The Moldovan Medical Journal最新文献_第7页

Environmental toxic factors and clinical pattern of Parkinson’s disease 环境毒性因素与帕金森病的临床模式

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.13

L. Rotaru

{"title":"Environmental toxic factors and clinical pattern of Parkinson’s disease","authors":"L. Rotaru","doi":"10.52418/moldovan-med-j.64-4.21.13","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.13","url":null,"abstract":"Background: Parkinson’s disease (PD) – the most common neuro-degenerative movement disorder – is considered a result of a multifactorial pathogenic process modulated by cumulative and interactive effects of genes and exposures. An environmental exposure could enhance or create dopaminergic neurons vulnerability and increase PD risk. The purpose of the study was to find if excessive exposure to toxic environmental factors may influence clinical pattern of PD. Material and methods: The study was conducted on 111 patients diagnosed with PD, study group being defined as PD exposed to toxins (33 patients), control group including PD patients without toxin exposure (78 patients). General epidemiological data and clinical data were recorded. Results: Toxin exposure was found in 33 patients (29.73%), more of them – men and rural residents. Toxin exposed PD patients had an insignificantly younger age. The most common disease phenotype in the study group was the akinetic-rigid phenotype (64.7%, p = 0.040), bradykinesia being the most common sign at the disease onset (57.6%, p = 0.008). Levodopa equivalent daily dose also was higher in the study group (659.02 ± 232.46, p = 0.042). Conclusions: Excessive exposure to toxic environmental factors may influence the clinical pattern of PD. In this study the akinetic-rigid type was the predominant disease phenotype associated with toxin exposure. Doses needed for treatment were higher in PD patients exposed to toxins, as an indicator of a more severe motor impairment in this group","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45347763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the spectrophotometric method for the dosing of some combined capsule 分光光度法测定某复方胶囊剂量的验证

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.02

Livia Uncu, Vladilena Evtodienco, Ecaterina Mazur, Elena Donici, V. Valica

{"title":"Validation of the spectrophotometric method for the dosing of some combined capsule","authors":"Livia Uncu, Vladilena Evtodienco, Ecaterina Mazur, Elena Donici, V. Valica","doi":"10.52418/moldovan-med-j.64-4.21.02","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.02","url":null,"abstract":"Background: UV-Vis spectrophotometry remains the most accessible spectral method with a high degree of sensitivity and information. The advantage of the method consists in its universality, the ability to combine with other methods, the minimum error, as well as its economic efficiency. The objective of this study was the determination of some validation parameters for the spectrophotometric method of dosing piracetam and nicergoline in combined capsules. Material and methods: Agilent 8453 UV-Vis spectrophotometer, reference standards of piracetam and nicergoline, 0.1 M HCl methanolic solution. Validation of the spectrophotometric method according to the requirements of the ICH guide “Q2R1: For analytical procedures and validation”. Results: Linearity was investigated on concentration ranges 5-40 µg / mL. The regression (R2 ) values were 0.9998 for nicergoline and 0.998 for piracetam, respectively. The limit of detection was 1.737 µg / mL for nicergoline and 0.369 µg / mL for piracetam. Quantification limit values were also calculated as 5.265 and 1.118 µg / mL for nicergoline and piracetam, accordingly. The results obtained showed that the developed spectrophotometric method is accurate, precise and robust, because the value of the relative standard deviation was less than 1.0%. Conclusions: The developed spectrophotometric method showed specificity, linearity, accuracy, precision and robustness, and can be applied on the concentration range between 80-120% of the nominal value of the content of nicergoline and piracetam in the preparation.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44953305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose anticholinergic therapy causes cognitive impairment in Parkinson's disease patients 低剂量抗胆碱能治疗导致帕金森病患者认知障碍

