‘Endgame’ – Long term impacts of COVID-19最新文献

{"title":"P221 Does virtual group breathing pattern retraining improve symptoms of breathlessness in patients with breathing pattern disorder following COVID-19 infection?","authors":"R. Gore, L. Williamson, T. Elliott-Cooper, K. Roze, M. Heightman, T. Hillman, R. Livingston","doi":"10.1136/thorax-2022-btsabstracts.353","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.353","url":null,"abstract":"P221 Table 1Virtual group BPR treatment improved breathing pattern and breathlessness for patients within the post covid BPD. With social distancing regulations, VGT offers an effective alternative to face to face group treatment. This saved clinician time which could enable reduced wait times for treatment.British Thoracic Society. British thoracic society guidance on respiratory follow up of patients with a clinico-radiological diagnosis of COVID-19 pneumonia, 2020.Heightman M, Prashar J, Hillman TE, et al. Post-COVID-19 assessment in a specialist clinical service: a 12-month, single-centre, prospective study in 1325 individuals. BMJ Open Resp Res, 2021;8.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128707611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P230 Assessment of Cardio-pulmonary function in children and adolescents with suspected long COVID","authors":"R. Langley, PD Burns, P. Davies, C. Presslie","doi":"10.1136/thorax-2022-btsabstracts.362","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.362","url":null,"abstract":"IntroductionPersistent respiratory symptoms and exercise intolerance following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents is common.1 Our aim was to review the clinical data on patients who had been referred with suspected long COVID (LC). Unfortunately, there is a lack of an agreed definition for LC. The patient cohort were referred with persistent respiratory symptoms/signs (cough, exertional dyspnoea or wheeze) for at least 3 months following confirmed (PCR or antigen test positive) mild SARS-CoV-2 infection that did not require hospitalisation.MethodsThis was a retrospective analysis of clinical data obtained during clinical assessment. Patients had undergone pulmonary function tests (PFTs) including;spirometry, Single breath transfer factor (TLCO) and static lung volume measurements (Vyntus Body – VyaireTM Medical) followed by an incremental maximal ramp cardiopulmonary exercise testing (CPET) performed on a cycle ergometer (Jaeger CPX & Vyntus ONE – VyaireTM Medical).ResultsSeven patients (four male) with suspected LC had undergone PFTs and CPET. Demographics and summary data are presented (table 1). Five had normal PFT results. Of the two that had abnormal PFTs both had co-existing morbidities. One had mild airflow obstruction (previous pneumothorax) and the other had a restrictive defect (Di-George syndrome and obesity). Three patients had a reduced peak Oxygen uptake (VO2peak < 85% predicted). The cardiovascular and gas exchange response to incremental exercise were normal and there was no evidence of ventilatory limitation or dysfunctional breathing in any of the patients.ConclusionsAlthough only a small cohort was examined, this study suggests that SARS-CoV-2 infection does not seem to be causing any longstanding cardiopulmonary function impairment in children and adolescents. Whilst there may be pathophysiological changes following SARS-CoV-2 infection, as previously reported in adults,2 a reduced aerobic capacity is seen in some of these patients and this may due to physical de-conditioning rather than any physiological impairment caused by SARS-CoV-2 infection.ReferencesDobkin S et al. (2021) Protracted respiratory findings in children post-SARS-CoV-2 infection Pediatr Pulmonol.Rinaldo RF et al. (2021). Deconditioning as main mechanism of impaired exercise response in COVID-19 survivors. ERJ 2021 58:2100870.