JURNAL FARMASIMED (JFM)最新文献

ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS 花椰菜乙醇提取物对白种雄性大鼠的抗糖尿病活性试验

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-30 DOI: 10.35451/jfm.v5i2.1587

Novandi Purba, Diah Tri Handayani, Kristian Cahayani Zebua

{"title":"ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS","authors":"Novandi Purba, Diah Tri Handayani, Kristian Cahayani Zebua","doi":"10.35451/jfm.v5i2.1587","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1587","url":null,"abstract":"Diabetes is a chronic disease characterized by excessive blood glucose levels caused by absolute and relative insulin deficiency. The stages in this study were sampling, identification of samples/plants, simplification, simplification screening, and preparation of extracts by maceration. The method used in the diabetes activity test uses a glucometer to induce alloxan in rats at a dose of 150 mg/kg body weight. The test animals were 25 rats which were divided into 5 treatment groups namely CMC Na 0.5% (negative control), glibenclamide (positive control) 0.45 mg/kg body weight and EEB dose 200 mg/kg body weight, 400 mg/kg body weight and 600. mg/kg body weight. kg B.W. kg body weight as a test material given orally. Measurement of blood glucose values according to Allox and on days 3, 5, and 7 after administration of the test substance, namely EEB. The test results data were analyzed statistically using one-way ANOVA at a 95% confidence level followed by Tukey's post hoc test. The results of the phytochemical screening showed that EEB contains alkaloids, flavonoids, tannins, saponins, and glycosides. The results of the diabetes efficacy test showed that EEB doses of 200, 400, and 600 mg/kg BW had an anti-diabetic effect on male white rats. The EEB dose of 600 mg/kg is the most effective. Post hoc Tukey test results showed that EEB doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg were not significantly different from the positive control glibenclamide 0.45 mg/kg (p>0.05) and 200,400 ug. and 600 mg/kg BW were significantly different from the negative control CMC Na 0.5% (p<0.05).","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"53 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132638964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRANSPARENT SOAP FORMULATION WITH VARIOUS LEVELS OF CONCENTRATION OF TEAK LEAF EXTRACT (TECTONA GRANDIS L.F.)AS ANTIBACTERIAL SOAP 透明皂配方，含有不同浓度的柚木叶提取物(tectona grandis l.f .)抗菌肥皂

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-30 DOI: 10.35451/jfm.v5i2.1401

C. Pranata, R. Irwanto, A. S

{"title":"TRANSPARENT SOAP FORMULATION WITH VARIOUS LEVELS OF CONCENTRATION OF TEAK LEAF EXTRACT (TECTONA GRANDIS L.F.)AS ANTIBACTERIAL SOAP","authors":"C. Pranata, R. Irwanto, A. S","doi":"10.35451/jfm.v5i2.1401","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1401","url":null,"abstract":"The purpose of this study was to examine the organoleptic, homogeneity and antibacterial properties of transparent soap. The treatment used is; F1 (3% teak leaf extract), F2 (6% teak leaf extract), F3 (9% teak leaf extract), and F4 (12% teak leaf extract). The implementation of the research begins with product optimization in advance of the proportion of the use of raw material components. The results of the homogeneity test experiment showed that all formulas were homogeneous and in accordance with SNI standards, then the results of the water content obtained from each preparation proved to meet the requirements set by SNI ( Indonesian National Standard). The results of the pH measurements showed that at pH F0 it remained at 8. The results for measuring pH F1 showed results with a pH of 8. Meanwhile, pH F2 had a pH of 8. The last measurement for pH at pH F3 showed the same pH results as the other formula, namely at pH 8. So that F0, F1, F2, and F3 have the same pH, namely pH 8, where pH 8 is the pH of the positive control, namely soap on the market. Staphylococcus aureus with a concentration of 3% by 13 mm, 6% by 15 mm, 9% by 17 mm, 12% by 20 mm. The greater the concentration of teak leaf extract in transparent solid coir, the greater the inhibition of bacterial growth.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130113284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF DRUG INFORMATION SERVICES IN PATIENTS WITH DIABETES MELLITUS IN OUTPATIENT INSTALLATIONS GENERAL HOSPITAL PHARMACY COAL REGION 煤炭地区综合医院药房门诊糖尿病患者用药信息服务评价

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-30 DOI: 10.35451/jfm.v5i2.1636

