Journal of Rhinology最新文献

Treatment Outcomes of Sinonasal Seromucinous Hamartoma: A Single-Center Experience. 鼻窦浆液黏液错构瘤的治疗结果：单中心经验。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00032

Dong Hoon Lee, Sang Chul Lim

{"title":"Treatment Outcomes of Sinonasal Seromucinous Hamartoma: A Single-Center Experience.","authors":"Dong Hoon Lee, Sang Chul Lim","doi":"10.18787/jr.2025.00032","DOIUrl":"10.18787/jr.2025.00032","url":null,"abstract":"Background and objectives: Seromucinous hamartoma is a rare, benign epithelial tumor of the sinonasal tract, most commonly originating from the posterior nasal septum. Accurate diagnosis is essential due to its histopathological resemblance to low-grade sinonasal adenocarcinoma. This study aimed to evaluate the clinical characteristics, diagnostic considerations, and treatment outcomes of patients with seromucinous hamartoma treated at a single tertiary referral center.Methods: We retrospectively reviewed the medical records of six patients with histologically confirmed seromucinous hamartoma treated between January 2010 and May 2025. Data collected included demographic characteristics, presenting symptoms, imaging findings, histopathological features, and surgical outcomes.Results: Six patients with a total of seven lesions were identified; one patient presented with bilateral nasal involvement. The mean age at diagnosis was 33.9 years, and four patients were female. The most common presenting symptom was nasal obstruction, followed by epistaxis and rhinorrhea. Lesions were primarily located on the nasal septum, while some involved the inferior turbinate and sphenoid sinus. All patients underwent complete transnasal endoscopic resection. No recurrences were observed over a mean follow-up period of 58.6 months. One patient required medial maxillectomy due to difficulty distinguishing the lesion from adenocarcinoma.Conclusion: Seromucinous hamartoma may arise at atypical sites and can mimic malignant tumors. Awareness of its variable presentation, along with complete surgical excision, is essential for optimal management and to avoid unnecessarily aggressive treatment.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Particulate Matter on Obstructive Sleep Apnea and Obesity. 颗粒物对阻塞性睡眠呼吸暂停和肥胖的影响。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00016

Hye Jun Lee

{"title":"Effects of Particulate Matter on Obstructive Sleep Apnea and Obesity.","authors":"Hye Jun Lee","doi":"10.18787/jr.2025.00016","DOIUrl":"10.18787/jr.2025.00016","url":null,"abstract":"With accelerated global urbanization, understanding the impact of pollutant emissions and air pollution on obstructive sleep apnea (OSA) and obesity has become increasingly important. Particulate matter (PM) is a major component of air pollution. Recent studies have reported that PM influences OSA, obesity, and obesity-related metabolic disorders. The primary mechanisms proposed to underlie the effects of PM on OSA involve chronic inflammation and oxidative stress in the nasal epithelia. Regarding obesity, PM induces chronic inflammation in the hypothalamus, adipose tissue, skeletal muscle, and mitochondria; oxidative stress in white adipose tissue, the lungs, and the thyroid; activation of lipogenesis genes; changes in adipose tissue distribution; dysbiosis of the intestinal microbiome; and disruption of circadian rhythms. Therefore, reducing air pollution, including PM concentrations, represents a potential strategy for treating OSA and obesity and preventing related complications. Further prospective longitudinal studies in human participants are needed to clarify the effects of PM on the risk of OSA and obesity and to elucidate the underlying mechanisms.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"67-75"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic Analysis of Nasal CD69+ CD4+ Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps. 嗜酸性慢性鼻窦炎伴鼻息肉患者鼻腔CD69+ CD4+组织驻留记忆T细胞表型分析。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00025