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124061278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P227 Reduced respiratory muscle strength, lung function, and functional status and symptomology in patients referred to Long COVID clinics, an observational cohort analysis","authors":"M. Faghy, R. Ashton, R. Owen, J. Yates, C. Thomas, T. Maden-Wilkinson, S. V. N. Santhosh Kumar, R. Gururaj, C. Ozemek, R. Arena, T. Bewick","doi":"10.1136/thorax-2022-btsabstracts.359","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.359","url":null,"abstract":"IntroductionOne in ten people will develop Long COVID (LC) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite broad-ranging and episodic symptomology, there are no data that demonstrate changes in functional status (FS), respiratory muscle strength and lung function over time. We conducted a sixteen-week cohort observation of LC patients to determine changes in FS, respiratory muscle strength and lung function.MethodSixty-six patients (n=48 females, mean age 51 ± 10 years, n=8 hospitalised, mean time post-infection 6.2 ± 1.8 months) were recruited from LC clinics in the United Kingdom (CPMS ID: 52331). Patients completed five face-to-face visits (day 0, 28, 56, 84 and 110 ± 3 days) and bi-weekly telephone consultations (day 14, 42, 70 and 98 ± 3 days). FS was assessed via the post-COVID functional status scale (PCFS) and the six-minute walk test (6MWT). Maximum inspiratory (MIP) and expiratory (MEP) respiratory muscle pressure and lung function (forced vital capacity (FVC) and forced expired volume in one second (FEV1) were assessed during face-to-face visits according to published standards.ResultsPCFS was 2.7 ± 0.4 AU, P=0.02 at baseline and improved at 16-weeks (2.1 ±1.1 AU) and still highlighted impaired FS. 6MWT was 322 ± 133 meters at baseline and improved at 16 weeks (430 ± 150 meters, P<0.01) but remained lower than normative values for healthy age-matched controls. MIP was 77 ± 21 cmH2O at baseline (86% predicted) and was unchanged post 16 weeks (88 ± 25 cmH2O, 92% predicted, P>0.05). Baseline MEP was 115 ± 41 cmH2O (96% and was unchanged post-16-weeks (119 ± 48 cmH2O, 92% predicted, P>0.05). Lung function data were below predicted values and unchanged over 16 weeks (baseline FVC: 3.10 ± 0.53 L.s-1, 72% predicted, post 16 weeks: 3.16 ± 0.34 L.s-1, 73% predicted, P>0.05 and baseline FEV1: 2.68 ± 0.39 L.s-1, 85% predicted, post 16 weeks: 2.75 ± 0.36 L.s-1, 85% predicted).ConclusionLC patients demonstrate reduced respiratory muscle strength and lung function which could be associated with reduced FS and should be addressed via specific rehabilitation approaches.Please refer to page A216 for declarations of interest related to this .","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117037376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P220 Thoracic mobilisation techniques combined with stretches improves thoracic compliance and respiratory rate in long COVID","authors":"D. Boiskin, G. Jayasekera","doi":"10.1136/thorax-2022-btsabstracts.352","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.352","url":null,"abstract":"BackgroundA number of patients with COVID-19 experience prolonged symptoms, known as ‘Long COVID’. Fatigue, dyspnoea and chest wall tightness are common symptoms. These symptoms limit exercise tolerance and cause anxiety. They require thorough and costly investigations that do not always provide a pathway to traditional treatments. We present the impact of thoracic mobilisation, a combination of stretches and general advice on abdominal breathing on long COVID symptoms.MethodsConsecutive adult long COVID patients attending a general respiratory physiotherapy clinic with breathlessness and chest wall tightness were included. All patients were assessed for thoracic expansion using a cloth tape, measuring at T6 level from resting expiration to maximum inspiration. Resting respiratory rate (RR) was also measured as breaths per minute (bpm). All patients were then treated with a single application of thoracic mobilisation techniques (muscle energy techniques and/or rib stacking) and combinations of muscle stretches including serratus anterior, pectoralis minor and diaphragm stretches. General advice regarding abdominal breathing was also demonstrated.ResultsThirty four consecutive long COVID patients were included (mean age 52 y, 16♂). Nine patients (26%) had pre-existing respiratory co-morbidities including asthma, COPD and sleep-disordered breathing and 12 patients (35%) had