy with a previous diagnosis of dysplasia or early adenocarcinoma were enrolled for experimental imaging using MuSE in a pilot clinical study. Patients with clearly visible lesions were selected to allow co-registration of the image cubes with pathology of biopsies. Here, we present the results from these first-in-human tests of MuSE, including evaluation of the image quality and classification potential of the multispectral image cubes.","PeriodicalId":342044,"journal":{"name":"Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134048142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic needle tracking with a high-finesse Fabry-Perot fiber optic hydrophone (Conference Presentation) 高精细度法布里-珀罗光纤水听器的超声针跟踪(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2509670

S. Mathews, S. Mosse, W. Xia, D. I. Shakir, Y. Kunpalin, E. Zhang, P. Beard, S. West, A. David, A. Desjardins

{"title":"Ultrasonic needle tracking with a high-finesse Fabry-Perot fiber optic hydrophone (Conference Presentation)","authors":"S. Mathews, S. Mosse, W. Xia, D. I. Shakir, Y. Kunpalin, E. Zhang, P. Beard, S. West, A. David, A. Desjardins","doi":"10.1117/12.2509670","DOIUrl":"https://doi.org/10.1117/12.2509670","url":null,"abstract":"Many percutaneous needle-based procedures such as foetal interventions, tumor biopsies, nerve blocks, and central venous catheterizations are guided by ultrasound (US) imaging to identify the procedural target and to visualize the needle. A key challenge associated with ultrasound-guided needle insertions is accurate and efficient identification of the needle tip, as thin needles can readily stray from the imaging plane and can have poor visibility at large insertion angles. Ultrasonic tracking is a method for localising the needle tip relative to the imaging plane in real-time, using an ultrasonic transmitter or receiver integrated into the needle that is in communication with an external ultrasound imaging probe. This study had two foci. The first was to increase the sensitivity with which ultrasound reception was performed, using a custom fiber optic hydrophone with a high-finesse Fabry-Perot cavity based ultrasound sensor. This sensor, which comprised of a polymer layer sandwiched between dielectric mirrors, was interrogated continuously during insertions into tissue. The second focus of the study was to develop a custom needle stylet into which the fiber optic hydrophone was integrated, which was fully compatible with clinical practice and which could be adapted to different needles. We tested the sensitivity of the sensorized stylet across a wide range of needle angulations, depths and insertion angles in different biological tissues. We demonstrated, for the first time, needle tip localization in ex-vivo tissues at depths beyond 6 cm and insertion angles steeper than 80°. We conclude that ultrasonic tracking with high-finesse Fabry-Perot fiber optic hydrophone is very promising for use in clinical practice.","PeriodicalId":342044,"journal":{"name":"Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116696899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Intraoperative molecular chemical imaging endoscopy for the in vivo detection of anatomical structures (Conference Presentation) 术中分子化学成像内镜在体解剖结构检测(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2510216

Shona Stewart, Aaron Smith, Heather Gomer, Jihang Wang, C. Gardner, J. Post, Jeffrey A. Cohen, P. Treado

引用次数: 0

Impact of the regulatory climate in Europe on healthcare innovations in the field of biophotonics (Conference Presentation) 欧洲监管环境对生物光子学领域医疗保健创新的影响(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2522255

R. Verdaasdonk

引用次数: 0

Bedside anticoagulation monitoring during cardiac surgery with a drop of whole blood (Conference Presentation) 心脏手术中一滴全血床边抗凝监测(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2510608

D. Tshikudi, A. Wirth, Michael N. Andrawes, S. Nadkarni

引用次数: 0

A web-based multiresolution viewer to measure expert search patterns in large microscopy images: towards machine-based dimensionality reduction (Conference Presentation) 基于网络的多分辨率查看器，用于测量大型显微镜图像中的专家搜索模式:面向基于机器的降维(会议报告)

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII Pub Date : 2019-03-07 DOI: 10.1117/12.2510459

Hui Zhuge, J. Brown

引用次数: 2