Peer Community In Mathematical and Computational Biology最新文献_第2页

The importance of model assumptions in estimating the dynamics of the COVID-19 epidemic 模型假设在估计COVID-19流行动态中的重要性

Peer Community In Mathematical and Computational Biology Pub Date : 2021-07-27 DOI: 10.24072/pci.mcb.100004

Valery Forbes

引用次数: 0

An efficient implementation of legofit software to infer demographic histories from population genetic data 一个有效的实现乐高软件从人口遗传数据推断人口历史

Peer Community In Mathematical and Computational Biology Pub Date : 2021-05-19 DOI: 10.24072/PCI.MCB.100003

Matteo Fumagalli

引用次数: 0

Comparing reconciled gene trees in linear time 线性时间内调和基因树的比较

Peer Community In Mathematical and Computational Biology Pub Date : 2020-12-24 DOI: 10.24072/pci.mcb.100002

Céline Scornavacca

引用次数: 0

Modeling the effect of lockdown and other events on the dynamics of SARS-CoV-2 in France 模拟封锁和其他事件对法国SARS-CoV-2动态的影响

Peer Community In Mathematical and Computational Biology Pub Date : 2020-09-09 DOI: 10.24072/pci.mcb.100001

V. Forbes

{"title":"Modeling the effect of lockdown and other events on the dynamics of SARS-CoV-2 in France","authors":"V. Forbes","doi":"10.24072/pci.mcb.100001","DOIUrl":"https://doi.org/10.24072/pci.mcb.100001","url":null,"abstract":"This study [1] used Bayesian models of the number of deaths through time across different regions of France to explore the effects of lockdown and other events (i.e., holding elections) on the dynamics of the SARS-CoV-2 epidemic. The models accurately predicted the number of deaths 2 to 3 weeks in advance, and results were similar to other recent models using different structure and input data. Viral reproduction numbers were not found to be different between weekends and week days, and there was no evidence that holding elections affected the number of deaths directly. However, exploring different scenarios of the timing of the lockdown showed that this had a substantial impact on the number of deaths. This is an interesting and important paper that can inform adaptive management strategies for controlling the spread of this virus, not just in France, but in other geographic areas. For example, the results found that there was a lag period between a change in management strategies (lockdown, social distancing, and the relaxing of controls) and the observed change in mortality. Also, there was a large variation in the impact of mitigation measures on the viral reproduction number depending on region, with lockdown","PeriodicalId":326568,"journal":{"name":"Peer Community In Mathematical and Computational Biology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116861233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How mammals adapt their breath to body activity – and how this depends on body size 哺乳动物是如何使呼吸适应身体活动的——这又是如何取决于体型的

Peer Community In Mathematical and Computational Biology Pub Date : 2020-05-04 DOI: 10.24072/pci.mcb.100005

F. Noel, C. Karamaoun, J. Dempsey, B. Mauroy

{"title":"How mammals adapt their breath to body activity – and how this depends on body size","authors":"F. Noel, C. Karamaoun, J. Dempsey, B. Mauroy","doi":"10.24072/pci.mcb.100005","DOIUrl":"https://doi.org/10.24072/pci.mcb.100005","url":null,"abstract":"A model of optimal control of ventilation recently developed for humans has suggested that the localization of the transition between a convective and a diffusive transport of the respiratory gas determines how ventilation should be controlled to minimize its energetic cost at any metabolic regime. We generalized this model to any mammal, based on the core morphometric characteristics shared by all mammals' lungs and on their allometric scaling from the literature.Since the main energetic costs of ventilation are related to the convective transport, we prove that, for all mammals, the localization of the shift from an convective transport into a diffusive transport plays a critical role on keeping that cost low while fulfilling the lung's function. Our model predicts for the first time where this transition zone should occur in order to minimize the energetic cost of ventilation, depending on the mammals' mass and on the metabolic regime. From that optimal localization, we are able to derive predicted allometric scaling laws for both tidal volumes and breathing rates, at any metabolic regime. We ran our model for the three common metabolic rates -basal, field and maximal- and showed that our predictions accurately reproduce the experimental data available in the literature. Our analysis supports the hypothesis that the mammals' allometric scaling laws of tidal volumes and breathing rates are driven by a few core geometrical characteristics shared by the mammals' lungs, the physical processes of respiratory gas transport and the metabolic needs.","PeriodicalId":326568,"journal":{"name":"Peer Community In Mathematical and Computational Biology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116014737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6