no past medical history. Prior to intervention mean thoracic expansion was 1.92 cm (±1.15) and mean RR was 17.6 bpm (±5.1). After intervention, thoracic expansion improved to 3.89 cm (±1.32) and RR to 11.2 bpm (±4.6). There were significant improvements in both thoracic expansion and respiratory rate (p<0.0001).ConclusionNormal thoracic expansion is approximately 3.5 – 7 cm. This group of long COVID patients displayed suboptimal thoracic expansion at T6. This appears to have had an effect on resting respiratory rate. Post mobilisation both thoracic expansion and resting respiratory rate improved. This is likely due to improved thoracic compliance with mobilisations and stretches, reducing the work of breathing in these patients. The addition of simple breathing advice, rather than longer breathing re-education sessions helped to further reduce and correct respiratory rate.A single application of thoracic mobilisation techniques combined with stretches and simple advice on breathing can improve thoracic expansion and resting respiratory rate in long COVID.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121379420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P226 DYNAMO Covid-19. Dynamic assessment of multi organ level dysfunction in patients recovering from Covid-19: insulin resistance and metabolic flexibility","authors":"A. Gutpa, R. Nicholas, JJ McGing, O. Mougin, CR Bradley, AV Nixon, JE Mallinson, J. Bonnington, T. Mckeever, IP Hall, JM Lord, RA Evans, P. Greenhaff, ST Francis, C. Bolton","doi":"10.1136/thorax-2022-btsabstracts.358","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.358","url":null,"abstract":"P226 Figure 1ConclusionPatients recovering from severe Covid-19 have worse insulin sensitivity compared to controls, but similar metabolic flexibility. Physical inactivity and liver adiposity may play a role in these observations.FundingNIHR Nottingham BRC (NoRCoRP), PHOSP UKRI, Nottingham Hospitals Charity, University of Nottingham alumni donation.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114484252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P224 Using the Sit to Stand tests to assess functional status and oxygen desaturations following COVID-19","authors":"E. Dickerson, O. Revitt, L. Houchen-Wolloff, S. Singh, E. Daynes","doi":"10.1136/thorax-2022-btsabstracts.356","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.356","url":null,"abstract":"IntroductionCOVID-19 leads to persistent symptoms and in some instances oxygen desaturation (>3%) (Greenhalgh et al, 2020). Field walking tests are used in respiratory diseases to assess oxygen desaturation and exercise capacity due to their high reliability (Hernandes et al, 2014). However, under COVID-19 restrictions these tests became problematic to perform due to limitations of space, time, and equipment. This project aims to investigate sit to stand test’s (1STS & 5STS) in comparison to the Incremental shuttle walk test (ISWT) to assess function and oxygen desaturation (SpO2) in patients following COVID19 infection. In addition, to investigate if there is a difference in results to patients who received hospital care during the acute stage of COVID-19, to those who were managed in the community.MethodsPatients attending out-patient COVID-19 rehabilitation comprised of those hospitalised for acute COVID-19 and community managed referrals. Oxygen saturation was recorded directly before and after the tests. An independent T- test was used to measure group means for statistical difference and Pearson’s correlation was used to compare 5STS, 1STS and ISWT performance outcomes.ResultsTwenty-nine patients were eligible for analysis, mean (SD) age 54 (7.8) years (65.5% female and 69% White British) 7 (24%) participants had hospital admissions with a mean time from discharge to assessment of 347 days. There were desaturations of >3% in 3 (10%) participants during the 1STS and 9 (38%) in the ISWT and no desaturations of >3% during the 5STS. The difference between patient groups and SPO2 desaturations are non-significant at 0.559 for ISWT, 0.447 for 1STS and 0.447 5STS. There was no significant difference between SpO2, RPE and BORG for patient groups in each test condition. There was a strong correlation (R=-0.88) between the 1STS repetitions and 5STS time. There was a moderate correlation between ISWT and both STS tests (5STS R=-0.53 and 1STSR=-0.66).ConclusionsThe 5STS does not detect desaturation, whilst the ISWT detected meaningful desaturation in 38% of the population. There was a strong correlation with respect to performance on both STS tests, but not with the ISWT.