International Conferences on Biomedical and Bioinformatics Engineering最新文献_第2页

Pharmacokinetics Analysis of Controlled Insulin Delivery from Biodegradable Polymer Matrix 可生物降解聚合物基质控制胰岛素递送的药代动力学分析

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301902

Ruojia Li

{"title":"Pharmacokinetics Analysis of Controlled Insulin Delivery from Biodegradable Polymer Matrix","authors":"Ruojia Li","doi":"10.1145/3301879.3301902","DOIUrl":"https://doi.org/10.1145/3301879.3301902","url":null,"abstract":"Diabetes is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period. As of 2015, an estimated 415 million people had diabetes worldwide. Insulin is the most effective and safe medicines needed to stable the blood sugar level and so treat diabetes. Current insulin administration requires daily subcutaneous injection, which is not a favorable choice of patients and physicians. Biodegradable polymer delivery systems have been developed and demonstrate enormous potentials for therapeutics, including those within insulin. However, there is no well-developed pharmacokinetic model to analyze and predict the insulin release from polymer delivery system. In this presented work, we have developed a pharmacokinetic compartment model to describe insulin delivery from polymer matrix. PLGA degradation model was incorporated into the compartment model, which enables quantitative comparison between PLGA insulin controlled release and conventional insulin injection. Further, this model revealed that PLGA chemical properties significantly influence the insulin controlled release in pharmacokinetics. This novel model overcomes drawbacks of the conventional compartment models developed so far and provides insight into insulin controlled drug delivery system designing for more patient-friendly and personal diabetic treatment.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125442802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Matching Pursuit for Inter-Scatterer Spacing Estimation from Ultrasound RF Echo Signals 超声射频回波信号间散射体间距估计的匹配追踪

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301895

Xiuhua Zeng, Yufeng Zhang

{"title":"Matching Pursuit for Inter-Scatterer Spacing Estimation from Ultrasound RF Echo Signals","authors":"Xiuhua Zeng, Yufeng Zhang","doi":"10.1145/3301879.3301895","DOIUrl":"https://doi.org/10.1145/3301879.3301895","url":null,"abstract":"The pathological changes in the diseased tissues could alter the spatial organization of the microstructures of their normal tissues. Ultrasound RF echo signals carry the microstructure information of the tissues whose regular scatterer spacing (SS) can be analyzed and applied as a signature for the quantitative diagnosis of diseases. In this paper, we propose a novel approach based on the matching pursuit (MP) algorithm to improve the ISS estimation from the ultrasound RF echo signals. The signals are decomposed into a linear combination of the Gabor atoms, and then the atoms highly matched the regular component are selected based on the critical point in the curve of the first order difference (FOD) of the reconstructed signal to residue ratio (RSRR). Accordingly, the ISSs can be estimated with the adjacent location indexes of the selected Gabor atoms. Results of simulation experiments with the MP-based and WT-based methods are presented. The results demonstrate that the MP-based method can improve the ISS estimation, especially for those simulated signals with low regular components, and potentially provide more accurate information for the disease diagnosis.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122044858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Accelerated Myocardial Viability Imaging Using Both Simultaneous Multi-Slice and Partially Parallel Acquisition 同时多层和部分平行采集加速心肌活力成像

