Bogazici Tip Dergisi最新文献

The effects of inhaled corticosteroids on bone mineral density, bone formation/resorption markers and quality of life in premenopausal asthmatic women 吸入皮质类固醇对绝经前哮喘妇女骨密度、骨形成/骨吸收指标和生活质量的影响

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2022.33254

A. Atıcı

引用次数: 0

Magnetic Resonance Imaging/Ultrasound Fusion-Guided Corticosteroid Injection to Synovial and Ligamentous Portion of Sacroiliac Joint in Patients with Axial Spondyloarthritis 磁共振成像/超声融合引导下骶髂关节滑膜和韧带部分皮质类固醇注射治疗轴型颈椎病

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2022.65882

K. Sarı

引用次数: 0

Treatment Adherence in Multiple Sclerosis: The Effect of Drug Administration Methods and Neuropsychiatric Comorbidities 多发性硬化症的治疗依从性:给药方法和神经精神合并症的影响

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2023.43265

Sena Destan Bunul

{"title":"Treatment Adherence in Multiple Sclerosis: The Effect of Drug Administration Methods and Neuropsychiatric Comorbidities","authors":"Sena Destan Bunul","doi":"10.14744/bmj.2023.43265","DOIUrl":"https://doi.org/10.14744/bmj.2023.43265","url":null,"abstract":"Objectives: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting young adults. While disease-modifying drugs (DMDs) help manage and decelerate disease progression, adherence to these treatments is a significant challenge. This study aimed to investigate the relationship between treatment adherence and different drug administration methods in MS patients in the context of neuropsychiatric evaluations. Methods: A prospective cohort study was conducted at the University Hospital of Neurology Clinic using the 2017 revised McDonald criteria for MS diagnosis. Demographic data, MS-related metrics, and DMDs were recorded. Participants were stratified based on their DMDs into oral, injectable, and infusion treatments. The MS Treatment Adherence Questionnaire, Beck Depression Inventory, and State-Trait Anxiety Inventory were administered. Results: Of the 89 patients, treatment adherence was 45%. There were significant differences in side effect scores between the non-adherent and adherent groups for both oral and injectable DMDs. The Beck Depression Inventory average score was 12.49±9.81, while the State-Trait Anxiety Inventory average scores for STAI1 and STAI2 were 38.95±10.41 and 47.89±10.66, respectively. Significant differences were observed in disease duration, the average expanded disability status scale score, and the average STAI score. Conclusion: Adherence rates varied with the method of drug administration, with oral treatments having 34.4% adherence and injectable treatments having 53.4%. Factors like perceived efficacy, depression, and anxiety influenced treatment adherence. No significant correlations were found between demographic factors like age, gender, or education and adherence rates. Treatment adherence is crucial in managing MS. This study highlights the role of drug administration methods and neuropsychiatric comorbidities in influencing adherence. A comprehensive assessment considering these factors is vital in choosing an appropriate DMD for MS patients","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135316621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal and Maternal Effects of Amnioinfusion Applied during Delivery in Oligohydramniotic Meconium- Stained Pregnancies 羊水过少胎粪染色妊娠分娩中应用羊膜输注对胎儿和母体的影响