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.12

O. Gavriliuc, A. Andrusca, Lilian Popil, M. Gavriliuc

{"title":"Low-dose anticholinergic therapy causes cognitive impairment in Parkinson's disease patients","authors":"O. Gavriliuc, A. Andrusca, Lilian Popil, M. Gavriliuc","doi":"10.52418/moldovan-med-j.64-4.21.12","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.12","url":null,"abstract":"Background: Before L-Dopa’s discovery, anticholinergic drugs were among the first treatments for Parkinson’s disease. Only now trihexyphenidyl (THP) is approved to treat unresponsive L-dopa tremors in young, cognitively unaffected Parkinson’s disease patients. However, there are no specific recommendations for disease duration, medication dose, or cognitive status. In low-income countries, THP is still frequently used in Parkinson’s disease patients with tremor. The objective of the current study was to evaluate cognitive performance in Parkinson’s disease patients receiving a low dose of THP. Material and methods: The study was performed on nineteen PD patients, nine of whom were on THP. All patients completed MoCA cognitive assessment. The patients were matched depending on their age, disease severity based on UPDRS III and duration of the disease. Results: The THP patients were taking an average dose of 3.3 mg of THP daily for an average of 1.8 years. There were no statistical differences between THP patients and non-THP patients in age (64.8± 4.8 vs 67.2±6.9, p=0.4), UPDRS III (32.1±8.9 vs 41.5±20.6, p=0.2) and disease duration (6.2±4.9 vs 7.0 ± 4.0, p=0.7). The THP patients had lower cognitive performance, with a total MoCA of 19.22 ± 3.3 vs. non-THP patients 24.2±3.0, p=0.003. Conclusions: In Parkinson’s disease patients, even a low dose of THP causes significant cognitive loss.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41438695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mast cells in luminal vs non-luminal breast cancers 肥大细胞在管腔与非管腔乳腺癌中的作用

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.06

Ecaterina Carpenco, V. Fulga, Valeriu David, Ecaterina Foca, L. Saptefrati

{"title":"Mast cells in luminal vs non-luminal breast cancers","authors":"Ecaterina Carpenco, V. Fulga, Valeriu David, Ecaterina Foca, L. Saptefrati","doi":"10.52418/moldovan-med-j.64-4.21.06","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.06","url":null,"abstract":"Background: Tumor growth and development is determined by the mutual interaction between the cancer cells themselves and the microenvironment. It contains various elements, including immune cells. Of all, mast cells have one of the most controversial roles. The aim of the present study was to evaluate the expression of mast cell tryptase in the luminal and non-luminal subtypes of breast cancer and establish a possible link between infiltration with MCs and expression of hormone receptors. Material and methods: The experimental study included 80 cases of breast carcinomas that were analyzed immunohistochemically in order to establish the molecular profile and the expression of tryptase, a specific marker of mast cells. The data were processed using the SPSS program. Pearson’s coefficient (r) and the other values were considered statistically significant in case of p≤0.05. Results: Both intratumoral mast cells (MCit) and peritumoral mast cells (MCpt) correlated with the expression of hormone receptors for estrogen (ER) and progesterone (PR). Thus, the following relations were established: MCit and ER (r=0.343, p=0.002), MCpt and ER (r=0.394, p=0.000295) and MCpt and PR (r=0.386, p=0.000409). Statistically significant correlations between HER2 expression and mast cells content have not been established. Conclusions: Mast cells invasion, peri- and intratumoral, is strongly influenced by the expression of hormone receptors. The luminal subtypes of breast cancer are characterized by a higher density of mast cells.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42703900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation of the magistral semisolid formulations with furazidine used in urogenital infections 泌尿生殖道感染用呋喃嗪半固体制剂的优化

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.03

D. Guranda, C. Ciobanu, N. Ciobanu, Rodica Solonari

{"title":"Optimisation of the magistral semisolid formulations with furazidine used in urogenital infections","authors":"D. Guranda, C. Ciobanu, N. Ciobanu, Rodica Solonari","doi":"10.52418/moldovan-med-j.64-4.21.03","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.03","url":null,"abstract":"Background: Urinary tract infections are the most common urogenital diseases, with an increased incidence in men and older people. Urogenital infections are caused by Gram-negative bacteria, in which Escherichia coli predominates with a share of 80%. The evolution of microbial resistance to preparations used in curative-prophylactic institutions, induces the need of the reintroduction of nitrofurans, noteworthy for their wide spectrum of antibacterial activity. Material and methods: For the study, suppositories with furazidine were prepared by hand rolling and by melting and molding methods. Quantitative analysis was performed spectrophotometrically on a UV-VIS Perkin Elmer Lambda 40 spectrophotometer. All solvents and reagents had the degree of purity ”pure for analysis” and ”chemically pure”. Results: Duble cast method was applied to identify the exact mass of hydrophobic (cocoa butter, suppocire) and hydrophylic (polyethylene glycol mixtures) excipients. All the formulated suppositories were subjected to quality tests and showed acceptable physical characteristics and uniformity of drug contents. The UV-VIS spectrophotometric method for quantitiative determination of furazidine was developed and validated. The validation results showed that the developed method is simple, fast, accurate and robust. Conclusions: Suppositories with furazidine were prepared by classic technological methods. Preparation of the suppositories with furazidine on cocoa butter excipient is a suitable alternative for individual medicinal prescriptions. The UV-VIS spectrophotometric dosing method for furazidine in suppositories was developed and validated","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47815192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diastolic disorder inherent to doxorubicin cardiotoxicity 阿霉素心脏毒性引起的舒张功能紊乱

