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Cardiac Stem Cell–Derived Treatment for Ischemic Heart Disease: A Review 心脏干细胞衍生治疗缺血性心脏病:综述
Georgetown Medical Review Pub Date : 2023-09-07 DOI: 10.52504/001c.87728
Seetha Aribindi, Jessica Jiang, Umayr Shaikh, Adam Hidad
{"title":"Cardiac Stem Cell–Derived Treatment for Ischemic Heart Disease: A Review","authors":"Seetha Aribindi, Jessica Jiang, Umayr Shaikh, Adam Hidad","doi":"10.52504/001c.87728","DOIUrl":"https://doi.org/10.52504/001c.87728","url":null,"abstract":"Current first-line pharmacologic therapies for ischemic heart disease (ISD) have proven largely ineffective, leading to the exploration of alternative treatments. Various stem cell–like/progenitor cell lineages have been studied, especially c-kit+ cardiac stem cells (CSCs) due to their true stem cell origin and differentiation capabilities. These CSCs reside in the heart after birth and possess regenerative potential, providing a means of maintaining and repairing myocardial tissue. Previous studies have demonstrated the therapeutic potential of CSCs for patients with ISD. However, counterarguments have focused on the inflammatory state present in diseased hearts, which may limit the benefits of c-kit+ CSCs. Nonetheless, we argue that a thorough examination of the literature supports the potential of c-kit+ CSCs as a safe and effective therapeutic approach for restoring lost cardiac tissue and function in patients with ISD. Though promising, we believe further scientific inquiry is necessary to discern the exact mechanisms by which c-kit+ CSCs function, which could pay dividends in the approach to treating ISD.","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123741122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Le entiendo: The Power of Intermediate-Level Fluency in Patient Care 中级流利度在病人护理中的作用
Georgetown Medical Review Pub Date : 2023-09-07 DOI: 10.52504/001c.85166
Mckenna Brownell
{"title":"Le entiendo: The Power of Intermediate-Level Fluency in Patient Care","authors":"Mckenna Brownell","doi":"10.52504/001c.85166","DOIUrl":"https://doi.org/10.52504/001c.85166","url":null,"abstract":"","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130128475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Corner of Control 控制的一角
Georgetown Medical Review Pub Date : 2023-09-07 DOI: 10.52504/001c.87495
Jaytin Gupta
{"title":"A Corner of Control","authors":"Jaytin Gupta","doi":"10.52504/001c.87495","DOIUrl":"https://doi.org/10.52504/001c.87495","url":null,"abstract":"“A Corner of Control” is a story about “Sarah” (pseudonym), a young woman identifying as Black American who was urgently referred from a routine prenatal visit to the labor and delivery antepartum triage unit for decreased fetal movement and was told by the inpatient obstetrics resident/attending team that she needed to be admitted for induction of labor. Feeling backed into a corner, she decided she wanted to leave against medical advice. I, the medical student, was responsible for mediating between the 2 parties, navigating my position at the bottom of the team’s hierarchy with my duty to listen and provide the best care to my patient. The story ventures into our fear and compulsion in carving a corner of control by implementing treatment courses that could significantly impact not only my medical career and the hospital’s reputation, but most importantly, Sarah and her baby’s life.","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124631901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fear, Love, and News: How US News Coverage of Immigration Negatively Impacts the Mental Health and Well-Being of Immigrant Families 恐惧、爱和新闻:美国新闻报道如何对移民家庭的心理健康和福祉产生负面影响
Georgetown Medical Review Pub Date : 2023-07-26 DOI: 10.52504/001c.84314
Jordan Maurer
{"title":"Fear, Love, and News: How US News Coverage of Immigration Negatively Impacts the Mental Health and Well-Being of Immigrant Families","authors":"Jordan Maurer","doi":"10.52504/001c.84314","DOIUrl":"https://doi.org/10.52504/001c.84314","url":null,"abstract":"","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"4 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126350565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Untreated Major Depression During Gestation: The Physical and Mental Implications in Women and Their Offspring 妊娠期未治疗的重度抑郁症:对妇女及其后代的生理和心理影响
Georgetown Medical Review Pub Date : 2023-07-17 DOI: 10.52504/001c.83340
F. Quinones, Carlynn G. Winters, Lydia Hu, Advait Suvarnakar
{"title":"Untreated Major Depression During Gestation: The Physical and Mental Implications in Women and Their Offspring","authors":"F. Quinones, Carlynn G. Winters, Lydia Hu, Advait Suvarnakar","doi":"10.52504/001c.83340","DOIUrl":"https://doi.org/10.52504/001c.83340","url":null,"abstract":"While postpartum depression has been extensively studied and is a concern surrounding major depression in women, the effects of major depression during pregnancy alone should also be considered. The purpose of this review article was to explore in longitudinal fashion, from neonate to adulthood, the lasting physical and mental implications that depression during gestation can present in offspring. Consideration of various sources pulled from the OVID Medline database yielded findings consistent with negative associations between gestational depression and offspring outcomes. In mothers, gestational depression presents with physical implications, such as preeclampsia and preterm delivery, leading to low birth weight and neurodevelopmental complications in neonates. As the children grow older, these complexities manifest