Annals of Basic and Medical Sciences最新文献

{"title":"Prevalence of Proteinuria among Type 2 Diabetic Patients Attending Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria","authors":"AbdulRahman Muhammad B., K. Saidu","doi":"10.51658/abms.202232.3","DOIUrl":"https://doi.org/10.51658/abms.202232.3","url":null,"abstract":"Background: Diabetes mellitus has been reported to be the primary cause of end-stage renal disease in some Asian and American countries. However, no such data were available among type 2 diabetic patients in North-Western Nigeria. This study was aimed to assess the prevalence and associated risk factors of proteinuria among type- 2 diabetic patients by measuring the total protein-to-creatinine ratio (TPCR) and to provide some possible recommendations to enhance the level of health care rendered to the patients. Methods: This was a cross-sectional study. Spot urine TPCR was performed on 182 diabetic patients who attended the diabetic clinic at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, from January 2018 to December 2018. Other relevant parameters were extracted from the Chemical Pathology Department register, and the patients' case folders. The data were statistically analysed using SPSS version 23.0 (Chicago IL). Results: Among the total of 182 diabetic patients recruited during the study period, 66(36.3%) were males and 116(63.7%) were females. Out of the patients, (82)45.1% had hypertension; and (105)57.7% of the study population were obese. The overall prevalence of pathological proteinuria (TPCR ≥ 150 mg/mmol creatinine) was found in 116 (63.7%) of the study population. Conclusions: The prevalence of proteinuria is high in the study subjects (63.7%). The high prevalence observed might be a result of kidney disease in a primary healthcare setting. However, this study is a hospital-based finding with a small sample size, therefore, a larger study population size is recommended for future studies. Keywords: prevalence, proteinuria, type 2 diab","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114269606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Serum Sialic Acid, Serum Lipids, Cardiac Troponin I and Myoglobin among Women on Combined Oral Contraceptives","authors":"Idris Mohammed, Usman Datti, H. Abdullahi, A. Busari","doi":"10.51658/abms.202232.13","DOIUrl":"https://doi.org/10.51658/abms.202232.13","url":null,"abstract":"Background: Women using combined oral contraceptives have an increased risk of developing cardiovascular disease. While the utility of biomarkers such as serum lipids have been well evaluated, serum sialic acid, which has shown some promise as a marker of cardiovascular disease progression has been poorly studied. This study aimed to determine the correlation between sialic acid and lipid profile as risk factors of cardiovascular disease in women on combined oral contraceptives. Materials and Methods: This was a cross-sectional study involving 143 women on combined oral contraceptive pill as the study group and 100 age and sex matched healthy controls. Serum levels of Total Sialic Acid (TSA), lipids, and some cardiac biomarkers (Myoglobin, Creatine Kinase-MB and Troponin-I) were measured, summarized as mean (±SD) and compared. Correlation between serum level of sialic acid and each of the measured serum lipid component was subsequently determined using correlation analysis. Results: Sialic acid (1.070±0.117 vs 0.837±0.272), Total cholesterol (3.944±0.918 vs 3.106±0.635), Low density lipoprotein cholesterol (2.408±1.085 vs 1.088±0.392), High density lipoprotein cholesterol (1.049±0.421 vs 0.902±0.542) & Triglycerides (1.620±0.703 vs 1.052±0.514) were all significantly (P<0.05) higher in the combined oral contraceptive group than controls respectively. Sialic acid demonstrated a weak but positive correlation with Myoglobin (r= +0.403), Creatine kinase-MB (r= +0.441) and Troponin-I (r= +0.424). While TGs and sialic acid were shown to have a very weakly positive association (r= +0.089), TC, LDL-C, and HDL-C all had very weakly negative correlations (r= -0.136, -0.146, and -0.006, respectively). Conclusion: Combined oral contraceptives use confers an artherogenic lipid profile imparting a positive cardiovascular disease risk. Although sialic acid is significantly higher among combined oral contraceptive users and shows a positive relationship with cardiac biomarkers, it correlates poorly with serum lipids suggesting its limited utility as a CVD marker.","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125486124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Plasma Glucose and