Pharmacology and Clinical Pharmacy Research最新文献

Lacked of Breast Cancer Awareness of Indonesian Rural Women: A Descriptive Study to Adult Women in District Pangandaran, Indonesia 印度尼西亚农村妇女缺乏乳腺癌意识：对印度尼西亚邦甘达兰地区成年妇女的描述性研究

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-03-04 DOI: 10.15416/pcpr.v8i3.53586

N. M. Alfarafisa, M. Bashari, H. Usman, Arima Ksd Nurcahyani, Defi A. Pramesti, Dika WN. Azizah, Lala Yuliani, Putri HA. Rakhman, Fathul Huda

{"title":"Lacked of Breast Cancer Awareness of Indonesian Rural Women: A Descriptive Study to Adult Women in District Pangandaran, Indonesia","authors":"N. M. Alfarafisa, M. Bashari, H. Usman, Arima Ksd Nurcahyani, Defi A. Pramesti, Dika WN. Azizah, Lala Yuliani, Putri HA. Rakhman, Fathul Huda","doi":"10.15416/pcpr.v8i3.53586","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.53586","url":null,"abstract":"Breast cancer remains a significant global health challenge, particularly in low and middle-income countries like Indonesia. Patients with advanced metastatic breast cancer have a dismal prognosis. A cancer promotion program’s failure can be attributed to low awareness of breast cancer. This descriptive study aimed to evaluate breast cancer awareness among adult women in District Pangandaran, Indonesia. Data was gathered in July 2018 from 189 individuals using a verified Breast Cancer Awareness Measure instrument developed by Cancer Research UK. Results revealed a concerning lack of awareness among participants regarding various breast cancer risk factors, symptoms, and screening practices. Additionally, reluctance to seek medical help due to fear of diagnosis was observed, particularly among housewives without health insurance. These findings highlight the urgent need for comprehensive health programs to enhance breast cancer awareness and promote early detection strategies tailored to the Indonesian population, especially in rural areas. Healthcare providers and public health workers play a vital role in this effort, along with implementing innovative health promotion policies by the government to improve cancer prevention programs.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Off-Label Drug Use in Acute Respiration Infection Patient at Pangandaran Hospital, Pangandaran District, West Java - Indonesia 印度尼西亚西爪哇邦甘达兰县邦甘达兰医院急性呼吸道感染患者的标示外用药

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-02-06 DOI: 10.15416/pcpr.v8i3.48103

Nur Rahayuningsih, M. Priatna, Dewi A. Sulistiani

{"title":"Off-Label Drug Use in Acute Respiration Infection Patient at Pangandaran Hospital, Pangandaran District, West Java - Indonesia","authors":"Nur Rahayuningsih, M. Priatna, Dewi A. Sulistiani","doi":"10.15416/pcpr.v8i3.48103","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.48103","url":null,"abstract":"Acute respiratory infections (ARIs) are infectious diseases of the upper or lower respiratory tract that cause a spectrum of illnesses from mild to severe infections. ARI is one of the leading causes of death in children in developing countries. The high incidence of ARI in children results in the use of off-label drugs. Off-label medicine is the use of drugs outside the provisions of the license relating to dose, age, route of administration, contraindications. This study aims to determine the use of off-label drugs in children with a diagnosis of ARI at Pandega Pangandaran Hospital, Pangandaran District, West Java - Indonesia. This study was an observational study with a cross sectional design and data collection was done retrospectively using Chi-square data analysis with a significance level of 0.05. Of the 84 patients who fit the inclusion criteria, there was an off-label drug use of 16.01% with the categories of off-label age (11.16%), off-label dose (4.37%), and off-label indication (0.48%) while in the category of route of administration and contraindications no off-label drug use was found. The most common type of off-label drug used was cetirizine antihistamine. Based on the results, pharmacist’s supervision related to the risk of drug use is strongly recommended.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"41 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats Ashitaba (Angelica keiskei (Miq.) Koidz.)汁液对顺铂诱导的 Wistar 大鼠总胆固醇水平的影响

