Proceedings of the 3rd International Conference on Medical and Health Informatics最新文献_第2页

Formation of Thrombosis and Its Potential Diagnosis and Treatment with Optoacoustic Technology 血栓形成及其潜在的光声诊断和治疗技术

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340040

Muqun Yang, T. Tan

引用次数: 1

Construction and Functional Analysis of Luciferase Reporter Plasmid Containing CAAP1 Gene Promoter 含CAAP1基因启动子的荧光素酶报告质粒的构建及功能分析

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340045

Hui-Min Zhang, Jun Wang, Xing-hua Liao

{"title":"Construction and Functional Analysis of Luciferase Reporter Plasmid Containing CAAP1 Gene Promoter","authors":"Hui-Min Zhang, Jun Wang, Xing-hua Liao","doi":"10.1145/3340037.3340045","DOIUrl":"https://doi.org/10.1145/3340037.3340045","url":null,"abstract":"Megakaryoblastic leukemia 1 (MKL1) was closely related to the pathogenesis of various human malignant cancers, It has been reported in the literature that MKL-1 could promote the proliferation of gastric cancer cells and affect the cell cycle. And could affect the value-added and migration ability of lung cancer cells.However, The mechanism of MKL-1 affecting autophagy and apoptosis of tumor cells was not clear. Caspase activity and apoptosis inhibitor 1 (CAAP1) was reported to be involved in cell apoptosis, It can participate in the regulation of apoptosis in tumor cells. In this study, human CAAP1 promoter luciferase reporter construct was successfully constructed. Then transfected overexpression vectors of human MKL-1 into 293T cells,and detected the activation of the CAAP1 promoter by luciferase reporter assay. The result showed that transfected the overexpression MKL-1 vectors can enhance the transcriptional activity of CAAP1. Our research will further reveal the apoptosis of gastric cancer cells and may provide theoretical foundations for methods to cure gastric cancer.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"61 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131872285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant Functional Connectivity Dynamics of Superior Temporal Sulcus and Its Associations with GABA Genes Expression in Autism 自闭症患者颞上沟异常功能连接动态及其与GABA基因表达的关系

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340049

Xiaonan Guo, Changchun He, Xujun Duan, Shaoqiang Han, Jinming Xiao, Huafu Chen

{"title":"Aberrant Functional Connectivity Dynamics of Superior Temporal Sulcus and Its Associations with GABA Genes Expression in Autism","authors":"Xiaonan Guo, Changchun He, Xujun Duan, Shaoqiang Han, Jinming Xiao, Huafu Chen","doi":"10.1145/3340037.3340049","DOIUrl":"https://doi.org/10.1145/3340037.3340049","url":null,"abstract":"Autism spectrum disorder (ASD) is associated with functional coordination disturbances among brain regions. Genetic studies implicated that dysfunctional gamma-aminobutyric acid (GABA) system may play an important role in autism etiology. Based on previous reported static functional connectivity abnormalities of the posterior superior temporal sulcus (pSTS) in ASD, the current study aimed to explore the dynamic functional connectivity (dFC) variability of the pSTS in ASD and its associations with GABA receptor genes expression. Resting-state functional magnetic resonance imaging data obtained from the Autism Brain Imaging Data Exchange repository were analyzed in 209 males with ASD and 298 demographically-matched control males. For each subject, dFC maps of the bilateral pSTS were constructed through Flexible Least Squares strategy, and the variance of the dFC time series at each voxel was further calculated to quantify the temporal variability. Finally, gene expression decoding analysis was performed using NeuroVault to associate the dFC variability abnormalities with expression data of the GABA receptor genes. Compared with typical controls, individuals with ASD showed increased dFC variability between the left pSTS and right temporal regions, including the middle temporal gyrus and fusiform gyrus. In addition, decreased dFC variability was found between the right pSTS and bilateral posterior cingulate cortex in ASD. Gene expression decoding result showed that aberrant dFC variability patterns of the bilateral pSTS were related to GABA receptor genes expression. These findings suggest abnormal dFC variability of the pSTS in ASD and implicate the potential links between these connectivity abnormalities and GABA genes expression.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121930452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Automatic Prediction of Depression in Older Age 老年抑郁症的自动预测