A. S, Nur Ulina M. Br Turnip, Mahliza .

{"title":"EVALUATION OF DRUG INFORMATION SERVICES IN PATIENTS WITH DIABETES MELLITUS IN OUTPATIENT INSTALLATIONS GENERAL HOSPITAL PHARMACY COAL REGION","authors":"A. S, Nur Ulina M. Br Turnip, Mahliza .","doi":"10.35451/jfm.v5i2.1636","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1636","url":null,"abstract":"Based on people's unhealthy lifestyle habits and from data on the five biggest diseases for the period July – September 2022 which shows that diabetes mellitus occupies the second level of the five biggest diseases in Batu Bara Hospital, and drug information services are very necessary because there are many patients who still do not understand what to do about drugs, this is done to minimize abuse and interactions between drugs that are not wanted by patients. To find out how drug information services are for DM patients at the Batu Bara Hospital pharmacy installation on an outpatient basis, and to identify the completeness of the information provided by pharmaceutical staff to patients at the Framing Installation at the Batu Bara General Hospital, and also to find out the problems found in technical drug information services provided to patients at the Batu Bara Regional Hospital Pharmacy Installation. This type of research is an observational study. The design of this study is qualitative by making direct observations or observations, interviews and documentation. Drug information services for diabetes mellitus patients in outpatient care at the Batu Bara Hospital pharmacy installation were in the very good category with a result of 96%. Drug information services performed by eight pharmacists consisting of six pharmacists and two pharmacy technicians for outpatient diabetes mellitus patients at the Batu Bara Hospital pharmaceutical installation have met the standards in the very good category with a yield of 96%.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133409361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALIYSIS OF RHODAMINE B DYESTUFFS ON LIPTINT USING UV-VIS SPECTROPHOTOMETRY METHOD 紫外-可见分光光度法分析罗丹明b染料对lipting的影响

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-30 DOI: 10.35451/jfm.v5i2.1295

S. Wulandari, Amalia Nur Rahma, Siti Wahyuni, Basyariah Lubis

{"title":"ANALIYSIS OF RHODAMINE B DYESTUFFS ON LIPTINT USING UV-VIS SPECTROPHOTOMETRY METHOD","authors":"S. Wulandari, Amalia Nur Rahma, Siti Wahyuni, Basyariah Lubis","doi":"10.35451/jfm.v5i2.1295","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1295","url":null,"abstract":"Background : Rhodamine B is a synthetic dye that is generally used as a dye for paper, textiles or inks. The use of Rhodamine B is certainly very dangerous for health. Rhodamine B if used directly on the human body will cause irritation of the respiratory tract and can cause cancer and liver damage. Although there are negative impacts, the use of these dyes is still often done, especially for food and cosmetic products. Purpose : This research was conducted to identify and determine levels of Rhodamine B in liptint traded in Lubuk Pakam sub-District. Method : Qualitative analysis of Rhodamine B was carried out by Thin Layer Chromatography (TLC) using ethylacetate-methanol-ammonia (45:25:30), while quantitative analysis for assay was carried out using UV-VIS Spectrophotometry at a wavelength of 545 nm. The linear calibration curve in the range of 1 - 5 μg /ml resulted in the regression equation y = 0.0091x - 0.009. Results : The results of the qualitative analysis showed that the three samples containing Rhodamine B with each Rf value of 0.87 cm (sample A), 0.96 cm (sample B), 0.98 cm (sample C) and quantitatively the levels for sample A were known is 13,144 mg/g, sample B is 27,704 mg/g and sample C is 20,386 mg/g. Conclusion : From this research, it is known that there is still the use of Rhodamine B as a dye in liptint traded in Lubuk Pakam sub-district","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133401999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF THE USE OF ANTIHYPERTENSION DRUG IN HYPERTENSION PATIENTS AT THE GRANDMED LUBUK PAKAM HOSPITAL INSTALLATION IN 2022 对2022年老卢巴克医院高血压患者使用降压药的评价

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-30 DOI: 10.35451/jfm.v5i2.1613