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-02-06 DOI: 10.15416/pcpr.v8i3.51827

Ika Wahyuni, D. Aulifa, A. M. Rosdianto, J. Levita

{"title":"The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats","authors":"Ika Wahyuni, D. Aulifa, A. M. Rosdianto, J. Levita","doi":"10.15416/pcpr.v8i3.51827","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.51827","url":null,"abstract":"Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol and triglycerides in animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant and nephroprotective activity. This study aims to determine the activity of A. keiskei sap on total cholesterol levels of cisplatin-induced Wistar rats. The sap of A. keiskeiwas freeze-dried until a yield of 3.62% w/v was obtained. The fat content in A. keiskei sap powder was obtained at 7.36%. A total of 60 g of A. keiskei sap powder was macerated with 96% ethanol solvent (1:10) for 5 x 24 h until the ethanol extract of A. keiskei sap (ASEE) of 82.08% w/w was obtained. The pharmacology activity was conducted on male Wistar rats, which were divided into 5 groups, namely normal (treated with CMC Na 0.3%), negative (nephrotoxicity induced with cisplatin 5 mg/kg BW), positive (nephrotoxicity induced with cisplatin 5 mg/kg BW and treated with quercetin 20 mg/kg BW), and two test groups which were nephrotoxicity induced with cisplatin 5 mg/kg body weight and treated with ASEE 1000 mg/kg BW, and ASEE 1500 mg/ kg BW. It was found that neither dose of ASEE altered the total cholesterol levels in cisplatin-induced male Wistar rats and could maintain the cholesterol levels in the normal range.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"44 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FABP4 and Metabolite Profile in Lipopolysaccharide-Induced Mice Model Treated with Moringa oleifera Ethanol Leaf Extract 用油辣木乙醇叶提取物治疗脂多糖诱导的小鼠模型的 FABP4 和代谢物概况

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-01-31 DOI: 10.15416/pcpr.v8i3.50860

Cenia P. Hanifah, Ifa Sulistiyorini, V. A. Sumirat, N. Anggraeni, M. Putri, Mohammad Ghozali, M. Syamsunarno

{"title":"FABP4 and Metabolite Profile in Lipopolysaccharide-Induced Mice Model Treated with Moringa oleifera Ethanol Leaf Extract","authors":"Cenia P. Hanifah, Ifa Sulistiyorini, V. A. Sumirat, N. Anggraeni, M. Putri, Mohammad Ghozali, M. Syamsunarno","doi":"10.15416/pcpr.v8i3.50860","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.50860","url":null,"abstract":"Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, induces changes in blood cells and metabolic alterations. Fatty acid binding protein 4 (FABP4), a lipid chaperone predominantly expressed in adipose tissue, is modulated in sepsis and may contribute to metabolic and immunologic changes. Moringa oleifera (M. oleifera) leaf extract (MOLE) is known to modulate immune system activity, but its potential for treating acute inflammatory conditions like sepsis remains unclear. This study investigates the ability of MOLE to modulate metabolite and hematological profiles in lipopolysaccharide (LPS)-induced sepsis in mice. Thirty-five male Swiss Webster mice (Mus musculus) were divided into five groups, including healthy control pre-treated with 0.5% carboxymethyl cellulose (CMC), an LPS-induced negative control, an LPS-induced positive control treated with dexamethasone (DMX) 7mg/KgBW/day and two MOLE treatment groups with doses of 5.6 and 11.2 mg/20 gBW. Mice received MOLE pre-treatment for three days before LPS induction. Three hours post-LPS injection, the LPS-induced group exhibited leukopenia (1.4 [0.9-2.5] x109 cells/L) and a 68.3% increase in triglyceride levels. However, the MOLE-treated group showed improved erythrocyte levels compared to the positive control group; [(9.9(9.3-10.0) x1012 cell/L) vs (7.7(7.0-9.0) x1012 cells/L), p<0.05]. The study suggests that MOLE administration may positively impact sepsis conditions, particularly by enhancing RBC levels. Further research with an extended observation period is recommended to address limitations in metabolite level assessment. ","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Drug Adherence and Adverse Effects of Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients of Rheumatoid Arthritis Attending a Tertiary Care Hospital in India 对印度一家三级医院类风湿关节炎患者的服药依从性和改良性抗风湿药物（DMARDs）不良反应的评估

