Innovations in Digital Health, Diagnostics, and Biomarkers最新文献

{"title":"Abstracts Presented at the 2nd Annual Advancing Healthcare Innovation Summit: Nov 11, 2022, Cincinnati, OH","authors":"","doi":"10.36401/iddb-22-x2","DOIUrl":"https://doi.org/10.36401/iddb-22-x2","url":null,"abstract":"","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"294 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131610089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of Digital Health in Public Health: The China Experience","authors":"I. Cheong, Hui Wang","doi":"10.36401/iddb-21-05","DOIUrl":"https://doi.org/10.36401/iddb-21-05","url":null,"abstract":"","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125898680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Phototoxicity Sensitivity by the Neutral Red Uptake Method for BALB/c 3T3, HaCaT, and HDFa Cells In Vitro","authors":"Qiuwen Liang, Feifei Wang, Xiao Ma","doi":"10.36401/iddb-21-02","DOIUrl":"https://doi.org/10.36401/iddb-21-02","url":null,"abstract":"\u0000 \u0000 \u0000 Phototoxicity is an acute photoinduced reaction. The 3T3 neutral red uptake (NRU) phototoxicity test has high sensitivity for the determination of phototoxic substances. To further optimize the method, this study mainly focused on comparing the phototoxicity sensitivity by using the NRU method for BALB/c 3T3, HaCaT, and HDFa cells in vitro.\u0000 \u0000 \u0000 \u0000 The NRU method was used to evaluate the phototoxicity of chlorpromazine hydrochloride (CPZ), amiodarone hydrochloride (Amiodar), and L-histidine (L-His) on BALB/c 3T3 cells, HaCaT cells, and HDFa cells. The sensitivity of different cells to ultraviolet (UVA) irradiation in vitro was studied.\u0000 \u0000 \u0000 \u0000 L-His showed no phototoxicity, but the phototoxicity of CPZ and Amiodar showed different sensitivities among the three kinds of cells. The in vitro phototoxicity evaluation of HaCaT cells is closer to that of primary human fibroblasts.\u0000 \u0000 \u0000 \u0000 This study provides a reference for cell line selection to optimize the existing in vitro evaluation method of 3T3 NRU phototoxicity.\u0000","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126903277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a Mobile Health (mHealth) Platform for Remote Assessment of Suicidal Ideation, Depression, and Anxiety: A Longitudinal Retrospective Study","authors":"A. Pardes, William Lynch, Matthew Miclette, Ellen McGeoch, B. Daly","doi":"10.36401/iddb-21-03","DOIUrl":"https://doi.org/10.36401/iddb-21-03","url":null,"abstract":"\u0000 \u0000 \u0000 There is growing support for the use of integrated measurement-based care to capture symptom data in real time so treatment providers can make informed decisions about intervention strategies for mental health problems, such as depression and anxiety, both of which are known to increase suicide. We examined the potential scalability and effectiveness of a mobile health (mHealth) application with integrated behavioral health functions to capture remote patient-reported measurement of suicidal ideation and overall symptoms of depression and anxiety.\u0000 \u0000 \u0000 \u0000 This study was an observational retrospective review of deidentified patient data, including symptoms of suicidal ideation, depression, and anxiety as measured by the Patient Health Questionnaire-9 (PHQ-9) or Generalized Anxiety Disorder 7 (GAD-7) scale, which were administered to and completed by patients on a smartphone or desktop application. After controlling for age, sex, and the presence of moderate versus severe symptoms at baseline, mean scores were analyzed with the Student's t-test.\u0000 \u0000 \u0000 \u0000 Of patients who took the PHQ-9 assessment at baseline and 8 weeks later (n = 764), the proportion who endorsed suicidal thinking decreased from 25% to 14.66% (p < 0.001) over 8 weeks. The mean PHQ-9 score was reduced from 14.69 (standard error [SE], 4.09) to 10.50 (SE, 5.94; p < 0.001), and a subset of individuals who continued use and took the PHQ-9 again at 24 weeks (n = 185) had a further decrease to 9.03 (SE, 7.09, p < 0.01). Although 21.62% of this subset still had suicidal thinking, the frequency of suicidal thoughts decreased. Of patients who took the GAD-7 at baseline and 8 weeks (n = 797) the mean score decreased from 14.20 (SE, 3.31) to 10.08 (SE, 5.55; p < 0.001) at 8 weeks and to 7.48 (SE, 6.54; p < 0.001) for a subset (n = 278) who continued use and took a GAD-7 at 24 weeks (n = 278). The sum of subgroup samples is larger than the whole because of instances of comorbid depression and anxiety.\u0000 \u0000 \u0000 \u0000 Remote assessments within technology-supported integrated behavioral health care were feasible at scale. Change in symptoms could be observed at the individual and group level in real time, which may allow clinical teams to adjust treatments and improve outcomes. Prospective controlled studies are needed to determine what factors contribute to reductions in symptom severity.