Iraq Medical Journal最新文献

{"title":"Association between genotyping of transforming growth factor Beta 1 with oxidative status in type 2 diabetic nephropathy Complications","authors":"","doi":"10.22317/imj.v5i2.995","DOIUrl":"https://doi.org/10.22317/imj.v5i2.995","url":null,"abstract":"Objectives: To assess the association between Transforming Growth Factor β1 gene polymorphism (T869C) and type 2 diabetes mellitus with and without nephropathy complications with endogenous antioxidant reduced glutathione levels in type 2 diabetic patients with/without nephropathy complications of Kerbala province: Iraq. Methods: A case-control study was performed at which 100 patients with diabetic nephropathy, 100 patients with only type 2 diabetic and another 100 apparently healthy individuals as control were recruited. Fasting blood glucose, HbA1c%, urea, creatinine and glutathione were measured by spectrophotometric methods using enzymatic procedures. Transforming growth factor β1 gene was genotyped for the T>C (T869C) SNP by PCR-ARMS technique. Results: The genotype and allele frequencies of TGFβ1 gene polymorphism in type 2 diabetes mellitus, type 2 diabetic nephropathy, and control were examined. The transforming growth factor β1 (T869C) C allele, TC and TC + CC genotypes were significantly higher in patients; the T allele and TT genotype were significantly higher in controls (P ≤ 0.001). Glutathione give also a significant result in diabetic patients with and without nephropathy in when compared with controls. Conclusion: The observed data indicated that TGFβ1 (T869C) codon 10, allele C, and C allele-containing genotypes may be susceptible, and the T allele / TT genotype may be protective factors for type 2diabetic nephropathy complications. The results of glutathione showed that it may be one of the causes of presence high oxidants compounds, which is lead to the damage and destruction of mutations in the DNA of the cell.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85830372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation of thyroid diseases with anemia among Iraqi patients","authors":"Hadi M. A. Al-Mosawi, E. A. Abbas","doi":"10.22317/IMJ.V5I1.1024","DOIUrl":"https://doi.org/10.22317/IMJ.V5I1.1024","url":null,"abstract":"Objective: To assess the relation between types of thyroid diseases with types of anemia. Methods: This prospective study of 123 cases of patients with different thyroid goiters. The blood samples were collected and complete blood count was done for them, each patient with low PCV (<35%) the blood film was done for them to classify the type of anemia. Surgical operation thyroidectomy, paraffin block and hematoxylin and eosin stain was performed, the slides assess and read by pathologist to classify the thyroid goiter to (thyroiditis, thyroid tumor, multinodular goiter) other the causes of anemia are excluded by history like (vaginal bleeding, gastric bleeding, hemorrhoid). Results: Among 123patients, 84 patients with thyroid diseases without anemia, 39 patients with thyroid diseases had anemia, 21 patients with thyroid diseases had iron deficiency anemia, 18 patients with thyroid diseases had anemia of chronic diseases. Conclusion: Most common type of anaemia in different thyroid diseases is iron deficiency anaemia (IDA), the common age group of anaemia and thyroid diseases is middle age (40-49) years. The female incidence of anemia and thyroid diseases is more in female than male and the multinodular goiter (MNG) is the common thyroid diseases.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90799038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use, Knowledge and perception About Ketogenic Diet Amongst University Students from Medical and Health Sciences Faculties","authors":"","doi":"10.22317/imj.v5i1.953","DOIUrl":"https://doi.org/10.22317/imj.v5i1.953","url":null,"abstract":"Objectives: This study aimed to determine the use, knowledge and perception amongst medical students at An-Najah National University. Methods: a cross-sectional study has been followed to collect data from students of Faculty of Medicine and Health Sciences using electronic questionnaire in October 2020. The questionnaire was consisted of 5 sections regarding; sociodemographic variables, dietary information, usage of KD, knowledge and perceptions toward KD. Differences between KD users and non-users and with associations to knowledge and perceptions were statistically analysed using Chi square. While independent samples t-test and ANOVA test were conducted to examine the differences for the total score of the KD knowledge. Results: Total respondent were 227 students with 71.8% were females. The mean age was 20±3 and ranged from 18–24-year-old. More than half of the participants have used a kind of diet mainly for weight management with only 7.5 % were using KD for an average of 6 months, half of the students referred to