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2023.63308

Mustafa Karadeniz

{"title":"Fetal and Maternal Effects of Amnioinfusion Applied during Delivery in Oligohydramniotic Meconium- Stained Pregnancies","authors":"Mustafa Karadeniz","doi":"10.14744/bmj.2023.63308","DOIUrl":"https://doi.org/10.14744/bmj.2023.63308","url":null,"abstract":"Objectives: This study aimed to investigate the fetal and maternal effects of amnioinfusion applied during delivery in meconium-stained pregnancies. Methods: Sixty singleton pregnancies with cervical dilation >2 cm, normal fetal heart rate, and amniotic fluid index below 5 cm, at or beyond 37 weeks of gestation were included in this study. Thirty patients were randomly assigned to the amnioinfusion group and the other 30 patients formed the control group. Results: After amnioinfusion was applied to both groups, maternal fever, fetal tachycardia, fetal heart rate tracings, operation rates, Apgar scores, presence of meconium under vocal cords and oropharynx, and incidence of meconium aspiration syndrome (MAS) were evaluated. Patients requiring operative intervention due to fetal distress were 3% (1/30) in Group 1 and 37% (11/30) in Group 2, which was statistically significant (p=0.002). Apgar scores below 7 at 1 min in Group 1 was 10% (3/30), while it was 40% (12/30) in Group 2, which was statistically significant (p=0.01). In Group 1, no infants had an Apgar score below 7 at 5 min, while in Group 2, 24% (7/30) of infants had an Apgar score below 7, which was statistically significant (p=0.01). Meconium under the oropharynx was found to be 24% (7/30) in Group 1 and 70% (21/30) in Group 2, while the presence of meconium under the vocal cords was 6% (2/30) in Group 1 and 44% (13/30) in Group 2, and both of these differences were statistically significant (p=0.0006, p=0.002). The incidence of MAS observed in Group 1 was 0 and 20% (6/30) in Group 2, which was statistically significant (p=0.02). Conclusion: Amnioinfusion is one of a series of interventions aimed at reducing mortality and morbidity related to meconium aspiration. Although our clinical study showed positive results, randomized controlled trials, and meta-analyses are needed to clarify whether routine amnioinfusion provides clinical benefits, and prospective randomized controlled studies should be supported.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Differences Between the Frequency of Getting Sick of Health Personnel of Samsun Education and Research Hospital During the Second and Third Wave Period of COVID-19: A Cross-Sectional Study 第二波和第三波新冠肺炎疫情期间三星教研院医护人员患病频次差异的横断面研究

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2022.69672

Vaner Koksal

引用次数: 0

Repeated Intravenous Thrombolytic Treatment Experience with Tissue Plasminogen Activator In Patients with Acute Ischemic Stroke: Case Series 组织型纤溶酶原激活剂在急性缺血性脑卒中患者中反复静脉溶栓治疗的经验:病例系列

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2022.58070

Kadriye Güleda Keskin

引用次数: 0

Side effects of clozapine treatment in patients with schizophrenia and schizoaffective disorder and their role in discontinuation of treatment 氯氮平治疗精神分裂症和分裂情感性障碍的副作用及其在停药中的作用

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2022.59254

Rumeysa Tasdelen

引用次数: 0

Do TNF Inhibitors Increase the Frequency of Thyroid Nodules in Axial-spondyloarthritis Patients? A Case–control Study TNF抑制剂会增加轴性脊柱性关节炎患者甲状腺结节的发生频率吗?病例对照研究

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2023.98216

Esra Dilşat Bayrak

{"title":"Do TNF Inhibitors Increase the Frequency of Thyroid Nodules in Axial-spondyloarthritis Patients? A Case–control Study","authors":"Esra Dilşat Bayrak","doi":"10.14744/bmj.2023.98216","DOIUrl":"https://doi.org/10.14744/bmj.2023.98216","url":null,"abstract":"Objectives: Tumor necrosis factor (TNF) inhibitors have made great progress in the management of axial spondy-loarthritis (axSpA). An increase in malignancies associated with TNF inhibitors has always raised suspicions but is unproven. The aim of this study is to investigate whether there is an increase in the frequency of thyroid nodules in axSpA patients treated with TNF inhibitors and to determine the predictive factors. Methods: In this retrospective case–control study, axSpA patients who received and did not receive TNF inhibitor treatment were divided into two groups. Patients were enrolled by age, gender, symptom duration, duration of anti-TNF therapy, human leukocyte antigen B27 (HLA-B27) status, smoking history (current smokers), and family history of thyroid malignancy. Thyroid ultrasound was performed in all patients, and thyroid nodule positivity, number, and nodule characteristics were recorded. Results: A total of 75 patients with axSpA (37 patients were in the TNF inhibitor group and 38 patients were in the control group) were included in the study. Nodule positivity was similar in both groups (p=0.571), and no malignancy was detected in patients with thyroid nodules. No difference was found between nodule positivity and gender, HLA B27, smoking, or family history (p=0.10, p=0.10, p=0.726, and p=0.843, respectively). Age was the only predictor for thyroid nodule positivity in all axSpA patients (p:0.009, 95% of CI: 0.004–0.02). Conclusion: TNF inhibitors do not increase thyroid nodules or malignancies in axSpA patients.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Epidural Ewing’s Sarcoma Presenting with Rapid Progression: A Case Report 宫颈硬膜外尤文氏肉瘤进展迅速1例