Min-Seok Rha, Gyeongyeob Kim, Sol Lee

{"title":"Phenotypic Analysis of Nasal CD69+ CD4+ Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.","authors":"Min-Seok Rha, Gyeongyeob Kim, Sol Lee","doi":"10.18787/jr.2025.00025","DOIUrl":"10.18787/jr.2025.00025","url":null,"abstract":"Background and objectives: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their phenotypic and functional characteristics in the nasal tissue of patients with eosinophilic CRS (ECRS) remain poorly defined.Methods: Nasal polyp tissue and/or peripheral blood (PB) samples were obtained from patients with ECRS undergoing endoscopic sinus surgery. The phenotypes and functions of nasal CD69+ CD4+ T cells were analyzed using flow cytometry.Results: The frequency of CD69+ CD103- cells among nasal CD4+ T cells was significantly higher in patients with ECRS compared to controls. Analysis of paired PB and nasal tissue samples from ECRS patients revealed that CD69+ CD103- CD4+ T cells were almost exclusively present in nasal tissues and exhibited tissue-resident phenotypes, marked by high expression of CD49a and CXCR6. In ECRS, these nasal CD69+ CD103- CD4+ T cells expressed high levels of T helper 2 (Th2) cell markers, including CRTH2 and GATA3. Consistently, these T cells demonstrated a robust capacity to produce IL-4 and IL-5. These findings were corroborated by analyses of publicly available single-cell RNA sequencing datasets. Furthermore, the frequency of nasal CD69+ CD103- CD4+ T cells was significantly associated with higher Lund-Mackay CT scores and reduced olfactory function in patients with ECRS.Conclusion: The current investigation demonstrates that nasal CD69+ CD103- CD4+ TRM cells include a high frequency of Th2 cells and are associated with severe disease.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"91-98"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor Regarding the Article "Salvaging Vision: A Study of Non-Traumatic Optic Neuropathies". 关于文章“挽救视力：非创伤性视神经病变的研究”的致编辑信。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2024.00034

Yeon Hee Im

引用次数: 0

A Rare Case of Sinonasal Oncocytic Papilloma. 鼻嗜瘤细胞乳头状瘤1例。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00017

Nikita Miriam John, Ramesh Kumar E

引用次数: 0

Malignant Transformation of a Leiomyoma Originating From the Inferior Turbinate. 起源于下鼻甲的平滑肌瘤的恶性转化。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00028

Hye-Jin Park, Soo Kweon Koo, Kyung-Un Choi, Kyu-Sup Cho

引用次数: 0

Stem Cell Niches for Olfactory Regeneration and Their Therapeutic Applications. 嗅觉再生干细胞龛及其治疗应用

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00013

Yun Jin Kang, David W Jang, Do Hyun Kim

{"title":"Stem Cell Niches for Olfactory Regeneration and Their Therapeutic Applications.","authors":"Yun Jin Kang, David W Jang, Do Hyun Kim","doi":"10.18787/jr.2025.00013","DOIUrl":"10.18787/jr.2025.00013","url":null,"abstract":"Olfactory dysfunction affects many individuals and may result from infections, trauma, neurodegenerative diseases, or genetic disorders. Unlike most neurons in the mammalian nervous system, olfactory sensory neurons (OSNs) continuously regenerate throughout life, a process facilitated by specialized stem cell niches in the olfactory epithelium. Horizontal basal cells are typically dormant under normal conditions but become activated following injury, differentiating into globose basal cells (GBCs) and other cell types. GBCs serve as the primary source for OSN regeneration and are regulated by key transcription factors such as Sox2, Pax6, and Ascl1. Olfactory ensheathing cells play a vital role in regeneration by guiding newly formed axons toward the olfactory bulb and secreting neurotrophic factors, including glial cell-derived neurotrophic factor. In addition, the olfactory bulb synthesizes trophic factors like brain-derived neurotrophic factor and nerve growth factor, which support neuronal survival and integration. Despite this intrinsic regenerative capacity, many cases of olfactory dysfunction remain challenging to treat. Current therapeutic strategies include corticosteroids, biologics, surgical interventions, and olfactory training, although their effectiveness varies. Advances in molecular and cellular research have provided insights into the regulatory mechanisms of olfactory neurogenesis, underscoring the need for further exploration of stem cell activation, neuronal survival, and olfactory circuit reorganization. Future research should focus on optimizing regenerative therapies-including stem cell-based approaches and neurotrophic factor modulation-to improve outcomes for patients with severe olfactory impairment.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contamination Assessment in Continuous Positive Airway Pressure Devices Using a Complete Disassembly Cleaning Protocol: Two Years of Experience. 使用完全拆卸清洁方案的连续气道正压设备的污染评估：两年经验。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00027