\u0000","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134360084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Innovation: Will COVID-19 be a Transformative Experience?","authors":"Z. Kozlakidis, D. Catchpoole","doi":"10.36401/IDDB-21-X2","DOIUrl":"https://doi.org/10.36401/IDDB-21-X2","url":null,"abstract":"Healthcare Innovation: Will COVID-19 be a Transformative Experience? Zisis Kozlakidis, Daniel Catchpoole Laboratory Services and Biobanking, International Agency for Research on Cancer, World Health Organization, Lyon, France The Tumour Bank, The Children’s Cancer Research Unit, Kids Research, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia Faculty of Engineering and Information Technology Sydney, Sydney, New South Wales, Australia","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121984228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time Dynamic Tiered e-Consent: A Novel Tool for Patients' Engagement and Common Ontology System for the Management of Medical Data","authors":"D. Ivanova, P. Katsaounis","doi":"10.36401/iddb-21-01","DOIUrl":"https://doi.org/10.36401/iddb-21-01","url":null,"abstract":"","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133223623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Opinions of Egyptian Medical Students Toward Biobanking Issues","authors":"A. Abdelhafiz, W. Khairy, Merhan A. Fouda, Rania M Labib, E. Sultan, H. Ziady, D. Sayed","doi":"10.36401/IDDB-20-08","DOIUrl":"https://doi.org/10.36401/IDDB-20-08","url":null,"abstract":"\u0000 \u0000 \u0000 Biobanking is an emerging concept in Egypt. Medical students represent important future stakeholders in the research community. The objective of this work was to evaluate the knowledge, attitude, and opinions of Egyptian medical students toward biobanking issues.\u0000 \u0000 \u0000 \u0000 We designed a structured survey about these issues, which was communicated online with medical students at three universities in Egypt.\u0000 \u0000 \u0000 \u0000 A total of 315 of 364 questionnaires were completed. More than half the students have heard the term “biobanking” before. Approximately 77% had a general positive attitude toward the concept of biobanking; however, only 57.7% were willing to participate with their own or family samples. The positive attitude toward donation was significantly higher in participants with negative family history of inherited diseases (p = 0.02).\u0000 \u0000 \u0000 \u0000 Although some students had limited knowledge of biobanking, they had a positive attitude toward the concept in general. However, this was not reflected in a similar attitude toward donating biospecimens, especially in those with a family history of inherited disease. Moreover, they expressed concerns about data protection and samples sharing with different stakeholders. Taking all these into account, educational activities about biobanking should be given to medical students to fill the knowledge gap on the subject.\u0000","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"35 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130449310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Untapped Social Impact of Artificial Intelligence for Breast Cancer Screening in Developing Countries: A Critical Commentary of DeepMind","authors":"Joe Logan, Paul J. Kennedy, D. Catchpoole","doi":"10.36401/IDDB-20-07","DOIUrl":"https://doi.org/10.36401/IDDB-20-07","url":null,"abstract":"In January 2020, Google’s DeepMind team published an article demonstrating that a deep neural network– based artificial intelligence (AI) system could outperform a human radiologist at the task of interpreting mammograms. The most ground-breaking aspect of this study is not the machine learning architecture itself, rather it is the fact that the authors trained their system by using a wholly histologically labelled dataset, rather than data that used the radiologist’s opinion as the ground truth. With DeepMind focusing exclusively on British and American patients, this commentary discusses how they may have missed the social impact use-case for the technology to address the needs of the 5 billion women who do not undergo breast cancer screening in the developing world. The incidence of breast cancer is rapidly growing in the developing world, regions that do not have the financial or human resources to implement a traditional radiologist-led screening program. In these circumstances, the scalability and low cost of AI systems, such as that put forward by DeepMind, could be a viable solution. According to the current position statement of the World Health Organization (WHO):","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126956685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Najia” Story: A WhatsApp Support Group For Patients With Breast Cancer","authors":"Atlal