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2023.53824

Pınar Kuru Bektaşoğlu

{"title":"Cervical Epidural Ewing’s Sarcoma Presenting with Rapid Progression: A Case Report","authors":"Pınar Kuru Bektaşoğlu","doi":"10.14744/bmj.2023.53824","DOIUrl":"https://doi.org/10.14744/bmj.2023.53824","url":null,"abstract":"Primary extraskeletal Ewing’s sarcoma is a highly malignant and extremely rare tumor araising from the soft tissues. There is a peak incidence in the second decade of life. A 24-year-old female presented with rapid loss of weight within 1 month, palpable mass lesion in cervical region, right upper limb pain, weakness in all extremities especially in the right upper limb, difficulty in walking, and urinary incontinence. In her neurological examination, her right upper extremity was parethic (3/5). Spinal magnetic resonance imaging (MRI) revealed an epidural mass lesion located at C7-T1 vertebral level, with prominent spinal cord compression. In T1-and T2-weighted images, the tumor was isointense and heterogeneous contrast-enhancement was prominent. An emergency surgery was undertaken because of rapid deterioration of neurological status. A gross total excision was achieved. Early post-operative neurological examination was normal. The pathology report was Ewing’s sarcoma. In her post-operative 1 st month, when planning to start oncological treatment, she was referred with right upper extremity paresis and recurrent lesion located at C6-T2 level with spinal cord compression. Urgent surgical intervention was performed due to rapid neurological deterioration. Gross total excision was achieved. Her recurrent pathology was also consistent with Ewing’s sarcoma. Oncological treatment was planned with radiotherapy and chemotherapy (Vincristine, actinomycin D, and cyclophosphamide). A repeat MRI was performed at the completion of her treatment which showed no residual tumor at 6 th month after surgery. This case highlights the possibility of rapid progression in extraskeletal Ewing’s sarcoma and the importance of early diagnosis and intervention.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal Aflibercept Therapy in Intravitreal Bevacizumab/Ranibizumab Treatment-resistant Exudative Age-related Macular Degeneration 贝伐单抗/雷尼单抗治疗抵抗性渗出性老年性黄斑变性的玻璃体内阿非利塞普治疗

Bogazici Tip Dergisi Pub Date : 2023-01-01 DOI: 10.14744/bmj.2023.18199

Neslihan Sevimli

{"title":"Intravitreal Aflibercept Therapy in Intravitreal Bevacizumab/Ranibizumab Treatment-resistant Exudative Age-related Macular Degeneration","authors":"Neslihan Sevimli","doi":"10.14744/bmj.2023.18199","DOIUrl":"https://doi.org/10.14744/bmj.2023.18199","url":null,"abstract":"Objectives: The objective of the study was to evaluate the functional and anatomical results of intravitreal afliber-cept (IVA) in cases resistant to intravitreal bevacizumab (IVB)/ intravitreal ranibizumab (IVR) for exudative age-related macular degeneration (AMD). Methods: Patients who did not have an increase in best-corrected visual acuity (BCVA) or intraretinal fluid (IRF)/ subretinal fluid (SRF) fluid regression despite at least three doses of IVB/IVR. The files of the patients were scanned and central macular thickness (CMT), presence of IRF/SRF, and height of pigment epithelial detachment (PED) were recorded before IVA, after 3 months of loading IVA, and 1 year after IVA and compared. Results: A total of 31 patients with a mean age of 74.2±10.53 were included in the study. The mean BCVA, CMT, and PED heights before IVA were 0.52±0.31 LogMAR, 301.10±76.27 µm, and 130.81±73.72 µm, respectively. After three doses of IVA loading, mean BCVA, CMT, and PED heights were 0.51±0.28 LogMAR, 262.86±69.74 µm, and 96.00±57.66 µm, respectively. A significant decrease was found in CMT and PED height values compared to the results obtained before IVA (p=0.001 and p=0.006). In the 1-year of IVA, mean BCVA, CMT, and PED heights were 0.53±0.33 LogMAR, 257.61±92.05 µm and 95.61±66.67 µm, respectively. There was a significant decrease in CMT and PED values compared to the values obtained before IVA treatment (p=0.004 and p=0.04). Conclusion: In exudative AMD patients resistant to IVB/IVR treatment, improvement in anatomical results is observed in the short and long term, while functional success is not affected by switch therapy.","PeriodicalId":34126,"journal":{"name":"Bogazici Tip Dergisi","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0