Late breakers最新文献

O20.1 A Clinical Endocervical Neisseria gonorrhoeae Isolate Transiently Colonizes the Nonhuman Primate Lower Genital Tract O20.1临床宫颈内分离淋病奈瑟菌短暂定植在非人灵长类动物下生殖道

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/SEXTRANS-2021-STI.164

O. Soge, Y. Cosgrove-Sweeney, R. Pascual, D. Patton

引用次数: 0

O20.3 Quantitative Chlamydia trachomatis Pgp3 seropositivity and reproductive sequelae among women, National Health and Nutrition Examination Survey, United States, 2013–2016 O20.3女性沙眼衣原体Pgp3血清学阳性与生殖后遗症分析，全国健康与营养调查，2013-2016

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/SEXTRANS-2021-STI.166

G. Anyalechi, Jaeyoung Hong, Damien C. Danavall, D. Martín, S. Gwyn, P. Horner, Brian H. Raphael, R. Kirkcaldy, E. Kersh, K. Bernstein

引用次数: 0

O20.6 Chlamydia trachomatis viable load at six different anatomical sample sites in women (CHLAMOUR) O20.6女性6个不同解剖样本部位沙眼衣原体活菌载量(CHLAMOUR)

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/SEXTRANS-2021-STI.169

K. Janssen, M. Lucchesi, C. Weijzen, N. Dukers-Muijrers, P. Wolffs, C. Hoebe

{"title":"O20.6 Chlamydia trachomatis viable load at six different anatomical sample sites in women (CHLAMOUR)","authors":"K. Janssen, M. Lucchesi, C. Weijzen, N. Dukers-Muijrers, P. Wolffs, C. Hoebe","doi":"10.1136/SEXTRANS-2021-STI.169","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.169","url":null,"abstract":"Background Nucleic acid amplification tests (NAATs) have revolutionized our ability to diagnose Chlamydia trachomatis (CT). Sometimes, in addition, assessment of CT viability would help to gain more insight in the clinical impact of a positive NAAT. Methods to assess the CT viability have become available in research settings (e.g. viability-PCR; V-PCR). Here we assess viability in six different anatomic sites in women. Methods Immediately prior to treatment (STI clinic South Limburg), 28 vaginal NAAT-CT-positive (COBAS4800 CT/NG) adult women, were included in the ‘CHLAMOUR’ study. We used V-PCR to assess CT viable load (log10 CT/ml) in same clinician taken standardized samples from the cervix, vagina, perineum, anus, optional rectum, and pharynx. Mean loads were compared using t-tests. Results Twenty-eight women were included of whom 68% (19/28) consented to proctoscopic examination (rectal). NAAT-CT-positive rate was 75% for cervix, 79% vagina, 64% perineum, 64% anus, 74% rectum, and 21% for pharynx. Viable load was detected in 90% (19/21) CT positive cervix, 77% (17/22) vagina, 11% (2/18) perineum, 61% (11/18) anal, 93% (13/14) rectal, and 0% (0/6) pharynx samples. The mean viable load was marginally higher in cervical compared to vaginal samples (4.37 [SD:1.35] vs. 3.45 [SD:1.05], p=0.055). Mean viable load was higher in rectal compared to anal samples (3.51 [SD:0.51] vs. 2.70 [SD:0.42], p=0.01). Viable load was 2.72 [SD:1.69] CT positive perineum samples. Conclusions The amount of viable CT varied by anatomic site, and were highest ‘upward in the body’, which is thus likely to represent actual site of infection. Still, the vaginal and anal sites (that are usually self-sampled) had high concordance with the cervical and rectal sites. CT at the perineum may indicate autoinoculation. Notably, the presence of viable CT in anorectal samples indicated the presence of an active anorectal infection, which should be accounted for in comprehensive CT management.","PeriodicalId":333492,"journal":{"name":"Late breakers","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127334690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

O20.2 Ertapenem is non-inferior to ceftriaxone for the treatment of anogenital gonorrhea: the NABOGO randomized double blind non-inferiority trial O20.2厄他培南治疗肛门生殖器淋病不劣于头孢曲松:NABOGO随机双盲非劣效性试验

