Annals of Child Neurology最新文献_第5页

Identification of Preventable Risk Factors for Developmental Delay in Children: A Pilot Study 儿童发育迟缓可预防危险因素的识别：一项初步研究

Annals of Child Neurology Pub Date : 2023-03-22 DOI: 10.26815/acn.2022.00416

Tejanjani Vathada, L. Lingappa

{"title":"Identification of Preventable Risk Factors for Developmental Delay in Children: A Pilot Study","authors":"Tejanjani Vathada, L. Lingappa","doi":"10.26815/acn.2022.00416","DOIUrl":"https://doi.org/10.26815/acn.2022.00416","url":null,"abstract":"Purpose: Developmental delay (DD) is reported to be frequent in developing countries, such as In-dia. Hence, this study was carried out to evaluate preventable risk factors that can predispose children to DD, through observations of pediatric neurology outpatients. Methods: This was a prospective, observational, and descriptive cross-sectional single-center hospital-based study for a period of 30 days, split into two separate time periods due to the impact of the coronavirus disease 2019 pandemic. Children who newly presented to the pediatric neurology outpatient department were considered. There were a total of 151 boys and girls, from 6 months to 14 years of age. Detailed demographic information on prenatal, natal and postnatal risk factors relevant to the neurological diagnosis was collected. Antenatal education for mothers about breastfeeding and newborn care, place of delivery, the availability of round-the-clock pediatric care during the delivery, gestational age, maternal fever, encephalitis, seizures, meningitis, blood pressure, gestational diabetes mellitus, infections, history of consanguinity, and genetic disorders were all considered. The data were analyzed with odds ratios and multivariable logistic regression. Results: Forty-three of the 151 enrolled children had DD. Significant associations were found between consanguinity and DD (adjusted odds ratio [AOR], 6.50;95% confidence interval [CI], 1.96 to 21.51;P<0.002) and between prematurity and DD (AOR, 2.34;95% CI, 1.07 to 5.13;P<0.033). Conclusion: This study shows that consanguineous marriages and prematurity predisposed children to DD when prenatal, natal, and postnatal risk factors were comprehensively considered. © 2023 Korean Child Neurology Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48195296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Profile of Children with Primary Headache at a Tertiary Care Center in North India: A Retrospective Study 印度北部三级保健中心儿童原发性头痛的临床概况:一项回顾性研究

Annals of Child Neurology Pub Date : 2023-03-22 DOI: 10.26815/acn.2023.00017

Rahul Sinha, Dharmesh Soneji, Gautam Kamila, Sonali Singh, A. Upadhyay

{"title":"Clinical Profile of Children with Primary Headache at a Tertiary Care Center in North India: A Retrospective Study","authors":"Rahul Sinha, Dharmesh Soneji, Gautam Kamila, Sonali Singh, A. Upadhyay","doi":"10.26815/acn.2023.00017","DOIUrl":"https://doi.org/10.26815/acn.2023.00017","url":null,"abstract":"Purpose: The present study investigated the clinical profile of children with primary headache at a tertiary care center in North India. Methods: A retrospective observational study was conducted between January 2021 and October 2022. In total, 100 children 5 to 18 years of age who attended the pediatric outpatient department or the emergency department with primary headache were included. Children with secondary causes of headache were excluded. Results: This study included 100 children (40 boys, 60 girls), and the female-to-male ratio was 1.5:1. The patients ranged in age from 5 to 18 years (mean±standard deviation, 10.1±2.8). Mi-graine headaches were most commonly reported (60%) followed by tension-type headache (28%) and others (12%). The throbbing type of pain was most common (43%), followed by the tightening type in 32%. The pain location was bilateral frontal in 47% of patients, followed by bitemporal in 20% and occipital in 17%. Most of the children (87%) had a headache duration of 2 to 4 hours. The common precipitating factors were skipped meals (25%), bright light (18%), lack of sleep (16%), and schoolwork (15%). A family history was present in around 62%. Around 70% of children required prophylactic medications (flunarizine and propranolol). Long screen time (2 to 4 hours/day) and a family history of headache were significantly associated with primary headache ( P <0.05). Conclusion: The present study highlights that migraine is most common cause of primary head-ache in children, and every effort should be made for the early detection and management of headaches among children.","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48847318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Usefulness of a Multiplex Molecular Panel for Central Nervous System Infection: An 11-Month Experience at a Tertiary Center in Korea 多重分子小组治疗中枢神经系统感染的临床实用性：韩国一家三级中心11个月的经验

Annals of Child Neurology Pub Date : 2023-03-21 DOI: 10.26815/acn.2022.00388

Yoo Jung Lee, Eun Hye Yang, Yoon Hee Jo, Soo-Han Choi, H. W. Yoo, Ha Young Cho, M. Kwak, S. J. Park, Kyung-Hee Park, Young Mi Kim

引用次数: 0

Early Successful Treatment in a Child with Febrile Infection-Related Epilepsy Syndrome 小儿发热性感染相关癫痫综合征的早期成功治疗