D. Kartika, S. ., Nur Atika

{"title":"EVALUATION OF THE USE OF ANTIHYPERTENSION DRUG IN HYPERTENSION PATIENTS AT THE GRANDMED LUBUK PAKAM HOSPITAL INSTALLATION IN 2022","authors":"D. Kartika, S. ., Nur Atika","doi":"10.35451/jfm.v5i2.1613","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1613","url":null,"abstract":"Hypertension is a condition where there is an increase in blood pressure that exceeds the normal limit, namely systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. Most women suffer from hypertension because of the hormone estrogen. Patients with hypertension who are not given proper therapy will cause complications that can worsen the condition of hypertension. The higher the prevalence of hypertension sufferers, the use of antihypertensive drugs will increase. This will increase the risk of irrational use of antihypertensive drugs. The purpose of this study was to evaluate the rationality of the use of antihypertensive drugs in the Inpatient Installation of Grandmed Lubuk Pakam Hospital based on the right patient, the right indication, the right drug and the right dose. This research is a type of descriptive research. Data collection was carried out retrospectively by using past data in the form of medical records of hypertension patients for the period January 2021 – February 2022 which met the exclusion and inclusion criteria. The sampling technique used was the purposive sampling technique. The results of this study indicate that the most widely used antihypertensive drugs are combination therapy with Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ACEI) (30,6%); Calcium Channel Blokers (CCB) sebanyak (11%); Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ACEI) + Diuretik sebanyak (11,1%); while the low class of drugs is Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ARB) + Angiotensin Converting Enzyme Inhibitors (ACEI); and diuretics + Angiotensin Converting Enzyme Inhibitors (ACEI) were used (2,8%). The results showed that the rationality of the use of antihypertensive drugs obtained was that the patient was correct 100%, the indication was 100%, the drug was 97,2%, and the dose was 97,2%.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124121857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTIBACTERIAL TEST OF ETHANOLIC EXTRACT NANOPARTICLES FROM ARUM MANIS MANGO LEAVES (MANGIFERA INDICA L. VAR. ARUM MANIS) AGAINST STAPHYLOCOCCUS AUREUS 海芋芒果叶乙醇提取物纳米粒对金黄色葡萄球菌的抑菌试验

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-29 DOI: 10.35451/jfm.v5i2.1687

Nadya Frestika Lubis, Yayuk Putri Rahayu, Haris Munandar Nasution, M. S. Lubis

{"title":"ANTIBACTERIAL TEST OF ETHANOLIC EXTRACT NANOPARTICLES FROM ARUM MANIS MANGO LEAVES (MANGIFERA INDICA L. VAR. ARUM MANIS) AGAINST STAPHYLOCOCCUS AUREUS","authors":"Nadya Frestika Lubis, Yayuk Putri Rahayu, Haris Munandar Nasution, M. S. Lubis","doi":"10.35451/jfm.v5i2.1687","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1687","url":null,"abstract":"Secondary metabolites with antibacterial properties have been found in arummanis mango leaves. Alkaloids, flavonoids, tannins, saponins, triterpenoids, and steroids, especially the mangiferin molecule found in several mango varieties, are also present in arum manis mango leaf extract. Mangiferin has shown action on Staphylococcus aureus as an antibacterial agent that can prevent the development of bacteria. Staphylococcus aureus is one of the bacteria that triggers skin infections. In this research, extract nanoparticles and inhibition tests against staphylococcus aureus bacteria were prepared using extract nanoparticles and ethanol extract of arum manis mango leaves. The manufacture of nanoparticles in this study was carried out because smaller and nanometer-sized materials have more special chemical and glass characteristics; their small size has a greater surface area to volume ratio than larger particles. Nanoparticles are small particles ranging in size from 1 to 1000 nm. A particle size analyzer is used to characterize nanoparticles. Using the disc diffusion method, antibacterial activity tests were carried out at concentrations of 25%, 50%, and 75%, using nanoparticle extracts, and 2.5%, 5%, and 7.5% for extract concentration. The results of the extract nanoparticle size characterization were 40.2 nm. The bacterial inhibition zones of arum manis mango leaf extract obtained at concentrations of 25%, 50%, and 75% were 11.9, 14.4, and 15.4 mm, respectively. Meanwhile, the inhibition zones of nanoparticle bacteria extract 2.5%, 5%, and 7.5% were 15.5, 17.5, and 18.3 mm, respectively. The concentration of 2.5% nanoparticle extract has the inhibition power of bacteria equivalent to that of 75% ethanol extract, so it says that the nanoparticles can reduce the size dose and have an inhibition power in the moderate sensitivity category.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131530925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTIVENESS TEST ON PREPARATION GEL (Aleurites moluccana) AS ANTICEPTIC HAND SANITIZER AGAINST BACTERIA Staphylococcus aureus 制备凝胶对金黄色葡萄球菌抗菌洗手液的效果试验

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-28 DOI: 10.35451/jfm.v5i2.1258