Lipid Profile Dysregulation among Patients on Antipsychotics in Sokoto","authors":"A. Muhammad, Emeka E. Emordi, Mainasara Abdullahi, Bakare Abdulfatahi, Elbashir Jibril, B. Aminu, Fakku Abubakar, S. Kasimu, A. Aminu, D. Mohammed, M. Nasir, Ugege Modupe, B. Makun","doi":"10.51658/abms.202232.2","DOIUrl":"https://doi.org/10.51658/abms.202232.2","url":null,"abstract":"Background: Antipsychotic drugs used in the treatment of psychotic disorders have been implicated in negative effects on the blood glucose and lipid profile levels of patients. Methods: We studied the anthropometric parameters and then the plasma glucose and lipid profile levels of one hundred and seventy-two (172) patients between the ages of 18 and 45 years; who are on various oral antipsychotics. Also, forty (40) treatment-naïve psychiatric patients and forty (40) healthy controls were included in the study. The results were analysed using standard methods. Results: The mean plasma glucose level was significantly higher (p<0.05) in psychiatric patients on oral antipsychotic drugs compared to controls. The mean plasma glucose level of treatment-naïve psychiatric patients was also significantly higher (p<0.05) compared to that of healthy controls. Furthermore, there was a significant increase in plasma glucose levels of patients on second-generation antipsychotic drugs compared to those on first-generation antipsychotic drugs. The lipid profile of patients on antipsychotic drugs showed a similar trend. There were significant increases in the plasma levels of Total Cholesterol (TC), Low-Density Lipoprotein (LDL), Triglycerides (TG) and a significant decrease in the plasma level of High-Density. However, the plasma TG levels were significantly higher in the typical antipsychotic drugs group. Lipoprotein (HDL) levels of individuals that were on antipsychotics were significantly decreased when compared to healthy controls Conclusion: The lipid profile and plasma glucose concentration were altered by oral antipsychotic drugs in Sokoto, Nigeria. Therefore, it may be clinically expedient to vigorously assess the plasma glucose and lipid profile levels of all patients that are on oral antipsychotic drugs and interventions planned as appropriate. Keywords: Antipsychotic drugs, lipid profile, glucose, Cholesterol, Lipoprotein","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127411483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Behavioural Difficulties and Validation of the Hausa Version Strengths and Difficulties Questionnaire (SDQ) among Almajiris: A Comparative Study","authors":"Aishatu Abubakar-Abdullateef, A. Mohammed, Amina S. Kakangi, Hadiza D. Mohammed, M. D. Lasisi, M. Abdullahi","doi":"10.51658/abms.202231.1","DOIUrl":"https://doi.org/10.51658/abms.202231.1","url":null,"abstract":"Background: 'Almajiris' are children who have been sent far away from their homes to study the Quran under the care of a Muslim scholar, also known as 'Mallam'. The Almajiri education system is a common route onto the streets in Northern Nigeria and other parts of West Africa. They face numerous situations which render them vulnerable to developing behavioural difficulties. The aim of this study was to compare behavioural difficulties among Almajiris and pupils of public primary schools in Zaria. The validity of a Hausa version of the self-rated Strengths and Difficulties Questionnaire (SDQ) in screening for psychiatric morbidity was also assessed in the course of the study. Methods: A comparative cross-sectional design was employed. 401 participants were selected for inclusion, comprising 200 Almajiris (49.9%) and 201 (50.1%) public primary school pupils. All participants were administered a socio-demographic questionnaire, the Strengths and Difficulties Questionnaire (SDQ) and the Schedule for Affective Disorders and Schizophrenia for School-aged Children Present and Lifetime Version (K-SADS-PL). Data were analysed using the Statistical Package for Social Sciences Version 21 (SPSS-21). Results: Almajiri participants were noted from other parts of West Africa such as Niger Republic. Parents of Almajiris had less formal education than those of public primary school pupils. About 6 in 10 participants, 64.5% and 63.7% of Almajiris and public primary school pupils respectively screened positive for behavioural difficulties. Almajiris reported problems more often than public primary school pupils on the emotional problem, peer problems, hyperactivity and conduct problem scales of the SDQ. The Hausa-translated version of the self-rated SDQ demonstrated a cut-off point of 13 to best be suited for