Tropical Journal of Phytochemistry and Pharmaceutical Sciences最新文献

{"title":"Effect of Ethanol and N-Hexane Combined Extracts of Selected Plants on Liver Enzymes in Wistar Rats","authors":"","doi":"10.26538/tjpps/v2i4.4","DOIUrl":"https://doi.org/10.26538/tjpps/v2i4.4","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"37 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutraceuticals: A Remedy to Various Maladies","authors":"","doi":"10.26538/tjpps/v2i4.1","DOIUrl":"https://doi.org/10.26538/tjpps/v2i4.1","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"120 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antioxidant Activity of the Stem Bark Extracts of Anacardium occidentale (Linn) Anacardiaceae","authors":"","doi":"10.26538/tjpps/v2i2.4","DOIUrl":"https://doi.org/10.26538/tjpps/v2i2.4","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"243 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134269239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Phytochemical Composition and Functional Group Detection of Annona muricata Linn Seeds and Leaves","authors":"","doi":"10.26538/tjpps/v2i2.3","DOIUrl":"https://doi.org/10.26538/tjpps/v2i2.3","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128442235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Phytochemical and Antioxidant Properties of Cold, Hot Water and Wine Extracts Produced from Ficus capensis Leaf","authors":"","doi":"10.26538/tjpps/v2i2.1","DOIUrl":"https://doi.org/10.26538/tjpps/v2i2.1","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121993729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Aqueous Leaf Extract of Justicia carnea on Hematological Parameters of Male Wistar Rats Exposed to Thioacetamide","authors":"","doi":"10.26538/tjpps/v2i2.2","DOIUrl":"https://doi.org/10.26538/tjpps/v2i2.2","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115093102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Assessment and Antimicrobial Investigation of Pure Compound; 3,5,6,7- Tetrahydroxy-19-Vouacanoic Acid;(3β, 5α, 6β, 7β)-form,6,7-Dibenzoyl (Pulcherrimin A) Isolated from Caesalpinia pulcherrima Stem Bark","authors":"","doi":"10.26538/tjpps/v2i1.1","DOIUrl":"https://doi.org/10.26538/tjpps/v2i1.1","url":null,"abstract":"","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126328102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Function and Blood Pressure Regulation: From Bioenergetics to Pathophysiology","authors":"I. Igbe, O. Edosuyi","doi":"10.26538/tjpps/v1i1.2","DOIUrl":"https://doi.org/10.26538/tjpps/v1i1.2","url":null,"abstract":"The mitochondrion is the powerhouse of all living cells as it provides the energy needed to maintain obligatory regulatory functions.1 The generation of adenosine triphosphate (ATP) via oxidative phosphorylation underlies the principal role of the mitochondrion in cell survival. Aside this basic contribution to energy generation, the mitochondria has been established to regulate cell death (apoptosis), redox and ion signaling.2 The crosstalk between redox signaling and a myriad of pathological disorders created a nexus between the mitochondrion and the cardiorenal system.3,4 Similarly, the high distribution of mitochondria in organs of the cardiorenal system, meant that these organs such as the kidney, are subject to the effect of mitochondria-induced alterations in redox signaling.5 For instance, mitochondrial dysfunction has been linked to the pathophysiology of kidney disorders.6 Considering the intricate link between the kidneys and blood pressure regulation, mitochondrial dysfunction was suggested to contribute significantly to distortions in renal control of blood pressure. Recently, it was reported that the tricarboxylic acid (TCA) cycle plays a role in the etiology of genetic hypertension.7 This novel iscovery linked the activity of the TCA cycle enzyme, fumarase to a reduction in nitric oxide production and an upregulation in redox signaling in the renal medulla of salt-sensitive rats.7,8 In these animals, an innate mutation in the fumarase enzyme, reduced its activity and increased cellular levels of its substrate, fumarate. Hence, the role of these TCA cycle intermediaries was shifted from being ‘mere’ participants in the generation of energy to endogenous ligands with biochemical targets that alter renal function and by extension, blood pressure. Furthermore, fumarate was shown to reduce blood pressure and modulate the expression of genes that ameliorated hypertension induced renal damage in deoxycorticosterone acetate (DOCA) hypertension, a non-genetic form of hypertension.9 Subsequently, succinate, the upstream product of fumarate was reported to directly stimulate GPR91 receptors to increase blood pressure.10 These actions of fumarate and its intermediaries, exceed the renal system as reports have shown a cardioprotective role via upregulation of nuclear erythroid factor-2 (Nrf2).11 Fumarate is now known to regulate the expression of genes such as hypoxia inducible factor (HIF-1), transforming growth factor (TGF-β), kidney