Acta Biomedica Scientifica最新文献

{"title":"Current concepts of Peyronie’s disease (clinical lecture)","authors":"K. B. Lelyavin","doi":"10.29413/abs.2023-8.4.15","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.15","url":null,"abstract":"The article is presented in the format of a lecture. Peyronie’s disease (induratio penis plastica) is a progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and can cause penile deformity. The issues of etiology, pathogenesis, clinical picture and diagnosis of Peyronie’s disease (PD) are reviewed in the lecture from the modern points of view. PD is frequently associated with penile pain, erectile dysfunction, and a secondary anxiety-depressive state. Despite the existence of this problem for several centuries, no unified concept of the Peyronie’s disease pathogenesis can be found in literature. A growing amount of research has shown that PD is a chronical disorder of local wound healing process within the tunica albuginea and the Smith’s space. Over the past 40 years, multiple lines of evidence have pointed to a genetic factor that predisposes some men to the development of Peyronie’s disease. Treating men with PD remains a challenging problem for clinicians working in urology. Given the high prevalence of PD and its significant impact on affected men, its better understanding is essential. Treatment methods for PD are varied and include oral, local, intralesional and traction therapy, and surgical treatment. Current clinical care standards for PD are aimed at the symptom suppression, as there are currently no treatment for PD that can eliminate its causes or progression. Clostridium histolyticum collagenase has shown its effectiveness in treating PD, but its efficacy and safety remain controversial. Surgery remains the most effective method for PD treatment and is considered to be “gold standard”. The choice of the surgical technique depends on the length of the penis, degree of deformity, erectile function, patients’ expectations and surgeon’s preferences. Various surgical techniques and grafting materials (autologous and non-autologous) can be used for the coverage of the tunica albuginea defect after partial plaque excision or incision.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135745163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the course of the gestational process using survey method and depending on the laboratory confirmed prenatal alcohol use (cross-section study)","authors":"A. Yu. Marianian, A. N. Kalkova, M. A. Rashidova, N. V. Semenova, A. V. Belskikh, E. V. Belyaeva, A. Yu. Sambyalova, A. V. Atalyan, D. P. Tiumentceva, A. B. Ilyina, L. I. Kolesnikova","doi":"10.29413/abs.2023-8.4.6","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.6","url":null,"abstract":"Background . Studying the problem of alcohol consumption by pregnant women using modern laboratory research methods has valuable theoretical and practical significance. The aim of the study . To determine the characteristics of the pregnancy course in women consuming alcohol in the prenatal period confirmed by survey and laboratory tests, depending on the phosphatidylethanol levels. Materials and methods . We examined 863 women under observation at the Irkutsk Regional Perinatal Center for the period from 2014 to 2021. To confirm the fact of alcohol consumption in the prenatal period, 545 women were surveyed, 318 women were examined using laboratory analysis. The diagnostic biomarker for alcohol was PEth:16:0/18:1. To assign pregnant women to the control group, a PEth concentration of ≤ 8 ng/ml was taken. If the PEth concentration was > 8 ng/ml, pregnant women were classified as heavy drinkers. Clinical and laboratory indicators of the course of pregnancy and childbirth were carried out in comparative groups. Results . It has been established that every second woman of reproductive age took alcohol before pregnancy. 24.2 % of women did not stop consuming alcohol in the prenatal period. At the same time, the risk of congenital malformations was high, since 20.4 % of women consumed alcohol in the first trimester of pregnancy. Based on the results of the survey, it was revealed that in women who consumed alcohol in the prenatal period, the following pathological conditions are statistically significantly more common: anemia, congenital heart defects in fetuses, prematurity of gestational age, labor anomalies, uterus subinvolution. Based on the results of laboratory confirmation of alcohol consumption, it was established that parity of birth, intrauterine growth retardation, and premature birth were statistically significantly more often in pregnant women who drink. Conclusion . Thus, in order to obtain the most meaningful and high-quality results, it is necessary to conduct larger studies. In addition, maternal blood biomarkers should be used to confirm levels of alcohol consumption throughout all trimesters of pregnancy.