social media as a source of nutritional information while only 25.6% of the participants has attended nutrition related courses at the university. Overall, the students’ knowledge regarding KD was low 3.4 ±3.6 out of 15. However. Faculty of Medicine, third and fourth year of study, KD-user and overweight/obese students have scored significantly higher. The majority of the participants have viewed KD as not easy to be followed and need medical supervision. The relationship between the knowledge score and the perception items has shown significant differences in all perception items. Meaning that positive perception has improved as knowledge has increased. Conclusion: the results have confirmed that knowledge amongst medical students with regard to KD was low. Sociodemographic variables were not associated with the knowledge scores however, having attended a nutrition course has improved both the knowledge and perception towards KD. Similar studies are warranted to implement nutritional courses in medical curriculum.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80999932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical spine fractures in multiple injured patients in Kurdistan Region, Iraq","authors":"Rabeea Muneer Ahmed Al-Tayyar","doi":"10.22317/imj.v5i1.1029","DOIUrl":"https://doi.org/10.22317/imj.v5i1.1029","url":null,"abstract":"Objectives: The aim of study to describe the main types of cervical spine fractures presented to the emergency department and to illustrate the main aspects of management and outcome. Methods: This is a prospective study of 72 patients with cervical injury out of 932 male patients with history of multiple injuries. All patients with cervical spine injury were admitted within 1 week of injury and follow up thereafter by regular outpatient visit. Cervical spine injuries were diagnosed by full radiological assessment according to NEXUS criteria (plain x-ray with lateral, anteroposterior, odontoid views in addition to cervical spine C.T for indicated patients) and evaluated neurologically. Results: Mean age of patients at time of accident was 25 years ranging from 7-73years, 50% of them were in the third decade of life. Road traffic accidents constitute 58.3% of causes of cervical injury followed by fall from height (19.5%). Results has shown that mid and lower cervical spine injuries constitute 87.5% of all types of vertebra involved while upper cervical spine injuries constitute only 12.5% of them. Associated injuries were found in 42 patients (58.3%) and the most common associated injury was cerebral concussion. 50% of patients had no history of neural deficit at time of admission, while the others had neurological abnormalities (27.7%) of them with complete deficit at time of admission. The most common type of skeletal injury was wedge fracture (28 patients, 38.8%), followed by spinous process fracture and burst fracture (18 patients, 25% and 12 patients, 16.6%) respectively. Respiratory complications were the most common in our series (12 patients of 72, 16.6%) followed by an equal share of urinary tract infection and neck pain (7 patients, 9.7%). Conclusion: Traffic accident constitutes the main reason for cervical spine fractures followed by falls. Cervical spine fractures affect the younger age group with mean age of 25 year. A collar is sufficient treatment for more un displaced fractures. Seat belt is one of the restrains that shares in reduction of fatality and severity of cervical spine injuries.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84884643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic evaluation of pulmonary vascular resistance in patients with type2 diabetes mellitus concerning diabetic duration and HbAlc level and its effect on the right ventricular function","authors":"J. Hassan, Basim Shanin Jasim, Aqeel Jassim Mehammed","doi":"10.22317/IMJ.V5I1.996","DOIUrl":"https://doi.org/10.22317/IMJ.V5I1.996","url":null,"abstract":"Objective: The study aims to non-invasive assessment of PVR by echocardiography in type 2 DM and its relation to duration of DM and HbAIc level and association of PVR to RV systolic and diastolic function. Methods: This cross-sectional comparative and analytic study was conducted on 62 consisting of patients with type 2 diabetes mellitus without a history of hypertension, established coronary artery disease, and chronic obstructive pulmonary disease. All diabetic patients were studied for age, sex. BMI, HbAlc level, and duration of diabetes, and echocardiography was performed to assess PVR systolic (TAPSE.MPI) and diastolic (E/A, E/ē) function of RV. Results: The study reveals there is no significant difference in PVR RV systolic and diastolic function concerning HbAIc level and DM duration. While there is significantly higher PVR and significantly lower TAPSE and E/A in DM (p<0.05) in comparison with normal control subjects. In correlation of PVR with systolic and diastolic function of RV, there were showed a strong negative relationship between PVR and systolic function and weak positive relationship with diastolic dysfunction P-value <0.05. Conclusion: significant-high pulmonary vascular resistance in type 2 DM and inverse correlation to systolic function and linear correlation to diastolic dysfunction of the right ventricle, while there is no relation of PVR to Hb Alc level and duration DM.