M. Abusanad","doi":"10.36401/iddb-20-01","DOIUrl":"https://doi.org/10.36401/iddb-20-01","url":null,"abstract":"Social media is becoming an essential part of every aspect of life. Different media platforms exist, and each has different features; however, all platforms provide the opportunity to interact, engage, and share. The use of social platforms has extended to the medical field. Online support groups for several medical conditions have progressively evolved with the expansion of Internet use. A Cochrane review evaluated the effect of online breast cancer support groups on women’s emotional distress, uncertainty, anxiety, depression, and quality of life. It included online support groups in six trials that lasted 6 to 30 weeks and included eight to 15 members. Because the included trials were small and of low quality, the review did not find robust evidence to show whether participation in online support groups was beneficial for women with breast cancer. Also, they did not specify the specific online platform in the reviewed trials. An abstract from India reported a 14week program that was created to provide physical and psychological interventions by doctors, nurses, and social workers for groups consisting of six to 10 women with metastatic breast cancer on WhatsApp. The intervention was short-lived, but the authors concluded that such groups might replace physical meetings. Saudi Arabia is considered one of the countries with rapidly increasing social media engagement. Sixty-eight percent of the Saudi population consists of active media users with an average use of 3 hours daily. Interestingly, Saudi Arabia ranked first among Arab countries and second worldwide in the use of Snapchat and WhatsApp and Facebook had the top rates of social networking platforms use. From our experience, many patients in Saudi Arabia prefer to keep silent about their cancer diagnosis or perhaps prefer to maintain anonymity while participating in an online group. Although the desire to engage and share with similar patients and caregivers is present, such barriers may present difficulties and challenges, especially to women who grew up in a conservative culture. Moreover, a reliable native language platform is not easily found. On consultation and discussion with the author’s patients about online platforms, many expressed their desire to be part of a trusted group to connect, exchange experiences, and obtain psychosocial support. It is essential to know that real-time support groups do not exist in our country for the same reasons that hinder open social participation. After considering these barriers, in 2016 a WhatsApp support group for women with breast cancer was created. It is called Najia, which is Arabic for ‘‘A lady survivor’’ and has an artistically designed turtle as a group logo to symbolize the endurance and persistence of patients with breast cancer during their treatments and wish for posttreatment longevity. The group is moderated and supervised by the author, making sure it serves its intended purpose. It is a shared partnership with patients. Each one ","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123563089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Nanomaterials: Current Progress and Future Directions","authors":"Jia-Le Xu, Li-wen Li, Yunpeng Luo, Sheng-Hao Yuan, Ning Liu","doi":"10.36401/iddb-20-03","DOIUrl":"https://doi.org/10.36401/iddb-20-03","url":null,"abstract":"\u0000 Fungal infection poses a severe threat to human health worldwide resulting in a serious problem in clinic. Due to the limited arsenal of existing antifungal drugs, the nanomaterials were thus regarded as the candidate for developing new antifungal drugs. On the one hand, the antifungal nanomaterials are divided into inorganic nanomaterials, organic nanomaterials, and hybrid nanomaterials, among which inorganic nanoparticles include metal and semiconducting categories. On the other hand, they can also be divided into inorganic particles, organic structures, and mixed nanostructures. Currently various directions for the research and development of antifungal nanomaterials are undergoing. To improve the antifungal effect, the chemical modification of nanomaterials and combination with the available drugs are two strategies widely used. In addition, optimizing the synthetic process of nanomaterials is also a major method to broaden their antifungal application. This review focuses on the current research progress and cutting-edge technologies of antifungal nanomaterials in the field of pharmacodynamics, synthesis and combination of drugs. The nanomaterial will provide a promising and broadly effective antifungal strategy and represent a potentially repositionable candidate for the treatment of fungal infections.","PeriodicalId":331225,"journal":{"name":"Innovations in Digital Health, Diagnostics, and Biomarkers","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122496612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}