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340042

Hui Yang, P. Bath

引用次数: 7

Influence of Online and Face-to-face Collaboration and Learning Style on Cognitive Load and Engagement in a Health Introductory Course 在线、面对面协作和学习方式对健康导论课程认知负荷和投入的影响

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340069

Cheng-Hsuan Lan, Meng-Huei Sheng, Yu-Chiung Hsu, Ya-Ming Shiue

{"title":"Influence of Online and Face-to-face Collaboration and Learning Style on Cognitive Load and Engagement in a Health Introductory Course","authors":"Cheng-Hsuan Lan, Meng-Huei Sheng, Yu-Chiung Hsu, Ya-Ming Shiue","doi":"10.1145/3340037.3340069","DOIUrl":"https://doi.org/10.1145/3340037.3340069","url":null,"abstract":"Although collaborative learning has received increasing attention, few studies have examined the differences between online and face-to-face (f2f) collaboration. This study utilized a two-factor experimental design to investigate the influences of collaboration mode (f2f versus online) and learning style on students' cognitive load and engagement. To assess the differences between online and f2f collaboration, cognitive load scale and engagement were collected from two different classes taking the same course at a university in Taiwan. The results show that online collaboration led to a higher cognitive load than that required for f2f collaboration because students have to learn how to use the online collaboration platform. However, online collaboration had higher engagement compared to that for f2f collaboration which represented student were more willing to engage in collaborative technologies. Students who preferred visual learning reported that the use of online collaboration led to less cognitive load and higher sustained attention than that experienced with verbal learning. No significant differences were found related to students' learning style in the f2f collaboration group.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123110372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Advances in the Prevention of Cardiovascular Diseases by Phytosterol 植物甾醇预防心血管疾病的研究进展

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340073

N. Bai

{"title":"Advances in the Prevention of Cardiovascular Diseases by Phytosterol","authors":"N. Bai","doi":"10.1145/3340037.3340073","DOIUrl":"https://doi.org/10.1145/3340037.3340073","url":null,"abstract":"Cardiovascular diseases, mainly atherosclerosis and coronary heart disease, are crucial causes for worldwide morbidity and mortality. Unhealthy lifestyle and diet with high low-density lipoprotein (LDL)-cholesterol level are the major risk factors. Preventions of CVDs need to be taken early in age by changing to more phytosterol-enriched diet. Phytosterol is plant-derived compound with similar structure and function as cholesterol, but when supplied with food, it can lower the serum cholesterol concentration. Studies recommend the daily intake of 2g to 2.5g supplement of phytosterol can significantly reduce plasma LDL-cholesterol level. There are many researches on the mechanisms of cholesterol-lowering effect of plant sterol and plant stanol. It has been found that the differences in solubility and hydrophobicity enable phytosterol to intervene cholesterol from incorporating into micelles and to co-precipitate with cholesterol into solid crystals in intestinal lumen and reduce the absorption of cholesterol. Phytosterol also promotes the transporter gene expression to increase the cholesterol excretion back into small intestine. Furthermore, phytosterol also affects cholesterol metabolism and its transport in blood stream. Therefore, food enriched with phytosterol can be an efficient and safe method of preventing CVDs.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115073099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Visualization Analysis of Cardiovascular Risk Factors Based on Knowledge Mapping 基于知识图谱的心血管危险因素可视化分析