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301885

Zhehao Zhang, Wenbo Sun, Yuan Zheng, Jian Xu, Yiping P. Du, Qun Chen

{"title":"Accelerated Myocardial Viability Imaging Using Both Simultaneous Multi-Slice and Partially Parallel Acquisition","authors":"Zhehao Zhang, Wenbo Sun, Yuan Zheng, Jian Xu, Yiping P. Du, Qun Chen","doi":"10.1145/3301879.3301885","DOIUrl":"https://doi.org/10.1145/3301879.3301885","url":null,"abstract":"Phase-sensitive inversion recovery (PSIR) has been a powerful cardiac magnetic resonance imaging (CMRI) method to assess myocardial viability, which can eliminate the background phase and preserve the sign of the desired magnetization during inversion recovery (IR). However, the conventional PSIR may bring heavy burdens to patients due to the long acquisition time and required breath-holds (BHs). In this study, we proposed a method to integrate simultaneous multi-slice (SMS) into PSIR without performing separate calibration scan to reduce the acquisition time and number of BHs. The acquired reference data in PSIR was also utilized to evaluate spatial coil sensitivity so that slice separation can be completed. Additionally, we also implemented this method with partially parallel acquisition (PPA) to further improve the acquisition efficiency, where the same reference data can be utilized for PPA, SMS and PSIR. Phantom and in-vivo experiments were performed to confirm that applying SMS without separate calibration scan is able to significantly reduce acquisition time without compromising image quality or limiting diagnosis. The proposed method can be a practical and efficient method for the assessment of myocardial viability.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"392 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131818279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saccular Brain Aneurysm Detection and Multiclassifier Rupture Prediction using Digital Subtraction and Magnetic Resonance Angiograms 用数字减影和磁共振血管成像检测脑囊性动脉瘤及多分类器破裂预测

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301899

S. Anjum, K. Malik, H. Soltanian-Zadeh, Hafiz Malik, G. Malik

{"title":"Saccular Brain Aneurysm Detection and Multiclassifier Rupture Prediction using Digital Subtraction and Magnetic Resonance Angiograms","authors":"S. Anjum, K. Malik, H. Soltanian-Zadeh, Hafiz Malik, G. Malik","doi":"10.1145/3301879.3301899","DOIUrl":"https://doi.org/10.1145/3301879.3301899","url":null,"abstract":"Saccular intracranial aneurysms corresponding to their berry or sac-like shape are characterized as most vulnerable to grow and rupture relatively quicker than other known types, such as, fusiform, distal and dissection. Approximately 80% of aneurysmal Subarachnoid Hemorrhage (aSAH) are reckoned due to burst of saccular aneurysms only. Therefore, timely detection of unruptured saccular brain aneurysms can greatly help neurosurgeons to treat them well before an aSAH occurs, and thus saves precious lives. Most of the research efforts in this respect involve statistical analysis of manually collected retrospective data to predict the risk of aneurysmal rupture. Whereas, geometrical, anatomical and textural characteristics of medical imaging, such as digital subtraction angiography (DSA) and magnetic resonance angiography (MRA), is not investigated for accurate detection of unruptured saccular aneurysms and their individualized prediction of rupture likelihood. The main contribution of this work is a) 98% accurate identification of aneurysms from both DSA and MRA using Multilayer Perceptron Neural Network trained upon robust Haralick textural features of individual regions of interest (ROIs) segmented through Watershed Segmentation and Distance Transformation; b) prediction of aneurysms rupture probability, by categorizing aneurysmal ROIs into 5 classes, using geometrical, anatomical and textural features, with 76.67% accuracy using Decision Support Trees, ensembled with Bagging classifier. Our evaluation is based upon de-identified dataset of 180 images (54 MRA, and 126 DSA), obtained from Henry Ford Hospital, Bloomfield Hills, MI, USA, after IRB approval (No. 11254).","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121320156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clustering Functionally Similar Genes Based on Genome-Wide Expression Patterns Across Multiple Environments 基于多环境全基因组表达模式的功能相似基因聚类

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301893

Puyao Ge, Wentong Li

引用次数: 0

A Phylogenetic Study of Monalysin Family of Proteobacterial Pore-Forming Toxins 变形杆菌成孔毒素单胞菌素家族的系统发育研究