Annals of Child Neurology Pub Date : 2023-03-09 DOI: 10.26815/acn.2022.00423

N. Gaspar, C. Melo, Jacinta Fonseca, R. Sousa, M. Sampaio

引用次数: 0

Epilepsy of Infancy with Migrating Focal Seizures in a Patient with Nonketotic Hyperglycinemia 非酮症性高血糖症患者的婴儿期癫痫伴迁移局灶性癫痫

Annals of Child Neurology Pub Date : 2023-03-09 DOI: 10.26815/acn.2022.00346

Muhamad Azamin Anuar, Sharifah Aishah Alsagoff, A. R. Mohamed, S. Murugesu

引用次数: 0

Efficacy and Safety of Lamotrigine Adjunctive Therapy in Lennox-Gastaut Syndrome 拉莫三嗪辅助治疗lenox - gastaut综合征的疗效和安全性

Annals of Child Neurology Pub Date : 2023-03-09 DOI: 10.26815/acn.2022.00437

Hui Jin Shin, A. Ko, S. H. Kim, Joon Soo Lee, H. Kim, Hoon-Chul Kang

引用次数: 0

Prevalence of Pediatric Autism Spectrum Disorder in Korea Using National Statistics Including the COVID-19 Pandemic, 2011 to 2021 2011 - 2021年包括COVID-19大流行在内的韩国儿童自闭症谱系障碍患病率统计数据

Annals of Child Neurology Pub Date : 2022-12-26 DOI: 10.26815/acn.2022.00360

H. Eom, Minji Kim, J. K. Yoo, Eunjoo Bae, J. Yi, Ji Young Lee

{"title":"Prevalence of Pediatric Autism Spectrum Disorder in Korea Using National Statistics Including the COVID-19 Pandemic, 2011 to 2021","authors":"H. Eom, Minji Kim, J. K. Yoo, Eunjoo Bae, J. Yi, Ji Young Lee","doi":"10.26815/acn.2022.00360","DOIUrl":"https://doi.org/10.26815/acn.2022.00360","url":null,"abstract":"Purpose: Regularly analyzing the prevalence of autism spectrum disorder (ASD) is important to inform policies and strategies for proper management. The present study aimed to esti-mate trends in ASD prevalence according to age and time in Korean children. Methods: We monitored the annual prevalence of ASD in children aged 2 to 18 years based on information from Statistics Korea and the Korean National Health Insurance Service. We estimated changes in prevalence between 2011 and 2021 after stratifying partici-pants into three age groups. Furthermore, we analyzed the prevalence of ASD by birth year. Results: The highest level of prevalence appeared in children aged 6 years, and thereafter, it declined with age. The prevalence of ASD in children aged 2 to 18 years increased from 0.05% in 2011 to 0.12% in 2021. During the same time, the prevalence in preschool children (2 to 5 years) remarkably increased from 0.04% in 2011 to 0.12% in 2021, while the prevalence in adolescents (13 to 18 years) increased from 0.05% in 2011 to 0.09% in 2021. The prevalence of ASD notably increased during the coronavirus disease 2019 (COVID-19) pandemic (2020 to 2021). Among children born between 2011 and 2015, the prevalence of ASD was higher for children with recent birth years, especially during the COVID-19 pandemic. Conclusion: The overall ASD prevalence in children and adolescents in Korea seems to be increasing, especially in preschool children during the COVID-19 pandemic. Early and more effec-tive interventions are necessary for Korean children. © 2023 Korean Child Neurology Society.","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46334857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Recognition of Pediatric Strokes in the Emergency Department: Epidemiology, Clinical Presentation, and Factors Impeding Stroke Diagnosis in Children 急诊科对儿童脑卒中的早期认识：流行病学、临床表现和影响儿童脑卒中诊断的因素