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135296065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related determinants of the metabolic syndrome in women of reproductive age of the main ethnic groups of the Baikal Region","authors":"L. V. Belenkaia, L. V. Suturina, M. A. Darenskaya, A. V. Atalyan, L. M. Lazareva, Ia. G. Nadelyaeva, N. I. Babaeva, L. F. Sholokhov, L. I. Kolesnikova","doi":"10.29413/abs.2023-8.4.5","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.5","url":null,"abstract":"The aim of the study . To determine the age limit of the initial manifestations of the metabolic syndrome in women of reproductive age of the Caucasian and Asian ethnic groups. Materials and methods . The study included women of reproductive age of the Russian and Buryat ethnic groups (n = 1231). We carried out general clinical examination, studied glycemia levels and lipid metabolism indicators. The analysis of the components of the metabolic syndrome was performed taking into account age characteristics and ethnicity. Threshold values for the age of metabolic disorders manifestation were determined. Results . It was found that the main components of the metabolic syndrome in women of reproductive age of the Russian and Buryat ethnic groups were a decrease in high-density lipoprotein (HDL), an increase in waist circumference, and an increase in blood pressure. The age-related determinants of the metabolic syndrome in the population of women of reproductive age in the Baikal region were determined. It was shown that the age-related determinants of the metabolic syndrome in Caucasian and Asian women do not differ significantly and amount to 33.5 years (95% confidence interval (95% CI): 32.5; 38.5) and 36.5 years (95% CI: 27.5; 52.5), respectively. A universal critical age value was determined as 34.5 years (95% CI: 32.5; 38.5), which is associated with a significant increase in the prevalence of the metabolic syndrome in accordance with the ATP III criteria. The ranking of metabolic syndrome criteria in the studied groups revealed the following order of their occurrence: the decrease in HDL index prevailed, followed by the increase in waist circumference, blood pressure, glucose and triglycerides; no dependence on the ethnicity was found. Conclusion . When assessing the age-related determinants of the metabolic syndrome in the mixed Caucasoid-Asian group, it is advisable to use universal approaches, taking into account the cut-off point of age, which is 34.5 years. The determination of age criteria for the correct classification of patients with respect to the manifestations of the metabolic syndrome is necessary to analyze the contribution of the age factor to the implementation of various metabolic syndrome predictors, to develop prognostic models, and to use effective age-determined markers of metabolic disorders.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135296066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and whole genome sequencing of a lipophilic anaerobic bacterium, a representative of the species complex <i>Corynebacterium tuberculostearicum</i>, from a tuberculosis focus","authors":"O. B. Ogarkov, A. E. Suzdalnitsky, I. G. Kondratov, Yu. S. Bukin, E. A. Orlova, V. V. Sinkov, S. N. Zhdanova, N. L. Belkova, L. V. Rychkova, L. I. Kolesnikova","doi":"10.29413/abs.2023-8.4.2","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.2","url":null,"abstract":"Background . The study of the lower respiratory tract microbiome has been actively developed inrecent years with the help of whole genome sequencing (WGS) methods. Due to this, it became clear that the nature of the lungs microbiota is very different from other microbial communities inhabiting the human body. One of the important directions in the study of pathological lungs biocenosis is the study of the role of the satellite microbiota of the tuberculosis focus. The aim of the work . To isolate and characterize oxygen-tolerant anaerobes from the necrotic contents of tuberculomas. Materials and methods . Biopsy material from 5 patients with pulmonary tuberculosis was obtained during a planned surgical treatment of tuberculoma. A pure culture was isolated from one sample during anaerobic cultivation. Lipase activity of strain was determined by plating on brain heart infusion agar (HIMEDIA, India) supplemented with 0.1 % Tween-80 and 10 mM of CaCl 2 . Antibiotic susceptibility was determined by RAPMYCO and SLOWMYCO of TREK Diagnostic Systems (Thermo Fisher Scientific, USA). DNA from the sediment of the broth culture was isolated by the CTAB chloroform method. Whole genome sequencing was performed on a DNBSeq-G400 NGS sequencer by Genomed (Russia). Results . Based on WGS results and phylogenetic analysis, the strain was identified as Corynebacterium kefirresidentii. The strain was characterized by high lipase activity and resistance only to Isoniazid, Ethionamide and Trimethoprim/Sulfamethoxazolin. Conclusion . The isolation of a lipophilic anaerobic representative of the Corynebacterium tuberculostearicum species complex from a tuberculous focus indicates a possible role of the non-tuberculous microbiota in the liquefaction of caseous necrosis. We assumed that in some cases, favorable conditions are created inside the tuberculous focus for the development of satellite anaerobic lipophilic microbiota.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135587373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-to-end convolutional neural network for automatic encoding facial descriptor (N-CNN) in the diagnosis of intrauterine distress","authors":"N. V. Korotaeva, L. I. Ippolitova, E. S. Pershina","doi":"10.29413/abs.2023-8.4.4","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.4","url":null,"abstract":"Background . Existing methods for studying intrauterine distress, despite their prevalence, still have their limitations, so studying and assessment of fetal movements during ultrasound diagnostics can become a convenient and affordable additional tool for diagnosing this pathological condition. The aim of the study . To assess the prevalence and diagnostic significance of a known set of fetal facial movements for the timely determination of intrauterine distress. Methods . This prospective single-center study included 225 fetuses of a