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-01-20 DOI: 10.15416/pcpr.v8i3.39664

Tejal C. Patel, Prasad R. Pandit, Zankrut R. Doshi, Vikram A. Londhe

{"title":"Assessment of Drug Adherence and Adverse Effects of Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients of Rheumatoid Arthritis Attending a Tertiary Care Hospital in India","authors":"Tejal C. Patel, Prasad R. Pandit, Zankrut R. Doshi, Vikram A. Londhe","doi":"10.15416/pcpr.v8i3.39664","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.39664","url":null,"abstract":"Adherence to drug treatment is one of the key factors in treating chronic diseases like rheumatoid arthritis (RA) to maintain remission and prevent functional disability. Poor medication adherence is directly associated with a worse prognosis and an increase in healthcare utilization, adding to a financial burden. Hence, the present study was proposed to assess drug adherence in diagnosed patients of RA attending a tertiary care hospital. The study was initiated after obtaining institutional ethics committee permission, and written informed consent was requested from all the eligible patients before their enrolment. This cross-sectional questionnaire based study was conducted on RA patients attending the rheumatology outpatient department. The patient’s adherence to the drugs prescribed was assessed using the 19-item Compliance Questionnaire Rheumatology (CQR), and the correlation betweendrug adherencewithvariousdemographic,disease,andmedication-relatedvariableswasstudied. After screening 103 patients, 75 patients fulfilling the selection criteria were enrolled, and theirdatawasanalyzed. The adherence measured using the CQR score was in therange of 54.39% to 68.42%, with a mean CQR score of 62.27 ± 2.76.Anegative correlation was found between the CQR score and the number of ADRs (r=-0.12,p>0.05) and age (r=-0.06, p>0.05). A positive correlation was found between the CQR score and variables like sex, education, and number of medications, but none were statistically significant. Unsatisfactory compliance was evident in the present study. Therefore, integrating drug treatment with strategies to improve patient adherence may improve clinical outcomes and quality of life, reducing healthcare costs.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"154 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-Effectiveness Analysis of Favipiravir and Remdesivir as COVID-19 Treatment in South Tangerang, Banten Province - Indonesia 印度尼西亚万丹省南坦格朗地区将法韦拉韦和雷米地韦作为 COVID-19 治疗药物的成本效益分析

Pharmacology and Clinical Pharmacy Research Pub Date : 2024-01-10 DOI: 10.15416/pcpr.v8i3.50046