Cucu Arum Dwi Cahya, Devi Febby Yola Lubis

{"title":"EFFECTIVENESS TEST ON PREPARATION GEL (Aleurites moluccana) AS ANTICEPTIC HAND SANITIZER AGAINST BACTERIA Staphylococcus aureus","authors":"Cucu Arum Dwi Cahya, Devi Febby Yola Lubis","doi":"10.35451/jfm.v5i2.1258","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1258","url":null,"abstract":"Salah satu cara yang efektif untuk menjaga kesehatan tubuh adalah dengan menjaga kebersihan, salah satunya adalah kebersihan tangan. Salah satu bakteri yang paling sering mengkontaminasi kulit tangan adalah Staphylococcus aureus. Penggunaan gel antiseptik (Hand sanitizer) yang mudah dan praktis semakin diminati masyarakat. Kebanyakan produk gel antiseptik tangan menggunakan alkohol sebagai antibakteri. Kemiri adalah salah satu tumbuhan dengan berbagai manfaat pada setiap bagian pohonnya. Kemiri dapat dimanfaatkan baik sebagai obat-obatan tradisional, bahan makanan, bahan pewarna, penerangan dan berbagai kegunaan lain. Namun belum ada studi yang meneliti apakah formulasi sediaan Gel Hand sanitizer minyak kemiri (Aleurites moluccana) efektif sebagai antibakteri. Penelitian ini untuk mengetahui efektivitas antibakteri minyak kemiri terhadap bakteri Staphylococcus aureus setelah diformulasikan dalam sediaan gel Hand sanitizer pada 3 formula dengan konsentrasi F1=5%, F2=10% dan F3=15%. Penelitian ini adalah penelitian eksperimental. Untuk mengetahui efektivitas anti bakteri minyak kemiri (Aluerites moluccana) terhadap bakteri Staphylococcus. aureus setelah diformulasikan kedalam sediaan gel Hand sanitizer. Penelitian ini menunjukkan bahwa pada formulasi F3 dengan kosentrasi 15% dapat menghambat aktivitas bakteri Staphylococcus aureus dengan zona hambat sebesar 19 mm dengan hasil sediaan gel yang homogen, pH sebesar 5 mendekati pH kulit, tidak mengiritasi kulit dan daya sebar menunjukkan hasil yang merata ke seluruh permukaan kulit yaitu 5 cm. Terdapat penghambatan bakteri Staphylococcus aureus setelah minyak kemiri (Aleurites moluccana) diformulasikan kedalam sediaan gel Hand sanitizer.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125954363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ETHANOL EXTRACT LIQUID SOAP FORMULATION LEAVES OF CELERY (Apium graveolens L.) AGAINST Escherichia coli BACTERIA 芹菜叶乙醇提取液皂配方对抗大肠杆菌

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-28 DOI: 10.35451/jfm.v5i2.1584

R. Irwanto, Santa Dewi Apriani Girsang, Wira Maria Ginting, R. Novia

{"title":"ETHANOL EXTRACT LIQUID SOAP FORMULATION LEAVES OF CELERY (Apium graveolens L.) AGAINST Escherichia coli BACTERIA","authors":"R. Irwanto, Santa Dewi Apriani Girsang, Wira Maria Ginting, R. Novia","doi":"10.35451/jfm.v5i2.1584","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1584","url":null,"abstract":"Dirty hands will be a source of disease. Soap is a pharmaceutical preparation used to maintain health. Celery (Apium graveolens L.) is a plant of the Apiaceae tribe with a distinctive menthol aroma. This study aimed to determine the inhibitory power of celery leaf extract formulation (Apium graveolens L.) as an antibacterial hand-washing soap. This research method is a type of experimental research. The stages of the research were collecting samples, identifying plants, making simplicia, characterizing simplicia, screening phytochemicals, making extracts and making hand soap formulations of celery leaf extract (Apium graveolens L) at concentrations of 5%, 10%, 15% and antibacterial testing of celery leaves, against Escherichia coli bacteria. The results showed the celery leaf extract soap formulation contained phytochemical compounds of flavonoids, tannins and saponins. The organoleptic test found that the best soap formulation was the F2 formulation with a concentration of 10% at an average level of preference value, namely 3.67 for colour, 3.27 for aroma, and 3.80 for texture. The homogeneity test performed showed that all formulations produced soap with good homogeneity. The height and stability test of the resulting celery extract soap foam ranged from 61-71 mm. The irritation test of the resulting celery extract soap also showed no irritation for all the formulations. The value of the antibacterial activity test found that the F1 formulation showed antibacterial activity with an inhibition zone diameter of 3 (weak), F2 with an inhibition zone of 9 (moderate) and F3 with the antibacterial activity of 12 (strong).","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125355222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACTIVITY TESTS OF ANTIBACTERIAL CREAM OF BAY LEAF (Syzygium polyanthum) ETHANOL EXTRACT AGAINST BACTERIA Propionibacterium acnes 月桂叶乙醇提取物抑菌乳膏对痤疮丙酸杆菌的抑菌活性试验