gestational age from 32 to 40 weeks. The FIGO chart was used as fitting criteria of intrauterine distress. The assessment of facial movements in all fetuses was carried out using the BabyFACS technique, where the action unit (AU) used for the assessment; its coding is carried out in strict accordance with the chart of motor descriptors (MD). Statistical data processing was carried out using SPSS Statistics 20 (IBM Corp., USA). The Mann – Whitney test was used as the main statistical parameter, where a threshold level of 0.05 was chosen to interpret the p-tests value. Results . Despite the occurrence of AU1, AU2, AU3, AU4 in both groups, these MDs were recorded in the group with confirmed distress (p = 0.00001). Facial units such as AU9 and AU20 were found only in children with intrauterine distress, which, in the total amount of the MD assessment, can be considered one of the main search signs that specialists should first of all pay attention to. All motor descriptors showed high positive predictive value and diagnostic sensitivity, with the highest results registered for AU9 and AU20. Conclusion . Assessment of facial units during ultrasound diagnostics can be a convenient tool as an additional diagnosis of the development of intrauterine distress and requires further study.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135587079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor-in-Chief’s preface to Issue 4, 2023","authors":"S. I. Kolesnikov","doi":"10.29413/abs.2023-8.4.1","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.1","url":null,"abstract":".","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135587372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic consortiums: Structure and antagonistic activity against opportunistic bacteria and human normobiota (using the example of <i>Escherichia coli</i>) <i>in vitro</i>","authors":"A. S. Pendyukhova, N. L. Belkova, J. S. Savinova, N. M. Voropaeva, N. E. Smurova, E. S. Klimenko, I. G. Kondratov, N. V. Semenova, L. V. Rychkova","doi":"10.29413/abs.2023-8.4.3","DOIUrl":"https://doi.org/10.29413/abs.2023-8.4.3","url":null,"abstract":"Background . Using probiotic preparations based on consortia of microorganisms not only helps to restore the balance of the intestinal microbiota, but also increases the therapeutic effect of probiotics. Promising sources for obtaining probiotic consortia are milk products that have undergone natural fermentation with the help of spontaneously formed microbial consortia. The aim . To study the structure of five microbial consortia with probiotic properties from naturally fermented milk products and to assess in vitro their antagonistic activity against opportunistic bacteria and a representative of the human normobiota – Escherichia coli. Materials and methods . The structure of bacterial consortia was analyzed by sequencing methods. The antagonistic activity of the consortia was assessed by the disk diffusion method. Results . It has been established that the studied microbial consortiums are represented by Enterococcus spp. and Streptococcus spp. bacteria. In consortiums No. 1, No. 2, and No. 3, Enterococcus bacteria dominated, while in consortiums No. 4 and No. 5, Streptococcus dominated. Antagonistic activity was shown against four isolates of opportunistic bacteria: Klebsiella pneumoniae No. 493, Enterobacter hormaechei No. 372, Staphylococcus aureus No. 4 and Pseudomonas aeruginosa No. 25 IMB, as well as against one representative of the human normobiota – Escherichia coli No. 495. The highest growth delay zone is found in E. coli No. 495 isolate. Three test cultures (K. pneumoniae No. 509, E. coli ATCC25922 and P. aeruginosa No. 3 IMB) exhibited more dense growth around probiotic consortia. Conclusion . The results of the study showed that the effect of probiotic consortia differing in the composition of microorganisms can be neutral and bactericidal. The presence of antagonistic activity in the studied microbial consortia against multiresistant isolates of opportunistic bacteria is a prospect for creating probiotics with antibacterial properties.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135587081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-alcoholic fatty liver disease as a risk factor for anemia of chronic inflammation (experimental research)","authors":"T. V. Brus, A. G. Vasiliev, S. S. Pyurveev, A. Kravtsova, G. S. Veber","doi":"10.29413/abs.2023-8.3.23","DOIUrl":"https://doi.org/10.29413/abs.2023-8.3.23","url":null,"abstract":"The aim of the study. In recent years, non-alcoholic fatty liver disease (NAFLD) has been considered a hepatic manifestation of the metabolic syndrome. The main consequence of NAFLD is chronic hepatic inflammation, which leads to dyslipidemia, inflammation, increased oxidative stress, and endothelial dysfunction. Immune activation in response to interaction with agents of a metabolic nature induces the release of pro-inflammatory cytokines in the liver, which subsequently cause iron сhomeostasis disorder. This leads to a frequent association of NAFLD with anemia of various etiology. In this regard, we considered it important to assess the severity of the systemic inflammatory response in NAFLD in the experiment in order to -diagnose anemia of chronic inflammation.Materials and methods. The study was carried out on 26 male Wistar rats, which were divided into control and experimental groups. In animals of the experimental group, NAFLD was modeled according to the generally accepted method. In order to assess metabolic disorders, we determined the main biochemical parameters, a