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84444202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Protein Kinase C –B Isoform Level and Insulin Resistance in Pathogenesis of Iraqi Patients with Type 2 Diabetic Nephropathy Complications","authors":"Zahraa Abdul Adheem Al-Maiyaly, F. J. Al-Tu’ma, A. F. Al-Tu’ma","doi":"10.22317/imj.v5i1.980","DOIUrl":"https://doi.org/10.22317/imj.v5i1.980","url":null,"abstract":"Objective: The aim of the present study is to evaluate the association between serum PKC-B isoform activity levels and various biomarkers such as insulin resistance in sera of Iraqi patients with diabetic nephropathy complications. Methods: A cross-sectional study was performed on 100 samples obtained from Al-Hussein Teaching Hospital, Al-Hussein Medical City, Kerbala Health Directorates / Kerbala – Iraq during Nov., 2019 to Sep. 2020. Thirty patients have type 2 diabetic nephropathy, 40 patients with type 2 diabetic without nephropathy and 30 samples as apparently healthy control. Biochemical data, comprising serum PKC-B level, lipid profile, blood glucose, insulin, HOMA-IR and renal function tests such as urea, creatinine and GFR were investigated. Results: The study included 63% male and 37% female. The results indicated that there was a significant difference in blood glucose, HbA1c%, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), urea, creatinine, GFR and PKC-B between diabetic nephropathy and non-diabetic nephropathy groups (P-value <0.05). Serum PKC-B activity was significantly correlated with blood glucose, HOMA-IR, creatinine and GFR among diabetic nephropathy group, while, HbA1c% and blood glucose was positively correlated with PKC-B level in non-diabetic nephropathy group. Conclusion: The observed data conclude that PKC-B level is higher in patients with diabetic nephropathy complication as compared with T2DM and healthy control. Also there is a significant correlation between PKC-B level and renal function tests in DN group which indicate an important role of PKC-B level in pathogenesis of diabetic nephropathy complications.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72429595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of intestinal metaplasia and its relation to Helicobacter pylori infection in Iraq","authors":"Refka M. Al-dahhan, Muhsin A. Sahib","doi":"10.22317/IMJ.V5I1.1025","DOIUrl":"https://doi.org/10.22317/IMJ.V5I1.1025","url":null,"abstract":"Objectives: The aim of this study was to investigate the prevalence of intestinal metaplasia and its relation to H. Pylori infection, gastric atrophy, ulcer, age and gender in patients underwent esophagogastroduodenoscopy and gastric biopsy for upper gastrointestinal symptoms. Method: 200 gastric biopsy blocks examined for patients underwent esophagogastroduodenoscopy (EGD) and gastric biopsy, between January 2019 October 2020 at Gastroenterology and hepatology Hospital / Medical city / Baghdad / Iraq. Result: (67.5%) of patients examined in the study had H. pylori infection, while (20.5%) of the total number patients in the study had gastric intestinal metaplasia. There was significant association between Intestinal metaplasia with both active chronic inflammation and intestinal atrophy but there was no significant association between Intestinal metaplasia with both ulcer and H. pylori infection. Conclusion: gastric intestinal metaplasia encountered more in old age male patients with gastric atrophy and it is not solely related to h pylori, other risk factors could be responsible for it.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87848439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity of crude henna extract against Gram-positive bacteria","authors":"Samira M. S. Ibrahim, Chiman S. Rasool, Asaad Ab. Al-Asady","doi":"10.22317/imj.v5i3.1036","DOIUrl":"https://doi.org/10.22317/imj.v5i3.1036","url":null,"abstract":"Objectives: This study aimed to examine the effect of ethanolic extract of local Basra henna leaves on Gram-positive bacteria species. Also, to assess the antibacterial properties of henna crude extract in vitro and compare them with antibiotics. Methods: In this study, Lawsonia inermis (henna) leaves were extracted with ethanol using the solvent extraction technique. The pathogens were isolated from wound samples obtained from hospitalized patients in two different hospitals in Duhok city. The culture of thirty isolates had been recognized by routine