injury molecule (KIM-1) amongst others. What is evident from the foregoing is that the mitochondrion is no longer just an idle energy-generating center. It is now listed as a probable etiology in hypertension, and this has opened new vistas of possibilities as it relates to the pathophysiology of hypertension.8 Is it possible that these intermediaries are involved in the physiological control of blood pressure? Could they also be exerting direct vasoactive effects? Is it likely that they may be modulating the exp","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128297723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Physicochemical and Micromeritics Properties of Carboxymethylated Starches Derived from Vigna unguiculata Seeds and Pennisetum glaucum Grains with an Intermediate Degree of Substitution","authors":"Chukwuemeka P. Azubuike, Bukola A. Oseni, Amaeze I. Amaeze, Favour O. Isimoya, Cecelia I. Igwilo","doi":"10.26538/tjpps/v1i1.5","DOIUrl":"https://doi.org/10.26538/tjpps/v1i1.5","url":null,"abstract":"Conventional commercial sources of starch for industrial applications are mainly based on staple foods, due to the worsening economic situation, there is a need to explore other underutilized unconventional sources. This study aims to extract, modify, and characterize starch from unconventional sources: cowpea (Vigna unguiculata) seeds and pearl millet (Pennisetum glaucum) grains. Starch was extracted from cowpea seeds and pearl millet grains by milling and precipitation in sodium hydroxide solution and water respectively. Carboxymethylation of the starch was carried out using monochloroacetic acid. The native starch, modified starches, and commercial brand-sodium starch glycolate were subjected to physicochemical and micromeritic characterization as well as spectroscopic and thermal analysis. The starch yields of 16.01 and 46.60% were obtained from cowpea seeds and pearl millet grains respectively. Starch samples with an intermediate degree of substitution (0.52-0.60) were obtained from both sources. The starch samples complied with British Pharmacopoeia specification and carboxymethylation generally resulted in improved properties (reduced gelatinization temperature, increased swelling capacity and flow properties). The pearl millet was made of oval-shaped granules with higher starch yield, reduced moisture content, and improved flow than the owpea starch, however, the latter contained cuboid-shaped granules, had higher densities, and reduced redispersion time. Carboxymethyl functional group was introduced, and the structure of starch was intact upon modification. Carboxymethyl starches obtained from cowpea seeds and pearl millet grains have desirable properties and can be potential sources of low-cost excipients for pharmaceutical formulations.","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130424163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and Analgesic Investigations of Methanol Extract of Ganoderma lucidum","authors":"Osahon K. Ogbeide, Oscar N. Aghedo, Jeremiah O. Uadia","doi":"10.26538/tjpps/v1i1.4","DOIUrl":"https://doi.org/10.26538/tjpps/v1i1.4","url":null,"abstract":"Ganoderma lucidum is a popular woody and spongy mushroom (fungi) widely distributed throughout the world. It is commonly used in the production of nutriceuticals, functional foods and also serves as a therapeutic herb used in the treatment of several diseases. This study was aimed at evaluating the phytochemicals, proximate composition, antioxidant, anti-inflammatory and analgesic activities as well as acute toxicity of the crude methanol extract of G. lucidum. The phytochemicals, proximate composition and antioxidant potential were determined using already established methods. The formalin-induced inflammation and acetic acid-induced writhing techniques were applied to evaluate the anti-inflammatory and analgesic activities respectively. Phytochemicals detected were saponins, flavonoids and terpenoids. The moisture content, acid insoluble ash, water soluble ash, total ash, alcohol extractive value and water extractive value were 12.53 ± 0.18%, 1.45 ± 0.21%, 2.68 ± 0.51%, 3.31 ± 0.2%, 1.41 ± 0.00% and 1.07 ± 0.01% respectively. The IC50 values for the DPPH radical scavenging capacity of the extract and ascorbic acid standard) were 31.56 ± 1.30 and 18.84 ± 2.06 µg/mL respectively. The crude extract at the dose of 50 mg/kg body weight showed the highest % inhibition of edema after 4 hours and there was a significant decrease (p < 0.05) in the number of writhes in a dose dependent manner. In the oral administration of the crude extract to Swiss mice, 100% mortality was recorded at 5000 mg/kg. The study confirms that G. lucidum is a potential source of phytomedicine with substantial pharmacological and antioxidant properties but however, could be toxic at higher doses.","PeriodicalId":325370,"journal":{"name":"Tropical Journal of Phytochemistry and Pharmaceutical Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129704457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}