W. G. Putro, Andriani R. Fahriyati, Gilberto A. Julian, T. R. Amalia, Z. M. Riski

{"title":"Cost-Effectiveness Analysis of Favipiravir and Remdesivir as COVID-19 Treatment in South Tangerang, Banten Province - Indonesia","authors":"W. G. Putro, Andriani R. Fahriyati, Gilberto A. Julian, T. R. Amalia, Z. M. Riski","doi":"10.15416/pcpr.v8i3.50046","DOIUrl":"https://doi.org/10.15416/pcpr.v8i3.50046","url":null,"abstract":"COVID-19 is a contagious ailment primarily attributed to the severe acute respiratory syndrome coronavirus. Indonesia persists in confronting the COVID-19 pandemic, and South Tangerang City has emerged as one of the municipalities in Indonesia that has been significantly affected. There are two categories of medications employed for COVID-19 treatment according to government policies, namely favipiravir and remdesivir. This study aims to as- sess the cost-effectiveness of favipiravir and remdesivir medications at the South Tangerang General Hospital, Indonesia. The present study employs a retrospective research design characterized by a quantitative approach, utilizing cross-sectional methodologies. The analy- sis mostly consists of descriptive techniques. The sample consisted of 479 individuals, with 246 individuals receiving outpatient treatment and 233 undergoing inpatient treatment. The inclusion criteria for this study consisted of individuals diagnosed with COVID-19 who had tested positive for the antiviral medications favipiravir and remdesivir. The findings indicated that the Average Cost-Effectivenss Ratio (ACER) for inpatients treated with fa- vipiravir was IDR 2,354,319,859, but for those treated with remdesivir, it amounted to IDR 3,501,513,488. Regarding the outpatient population utilizing favipiravir, the total expendi- ture amounts to IDR 420,083,118. Similarly, patients utilizing remdesivir incur a total ex- penditure of IDR 797,282,432. It is worth noting that the Cost-Effectivenss Ratio (CER) for patients using favipiravir is IDR 1,545,621, whereas patients using remdesivir have a CER of IDR 2,309,705. This study makes a valuable contribution to the existing body of research by demonstrating the cost-effectiveness of favipiravir. Consequently, future studies inves- tigating the overall effectiveness of favipiravir in COVID-19 patients must employ more comprehensive criteria.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"31 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140510695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of probiotics in Autism Spectrum Disorders : A meta-analysis of RCTs 益生菌对自闭症谱系障碍的益处:一项随机对照试验的荟萃分析

Pharmacology and Clinical Pharmacy Research Pub Date : 2023-04-13 DOI: 10.15416/pcpr.v8i1.40063

Sharanabasayyaswamy B. Hiremath, Srinivas L. Devendrappa

{"title":"Benefits of probiotics in Autism Spectrum Disorders : A meta-analysis of RCTs","authors":"Sharanabasayyaswamy B. Hiremath, Srinivas L. Devendrappa","doi":"10.15416/pcpr.v8i1.40063","DOIUrl":"https://doi.org/10.15416/pcpr.v8i1.40063","url":null,"abstract":"Using probiotics as a pharmaceutical intervention is based on the fact that dysbiosis affects many people with autism spectrum disorders (ASD). This study aimed to quantify various probiotics’ overall and individualized benefits in treating ASD. Randomized or cross-over trials comparing the efficacy of placebo or active control vs. probiotics in patients of any age diagnosed with ASD based on DSM IV/V criteria were considered under inclusion criteria. An electronic database search in PUBMED and Cochrane Library was conducted using MeSH search terms “probiotics” AND “Autism.” Mean change in the total score of clinical parameters used to assess ASD symptom severity was the primary outcome measure analyzed. All the outcome measures were estimated by calculating the Standardized Mean Difference (SMD) values and their 95% Confidence Intervals (CI), considering the different clinical parameters used to assess the change in ASD symptoms in identified clinical trials. An insignificant decrease in the total score value of primary outcome measure by -0.14 (SMD: 0.14, 95% CI:-0.45 to 0.17) in patients treated with probiotics was observed. The quantity of decrease remained insignificant in subgroup analyses also. Observed insignificant clinical benefits of probiotics in ASD patients could be due to the presence of gastrointestinal symptoms as co-morbidity. We hypothesize that intolerance to dietary components is responsible for gastrointestinal symptoms and inflammation. Perhaps probiotics are still beneficial in ASD patients without gastrointestinal symptoms, while their combination with prebiotics is effective in patients with gastrointestinal symptoms.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135240010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenomic Considerations In Propofol: A Review 异丙酚的药物基因组学研究综述

Pharmacology and Clinical Pharmacy Research Pub Date : 2023-04-11 DOI: 10.15416/pcpr.v8i1.38749

Ziske Maritska, Tri U. Pratiwi, Muhammad J. Aldwin, Clinton F.M Sitanggang, Ferdy Rahadiyan

引用次数: 0

Impact of Antidepressant Treatment on Heart Rate Variability in Patients with Depression - A Cross Sectional Study 抗抑郁药物治疗对抑郁症患者心率变异性的影响-一项横断面研究

Pharmacology and Clinical Pharmacy Research Pub Date : 2023-04-10 DOI: 10.15416/pcpr.v8i1.39623

