Eureka Herba Indonesia最新文献

{"title":"Analysis of the Chemical Content of Jamblang Bark (Syzygium cumin (L) Skeels) Using Gas Chromatography-Mass Spectrometry and Fourier Transform Infrared","authors":"Himyatul Hidayah, Windi Ikhtianingsih, S. Amal, Eureka Herba","doi":"10.37275/ehi.v4i4.93","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.93","url":null,"abstract":"Jamblang plant (Syzygium cumini (L.) Skeels) is a plant that has the potential as anticancer, antioxidant, anti-inflammatory, anti-allergic, antibacterial, hepatoprotective, gastroprotective, cardioprotective, antidiabetic, antihyperlipidemic. Jamblang plants contain chemical compounds of alkaloids, flavonoids, resins, tannins, and essential oils. This study aimed to identify the class of flavonoid compounds contained in jamblang leaf isolates using gas chromatography-mass spectrometry and Fourier transform infrared. The results of the identification of jamblang leaves showed that the isolate contained flavonoid compounds, the flavonol group, which also had 69 potential bioactive compounds.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"1 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125868724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness Test of Avocado Seed Extract (Persea Americana Mill.) in Inhibiting the Growth of Staphylococcus aureus Bacteria In Vitro","authors":"I. B. Siregar, Isnandar, Rahmi Syaflida Dalimunte, Prilisa Melenia","doi":"10.37275/ehi.v4i4.92","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.92","url":null,"abstract":"Staphylococcus aureus can cause several health problems in the oral cavity, including stomatitis, tooth abscess, soft tissue infections, gingivitis, and periodontitis. The exploration of new therapeutic modalities for Staphylococcus aureus infection is urgent. Staphylococcus aureus has developed resistance to many of the antibiotics commonly used to treat bacterial infections. This study aimed to determine the antibacterial effectiveness of avocado seed extract (Persea americana Mill.) in inhibiting bacterial growth of Staphylococcus aureus in vitro. This study is an in vitro study in which 28 petri dishes have been added with 1-2 oses of bacterial culture Staphylococcus aureus and MHA (Mueller Hinton Agar) were used in this study. There were 7 test groups, namely 0.2% chlorhexidine as a positive control (K1), negative control, DMSO (K2), avocado seed extract treatment group 2%, 4%, 6%, 8%, and 10% respectively as K3-K7. Treatment of avocado seed extract with a concentration of 6% has the ability to grow bacteria Staphylococcus aureus better than the bacterial growth ability of the positive control, chlorhexidine. The increase in extract concentration was in line with the increase in the diameter of the bacterial inhibition zone Staphylococcus aureus. Avocado seed extract (Persea americana mill.) showed effectiveness in inhibiting bacterial growth of Staphylococcus aureus in vitro. \u0000 ","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127306998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP2A6 Gene Polymorphism Allele *4 Study in Hypertensive Patients with a History of Smoking","authors":"Erica Kusuma Rahayu Sudarsono, Christine Patramurti","doi":"10.37275/ehi.v4i4.91","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.91","url":null,"abstract":"Nicotine is a specific CYP2A6 substrate found in cigarettes. Nicotine levels in the blood are affected by the metabolic rate of the CYP2A6 enzyme, which is known to have a high level of polymorphism. High levels of nicotine in the blood can result in an increased risk of cardiovascular disease through the mechanism of increasing lipolysis and causing an increase in triglyceride levels in the blood. This study is an observational study conducted on 31 hypertensive men with a history of smoking. The purpose of this study was to determine the frequency of the CYP2A6 allele *4 genes in hypertensive patients with a history of smoking. Result analysis was performed on PCR products using electrophoresis, then the frequency of each allele was determined. The results showed that there was a CYP2A6 allele *4 gene in hypertensive patients with a history of smoking in Yogyakarta with an allele frequency of 62.90%, and only 2 respondents (6.45%) had the CYP2A6*1/*1 genotype or wildtype.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130089416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Environmental Sanitation and Socio-Cultural of Coastal Communities in Fishing Village, Medan Belawan District, Indonesia","authors":"Amalia Rahmi Nasution, Romiza Arika, Cut Nasywa, Kesuma Dany, M. Sri, Rezeki Dalimunthe, Desri Amrainum, Ella Fauziah, Fatma Salsabila, Indah Rizqika, Mayumi Ershanda, Muhammad Subhan","doi":"10.37275/ehi.v4i4.90","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.90","url":null,"abstract":"An overview of environmental and socio-cultural sanitation is very interesting to explore. Environmental sanitation and the social culture of coastal communities in fishing villages are inseparable aspects of their daily lives. This study aimed to understand the description of environmental sanitation and socio-culture of the coastal community of fishing village, Medan Belawan District, Indonesia, in order to create sustainable and equitable solutions for them. This study is a descriptive observational study. A total of 100 informants were included in this study. Data analysis was carried out univariately to present environmental sanitation and socio-cultural data. Waste processing in the environment is still very bad, where garbage is generally just piled up, and no waste management efforts are carried out. The community also does not have healthy latrines, which shows that sanitation conditions are still not a good report. The majority report also does not have refrigerators as food storage, and the community, in general, has not implemented a clean and healthy lifestyle. The source of clean water and processed drinking water treatment also still show things that are not good. Water sources and processing that are not optimal make the majority of people experience skin problems. The overview of environmental sanitation and the socio-culture of coastal communities in fishing villages shows how important it is to increase efforts to keep the environment clean and maintain cultural values in their daily lives.