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122763642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P219 Evaluation of the utility of the breathing pattern assessment tool in a post-covid syndrome MDT assessment clinic","authors":"L. Grillo, J. Turnbull, JS Lee, L. Froome, J. Maxwell, L. Webber, L. Weatherly, A. Curtis, L. Osman","doi":"10.1136/thorax-2022-btsabstracts.351","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.351","url":null,"abstract":"P219 Table 1Patient demographicsDemographics Age 43.14 (13.21) Gender Male n=22, Female n=51 Ethnicity White n=47 Black n=12 Asian n=7 Mixed n=7 Outcome measures from post covid clinic BPAT 3.44 (3.02) Nijmegen 27.82 (13.79) EQ5D 12.48 (11.71) Breathlessness NRS 4.17(2.39) Cough NRS 2.31 (2.93) Fatigue NRS 5.92 (2.41) Pain NRS 3.57 (3.41) Sleep NRS 4.74 (2.84) 1 minutes Sit to Stand 22.97 (11.47) GAD7 5.72 (6.96) PHQ9 5.97 (7.60) BPAT >4 n=28 (38%) Mean (standard deviation) unless otherwise stated;NRS: Numerical Rating ScaleConclusionThe BPAT Tool is a useful component of breathlessness assessment in the context of a PCS assessment clinic. It can provide a useful screening tool to identify patients with BPD who may benefit from specialist intervention with respiratory physiotherapists. Further understanding is required of how BPD responds to therapy and which type of treatments are important for this cohort.ReferencesHylton H, Long A, Francis C, et al. Real-world use of the Breathing Pattern Assessment Tool in assessment of breathlessness post-COVID-19. Clin Med (Lond). 2022 Jun 27.Todd S, Walsted ES, Grillo L et al. Novel assessment tool to detect BPD in patients with refractory asthma. Respirology. 2018;23(3).","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126016579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P218 The needs of long COVID service users in hampshire and isle of wight ICS: a prospective mixed methods evaluation","authors":"R. Barker, A. Sibley, R. Wheeler, R. Russell","doi":"10.1136/thorax-2022-btsabstracts.350","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.350","url":null,"abstract":"P218 Table 1The types of support people 1a) received or 1b) self-sought, 2) felt were essential, and 3) felt were desirable from the surveys, interviews, and focus groupsType of support* Examples Data source(I & FG: interviews and focus groups;S: survey) 1. a) Support people received Referred for or recommended by healthcare professionals: • ‘Your Covid recovery’ and ‘Living with’ app: https://www.yourcovidrecovery.nhs.uk/https://www.livingwith.health/products/covid-recovery/ I & FG;S • Steps to wellbeing service https://www.steps2wellbeing.co.uk/ S • Local authority helpline S • Mental health (virtual/telephone/app) programmes and/or counselling (virtual and face-to-face) (iTalk;Talking Change;Talking Therapies;private counselling [unknown providers] and psychotherapy [including Physiotherapy mental health unit and Primary Care Mental Health team]) I & FG;S • Medical reviews (general practitioner;respiratory;cardiology;neurological [private and NHS];gastroenterology;rheumatology [private];dermatology;chronic fatigue) I & FG;S • Non-medical professional reviews (physiotherapy;occupational therapy;social services [including reablement];dietetics;speech and language therapy) I & FG;S • Specialist Long COVID service referrals (Hobbs Rehabilitation Clinic [private] and NHS) I & FG • Sleepio app (insomnia) https://www.sleepio.com/#howSleepioWorks I & FG • Fatigue management advice (pacing;boom-bust cycle) I & FG • Co-morbid condition support groups (stroke – unnamed group) I & FG • Occupational health services I & FG;S • Human Resources support (e.g., keeping workplace updated and workplace rehabilitation support) S • Research projects: Portsmouth Long COVID