Raghav M V, Geetha A, Praveen Panchaksharimath, Nivetha Raj

{"title":"Impact of Antidepressant Treatment on Heart Rate Variability in Patients with Depression - A Cross Sectional Study","authors":"Raghav M V, Geetha A, Praveen Panchaksharimath, Nivetha Raj","doi":"10.15416/pcpr.v8i1.39623","DOIUrl":"https://doi.org/10.15416/pcpr.v8i1.39623","url":null,"abstract":"Heart rate variability (HRV) is a non-invasive index of cardiac autonomic regulation. HRV is reduced in depression, which indicates decreased Autonomic Nervous System flexibility. It is associated with an increase in the frequency of cardiac co-morbidities. Depression medications usually take six months for complete remission, but no data on patients on antidepressants for more than six months. Therefore, it becomes necessary to determine if anti-depressants have a better impact on HRV. The current study focused on analyzing the correction of HRV parameters after six months of antidepressant therapy. A cross-sectional study was conducted from February to September 2021 at the AFT lab inpatients. They were recruited from the Psychiatry department, Victoria Hospital, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India. The sample size was calculated to be 40 (20 Patients and 20 Healthy controls). AFT was done on all participants using Power Lab equipment and analyzed using Lab Chart 8 software. Heart rate variability parameters (AFT results) were analyzed using statistical software. The results with a p-value of >0.05% were considered statistically significant and taken up for the study. 55% of the patients with depression in our study were in the age group of 18-25 years, and the mean Ham-D (Hamilton Depression Rating Scale) score was found to be 9.8. There is a reduction in autonomic function flexibility among patients who are on antidepressants when compared to healthy controls, even after six months of treatment. No conclusion could arrive on the class of antidepressant which was more beneficial owing to its effect on autonomic functions. Hence, randomized controlled studies comparing various classes of antidepressants to assess efficacy in reducing autonomic complications of depression should be taken up","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"323 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135593538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing Pattern of Antifungal Drugs in a Tertiary Care Teaching Hospital in Western India 西印度某三级教学医院抗真菌药物的处方模式

Pharmacology and Clinical Pharmacy Research Pub Date : 2023-04-09 DOI: 10.15416/pcpr.v8i1.39238

Parth B. Patel, Akanksha Prajapati, Sumit Patel, Vipul Chaudhary, Vasu Rathod

{"title":"Prescribing Pattern of Antifungal Drugs in a Tertiary Care Teaching Hospital in Western India","authors":"Parth B. Patel, Akanksha Prajapati, Sumit Patel, Vipul Chaudhary, Vasu Rathod","doi":"10.15416/pcpr.v8i1.39238","DOIUrl":"https://doi.org/10.15416/pcpr.v8i1.39238","url":null,"abstract":"Fungal infections are prevalent in a tropical country like India. Pharmacotherapy of fungal disease has been revolutionized by the introduction of relatively less toxic oral drugs, com- bination therapy, and new formulations of older agents. However, data regarding antifungal drug usage patterns in India must be more present. Hence, this study was planned to study the prescribing pattern and to compare the cost of antifungal drugs in patients attending a tertiary care teaching hospital. It was a cross-sectional, observational study carried out at GCS Hospital, Ahmedabad, from April 2021 to Sept 2021. Prescriptions of 130 patients were collected and analyzed using Microsoft Excel version 2013. A total of 213 antifungal drugs were prescribed to 130 patients. Most patients, 81 (62.3%) were from the 18-40 age group. Combined antifungal treatment (Oral + Topical) was prescribed in 77(59.2%). The most common class of antifungal drugs was imidazole 107 (50.23%), and clotrimazole was the most familiar drug. The most common indication for antifungal therapy was tinea cruris (45.38%). An average of 3.75 drugs were prescribed per prescription, of which 1.63 were antifungal drugs. Combined treatment of oral and topical antifungal drugs was common in dermatological practice. However, the cost of the treatment can be reduced by prescribing generic drugs.","PeriodicalId":32814,"journal":{"name":"Pharmacology and Clinical Pharmacy Research","volume":"95 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135648402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0