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/SEXTRANS-2021-STI.165

H. D. Vries, V. Jongen, T. Heyman, C. M. Wind, J. D. Korne-Elenbaas, A. V. Dam, M. S. Loeff

{"title":"O20.2 Ertapenem is non-inferior to ceftriaxone for the treatment of anogenital gonorrhea: the NABOGO randomized double blind non-inferiority trial","authors":"H. D. Vries, V. Jongen, T. Heyman, C. M. Wind, J. D. Korne-Elenbaas, A. V. Dam, M. S. Loeff","doi":"10.1136/SEXTRANS-2021-STI.165","DOIUrl":"https://doi.org/10.1136/SEXTRANS-2021-STI.165","url":null,"abstract":"Background Neisseria gonorrhoeae (Ng) is a common sexually transmitted infection (STI). Emerging strains resistant to first-line ceftriaxone threaten Ng management. Hence, alternative treatments are needed. We evaluated the efficacy of ertapenem, gentamicin and fosfomycin as alternatives for Ng. Approach We included adults 18 years or older, with anorectal or urogenital gonorrhea in a randomized controlled, double-blind, non-inferiority trial (three experimental- and one control-arm). Participants were randomized (1:1:1:1) to receive: intramuscular (IM) 500mg ceftriaxone, IM 1000mg ertapenem, IM 5mg/kg gentamicin (maximum 400mg), or 6g fosfomycin orally. The primary outcome was the proportion of participants with a negative nucleic acid amplification test of the primary infected site, 7–14 days after treatment. Non-inferiority was established if the lower Hochberg-corrected 95% confidence interval for difference between experimental and control arms was greater than -10%. Outcomes Between 18 September 2017 and 5 June 2020, we assigned 346 participants to ceftriaxone (n=103), ertapenem (n=103), gentamicin (n=102), and fosfomycin (n=38). The fosfomycin arm was terminated early after interim analysis revealed Significance Single-dose 1000mg ertapenem is non-inferior to single-dose 500mg ceftriaxone in gonorrhea treatment. Given that ertapenem, an already registered antibiotic, is non-inferior to the standard of care, it may currently provide an alternative treatment option for gonorrhea if resistance against ceftriaxone becomes more widespread.","PeriodicalId":333492,"journal":{"name":"Late breakers","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124602095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O20.5 Love in Lockdown: Relationship Stress, Dating Violence and STI Risk in Adolescent and Young Adult Relationships during the COVID-19 Pandemic O20.5禁闭中的爱:2019冠状病毒病大流行期间青少年和年轻人关系中的关系压力、约会暴力和性传播感染风险

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/sextrans-2021-sti.168

P. Matson, J. Perin, Julia Rowell, A. Agwu, J. Coleman, C. Gaydos, M. Trent

{"title":"O20.5 Love in Lockdown: Relationship Stress, Dating Violence and STI Risk in Adolescent and Young Adult Relationships during the COVID-19 Pandemic","authors":"P. Matson, J. Perin, Julia Rowell, A. Agwu, J. Coleman, C. Gaydos, M. Trent","doi":"10.1136/sextrans-2021-sti.168","DOIUrl":"https://doi.org/10.1136/sextrans-2021-sti.168","url":null,"abstract":"BackgroundAdolescents and young adults (AYA) who experience dating violence (DV) are at increased STI risk. Social restrictions during the COVID-19 pandemic have stressed AYA relationships and may cut them off from sources of support. AYA have been shown to respond to relationship stressors with behaviors that increase STI risk. This work examines whether relationship stressors (jealousy and worry about the relationship) exacerbate violence and STI risk among urban AYA during the COVID-19 pandemic.MethodsParticipants from four sexual and reproductive health studies in Baltimore, Maryland (USA) were invited to complete a cross-sectional telephone survey on relationship experiences/sexual behavior during the pandemic. March 16, 2020 ‘stay-at-home’ order was used to define the pandemic period. Partner support, jealousy, worry about the relationship making it through the pandemic, current DV, change in DV during pandemic, and condom use at last sex were evaluated using regression analyses. Data collection is still underway in 2021.ResultsOf 194 participants surveyed, mean (sd) age 22.7 (2.8) years, 61% were in a romantic/sexual relationship. Of these, 14% reported current TDV, 6% experienced an increase in DV, 66% did not use a condom at last sex. AYA who worried their relationship would not make it through the pandemic were more likely to experience DV (OR: 5.64, 95%CI: 1.69, 18.9). AYA who felt jealous of other people their partner was talking to/hanging out with during the pandemic were more likely to experience DV (OR: 4.51, 95%CI: 1.39, 14.6). Greater partner support was associated with experiencing less DV (OR: 0.71, 95%CI: 0.56, 0.90). Relationship stressors were not associated with condom use.ConclusionsRelationship insecurity exacerbated by the COVID-19 pandemic may increase risk for DV among AYA. As DV and STI are interconnected, romantic relationship context must be a key focus of STI prevention strategies during and after the pandemic.","PeriodicalId":333492,"journal":{"name":"Late breakers","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123734837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

O20.4 Evaluation of global Treponema pallidum genetic diversity using representative sampling and high-throughput genomic analysis O20.4利用代表性采样和高通量基因组分析评估全球梅毒螺旋体遗传多样性

Late breakers Pub Date : 2021-07-01 DOI: 10.1136/SEXTRANS-2021-STI.167

F. Nindo, P. Pospíšilová, C. Hennelly, Kelly L. Hawley, A. Luthra, T. Davenport, A. Seña, Wentao Chen, Y. Jiang, Bin Yang, L. Yang, Heping Zheng, Mitch M Matoga, I. Hoffman, E. López, L. Ramirez, M. Caimano, J. Salazar, M. Moody, J. Rudolf, J. Juliano, D. Šmajs, J. Parr

引用次数: 1