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124422896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Effervescent Granules Ethanol Extract of Andaliman Fruit (Zanthoxylum acanthopodium DC) with Combination of Citric Acid-Tartaric Acid and Sodium Bicarbonate","authors":"Olivia Laurent, Tia Triyanti, Dika Suranda, L. Chiuman","doi":"10.37275/ehi.v4i4.89","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.89","url":null,"abstract":"The combination of citric acid-tartaric acid and sodium bicarbonate in effervescent granules has an important role in providing an effervescent effect. Citric acid and tartaric acid are organic acids that can react with sodium bicarbonate when they come in contact with water. This reaction results in the release of carbon dioxide gas, which has a splitting effect and makes the effervescent granules dissolve rapidly in water. Research on the formulation and evaluation of effervescent granules of andaliman fruit ethanol extract with a combination of citric acid-tartaric acid and sodium bicarbonate aims to optimize the stability, solubility, and release of the active ingredients from the granules. This study is an experimental research. Evaluation of effervescent granules is carried out in the form of an organoleptic test. This test can be observed directly from the granules through the shape, color, aroma, and taste produced. Granular specific gravity test, namely real specific gravity, compressed specific gravity, flow rate test, angle of repose test, and compressibility. Tests for dispersion time and pH tests were carried out in this study. FI, FII, and FIII meet the requirements of the organoleptic test, compressibility, flow rate, angle of repose, dispersion time, and pH test. Even though the pH test for the 3 formulas found a pH range of 5.5 to 5.7, but still declared to meet the requirements because it is still close to neutral pH. The best influence on the physical properties of granules effervescent, namely in FIII, as seen in the organoleptic test, flow rate, angle of repose, and dispersion time.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131349719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Physical Evaluation of CTM Tablets by Direct Compression Method: A Systematic Literature Review","authors":"Astriani Nurjanah, Neni Nurlelah","doi":"10.37275/ehi.v4i4.88","DOIUrl":"https://doi.org/10.37275/ehi.v4i4.88","url":null,"abstract":"The direct compression method is one of the well-known formulation approaches in tablet manufacture. In this method, the active ingredients and additives of the formulation are mixed together and then compressed into tablets using a special device such as a compression machine. This study is a systematic review that aims to explore the formulation and physical evaluation of CTM tablets by direct compression method. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the formulation and physical evaluation of CTM tablets by direct compression method. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. The direct compression method enables the manufacture of CTM tablets in a single production step, reducing the complexity and time required. The CTM tablet formulation process using the direct compression method involves homogeneous mixing of the raw materials and direct compression of the mixture into tablets using a compression machine. The direct compression method has advantages in production efficiency, simplicity, and cost-effectiveness, controlling the dosage of the drug contained in the tablet, and physical uniformity of the tablet. However, the direct compression method also has drawbacks, such as the risk of material segregation, difficulty in achieving controlled drug release, and the potential for direct effects on the active ingredients. Physical evaluation of tablets involves measuring the weight, thickness, and diameter of the tablets, as well as hardness or compressive strength tests to ensure the physical quality of the tablets produced. Drug release tests and dissolution tests were carried out to ensure that the CTM tablets released the drug consistently and under control according to regulatory requirements. Stability tests and chemical tests were carried out to check the physical and chemical changes of the tablets during storage and to ensure the integrity and purity of chlorpheniramine.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134150070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Using Jengkol Peel Extract (Pithecellobium lobatum Benth.) in Inhibits Bacterial Growth Staphylococcus aureus In Vitro","authors":"I. B. Siregar, Gostry Aldica, Dohude, Rahmi Syaflida Dalimunte, A. Rachma, Z. Amani","doi":"10.37275/ehi.v4i3.87","DOIUrl":"https://doi.org/10.37275/ehi.v4i3.87","url":null,"abstract":"Staphylococcus aureus is aerobic bacteria that are gram-positive and are one of the normal human flora on the skin and mucous membranes. Most infections in the oral cavity are caused by Staphylococcus aureus, which is a normal flora in the oral cavity that can turn into a pathogen if trauma or abrasion occurs on the mucosal surface. Jengkol peel is thought to contain tannin compounds, which have the potential as an anti-inflammatory, anti-diarrheal, antioxidant, treatment of infections of the skin and mouth, and treatment of burns. This study aimed to explore the potential of jengkol peel extract (Pithecellobium lobatum Benth.) as an antibacterial Staphylococcus aureus regularly in vitro. This study is an experimental research in vitro, where as many as 7 treatment groups were used in this study. Positive and negative controls and extract concentrations of 5%-80% were used as the treatment group. Analysis of the average diameter of the inhibition of bacterial growth was carried out using SPSS version 25 software. The potential inhibition of jengkol peel extract was in line with the increase in the concentration of jengkol peel extract. The higher the concentration of jengkol peel extract, the greater the inhibition of bacterial growth. Extract concentration of 20% has a comparable inhibition of bacterial growth control positive. Jengkol peel extract effectively inhibits the growth of Staphylococcus aureus bacteria. Jengkol peel extract concentration of 20% has effectiveness in inhibiting bacterial growth equivalent to 0.2% chlorhexidine in vitro.