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.04

L. Tacu, V. Cobet

{"title":"Diastolic disorder inherent to doxorubicin cardiotoxicity","authors":"L. Tacu, V. Cobet","doi":"10.52418/moldovan-med-j.64-4.21.04","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.04","url":null,"abstract":"Background: The doxorubicin (Dx) cardiotoxicity is manifested by a marked heart failure evolution. The impact of Dx on lusitrop functions of the heart and the inherent diastolic disorders have a theoretical and practical value for the connection cardiology-oncology. Material and methods: Dx cardiotoxicity was reproduced by its administration i/p in white rats in cumulative dose 16 mg/kg (Dx group n=9). Control group (n=9) received only physiological solution. The study was performed in vitro by using models of isolated heart perfusion in either isovolumic or exterior working regimens. The assayed indices of diastole functioning were: left ventricle (LV) end-diastolic pressure (LVEDP), diastolic stiffness, isovolumic relaxation velocity (-dP/dTmax) and protodiastolic pressure of LV (LVPDP). Results: The indices of diastolic disorders induced by Dx were elevation of LVEDP, diastolic stiffness and LVPDP in a range of 97-168% comparing to control as well as diminution of -dP/dTmax in the physiological pattern of hemodynamics. LVEDP increased more in conditions of calcium overloading or endothelin-1 (ET-1) action that are involved in pathogenesis of diastolic rigidity. Dx action led to decrease of myocardium resistance to ischemiareperfusion action resulting in the LVEDP elevation by 53% comparing to control. Conclusions: 1. Diastolic disorders inherent to Dx cardiotoxicity are manifested by the increase of LVEDP and diastolic stiffness. 2. Diastolic disorders compromised the volume-pressure relationship of LV, the adaptation of the heart to effort with volume, being more pronounced during the action of calcium excess and ET-1","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47530727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and paraclinical manifestations in patients suspected of being infected with COVID-19 疑似感染新冠肺炎患者的临床和临床旁表现

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.11

I. Sîrbu, S. Matcovschi

{"title":"Clinical and paraclinical manifestations in patients suspected of being infected with COVID-19","authors":"I. Sîrbu, S. Matcovschi","doi":"10.52418/moldovan-med-j.64-4.21.11","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.11","url":null,"abstract":"Background: It was intended to study the structure of the symptoms in patients suspected of having SARS-CoV-2 virus infection, as well as to find any correlations between the clinical, paraclinical and radiological manifestations in positive versus negative patients, in order to further facilitate the diagnosis and triage of patients. Material and methods: 101 patients seeking medical attendance at the COVID-19 Triage Center in Chisinau have been examined, presenting various respiratory symptoms. The frequency of symptoms and the results of the paraclinical investigations were evaluated based on the results of the PCR tests for SARS-CoV-2 infection and the assessment of correlations (Pearson). Results: Out of 101 subjects, 50 tested SARS-CoV-2 positive, and the remaining 51 – negative. The clinical manifestations of SARS-CoV-2 suspects were as follows: fatigue – 72%, sweating – 54%, chills – 52%, fever – 49%, subfebrility – 39%, myalgias and arthralgias – 37%, cough – 35% (sputum – 17% and hemoptysis – 2%), dyspnea – 34%, chest pain – 23%, anosmia – 12%, headache – 11%, dyspeptic syndrome – 8%. Infiltrates on chest radiography were found in 22% of cases. A weak inverse correlation (R = -0.22, P <0.05) between the leukocyte count and SARS-CoV-2 test results was found. An average direct correlation between the presence of fever (R = 0.36, P <0.05) and a positive COVID-19 test was also noticed. Conclusions: Certain symptoms such as anosmia were more commonly seen in patients with positive COVID-19 tests. The absence of pulmonary infiltrates and the presence of dyspnoea have been negative predictive factors for COVID-19. Leukopenia has been noticed only in SARS-CoV-2 positive patients. Subfebrility has not shown a predictive significance of COVID-19","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47788889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The general condition of patients requiring the alveolar bone crest reconstruction 牙槽骨嵴重建患者的一般情况