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-28 DOI: 10.35451/jfm.v5i2.1659

Debi Dinha Octora, D. Sari

{"title":"ACTIVITY TESTS OF ANTIBACTERIAL CREAM OF BAY LEAF (Syzygium polyanthum) ETHANOL EXTRACT AGAINST BACTERIA Propionibacterium acnes","authors":"Debi Dinha Octora, D. Sari","doi":"10.35451/jfm.v5i2.1659","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1659","url":null,"abstract":"Bay leaf (Syzygium polyanthum) is a plant that is widely used as a flavor enhancer. Based on research that has been done, bay leaves contain flavonoids, alkaloids, tannins, and saponins that have the ability to act as natural antibacterial agents. Improper use of antibiotics in the treatment of infections can cause resistance, so it is necessary to use antibiotics from natural ingredients that have an optimal working power and are relatively safe. P. acnes is one type of bacteria that can cause acne. The purpose of this research is to find out the effective antibacterial activity of bay leaf ethanol extract cream preparation against P. acnes bacteria. This research is an experimental research with 3 different concentration variations. The research results show that there is antibacterial activity at each concentration with an average diameter of the clear zone of 10.06 mm, 14.4 mm and 20.16 mm, the higher the concentration of EEDS, the higher the inhibitory power against P. acnes bacteria growth. The conclusion of the activity of salam leaves with a concentration of 5%, 10%, and 15% provides the most effective inhibition of bacterial growth with a concentration of 10%, 15% which is included in the strong category. Suggestions are expected to the next researcher to be able to test other bacteria and make a greater concentration than the previous research from EEDS.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115352076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TESTING OF THE EFFECTS OF BALAKACIDA (CHROMOLAENA ODORATA L.) LEAF EXTRACT OINTMENT ON WOUND HEALING IN GUINEA PIGS balakacid (chromolaena odorata l .)的药效试验叶提取物软膏对豚鼠伤口愈合的影响

JURNAL FARMASIMED (JFM) Pub Date : 2023-04-28 DOI: 10.35451/jfm.v5i2.1530

Vani Silvia Rosa, Fenny Hasanah, Desy Natalia Siahaan

{"title":"TESTING OF THE EFFECTS OF BALAKACIDA (CHROMOLAENA ODORATA L.) LEAF EXTRACT OINTMENT ON WOUND HEALING IN GUINEA PIGS","authors":"Vani Silvia Rosa, Fenny Hasanah, Desy Natalia Siahaan","doi":"10.35451/jfm.v5i2.1530","DOIUrl":"https://doi.org/10.35451/jfm.v5i2.1530","url":null,"abstract":"Kulit ialah area terbesar tubuh yang berguna untuk melindungi tubuh dari bahaya kimia dan fisik seperti goresan, luka yang terinfeksi, dan luka bakar. Luka yakni hilangnya atau rusaknya beberapa jaringan tubuh. Daun balakacida (Chromolaena odorata L.) memiliki getah dan air yang berkhasiat menyembuhkan luka, dapat menghentikan pendarahan pada luka dan lecet dengan cukup cepat. Metode pada penelitian ini yakni eksperimental. Pembuatan ekstrak etanol daun balakacida didapat melalui maserasi dengan pelarut etanol, selanjutnya diformulasikan pada salep dengan ekstrak etanol daun balakacida pada berbagai konsentrasi 5%,7,5%,10%, selanjutnya dilakukan perbandingan dengan kontrol positif (Betadine) serta kontrol negatif (Basis salep). Hasil skrining yang didapat menyatakan ekstrak etanol daun balakacida mengandung senyawa tanin, flavonoid, saponin, alkoloid serta triterpenoid/steroid. Hasil penelitian yang diperoleh sediaan salep ekstrak etanol daun balakacida dengan konsentrasi 5%,7,5%, serta 10% mampu menyembuhkan luka sayat pada marmut. Semua konsentrasi telah menunjukkan kemampuan menyembuhkan luka sayat. Ekstrak etanol daun balakacidayang memberikan efek terbaik pada penyembuhan luka yakni konsentrasi 10%.","PeriodicalId":326319,"journal":{"name":"JURNAL FARMASIMED (JFM)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134228770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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