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123839858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pharmacological Activity of Jamblang Plant (Syzygium cumini (L) Skeels) Based on Solvent Polarity: A Systematic Literature Review","authors":"Tia Laelasari, Ghofaro Nurul Azzahro, Muhammad Zein Latif, Himyatul Hidayah","doi":"10.37275/ehi.v4i3.86","DOIUrl":"https://doi.org/10.37275/ehi.v4i3.86","url":null,"abstract":"In recent years, there has been growing interest in the potential medicinal benefits of Syzygium cumini. This is due in part to the plant's rich content of antioxidants, flavonoids, and other phytochemicals. These compounds have been shown to have a variety of beneficial effects, including antidiabetic, anti-inflammatory, and anti-cancer properties. The solvent plays an important role in the extraction of compounds from Syzygium cumini. This study aimed to conduct a systematic review to explore the potential of jamblang plants (Syzygium cumini) based on solvent polarity. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the potential of jamblang in medicinal uses based on solvent polarity. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. The solvent plays an important role in the extraction of compounds from Syzygium cumini. The solvent must be able to dissolve the target compounds, but it must not also dissolve other compounds that are not desired. The solvent must also be compatible with the plant material and the extraction method. The solvent must be of the same polarity as the target compounds. For example, polar solvents such as water and ethanol are good for extracting polar compounds, such as flavonoids and anthocyanins. Non-polar solvents such as acetone and methanol are good for extracting non-polar compounds, such as terpenes and steroids.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128612448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Activity Test of Gambas Fruit Extract (Luffa Acutangula (L.) Roxb.) against Bacterial Growth Staphylococcus Aureus In Vitro","authors":"Elwin Stanlee, Indra Basar Siregar, Olivia Avriyanti Hanafiah, Isnandar","doi":"10.37275/ehi.v4i3.85","DOIUrl":"https://doi.org/10.37275/ehi.v4i3.85","url":null,"abstract":"One aspect that needs attention in dental and oral health is bacterial infection, including infections caused by Staphylococcus aureus bacteria. Staphylococcus aureus is a type of gram-positive bacteria that can be found in various parts of the human body, including the skin and nasal mucus. These bacteria usually do not cause problems if they remain within normal limits. However, when Staphylococcus aureus enters the oral cavity or surrounding tissue, it can cause various dental and oral health conditions. Gambas fruit (Luffa acutangula (L.) Roxb.), which is also known as Oyong fruit from the Cucurbitaceae family, has an antibacterial effect. This study aimed to determine the antibacterial activity of the ethanol extract of Gambas fruit (Luffa acutangula (l.) roxb.) on bacterial growth of Staphylococcus aureus in vitro. This type of research is a laboratory experimental design post-test only control group. Research data were analyzed using testone-way ANOVA with post-hoc LSD. The results showed that there was an inhibition diameter at each concentration of Gambas fruit extract. 25% Gambas fruit extract has an average diameter of 10.8 mm, 12.5% Gambas fruit extract has an average diameter of 9.4 mm, 6.25% Gambas fruit extract has an average diameter of 8 mm, l Gambas fruit extract 3.125% has an average diameter of 6.9 mm. Gambas fruit extract has antibacterial properties with a minimum inhibition level of 25% against the bacterial growth of Staphylococcus aureus.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122004859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jamblang (Syzygium cumini (L.)): A Review of Its Flower and Medicinal Uses","authors":"Khusniyah, Muthia Oktaviani Rahayu, Nayla Robiatul Adawiyah, Himyatul Hidayah","doi":"10.37275/ehi.v4i3.84","DOIUrl":"https://doi.org/10.37275/ehi.v4i3.84","url":null,"abstract":"The Jamblang flower is a part of the plant that rarely gets attention in the process of exploring its properties. Jamblang flower is a part of the plant that is quite rich in antioxidant compounds. Antioxidants help protect the body's cells from oxidative damage and can help prevent various degenerative diseases such as heart disease, cancer, and premature aging. This study aimed to carry out a systematic review regarding the potential of Jamblang flowers (Syzygium cumini) in medicinal uses. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the potency of Jamblang flower (Syzygium cumini) in medicinal uses. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Jamblang flowers have interesting potential health benefits. The active compounds contained in Jamblang flowers, including antioxidants, anti-inflammatory compounds, and anticancer compounds, can provide health benefits for the body.","PeriodicalId":324796,"journal":{"name":"Eureka Herba Indonesia","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128459668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}