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340059

Ling Yan, Zuojian Zhou, Yun Hu, Yihua Song, Weihong Zhou

{"title":"Visualization Analysis of Cardiovascular Risk Factors Based on Knowledge Mapping","authors":"Ling Yan, Zuojian Zhou, Yun Hu, Yihua Song, Weihong Zhou","doi":"10.1145/3340037.3340059","DOIUrl":"https://doi.org/10.1145/3340037.3340059","url":null,"abstract":"To provide guidance for the study of risk factors of cardiovascular disease in China, we analyze and compared the research hotspots and frontiers of cardiovascular risk factors in China and outside China in this paper. The CiteSpace software is used to visualize the research literature on cardiovascular risk factors from Cnki(China Knowledge Network Internet) and Web of Science core collection database from 2010-2018, and to draw the knowledge map of high-frequency words, research institutions and countries. In this project, a total of 318 Chinese literatures and 9,009 English literatures were screened out as research objects. The number of annual publications assumes an increasing tendency, most of which are concentrated in developed countries or regions. Study of cardiovascular risk factors outside China is significantly taken more seriously than in China. This study shows that the research frontier has already been extended to lifestyle, particulate air pollution, socioeconomic status, depression, stroke and breast cancer, etc. Moreover, children, adolescents and women have been more concerned in the target population. In consideration of the main reasons for cardiovascular disease---Hypertension, diabetes, coronary heart disease, obesity, atherosclerosis and metabolic syndrome, etc., we should pay close attention to the influence on the risk of cardiovascular disease produced by psychological state, living habits, regional differences, air pollution and so on. Meanwhile, we also need to take the screening and prevention of cardiovascular risk more seriously among adolescents.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122806609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Effective ROI Extracting Method for Color Brain Slice in Assisting the Diagnostic Analysis of Epilepsy 一种有效的彩色脑片ROI提取方法辅助癫痫诊断分析

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340041

Bin Liu, Mingzhe Wang, Song Zhang, L. Gao, Liang Yang

{"title":"An Effective ROI Extracting Method for Color Brain Slice in Assisting the Diagnostic Analysis of Epilepsy","authors":"Bin Liu, Mingzhe Wang, Song Zhang, L. Gao, Liang Yang","doi":"10.1145/3340037.3340041","DOIUrl":"https://doi.org/10.1145/3340037.3340041","url":null,"abstract":"For the epilepsy disease, many studies about the thickness of cortex among various brain regions haven been implemented. However, there is few research about the cell distribution of the gray matter of adjacent gyrus and sulcus. Our studies indicate it is possible different that the thickness of the GFAP-IR interlaminar astrocytes somas between in gyri and sulci in epilepsy. Based on this motivation, we proposed a color brain slice image ROI (region of interest) extracting method. A classifying method is imported to compute the comparability between two pixels in the slice image. An improved mechanism of color data query table is designed to accelerate the processing speed. Human brain tissue images acquired during surgical resection for epilepsy are utilized as the experimental object. The regions of most interest can be extracted and the 3D color gradient field can also be visualized. In conclusion, we can not only achieve the information of interlaminar astrocytes, but also provide a technic support for building the information network of epilepsy diseases.","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121443833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Situation and Experience of EHR in Primary Medical Institutions 基层医疗机构电子病历的现状与经验

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340046

Feng Tianyang

引用次数: 1

An Efficient Date-constraint Hierarchical Key Management Scheme with Fast Key Validation Checking for Mobile Agents in E-Medicine System 基于日期约束的电子医疗移动代理快速密钥验证分级密钥管理方案

Proceedings of the 3rd International Conference on Medical and Health Informatics Pub Date : 2019-05-17 DOI: 10.1145/3340037.3340065

Tian-Fu Lee, Chuan-Ming Liu

{"title":"An Efficient Date-constraint Hierarchical Key Management Scheme with Fast Key Validation Checking for Mobile Agents in E-Medicine System","authors":"Tian-Fu Lee, Chuan-Ming Liu","doi":"10.1145/3340037.3340065","DOIUrl":"https://doi.org/10.1145/3340037.3340065","url":null,"abstract":"A hierarchical key management scheme for mobile agents in e-medicine system enables users, such as patients, doctors, nurses and health visitors, to conveniently and securely access a remote hierarchical medical database system via public networks. Efficient hierarchical key management schemes do not require heavy computations even if the hierarchical structure has too many levels and participants. Chen et al. recently developed a hierarchical key management scheme with date-constraint for mobile agents. The key management scheme of Chen et al. is based the Elliptic Curve Cryptosystem and allows each secret key to be partnered with a validity period by using one-way hash chains. However, the scheme of Chen et al. fails to execute correctly, violates authenticated key security, and requires hundreds of hash functional operations. This investigation discusses these limitations, and proposes an efficient date-constraint hierarchical key management scheme for mobile agents in e-medicine system, which provides a fast key validation and expiration check phase to rapidly check whether the secret keys are valid and time-expired or not. The proposed key management scheme not only provides more security properties and rapidly checks the validation of secret keys, but also reduces the computational cost..","PeriodicalId":340774,"journal":{"name":"Proceedings of the 3rd International Conference on Medical and Health Informatics","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125187955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0