Annals of Child Neurology Pub Date : 2022-12-26 DOI: 10.26815/acn.2022.00367

S. Tan, W. Cher, S. Chong, A. Ang, S. Ganapathy, D. Chan, R. M. K. Tan

{"title":"Early Recognition of Pediatric Strokes in the Emergency Department: Epidemiology, Clinical Presentation, and Factors Impeding Stroke Diagnosis in Children","authors":"S. Tan, W. Cher, S. Chong, A. Ang, S. Ganapathy, D. Chan, R. M. K. Tan","doi":"10.26815/acn.2022.00367","DOIUrl":"https://doi.org/10.26815/acn.2022.00367","url":null,"abstract":"Purpose: Strokes are challenging to diagnose in pediatric emergency departments (EDs) as level of suspicion is low and atypical presentations are common. We analyzed clinical features, epidemiology and factors of delayed identification in arterial ischemic strokes (AIS) and hemorrhagic strokes (HS). Methods: Single-centre retrospective cohort study of children aged between 29 days and 18 years old diagnosed with stroke between July 2016 to June 2021. Results: Among 36 children, 11 (30.5%) had AIS, 25 (69.4%) had HS. Median age for AIS was 9 years (interquartile range [IQR], 2 to 9) and HS 9 years (IQR, 1 to 11.5) ( P =0.715). Focal neurological deficit was seen in 72.7% of AIS and 20% of HS ( P =0.006). Only 18.2% of AIS and 52.0% of HS presented within 6 hours of symptoms. Median time from symptom onset to ED presentation was 24 hours (IQR, 12 to 28) for AIS and 7 hours (IQR, 1.8 to 48) for HS ( P =0.595). Most (85.6%) arrived by own transport. Median time from presentation to neuroimaging was 7 hours (IQR, 0.9 to 7) for AIS and 4.8 (IQR, 1.3 to 16.8) hours for HS ( P =0.376). Eleven patients, 9/25 (36.0%) HS and 2/11 (18.2%) AIS, did not have stroke as differential diagnosis at ED ( P =0.714). Common initial diagnoses were viral illness or headaches. On univariate analysis, age <1 (odds ratio [OR], 17.5; 95% confidence interval [CI], 1.2 to 250.4; P =0.035) and absence of focal neurological deficit (OR, 13.091; 95% CI, 1.5 to 117.9; P =0.022) were significant factors for delayed identification. Conclusion: Index of suspicion for pediatric strokes among caregivers and clinicians should be increased. Public awareness campaigns are recommended","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46413953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Complex Febrile Seizures in Children with COVID-19 Infection COVID-19感染儿童的复杂热性惊厥

Annals of Child Neurology Pub Date : 2022-12-22 DOI: 10.26815/acn.2022.00374

L. Kim, J. Han, A. Cho, Hunmin Kim

{"title":"Complex Febrile Seizures in Children with COVID-19 Infection","authors":"L. Kim, J. Han, A. Cho, Hunmin Kim","doi":"10.26815/acn.2022.00374","DOIUrl":"https://doi.org/10.26815/acn.2022.00374","url":null,"abstract":"ported in Wuhan, China in 2019, is an infectious disease caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The incidence rate is lower in children than in adults, but as the number of infected patients has increased recently, the number of pediatric patients has also increased [1,2]. The typical symptoms of COVID-19 include fever, cough, chills, aches, headaches, anorexia, and anosmia [1]. Neurological manifestations can also occur in patients with COVID-19. Several studies have reported neurological manifestations of COVID-19 in children [1-4]. Panda et al. [4] reviewed these manifestations and reported that 16% of all such patients showed non-specific neurological symptoms, such as headache, myalgia, and fatigue, whereas 1% of them showed specific neurological symptoms, such as seizures and encephalopathy. Another study reported that neurological manifestations, including febrile and non-febrile seizures, were observed in 3% of children with COVID-19 [1]. Febrile seizures are relatively common neurologic disorders, affecting 2% to 5% of children under the age of 5 years. There are two types of febrile seizures: simple and complex seizures. Simple febrile seizures refer to generalized seizures pISSN 2635-909X • eISSN 2635-9103 Ann Child Neurol [Epub ahead of print] https://doi.org/10.26815/acn.2022.00374","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44590118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Diagnostic Utility of Short-Term Video Electroencephalography at a Tertiary Care Center in North India: A Retrospective Study 短期视频脑电图在印度北部三级医疗中心的诊断效用:一项回顾性研究

Annals of Child Neurology Pub Date : 2022-12-21 DOI: 10.26815/acn.2022.00332

Rahul Sinha, Sonali Singh, Gautam Kamila, A. Upadhyay

{"title":"The Diagnostic Utility of Short-Term Video Electroencephalography at a Tertiary Care Center in North India: A Retrospective Study","authors":"Rahul Sinha, Sonali Singh, Gautam Kamila, A. Upadhyay","doi":"10.26815/acn.2022.00332","DOIUrl":"https://doi.org/10.26815/acn.2022.00332","url":null,"abstract":"Purpose: This study investigated the diagnostic utility of short-term video electroencephalography (EEG) recordings at a tertiary care center in North India. Methods: A retrospective analysis was conducted of 30 minutes of video EEG recordings done between January 2021 and January 2022 in children between 1 and 10 years of age. Demographic and clinical data were collected from the EEG register. Age, sex, the clinical diagnosis, the number of anti-seizure medicines (ASMs), the activation procedures used, and EEG abnormalities were recorded. Results: Data from 100 children (male-to-female ratio, 1.9:1) were analysed. The mean age was 5.39±2.02 years. The indications for EEG recordings were epileptic disorders, neurodevelopmental disorders, paroxysmal non-epileptic events, and miscellaneous in 66%, 18%, 9%, and 7% of children, respectively. EEG abnormalities were seen in 50 children (50%) and about 45% of children were on two or more ASMs. EEG abnormalities in sleep were seen in 35 of 66 (53%) children, whereas abnormalities were observed on awake recordings with activation procedures (hyper-ventilation and photic) in 23 of 34 (68%) children; this difference was not statistically significant ( P =0.16) Conclusion: EEG abnormalities were significantly more common in children taking multiple ASMs; however, there was no statistically significant difference in the EEG yield between asleep and awake records with activation procedures. A better selection of patients for routine EEG, through an assessment of their clinical history and comorbidities, is warranted to increase its diagnostic yield.","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69138205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0