complete blood count with the calculation of erythrocyte indices, the concentration of the main pro-inflammatory cytokines – interleukin (IL) 1, IL-6. Results. In laboratory rats with NAFLD, a statistically significant increase of intrahepatic enzymes in blood serum was found. The state of the erythrocyte lineage of hematopoiesis in the experimental group progressively worsened and caused the development of anemic syndrome. Synchronously, a statistically significant increase in serum levels of IL-1, IL-6 was recorded, which confirms the correlation of NAFLD with anemia of chronic inflammation.Conclusions. A high concentration of IL-1, IL-6 cytokines in NAFLD inhibits iron absorption in the duodenum, leads to the activation of macrophages, blocking the release of iron processed from aging erythrocytes into plasma. Further study of the mechanisms of anemia in NAFLD provides important therapeutic targets in the treatment of both NAFLD and its comorbidities.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81707048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical symptoms and ECG data in women with acute coronary syndrome","authors":"A. Sumin, A. Vakhrushev, A. V. Shcheglova","doi":"10.29413/abs.2023-8.3.7","DOIUrl":"https://doi.org/10.29413/abs.2023-8.3.7","url":null,"abstract":"Background. There are many differences in chest pain symptoms between men and women in terms of location, nature, and additional symptoms. The issue of describing the differences in chest pain in men and women with acute coronary syndrome (ACS), as well as their correlation with changes in the electrocardiogram (ECG) and coronary angiography (CAG) remains relevant.Methods. The study included 588 patients of the cardiology department of the Novokuznetsk City Clinical Hospital No. 1 from 2013 to 2017 with a diagnosis of ACS. Depending on the gender, the subjects were divided into two groups: Group I – 330 men; Group II – 258 women.Results. ACS with ST elevation was more common in men (45.8 %) than in women (33.3 %; p = 0.002). There were no pathological ECG changes in women in 58.1 % of cases, in men – in 45.5 % (p < 0.001). ECG type Q/ST elevation was detected more often in men (45.8 %) than in women (33.3 %; p = 0.002). The absence of coronary artery lesions was observed in 27.9 % of men and 44.2 % of women (p < 0.001). Hemodynamically significant coronary artery stenosis was more common in men (57.6 %) than in women (38.7 %; p < 0.001). In a typical angina clinic, hemodynamically significant coronary artery disease in patients with Q/without ST elevation ACS was detected in 40.2 % of men and in 58.5 % of women (p = 0.002). In the atypical angina clinic, hemodynamically significant lesions of coronary artery were more common in men (40.6 %) than in women (34.1 %; p = 0.02).Conclusion. In women atypical chest pains and intact coronary arteries were detected more often than in men, and hemodynamically significant coronary artery stenosis were found less often than in men. In men, a more pronounced pathology of the coronary arteries in ACS was revealed, in women – great difficulties in diagnosing ACS.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78264244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the risk of cardiovascular complications in cancer surgery","authors":"K. Protasov, O. A. Barakhtenko","doi":"10.29413/abs.2023-8.3.20","DOIUrl":"https://doi.org/10.29413/abs.2023-8.3.20","url":null,"abstract":"Cardiac complications of non-cardiac surgeries are an actual and unresolved interdisciplinary problem of clinical medicine today. The incidence of cardiovascular events after non-cardiac surgery is higher than in the general population and does not tend to decrease. The risk of cardiac complications in cancer surgery is the highest. Evidence-based approaches to risk assessment and prevention of cardiovascular events in surgical patients with malignant neoplasms have not been developed. In current clinical guidelines on the prevention, prognosis and treatment of cardiac complications of non-cardiac surgeries, the aspects of this problem in surgical oncology are not considered separately.The aim of this review was to analyze the current sources of literature on the prediction of cardiovascular complications in surgical treatment of cancer patients. The distinctive features of cancer surgery and additional factors causing an increased risk of adverse cardiac outcomes in patients with malignant neoplasms are described. The article presents the results of large cohort studies on the search for reliable predictors of cardiac complications in non-cardiac surgery and on the development of stratification scales and algorithms for preoperative risk assessment. Particular attention is paid to the possibilities and prospects of using these predictive tools in the surgical treatment of cancer. The surgical risks of interventions for malignant neoplasms are described, as well as methods for calculating cardiac risk and functional status assessment that have been validated in oncological patients cohorts. The data of recent studies on the role of serum biomarkers of myocardial damage and increased cardiovascular risk (cardiac troponins and brain natriuretic peptide) in predicting postoperative cardiac events in non-cardiac surgery are presented. Further prospects for the inclusion of biomarkers in risk stratification systems in patients with malignant neoplasms are discussed.","PeriodicalId":32463,"journal":{"name":"Acta Biomedica Scientifica","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77111714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}