历史教训:阿尔茨海默病患者与牙龈卟啉单胞菌(一种主要牙周病细菌)的关系

Joao Carnio DDS, Anna Tereza Carnio
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摘要

阿尔茨海默病(AD)是一种影响老年人的致命神经退行性疾病,是全世界老年人的严重健康问题。AD的发病率随着年龄的增长而显著增加。在85岁的人群中几乎有50%的人患此病。[1]随着人口老龄化和寿命延长,AD患病率将上升。据估计,在未来50年内,约有1400万人将受到阿尔茨海默病的影响。改用更新的治疗方法有助于降低阿尔茨海默病的发病率。这些治疗方案可以有效地对抗潜在的危险因素并延缓发病。牙周炎在阿尔茨海默病中的作用是什么?本工作旨在对已发表的文献进行系统、综合的综述,以评估牙龈卟啉单胞菌(P. gingivalis)与阿尔茨海默病之间是否存在联系。部分(?)部分(?)牙龈卟啉卟啉可以作为阿尔茨海默病患者的治疗靶点。它还有助于降低病情的严重程度和发病率。阿尔茨海默病患者可能受益于预防性牙科保健和牙龈卟啉卟啉抑制神经毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lessons from History: Association of Porphyromonas Gingivalis (a Major Periodontopathic Bacteria) in Alzheimer’s Disease Patients
Alzheimer’s disease (AD), a fatal neurodegenerative condition that affects the elderly, is a serious health problem for geriatric subjects worldwide. AD incidence increases significantly with age. It is almost 50% common in 85 -yearolds. [1] AD prevalence will rise as the population grows older and lives spans increase. It is estimated that around 14 million people will be affected by AD in the next 50 years. Switching to newer treatments can help reduce the incidence of AD. These treatment options can be effective against potential risk factors and delay the onset. What is the role of periodontitis in Alzheimer’s disease? This work aims to do a systematic, integrative review on published literature to evaluate if there is a link between Porphyromonas gumivalis (P. gingivalis), and Alzheimer’s. Part of (?) Part of (?) P. gingivalis could serve as a therapeutic target for patients suffering from Alzheimer’s disease. It also help s to reduce the severity and incidence of the condition. Patients with Alzheimer’s disease could benefit from preventive dental care and the inhibition of neurotoxicity by P. gingivalis.
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