screening psychiatric morbidity. Conclusion: Emotional, conduct, hyperactivity and peer problems were higher among Almajiris than in a public primary school population. It is recommended that the Almajiri system of education in Nigeria be modified earnestly. Keywords: Almajiris, Public School, Northern Nigeria, Behavioural Difficulties","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123526253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentation of Prostatic Disease Patients in a Hospital Setting","authors":"K. Abdullahi, Mungadi I. Arzika, Agwu N. Peter, Abdulwahab-Ahmed Abdullah, Muhammad A. Sadiq, K. Abdullahi, A. Habibullah","doi":"10.51658/abms.202231.8","DOIUrl":"https://doi.org/10.51658/abms.202231.8","url":null,"abstract":"Background: Prostatic diseases are common urological conditions confronted by the urologist regularly. The clinical presentations may oftentimes be straightforward but at times challenging due to delayed patients' presentation in our setting, occasional overlap of symptoms and signs or when complications associated with the disease supervene. This study determines the difference in clinical presentations of patients histologically diagnosed with prostatic diseases among urology patients in our clinical setting. Materials and Methods: A prospective cross-sectional study conducted among 50 urology patients with indication for Transrectal ultrasound (TRUS) guided prostate biopsy at Usmanu Danfodiyo University Teaching Hospital, Sokoto, North-western, Nigeria. Data collected into a semistructured questionnaire and studied included: sociodemographic parameters, clinical symptoms and signs at presentation, International prostate symptoms score (IPSS), co-morbidities, Digital rectal examination (DRE), and histological findings. Results were analyzed using the computer software, IBM statistical package for the social sciences (SPSS) version 25 (SPSS Inc; Chicago, IL, USA). Relationships between variables were determined using Pearson's chi-square test, and Fisher's exact tests as appropriate. Results: A total of 50 patients were enrolled over the study period with a mean age of 67.32 ± 9.11 years and a range of 50-96 years. Thirty (60.0%) patients had benign prostatic hyperplasia (BPH) while 20 (40.0%) patients had prostatic adenocarcinoma (PCa). One (3.3%) patient with BPH had associated features of chronic prostatitis. The clinical presentations found to be statistically significant in favour of prostatic adenocarcinoma were weight loss, body weakness, cachexia, pallor, and abnormal digital rectal examination. Conclusion: The presence of weight loss, body weakness, cachexia, clinical pallor, and suspicious digital rectal examination at presentation are significant findings to raise a high index of suspicion of the prostate carcinoma. Hence, physicians and urologists coming in contact with prostatic disease patients should be well guided by this in our environment. Keywords: Clinical presentations, prostatic diseases, prostatitis, benign prostatic hyperplasia, prostatic adenocarcinoma","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125779067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Northern Nigerian Hospital: A Case Report and Review of Literature","authors":"G. Waziri, Sani K. Owolabi, Yusuf K. Gazali, Zainab Ali","doi":"10.51658/abms.202231.14","DOIUrl":"https://doi.org/10.51658/abms.202231.14","url":null,"abstract":"Basaloid squamous cell carcinoma occurs very rarely in the uterine cervix. Basaloid squamous cell carcinoma is a form of squamous cell carcinoma with a poor prognosis that primarily affects persons in their late sixties and early seventies. This paper describes a case of Basaloid squamous cell carcinoma in the fifth decade that had spread to the myometrium, ovaries, and fallopian tubes. The macroscopic findings of a total abdominal hysterectomy and bilateral salphingo-oophorectomy revealed an ulcerative fungating tumor distorting the whole cervix and macroscopic invasion of the posterior uterine wall. Histologic features revealed a Basaloid tumour disposed in nest exhibiting peripheral palisading and stromal retraction with most of the nest having comedo pattern of necrosis. The tumour cells are fairly small uniform round cells, with scanty cytoplasm having increased nuclei cytoplasmic ratio with vesicular to open nuclei. Immunohistochemical stains; Cytokeratins, EMA, p63 and Ki-67 showed cytokeratin positivity and EMA strong and diffuse positivity. Keywords: Basaloid Squamous cell Carcinoma, uterine cervix, p63, EMA, Ber-EP4","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127339992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunctival Bacterial Antibiotic Sensitivity Pattern in Patients Undergoing Cataract Surgery at the National Eye Centre, Kaduna, Nigeria","authors":"Zakiyya Mahmoud, M. Umar, Y. Mohammed, M. Alhassan, O. Babalola, Pamela Sarki, S. S. Bulus","doi":"10.51658/abms.202231.3","DOIUrl":"https://doi.org/10.51658/abms.202231.3","url":null,"abstract":"Background: Bacterial contamination from conjunctiva of surgical eye patients may lead to infective endophthalmitis and identification of conjunctival isolates and their antibiotic sensitivity would help in planning appropriate prophylactic interventions. The objective was to determine the predominant conjunctiva bacterial flora in patients scheduled for cataract surgery and their antibiotic sensitivity pattern. Materials and methods: The study comprised of 275 consecutive adult patients who underwent cataract surgery from January to April 2017 and met the inclusion criteria. The participants' socio-demographic characteristics, social, and medical history were obtained through interviewer-administered Questionnaire. Conjunctival swabs were collected from patients prior to cataract surgery and used to inoculate blood agar and chocolate agar plates and then incubated at 37°C for 18-24 hours. Bacterial identification was then carried out using standard. methods. Susceptibility testing was done on Mueller Hinton agar based on modified Kirby Bauer methods using the following drugs; Chloramphenicol, Ciprofloxacin, Ofloxacin, Levofloxacin, Imipenem, Cefuroxime, Ceftriaxone, Ceftazidime, Amikacin, Gentamicin, Tetracycline and Penicillin. Epi Info 7 software was used for univariate and bivariate data analysis as appropriate. Results: Bacterial growth was seen in 118 (42.9%) of the patients. The bacteria identified were: Staphylococcus epidermidis (48.3%); Staphylococcus aureus (44%); Gram positive bacilli (6%) and Streptococcus species (1.7%). The isolates were susceptible to Imipenem, Cefuroxime, Gentamicin, Chloramphenicol, Amikacin and Levofloxacin. Resistance to Tetracycline and Penicillin was also recorded. A statistically significant relationship was found between age and culture status (p = 0.0192). Conclusion: The predominant bacteria on the conjunctival sac were Staphylococcus epidermidis and Staphylococcus aureus, which were sensitive to some commonly perioperative antibiotics like chloramphenicol and gentamicin. Keywords: Cataract surgery; Conjunctival flora; Antibiotic sensitivity","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127629140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Toxicity Studies of Methanol Stem Bark Extract of Lannea acida A. Rich (Anacardiaceae) in Wistar Rats","authors":"J. Ovosi, B. Bello-Ovosi, A. Zezi, I. Abdu-Aguye","doi":"10.51658/abms.202231.16","DOIUrl":"https://doi.org/10.51658/abms.202231.16","url":null,"abstract":"Background: Despite the use of Lannea acida A. Rich for the treatment of many ailments, its safety profile has not been well-elucidated. We aim to determine the acute and subacute oral toxicity of methanol extract of stem bark of L. acida on Wistar rats. Materials and methods: For acute toxicity test, adult female Wistar rats (n = 5) received a single oral dose of 3000 mg/kg of methanol extract of stem back of L. acida by gavage at interval of 48 hours, and were observed for general behavior, adverse effects and mortality for 14 days. For subacute toxicity, 24 adult Wistar rats were divided into four groups (n = 6/group; male = female, 1:1). Group one received distilled water at th 10 ml/kg body weight while groups two, three and four received 250, 500 and 1000 mg/kg body weight of extract orally for 28 days. On the 29 day, rats were euthanized and morphological, biochemical, and hematological parameters determined. Results: Acute oral dose of 3000 mg/kg body weight did not produce any sign of toxicity or mortality in Wistar rats. Subacute treatment showed a decrease in the relative organ weight percent of the kidney at a dose of 1000 mg/kg body weight (P < 0.05); a decrease in the serum potassium across all the doses (P < 0.05), and a rise in serum alanine transaminase at 500 mg/kg (P < 0.05). Histology showed varying degrees of hepatic sinusoidal vascular congestion, peri-portal inflammation; as well as tubulointerstitial inflammation and glomerular necrosis at doses of 250, 500 and 1000 mg/kg. Conclusion: The acute oral median lethal dose (LD ) of methanol extract of the stem bark of L. acida is greater than 3000 mg/kg body weight. 