S. Fitzpatrick, D. Kerr, B. Fitzpatrick, S. Giannakidou, P-R J Domeyer, N. Fragakis, AP. Antoniadis, M. Sotiriadou, V. Vassilikos
{"title":"Supraventricular tachycardia","authors":"S. Fitzpatrick, D. Kerr, B. Fitzpatrick, S. Giannakidou, P-R J Domeyer, N. Fragakis, AP. Antoniadis, M. Sotiriadou, V. Vassilikos","doi":"10.1002/9781119547808.ch29","DOIUrl":"https://doi.org/10.1002/9781119547808.ch29","url":null,"abstract":"Introduction: the management of these patients. AV synchrony has been shown to improve stroke volume and is fundamental in the maintenance of appropriate cardiac output. The physiological pacing provided by dual chamber devices should reduce cardiovascular mortality and morbidity and improve patient quality of life (QOL). It is unclear however if the maintenance of AV synchrony achieved through the artificial means of physiological pacing correlates with intrinsi- cally maintained AV synchrony when comparing QOL scores and cardiac symptoms in these patients. QOL has become recognised as a valuable measure for assessing the benefits that therapeutic interventions such as pacemaker implantation can have on a patients’ well-being. Due to the life-long therapeutic intervention associated with pacemaker implant, there is increasing emphasis on improving QOL in these patients. This study is the first study to investigate the level of pacemaker dependency in patients with dual-chamber devices, its relationship to QOL and cardiac symptoms. Purpose: To determine the relationship between QOL, cardiac symptoms and the level of physiological dependency patients have on their dual chamber pacemaker to maintain AV synchrony. Methods: Thirty three patients with SSS or AV block were enrolled in a single centre, cross sectional study. To ensure patients had a dual chamber pacemaker implanted, participants were purposively recruited. Patients completed both the SF-36 QOL ques- tionnaire and the pacemaker specific Aquarel questionnaire to assess symptoms. The cumulative percentage of atrial and ventricular pacing required to maintain AV synchrony was recorded at clinic when the patient attended for their clinical review. Pacemaker dependency scores were correlated with SF-36 and Aquarel scores to determine if any relationship existed between pacemaker dependency and QOL and symptom scores. Results: Significant improvement in two SF-36 domains were reported by those patients who had increased pacemaker dependency; Vitality (r ¼ 0.41, p < 0.05) and social functioning (r ¼ 0.37, p ¼ < 0.05). Pacemaker dependency was also significantly correlated with the cognition domain of Aquarel (r ¼ -0.51, p ¼ < 0.05). Conclusion: No previous studies have examined relationships that exist between pacemaker dependency, QOL and symptoms in patients with dual chamber devices only. These findings will help supplement current clinical practice and patient educa- tion on QOL and symptom expectations following pacemaker implant. Conclusions: In our a routine is feasible, safe and effective in all procedures, thanks to An EA-EB Objective: The purpose of this study was to evaluate the impact on the quality of life (QoL), of interventional or medical treatment in patients with a history of supraventricular tachycardias (SVTs). Methods: 140 patients with SVTs were enrolled and divided into two groups accord- ing to the therapeutical approach of their personal choice. Group A consisted of 100 patien","PeriodicalId":341699,"journal":{"name":"Rapid Cardiac Care","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126239233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Fung, Honglin Luo, Ye Qiu, Decheng Yang, Bruce McManus
{"title":"Myocarditis","authors":"G. Fung, Honglin Luo, Ye Qiu, Decheng Yang, Bruce McManus","doi":"10.1002/9781119547808.ch27","DOIUrl":"https://doi.org/10.1002/9781119547808.ch27","url":null,"abstract":": Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention. ( Circ Res . 2016;118:496-514. DOI: chain reaction techniques for cellular infiltrates viral presence. myocardium is provided by the findings that elimination of the coxsackievirus-adenovirus receptor (CAR) specifically in the adult mouse hearts completely blocks viral infection of myocardial cells and virus-induced inflammation in the myocardium. These CVB3-infected mice exhibit improved cardiac function, whereas other tissues (eg, pancreas and spleen) that also express CAR are CVB3 positive. This study suggests that viral infection of cardiomyocytes and consequent productive viral replication within the myocardium is required for the development of myocarditis. CAR, a transmembrane protein in the family of adhesion molecules, localized predominantly at the intercalated disc and the cell–cell junctions of the AV node in the adult heart is required for virus entry into different cell types. 79,80 Studies from independent research groups revealed an important role of the in embryonic development and the maintenance of nor-mal AV conduction and cardiac function. 79–81 The the heart of patients adult young myocarditis. In CVB3 also determined by decay-accelerating factor (CD55) coreceptor in certain cell types. 83 For CVB3 with decay-accelerating factor on the apical surface of epithelial cells the interaction between virus and CAR, which is localized to the tight junction; normally inacces-sible to virus. The underlying direct been extensively studied. molecular protein signaling","PeriodicalId":341699,"journal":{"name":"Rapid Cardiac Care","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133096596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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