as socioemotional, behavioral, and linguistic development delays presenting as increased incidence in attention-deficit/hyperactivity disorder diagnoses, parental attachment issues, and lower emotional and verbal IQ. Research regarding adolescents and adults is sparse in comparison with that of earlier stages, but there are studies that examine the developmental outcomes of certain mood disorders, such as generational depression, in the offspring of birthing parents with prenatal depression. This review presents an extended timeline of the effects of gestational major depression in offspring, and it provides suggestions for future research regarding underlying biological explanations and certain risk outcomes.","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134496754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guidance for Physicians on the Yom Kippur Fast 医生赎罪日斋戒指南
Georgetown Medical Review Pub Date : 2023-07-13 DOI: 10.52504/001c.83342
N. Gupta, Jason Gusdorf
{"title":"Guidance for Physicians on the Yom Kippur Fast","authors":"N. Gupta, Jason Gusdorf","doi":"10.52504/001c.83342","DOIUrl":"https://doi.org/10.52504/001c.83342","url":null,"abstract":"It is important for physicians to understand the role they play in guiding their Jewish patients’ decisions on whether to fast on Yom Kippur. While the Yom Kippur fast is one of the most important spiritual events of the year, it is also prohibited if fasting will endanger one’s health. This article presents the Talmudic laws on fasting on Yom Kippur, interviews with 11 Georgetown students and faculty on the subjective importance of the fast, and a review of medical literature regarding contraindications to fasting. In conclusion, based on interviews and Talmudic passages, fasting is an important aspect of Yom Kippur and remains meaningful to Jewish people today. A review of contemporary research indicates fasting is primarily contraindicated by metabolic disorders that carry a risk of hypoglycemia and psychiatric eating disorders. Physicians should understand the nuances of fasting as a religious practice and be able to provide information regarding dangers of fasting to their patients.","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134414017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incentivizing Drug Development for Patients With Rare Diseases 鼓励罕见疾病患者的药物开发
Georgetown Medical Review Pub Date : 2023-07-10 DOI: 10.52504/001c.83275
Eric L. Wan
{"title":"Incentivizing Drug Development for Patients With Rare Diseases","authors":"Eric L. Wan","doi":"10.52504/001c.83275","DOIUrl":"https://doi.org/10.52504/001c.83275","url":null,"abstract":"","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122457560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case for Needle Exchange Programs: Not Letting Perfection be the Enemy of the Good 针具交换计划的案例:不要让完美成为好的敌人
Georgetown Medical Review Pub Date : 2023-07-10 DOI: 10.52504/001c.83277
M. Karsten
{"title":"A Case for Needle Exchange Programs: Not Letting Perfection be the Enemy of the Good","authors":"M. Karsten","doi":"10.52504/001c.83277","DOIUrl":"https://doi.org/10.52504/001c.83277","url":null,"abstract":"","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117133652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Questions We Ask 我们问的问题
Georgetown Medical Review Pub Date : 2023-07-03 DOI: 10.52504/001c.82124
A. Prasad
{"title":"The Questions We Ask","authors":"A. Prasad","doi":"10.52504/001c.82124","DOIUrl":"https://doi.org/10.52504/001c.82124","url":null,"abstract":"","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132494710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstacles and Avenues for Medical Students Interested in Global Health Work 对全球卫生工作感兴趣的医科学生的障碍和途径
Georgetown Medical Review Pub Date : 2023-06-16 DOI: 10.52504/001c.77832
Amanda Wibben
{"title":"Obstacles and Avenues for Medical Students Interested in Global Health Work","authors":"Amanda Wibben","doi":"10.52504/001c.77832","DOIUrl":"https://doi.org/10.52504/001c.77832","url":null,"abstract":"In 2012, the Association of American Medical Colleges reported that nearly 30% of graduating medical students participated in a global health elective at some point during their training.1 In our current M1 class of 203 students, that is approximately 41 students who will potentially train abroad. But of those 41, how many will be able to pursue a career in global health? In a survey of medical graduates from global health–related programs, only 41% reported participating in global health work after graduation. Of these physicians, most spent less than 10% of their total professional time on global health.2 At Georgetown, that correlates to fewer than 4 students in the class of 2026 who will spend significant time practicing internationally. As someone whose primary pursuit in medicine is to work in global health, this discrepancy is distressing. While many of us have likely been inspired by Physician and medical anthropologist Paul Farmer, or participated in international service trips or medical missions, the pathway to establishing a long-term career in global health is not guaranteed. Thus, it is important to understand the obstacles in the way of pursuing a career in global health medicine and to consider recommendations for students interested in committing their careers to international health care.","PeriodicalId":340325,"journal":{"name":"Georgetown Medical Review","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129770338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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