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.05

Alexandru Ghetiu

{"title":"The general condition of patients requiring the alveolar bone crest reconstruction","authors":"Alexandru Ghetiu","doi":"10.52418/moldovan-med-j.64-4.21.05","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.05","url":null,"abstract":"Objectives: To present the survey questionnaire used for the medical assessment of patients requiring alveolar ridge reconstruction as well as the study of concomitant pathologies and their influence on the healing process. Material and methods: The study involved 173 patients aged between 18 and 69 years. All patients have been assessed according to the survey questionnaire developed to determine the patient’s general condition, life anamnesis, and medical history. Results: Out of the total of 173 patients, 72 (41.6%) had no concomitant pathologies, 8 patients (4.6%) had concomitant pathologies that did not interfere with the operation, 40 (23.1%) had pathologies that might affect the outcome of alveolar ridge reconstruction but still were admitted to surgery, and 53 patients (30.6%) had pathologies that could affect the outcome of the reconstruction procedure and were not admitted to bone grafting. Conclusions: Assessment of patients with alveolar ridge defects during preparation and planning of preimplantation bone reconstruction identified a number of concomitant pathologies, more or less noticed by the patient, which may remain unclear due to superficial study of the patient’s condition that is able to influence the surgical treatment outcome. These issues can be both intraoperative and postoperative and lead to failure of surgical treatment and further reoperation.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70968412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current inconsistencies in the reporting of cases of intraabdominal retained textile foreign bodies 目前腹部滞留纺织品异物病例报告不一致

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.08

Serghei Gutu

{"title":"Current inconsistencies in the reporting of cases of intraabdominal retained textile foreign bodies","authors":"Serghei Gutu","doi":"10.52418/moldovan-med-j.64-4.21.08","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.08","url":null,"abstract":"Background: It is assumed that the incidence of textile foreign bodies (TFB) unintentionally left in abdominal cavity is underreported, mostly due to the legal implications of their detection. Material and methods: One hundred thirty-five responses were received to a specially developed anonymous questionnaire on the TFB problem, including medico-legal aspects. Of the total number of respondents, 81 were surgeons and 54 – gynecologists. Results: Over 80% of respondents consider that if TFB was removed from abdominal cavity during the surgical intervention, it should be indicated in the final diagnosis. At the same time, the fact of detecting and removing TFB retained in abdomen in the real cases known by respondents was reflected in the surgical report and in diagnosis in only 49.1%. False description in case of detection and removal of intra-abdominal TFB admits 29.6% from total number of respondents, but only 24.5% with a shorter length of work (<15 years), and 40.7% – with a work experience over 15 years. Conclusions: Surprisingly, about 20% of respondents consider it justified not to indicate retained TFB in the final diagnosis. Moreover, the real frequency of TFB diagnosis concealment is 1.6 times higher and sharply contradicts the declared intentions about the need to report the true cause of pathology. Almost half of surgeons with a long lasting work experience allow a false description of intraoperative findings and, as a result, the official diagnosis.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48087767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure of emergencies at the prehospital stage in Moldova from 2019-2020 years 2019-2020年摩尔多瓦院前阶段的紧急情况结构

The Moldovan Medical Journal Pub Date : 2021-10-01 DOI: 10.52418/moldovan-med-j.64-4.21.07

Boris Golovin, Mihail Pestereanu, Tatiana Bicic, Svetlana Lupu, Ludmila Petcu, Nicolae Doni

{"title":"Structure of emergencies at the prehospital stage in Moldova from 2019-2020 years","authors":"Boris Golovin, Mihail Pestereanu, Tatiana Bicic, Svetlana Lupu, Ludmila Petcu, Nicolae Doni","doi":"10.52418/moldovan-med-j.64-4.21.07","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.64-4.21.07","url":null,"abstract":"Background: In the last 2 years, some changes have occurred in the structure of emergencies at the prehospital stage in the Republic of Moldova, being largely influenced by the COVID-19 pandemic. Material and methods: Retrospective analysis of the Prehospital Emergency Medical Service (PEMS) Request Sheets of the National Centre of Prehospital Emergency Medicine (NCPEM) of the Republic of Moldova for the years 2019-2020. Results: According to the nosological profile in 2020 at the prehospital stage, respiratory emergencies were on the first place with 23% of the 761.416 of total number of requests. On the second – cardiovascular (20.6%), on the third – neurological (13.3%), infectious – 3.1%. In 2019, on the first place – cardiovascular with 22.3% of the 845.572 of total number of requests, followed by respiratory – 19.3%, neurological – 13.6%, infectious – 2.2%. In 2020, on the first place were respiratory emergencies, which compared to 2019 increased practically by 4% and the infectious emergencies by almost 1%. The number of endotracheal intubation procedures and medical-assisted transportations practically doubled in y.2020 compared to y.2019. Conclusions: All these changes: increased respiratory and infectious emergencies, intubation procedures, and assisted-medical transportations, have occurred exeptionally due to COVID-19 infection.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47498135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0