Tae Jong Kim, Kyung Soo Kim, Hyun Jin Min

{"title":"Contamination Assessment in Continuous Positive Airway Pressure Devices Using a Complete Disassembly Cleaning Protocol: Two Years of Experience.","authors":"Tae Jong Kim, Kyung Soo Kim, Hyun Jin Min","doi":"10.18787/jr.2025.00027","DOIUrl":"10.18787/jr.2025.00027","url":null,"abstract":"Background and objectives: Obstructive sleep apnea (OSA) is a prevalent disorder that is commonly managed with continuous positive airway pressure (CPAP) therapy. Although CPAP is clinically effective, issues related to device hygiene and contamination remain understudied. This study aims to present a practical protocol for CPAP disassembly and cleaning and to report the outcomes of its implementation over a 2-year period.Methods: We conducted a retrospective chart review of 359 OSA patients prescribed CPAP therapy between 2018 and 2025. Of these, 136 patients participated in a complimentary, comprehensive CPAP cleaning service. Contamination was assessed using a subjective visual analog scale (VAS) following photographic documentation of each device component. The relationship between contamination scores and device usage duration was analyzed.Results: Patients who received the cleaning service did not differ significantly from the overall cohort in terms of age, sex, apnea-hypopnea index, or average daily usage time, except that they had a significantly shorter total duration of usage. Contamination was found on all device components, including internal parts that are not routinely inspected. Positive correlations between contamination levels and usage duration were statistically significant for every component. The cleaning process required approximately 2 days per device and was feasible for routine clinical implementation.Conclusion: CPAP devices accumulate visible contamination over time, emphasizing the need for standardized cleaning protocols. Our experience indicates that physician-led education, patient cooperation, and dedicated involvement of paramedical staff are essential in reducing contamination risks. Interdisciplinary collaboration is recommended to develop evidence-based guidelines for CPAP hygiene management.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Granulomatosis With Polyangiitis Mimicking Chronic Sinusitis With Polyp. 肉芽肿合并多血管炎模拟慢性鼻窦炎合并息肉1例。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00036

Minji Oh, Sung Jae Heo

引用次数: 0

Representative Nasal Endoscopic Findings Suggestive of Allergic Rhinitis and Their Influencing Factors. 提示变应性鼻炎的典型鼻内镜表现及其影响因素。

Journal of Rhinology Pub Date : 2025-07-01 Epub Date: 2025-07-22 DOI: 10.18787/jr.2025.00022

Je Ho Bang, Su Jin Kim, Young Chan Lee, Kun Hee Lee

{"title":"Representative Nasal Endoscopic Findings Suggestive of Allergic Rhinitis and Their Influencing Factors.","authors":"Je Ho Bang, Su Jin Kim, Young Chan Lee, Kun Hee Lee","doi":"10.18787/jr.2025.00022","DOIUrl":"10.18787/jr.2025.00022","url":null,"abstract":"Background and objectives: Nasal endoscopy is an essential diagnostic tool for allergic rhinitis (AR); however, endoscopic findings vary from person to person. This study aimed to identify definitive nasal endoscopic findings suggestive of AR and to explore factors influencing these findings.Methods: Data were obtained from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES), which included 8,958 participants. Of these, 7,636 who completed nasal endoscopic examinations were enrolled. AR was defined as a positive diagnosis if any Immunoradiometric Assay (ImmunoCAP) result was level 1+ or higher. Demographic characteristics, blood test results, and comorbid diseases, including ENT evaluation, were investigated. The prevalence estimates of AR and nasal endoscopic findings were calculated using a complex sampling design. Factors influencing these findings were identified using complex-sample logistic regression analysis.Results: The weighted prevalence of AR was 13.6%. Nasal endoscopic findings suggestive of AR included watery secretion (WS) and mucoid discharge (MD), with prevalences of 22.2% and 9.6%, respectively. In multivariable analysis, age, nasal septal deviation, and sensitization to dog allergens were associated with WS. MD was associated only with nasal septal deviation. The correlation between AR symptoms and WS was stronger compared to MD. In a subgroup analysis of WS, higher levels of sensitization to dog allergens were associated with increased WS findings.Conclusion: WS and MD are representative endoscopic findings in AR. Nasal septal deviation impacts the mucosal environment, causing nasal secretion and altering discharge characteristics. WS is correlated with dog allergen sensitization, and its prevalence is influenced by the level of dog allergen sensitization.","PeriodicalId":33935,"journal":{"name":"Journal of Rhinology","volume":"32 2","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0