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301898

Mirudhula Mukundan, S. Krishnamurthy, Jhinuk Chatterjee

{"title":"A Phylogenetic Study of Monalysin Family of Proteobacterial Pore-Forming Toxins","authors":"Mirudhula Mukundan, S. Krishnamurthy, Jhinuk Chatterjee","doi":"10.1145/3301879.3301898","DOIUrl":"https://doi.org/10.1145/3301879.3301898","url":null,"abstract":"In order to thoroughly comprehend the working of a protein to make use of its features in wet lab analysis, a rigorous phylogenetic study is crucial to clarify its origins and better understand its mechanism of working. In this study, the pore-forming proteins belonging to the Monalysin family have been clustered with other families of Proteobacterial pore-forming toxins. The focus of this study has been divided into three stages, each one employing a different parameter to be used as the basis to form the dataset for the phylogenetic tree - multiple alignment, pair-wise alignment with a threshold score, and finally motif analysis. The resultant data was analysed and interpreted; and clear relatedness between the Monalysin, Aerolysin, Cytohemolysin and Channel-Forming Leukocidin Cytotoxin (Ctx) Family, with respect to their binary sequence alignment as well as the presence of the common pore-forming motif, ETX_MTX2 (with the exception of Cytohemolysin), which is found to be characteristic to the Monalysin family, was detected. The phylogenetic trees showed significant variation in their form, clearly illustrating the importance of the criteria used to select the pool of proteins, and depicting the patterns of evolution that led to the development of the characteristic features of the Monalysin family of pore-forming toxins. The results of this study can be made use of in the development of strategic, targeted biological control mechanisms to combat problems faced in various sectors, like agriculture.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131587012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement and Analysis of Calcaneus Morphometric Parameters from Computed Tomography Images 计算机断层扫描图像中跟骨形态测量参数的测量与分析

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301887

Irwansyah, J. Lai, T. Essomba, P. Lee

{"title":"Measurement and Analysis of Calcaneus Morphometric Parameters from Computed Tomography Images","authors":"Irwansyah, J. Lai, T. Essomba, P. Lee","doi":"10.1145/3301879.3301887","DOIUrl":"https://doi.org/10.1145/3301879.3301887","url":null,"abstract":"This study presents a measurement of the morphology parameters on three-dimensional calcaneus and finds out their correlation with age and body mass index. We included 49 males and 50 females healthy calcaneus as subjects, aged 21-58 years. 3D model of calcaneus was reconstructed directly from computed tomography images by reverse engineering technique. Thirteen linear distances and four angular parameters were measured with two different tools, computer-assisted measurement, and digital vernier scale device. T-tests and Pearson correlation analysis were performed to evaluate parameters relationships. Statistical result presented that significant differences between male and female calcaneal morphologic value found except for β and α angles. LAL, CFH, MXB, DAFL, &thetas;, β, and γ angles show a strong correlation. There was also a significant correlation between age with MAXL, CBL and γ angle. The p-value in the comparison between computer-assisted and manual measurement for each parameter was less than 0.05, indicating that computer-assisted measurement is an effective method for evaluating the calcaneus morphology parameters.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"12 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128855150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Implementation of SMART on FHIR in Developing Countries Through SFPBRF 通过SFPBRF在发展中国家实施FHIR SMART

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301881

Abrar Ahmad, F. Azam, Muhammad Waseem Anwar

{"title":"Implementation of SMART on FHIR in Developing Countries Through SFPBRF","authors":"Abrar Ahmad, F. Azam, Muhammad Waseem Anwar","doi":"10.1145/3301879.3301881","DOIUrl":"https://doi.org/10.1145/3301879.3301881","url":null,"abstract":"Fast Healthcare Interoperability Resources (FHIR) is an International health standard for health data developed by Health Level Seven -- (HL7) an international organization for the development of health data standards. FHIR enables data interoperability as it is based on lightweight open source RESTful services. Many developed countries which already running electronic health record systems are now focused on the adoption of FHIR to unlock its potential benefits by integrating other technologies like Substitutable Medical Applications, Reusable Technology (SMART) platform. In most of the developing countries electronic health record system does not exist because they lag in resources to invest in electronic health record systems and they are still operating on paper-based health record system, so they are unable to adopt FHIR and other related technologies like SMART. Due to which, interoperability is not enabled on this paper-based data. These countries remain at a distance from the benefits of FHIR and SMART platform to provide better patient care to their patients, quick and efficient clinical decision making and better diagnostics. This paper presents the implementation of SMART on FHIR in healthcare organizations of developing countries through a proposed framework SFPBRF which not only maps paper-based health record system's data to HL7's FHIR standard but also integrate the complete SMART on FHIR platform to run SMART apps on this FHIR conformed data. This paper presents successful translation (done by translation engine) of paper-based data to HL7 FHIR standard. It also shows the running of open source and internally developed SMART apps on this FHIR conformed data. Thus, by the successful mapping and implementation of SMART on FHIR through proposed framework SFPBRF we can conclude that FHIR can be adopted in healthcare organizations of developing countries and SMART on FHIR can help a lot in achieving better patient care, quick and efficient decision making and better diagnostics in developing countries.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126278803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Design for an in silico Platform of Precision Medicine on Cancer Therapy 肿瘤治疗精准医学的芯片平台设计

