Journal of Immunology and Infectious Diseases最新文献

Incidence of Secondary Microorganism Infections Following Utilization of Tocilizumab for the Treatment of COVID‑19 - A Matched Retrospective Cohort Study 托珠单抗治疗COVID - 19后继发微生物感染的发生率——一项匹配的回顾性队列研究

Journal of Immunology and Infectious Diseases Pub Date : 2021-08-16 DOI: 10.54137/ijiid1782

Joanna L. Moore, S. Stroever, Patricia E. Rondain, R. Scatena

{"title":"Incidence of Secondary Microorganism Infections Following Utilization of Tocilizumab for the Treatment of COVID‑19 - A Matched Retrospective Cohort Study","authors":"Joanna L. Moore, S. Stroever, Patricia E. Rondain, R. Scatena","doi":"10.54137/ijiid1782","DOIUrl":"https://doi.org/10.54137/ijiid1782","url":null,"abstract":"Introduction: immunological disorder agent’s area unit theorized to focus on the protein storm syndrome in COVID‑19. However, the downstream effects concerning susceptibilities to secondary infection risk stay unknown. This study seeks to work out risk variations for secondary infections among COVID‑19 patients World Health Organization did and failed to receive tocilizumab. Methods: we have a tendency to conducted a matched retrospective cohort study from 2 giants, acute care hospitals in Western Connecticut from March 1 to May 31, 2020. we have a tendency to collected variables exploitation manual case history abstraction. the first exposure variable was any dose of tocilizumab. the first outcome was any healthcare‑associated microorganism or mycosis as outlined by the National Care Safety Network. we have a tendency to performed a Kaplan–Meier analysis to assess the crude distinction within the additive likelihood of healthcare‑associated infection (HAI) across exposure teams. we have a tendency to conjointly performed a multivariable Cox multivariate analysis to work out the hazard quantitative relation for HAI by exposure group whereas dominant for potential confounders. Results: The Kaplan–Meier analysis incontestable no distinction within the additive likelihood of HAI across teams. The adjusted hazard of HAI for patients given tocilizumab was zero.85 times that of patients not given tocilizumab (95% confidence interval = zero.29, 2.52, P = 0.780) once dominant for relevant confounders. Conclusions: Tocilizumab failed to increase the incidence of secondary infection among COVID‑19 patients. Larger, irregular trials ought to valuate infection as a secondary outcome to validate this finding.","PeriodicalId":329598,"journal":{"name":"Journal of Immunology and Infectious Diseases","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134020109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auto inflammatory Diseases: The Repercussion of unconstrained Inflammasome activation 自身炎性疾病:炎性小体无约束激活的影响

Journal of Immunology and Infectious Diseases Pub Date : 2021-08-16 DOI: 10.54137/ijiid1739

Emma M. Creagh, S. Kenealy

{"title":"Auto inflammatory Diseases: The Repercussion of unconstrained Inflammasome activation","authors":"Emma M. Creagh, S. Kenealy","doi":"10.54137/ijiid1739","DOIUrl":"https://doi.org/10.54137/ijiid1739","url":null,"abstract":"Inflammasome area unit sensors at intervals the innate system that area unit chargeable for the regulation of caspase-1 activation and also the initiation of inflammatory responses following cellular infection or harm. a big variety of chronic inflammatory and metabolic diseases have recently been known to own inflammasome-mediated inflammation as a key driver of their pathogenesis; this space of analysis is beneath intense investigation at the moment. This review focusses on auto inflammatory diseases (AD), a apace increasing cluster of debilitating diseases that area unit related to severe general inflammation. AD ordinarily arise as a results of mutations to genes that code inflammasome elements. inheritable AD area unit comparatively rare as a result of they need totally penetrating mutations; but, they usually gift at birth and last a life. Clinical awareness of AD is lacking and it’s believed that, at present, several cases go unknown. This review specifically discusses variety of inflammasome-associated AD and metabolic disorders that give vital insight into our understanding of inflammasome signal pathways. These AD highlight the efficiency of inflammasomes in their ability to initiate and sustain general inflammation. The debilitating symptoms of AD additionally reveal the intensive consequences of uncontrolled inflammasome activity. Clinical therapies that concentrate on the inflammasome and interleukin-1β, a product of its activation, within the winning management of AD and bound metabolic diseases will be mentioned.","PeriodicalId":329598,"journal":{"name":"Journal of Immunology and Infectious Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130261673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from History: Association of Porphyromonas Gingivalis (a Major Periodontopathic Bacteria) in Alzheimer’s Disease Patients 历史教训:阿尔茨海默病患者与牙龈卟啉单胞菌(一种主要牙周病细菌)的关系

Journal of Immunology and Infectious Diseases Pub Date : 2021-08-16 DOI: 10.54137/ijiid1738

Joao Carnio DDS, Anna Tereza Carnio

{"title":"Lessons from History: Association of Porphyromonas Gingivalis (a Major Periodontopathic Bacteria) in Alzheimer’s Disease Patients","authors":"Joao Carnio DDS, Anna Tereza Carnio","doi":"10.54137/ijiid1738","DOIUrl":"https://doi.org/10.54137/ijiid1738","url":null,"abstract":"Alzheimer’s disease (AD), a fatal neurodegenerative condition that affects the elderly, is a serious health problem for geriatric subjects worldwide. AD incidence increases significantly with age. It is almost 50% common in 85 -yearolds. [1] AD prevalence will rise as the population grows older and lives spans increase. It is estimated that around 14 million people will be affected by AD in the next 50 years. Switching to newer treatments can help reduce the incidence of AD. These treatment options can be effective against potential risk factors and delay the onset. What is the role of periodontitis in Alzheimer’s disease? This work aims to do a systematic, integrative review on published literature to evaluate if there is a link between Porphyromonas gumivalis (P. gingivalis), and Alzheimer’s. Part of (?) Part of (?) P. gingivalis could serve as a therapeutic target for patients suffering from Alzheimer’s disease. It also help s to reduce the severity and incidence of the condition. Patients with Alzheimer’s disease could benefit from preventive dental care and the inhibition of neurotoxicity by P. gingivalis.","PeriodicalId":329598,"journal":{"name":"Journal of Immunology and Infectious Diseases","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133979987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Main Bacterial Peritonitis Infection Caused by Streptococcus pneumoniae 主要由肺炎链球菌引起的细菌性腹膜炎感染

Journal of Immunology and Infectious Diseases Pub Date : 2021-08-13 DOI: 10.54137/ijiid1781

S. Maraki, P. Moraitis, Sophia Barbagadakis, I. Vlachakis

引用次数: 0

Lessons from History: Methodological Problems arising from Comparing the Influenza A (H1N1) Pandemic 2009-10 to Seasonal Influenza 2010-2019 at the United States 历史教训:比较2009- 2010年美国甲型H1N1流感大流行与2010-2019年美国季节性流感所产生的方法问题

Journal of Immunology and Infectious Diseases Pub Date : 2021-08-13 DOI: 10.54137/ijiid1181

J. Koziol, J. Schnitzer

引用次数: 0