50 Twenty-eight day daily oral doses of more than 250 mg/kg may have nephrotoxic and hepatotoxic effects in Wistar rats. Keywords: Lannea acida, Wistar, toxicity, acute, sub-acute","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122637378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cephalometric Analysis of Sphenoid Sinus Dimensions for Sex Identification: A Radiologic Study","authors":"A. Abdulhameed, A. D. Zagga","doi":"10.51658/abms.202231.10","DOIUrl":"https://doi.org/10.51658/abms.202231.10","url":null,"abstract":"Background: Post-mortem identification of human remains with severe crushing and mutilating skeletal injuries from mass burials and natural disasters, is a challenging forensic procedure. Gender determination from skeletal remains requires a comparison between established ante-mortem data and post-mortem findings from mostly intact, easily recoverable parts of the skeleton, like the skull base sphenoid bone. Computed tomography, being the gold standard for radiological assessment of the paranasal sinuses, offers accurate and precise information about skeletal tissues. The aim of the study was to determine the sex of subjects from measurements of the sphenoid sinus using computerized tomography. Materials and Methods: Computerised tomography images of 323 adult sphenoid sinuses, obtained over a six-year period, from individuals whose ages ranged from 18 to 80 years were recruited, and the study was conducted at the Radiology Department of the Usmanu Danfodiyo University Teaching Hospital, Sokoto, following ethical approval. Images were taken with a GE Brightspeed Multidetector Helical CT Scanner, the anteroposterior, craniocaudal and transverse dimensions were measured on sagittal reformatted, axial and coronal reconstructed CT images respectively, and the volumes were determined. Measurements were taken in millimetres, between the widest points at the middle of the sinus walls from three-dimensional reconstructed images using the RadiAnt Version 4.2 (Medixant, 2017), powered by the Digital Imaging and Communication in Medicine (DICOM) viewer software. These images were viewed on bone windows. Results: Sinus volume and the transverse diameter, each correctly classified the sexes of subjects, in 60.4% of cases. However, when all the measured parameters of the sinus were analysed together as a single factor for sex determination, an overall value of 57.6% was obtained. Conclusion: Computerized Tomography measurements of sphenoid sinus dimensions could be useful in support of gender identification in unknown severely damaged human remains with speared sphenoid bone. Keywords: Sex, Sphenoid, CT, Forensic Anthropology","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122988371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Herpes Simplex Virus Type Two in Patients Attending General Outpatient Clinic in Sokoto","authors":"S. Hudu, N. Hamal","doi":"10.51658/abms.202231.6","DOIUrl":"https://doi.org/10.51658/abms.202231.6","url":null,"abstract":"Introduction: The herpes simplex virus type 2 (HSV-2) infection is a common sexually transmitted illness with a large disease burden, with the largest disease burden in Sub-Saharan Africa. Researchers and policymakers can benefit from a source of detailed data on the prevalence of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Objective: This study determined the seroprevalence of HSV-2 infection among patients presenting with fever at the specialist hospital Sokoto. Methodology: Commercial HSV type-1&-2 specific IgG Enzyme-Linked Immunosorbent Assay (ELISA) kits were used to analyse serum samples from 92 randomly selected patients. The association between infection and socio-demographic characteristics was determined using the Chi-square test using SPSS version 22 (IBM, Inc., Chicago, IL, USA). Results: The seroprevalence of HSV-2 was found to be 54.3% (n=50); antibodies to the virus were found in all of the patients. Male patients 21(67.7%) and single patients 23(63.9%) had a higher HSV-2 prevalence than married individuals who constituted 48% of the patients having seropositive HSV (P= 0.141). Those who did not practice protective sex had a higher seroprevalence of HSV-2 (52.8 %: 28/53). Conclusion: HSV-2 infection was found in more than half of the patients. It is therefore recommended that comprehensive, large nationally surveys should be carried out to guide policy and planning. Keywords: Sero-prevalence, HSV-2, Sokoto","PeriodicalId":330738,"journal":{"name":"Annals of Basic and Medical Sciences","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125769957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}