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301904

K. Hwa, Kreeti Kajal

{"title":"Design for an in silico Platform of Precision Medicine on Cancer Therapy","authors":"K. Hwa, Kreeti Kajal","doi":"10.1145/3301879.3301904","DOIUrl":"https://doi.org/10.1145/3301879.3301904","url":null,"abstract":"Cancer is one of the dreadful diseases taking many lives over the years. This disease can be diagnosed and cured but the reoccurrence of the disease is a common phenomenon as it is caused by genetic as well as environmental factors. Hence Precision Medicine, a personalized form of healthcare service can be the most effective treatment strategy for treating cancer, which includes individual genetics, environmental factors, and lifestyle data. Establishing a precision medicine platform integrating it with the data from the Next Generation Sequencing (NGS) will be one of the solutions for the researchers and clinicians in conducting their works. In this paper, we have designed workflows for genomics variants from data of the NGS and a platform for establishing a precision medicine database system which consists of information of genes responsible for various cancers and their corresponded drug information, which could serve the purpose of providing the best therapeutic modality for cancer treatment. Moreover, databases verified by the US Food and Drug Administration, an agency create a versatile and adaptable regulatory guideline for precision medicine with a focus on the data from the NGS. The main aim of these guidelines is to ensure patients to get precise, authentic and correct test results.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122193355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Activity While Waiting to Steer a Car: An fMRI Study 等待开车时的大脑活动:一项功能磁共振成像研究

International Conferences on Biomedical and Bioinformatics Engineering Pub Date : 2018-11-12 DOI: 10.1145/3301879.3301896

Yoshihisa Okamoto, T. Sasaoka, Toshihiro Yoshida, Kazuhiro Takemura, Z. Soh, T. Nouzawa, S. Yamawaki, T. Tsuji

{"title":"Brain Activity While Waiting to Steer a Car: An fMRI Study","authors":"Yoshihisa Okamoto, T. Sasaoka, Toshihiro Yoshida, Kazuhiro Takemura, Z. Soh, T. Nouzawa, S. Yamawaki, T. Tsuji","doi":"10.1145/3301879.3301896","DOIUrl":"https://doi.org/10.1145/3301879.3301896","url":null,"abstract":"In this paper, we report a novel approach to automobile development based on the understanding of the brain mechanism. We aim to realize fun to drive applying the neuroscientific findings of affective states. There are few studies about it, therefore using newly developed experimental unit, we are examining participants' brain activity affected by the load of steering operation task in the MRI scanner. We focused on the brain activity while waiting to steer, assuming that it reflects participants' affective state in preparation of the upcoming steering task. We observed activations in the anterior cingulate and insular cortices comprising the salience network, which is one of the intrinsic brain networks and involved in preparation for an upcoming task. Intriguingly, when waiting for the steering task having larger reaction force, the anterior cingulate cortex, known to be related to anxiety, was more active. Moreover, waiting for the condition in which the steering had to be operated with only the non-dominant arm, the amygdala, known to be associated with negative emotion, was significantly activated. Thus, our results newly show that the steering reaction force and the hand used for steering operation may influence brain activity while waiting for the upcoming steering task.","PeriodicalId":327934,"journal":{"name":"International Conferences on Biomedical and Bioinformatics Engineering","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124106675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0