Study Coverscan research project including webinars: https://perspectum.com/news/perspectum-launches-the-first-covid-19-recovery-study S 1. b) Support people self-sought Self-sought and available: • Personal training/physiotherapy/exercising (unnamed sources) I & FG;S • Restorative yoga (unnamed sources) I & FG • Walking groups (unnamed sources) I & FG • Walking App (unnamed) S • Swimming/aqua aerobics (unnamed sources) I & FG • Chiropody (unnamed source) S • Massage S • Counselling (private) I & FG;S • Social media support groups and advice forums (e.g., Facebook Long COVID Support Forum;Facebook group for doctors with Long COVID [unnamed];Long COVID Instagram pages [unnamed])‘AbSent’: https://www.facebook.com/AbScent.org/https://www.facebook.com/groups/longcovid/ I & FG;S • ShutEye app (sleep quality monitoring)https://www.shuteye.ai/ I & FG • ZOE COVID app (symptom monitoring)https://covid.joinzoe.com/about I & FG;S • Gupta programmehttps://www.guptaprogram.com/ I & FG;S • YouTube and other online Long COVID bloggers and podcasters (some unnamed sources)GezMedinger: https://www.youtube.com/channel/UCln_SCEd4JiGkHIUZd1VlXw I & FG;S • TV documentaries (unnamed source) S • Online/virtual exercise and stretching programmes (unnamed sources) I & FG • Support groups (for both the person living with L","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134393264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P228 Comparing cardiometabolic risk indicators between adults post-hospitalisation with COVID-19 and healthy controls","authors":"M. Bakali, T. Yates, M. Steiner, R. Evans","doi":"10.1136/thorax-2022-btsabstracts.360","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.360","url":null,"abstract":"P228 Table 1Comparing cardiometabolic measures between adults post-hospitalisation with COVID-19 and healthy controlsMeasure N= Adults post-hospitalisation with COVID-19 N= Adult Healthy controls Mean between group difference [SD] Age, years 38 62 [9] 17 62 [9] Comorbidities01More than 2 38 12 (31.6%)13 (34.2%)13 (34.2%) 17 15 (88.2%)1 (5.9%)1 (5.9%) Body mass index, kg/m2 38 30.1 [26.7–33.6] 17 24.9 [22.4–26.4] 5.86 [4.15] Resting systolic blood pressure, mmHg 38 142 [133–151] 16 114 [104–132] 25 [18] Resting diastolic blood pressure, mmHg 38 74 [68–80] 16 84 [77–87] -7 [5] Resting heart rate, beats/min 38 63 [59–73] 16 71 [61–77] -4 [3] Glucose, mmol/L 34 5.3 [4.9–5.7] 12 4.8 [4.5–5.1] 1.2 [0.9] Haemoglobin A1c, mmol/L 36 5.8 [5.3–6.2] 11 5.4 [5.3–5.6] 0.5 [0.4] HOMA-IR 23 2.8 [1.8–5.6] 11 1.1 [0.5–2.1] 4.8 [3.4] VO2 peak (ml/min/kg) 24 13.9 [11.6–19.7] 13 33.7 [24.8–36.4] -16.5 [11.7] Carotid-femoral pulse wave velocity, m/s 37 9.50 [8.15–11.50] 9 7.30 [6.75–10.45] 1.44 [1.02] Brachial-ankle pulse wave velocity, m/s 35 15.80 [13.60–17.50] 9 11.80 [11.0–14.90] 2.62 [1.85] Data presented as mean [SD] or median [IQR] depending on distributionOne participant in the post-COVID-19 group was taking beta-blockersConclusionsThis exploratory cross-sectional study shows that routinely used clinical tests of cardiometabolic risk indicate higher future risk for adults post-COVID compared to healthy controls. More detailed measures of cardiometabolic risk support this finding. It is unclear whether acute COVID-19 further contributes to pre-existing cardiometabolic risk. However, our small exploratory study supports the need for interventions such as aerobic exercise training which are proven to reduce aortic stiffness in adults with cardiometabolic disease or who are at future risk of cardiometabolic disease.","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132102527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P223 ‘I never felt like this before’ clinical presentations of patients referred to a tertiary airways service following Covid-19 infection","authors":"C. Slinger, K. Derbyshire, K. Prior, R. Slinger, H. Lever","doi":"10.1136/thorax-2022-btsabstracts.355","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.355","url":null,"abstract":"","PeriodicalId":338428,"journal":{"name":"‘Endgame’ – Long term impacts of COVID-19","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130785322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}