methods. Different concentrations of ethanol crude extract were acquired and bio-assayed in vitro to inhibit the growth of five human pathogenic Gram-positive bacteria. Agar well diffusion assay was used for achieving henna antibiotic activity. Moreover, an antibiotics susceptibility test was done by the disk diffusion method using the Muller-Hinton agar medium. Results: The growth of all tested bacteria was suppressed to various degrees by increasing the concentration of the extract. The data has revealed that Staphylococcus aureus was more sensitive than other examined isolates, where the diameter zone of inhibition was ranging from 16-27, 14-25, and 8-18 mm for Staphylococcus epidermidis, Lactobacillus spp. and Streptococcus pneumonia respectively. The antimicrobial activity of henna extract indicates that it is suitable for being used as significant certain medications. Consequently, henna is active to serve as an anti-bacterial agent against multi-drug resistant Gram-positive bacteria. Conclusion: The antimicrobial activity of henna extract indicates that it is suitable for being used as significant certain medications. Consequently, henna is active to serve as an anti-bacterial agent against multi-drug resistant Gram-positive bacteria.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79144930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ewing sarcoma of the kidney; a rare case report","authors":"Anmar Alharganee, Haydar Alabidi, Sarah Al-Kubaisi","doi":"10.22317/IMJ.V4I3.878","DOIUrl":"https://doi.org/10.22317/IMJ.V4I3.878","url":null,"abstract":"Kidney cancer is considered as one of the commonest urological malignancies globally. Primitive neuroectodermal tumor and ewing sarcoma pathology are commonly found  bone  cancers within the daily clinical practice especially in adulthood. \u0000In this article we will discuss a rare case report of ewing sarcoma family variant (ESFV) within the renal pelvis. Chemotherapeutic and radiation protocols already used in bone ewing sarcoma have been exploited to treat this variant pathological malignancy in the kidney considering the metastatic presentation of the case. Hence, the response to some of these management lines  was obvious during follow up appointments. Unfortunately, side effects were so severe especially the hematological adverse events. By conclusion, the administration of the same protocols as for bone ewnig sarcoma should be discussed carefully in treatment selection.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75161762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Prevalence and Pattern of Infections in Acute Exacerbations of Obstructive Airway Disease","authors":"C. Rao, Saswat Subhankar, Vivek D. Alone, D. P. Dash, J. Sabat","doi":"10.22317/IMJ.V4I3.879","DOIUrl":"https://doi.org/10.22317/IMJ.V4I3.879","url":null,"abstract":"Objective: To study the prevalence and pattern of infections causing exacerbations of obstructive airway diseases. \u0000Methods: A prospective cross sectional study which included 126 consecutive obstructive airway disease patients were enrolled for the study. All the included patients were subjected to detailed history, clinical examination and routine investigations including sputum Gram’s stain and aerobic culture after obtaining a written informed consent. Pharyngeal swab was collected and sent in Viral Transport Medium(VTM, Himedia) within 24hrs to Regional Medical Research Centre (ICMR),Bhubaneswar for detection of respiratory viruses. Samples were tested by Real Time reverse-transcription polymerase chain reaction (RT-PCR). \u0000Results: Among patients with COPD, Flu A/H3N2(9.375%) was found in highest number of patients followed by rhinovirus(7.3%). In bronchial asthma patients,virus was isolated only in 3 cases(13.6%).No virus was detected in bronchiectasis patients. Isolated bacterial infection was detected in 26 cases (20.63%).Acinetobacter baumanii and Klesiella pneumoniae were most common bacterial pathogens detected.Bacterial pathogens were commonly isolated among COPD patients.Co-infection with both bacteria and virus was detected in 12 patients (9.52%)of which 11 were diagnosed with COPD. Only 1 case of bronchial asthma reported a co-infection.Among cases with co-infection with both bacteria and virus,Acinetobacter baumanii and  Pseudomonas aeruginosa were found to be most common bacterial pathogens.There was no typical pattern in viral infection among the cases throughout the year. \u0000Conclusion: The risk of exacerbation due to viral etiology is perennial but might be self limiting. Recovery from exacerbation takes a long time and patients with exacerbations have an impaired quality of life, diminished exercise capacity and loss of lung function.","PeriodicalId":32555,"journal":{"name":"Iraq Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82460765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}