Majalah Obat Tradisional最新文献_第2页

Antioxidant Capacity from Ethyl Acetate Fraction of Kenikir (Cosmos Caudatus K) 锦葵(Cosmos Caudatus K)乙酸乙酯部分的抗氧化性能

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.84604

Khrisna Pangeran, Tatang Irianti Irianti, Hari Purnomo

{"title":"Antioxidant Capacity from Ethyl Acetate Fraction of Kenikir (Cosmos Caudatus K)","authors":"Khrisna Pangeran, Tatang Irianti Irianti, Hari Purnomo","doi":"10.22146/mot.84604","DOIUrl":"https://doi.org/10.22146/mot.84604","url":null,"abstract":"Antioxidant is an activity that inhibits oxidation reactions due to exposure to free radicals, the search for antioxidant compounds continues to be developed from natural sources. The purpose is to identify new sources of safe and inexpensive agents through antioxidant capacity from ethyl acetate fraction on kenikir leaves was evaluated through enzymatic and non-enzymatic in vitro models. The research began with the method of separating compounds from ethanol extracts and ethyl acetate fractions, quantification of total phenolics and flavonoids, antioxidant capacity tests with DPPH, and tyrosinase enzyme. The results of the study produced isolate E which was observed in a single stain with Rf 0,80. The compound has a typical marker worth 1734.07 cm-1 with an indication of stretching vibration movement on C-O. It has a maximum wavelength of ± 216 nm, with an abundance of 49.75% and a retention time of 27.20 minutes. TPC and TFC test results, the water fraction is the most dominant value with 0.430 mgGAE/g and 0.056 mQE/g. DPPH assay results, isolate E has an IC50 value of 162.03 ppm and a %inhibition of 12.73%. The tyrosinase inhibition test of L-DOPA substrate was resulting an IC50 value of 77.51 ppm compared to kojic acid of 16.48 ppm.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract 火龙果皮甲醇提取物体内外止泻活性研究

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.81216

Stephanie Renata Yosefa, Erny Tandanu, William Leslie, Silvia Fransisca, Evelyn Angie, Djamin Kartarino, Refi Ikhtiari

{"title":"In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract","authors":"Stephanie Renata Yosefa, Erny Tandanu, William Leslie, Silvia Fransisca, Evelyn Angie, Djamin Kartarino, Refi Ikhtiari","doi":"10.22146/mot.81216","DOIUrl":"https://doi.org/10.22146/mot.81216","url":null,"abstract":"Diarrhea is a global major health problem reported by 2.5 billion cases annually. Diarrhea accounts for 9% of child death worldwide or the second leading cause of death among toddlers. Many local people have used traditional medicine for diarrhea therapy. Dragon fruit is a herbal plant with high vitamins and various nutritious compounds. Therefore, this study determined antidiarrheal activity from dragon fruit peel methanolic extract (Hylocereus polyrhizus). This study was experimental with in vitro and in vivo models. The in vitro model used disc diffusion and microdilution assay against the diarrhea-causing pathogen (Escherichia coli). Meanwhile, the in vivo model used male Wistar rats induced by Castro oil. This study showed that the minimum inhibitory concentration (MIC) and minimum killing concentration (MKC) of dragon fruit peel extract against Escherichia coli were 50 and 100 mg/ml, respectively. The increased dose of dragon fruit peel methanol extract has increased the antidiarrheal index. The highest and lowest antidiarrheal index was found in the dragon fruit methanol extract-3 (76.56%) and dragon fruit methanol extract-1 (43.28%). The dragon fruit peel methanol extract can be proposed as antidiarrhea and antibacterial therapy against the diarrhea-causing pathogen.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Stability, Photostability, and Sunscreen Effectiveness of Combination Cream of Arabica Green Coffee Bean Extract (Coffea arabica) and Octyl Methoxycinnamate 阿拉比卡绿咖啡豆提取物(阿拉比卡咖啡)和甲氧基肉桂酸辛酯组合霜的物理稳定性、光稳定性和防晒效果

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.84443

Nanda Tsalasani Zulfaidah, Endang Lukitaningsih, Abdul Karim Zulkarnain

{"title":"Physical Stability, Photostability, and Sunscreen Effectiveness of Combination Cream of Arabica Green Coffee Bean Extract (Coffea arabica) and Octyl Methoxycinnamate","authors":"Nanda Tsalasani Zulfaidah, Endang Lukitaningsih, Abdul Karim Zulkarnain","doi":"10.22146/mot.84443","DOIUrl":"https://doi.org/10.22146/mot.84443","url":null,"abstract":"Arabica green coffee beans (AGCB) have antioxidant compounds as photo protectors. It’s used to stabilize and increase the SPF value of octyl methoxycinnamate in sunscreen because its effectiveness will be decreased when exposed to UV light. The purpose of this study was to determine the effect of a combination of various concentrations of arabica green coffee bean (AGCB) extract and octyl methoxycinnamate (OMC) on the physical properties and SPF value of sunscreen cream. AGCB extract with concentrations (F1) 0%; (F2) 2.5%; (F3) 5%; (F4) 7.5% (with the addition of OMC concentration of 7.5%), and (F5) 7.5% (without the addition of OMC). The formulas were tested for physical properties to determine stability in 4 weeks of storage, cycling test for 4 cycles, and photostability to determine the SPF value and irritation test on the best formula. The results of the physical stability test on the five formulas showed a sig value > 0.05 which means the preparation is stable. Formulas F1, F2, F3, F4, and F5 with exposure of 1 hour, 5 hours, and 10 hours obtained a significance value > 0.05, which means that the presence of UV light exposure in the AGCB extract combination cream can stabilize the decrease in SPF value. Formula 4, which is stable without separation during the cycling test and the stability of the SPF value of 41, then in the irritation test does not cause irritation so it can be concluded that formula 4 is the optimum formula.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Antidiabetic and Antidyslipidemic Activity of Ageratum conyzoides and Gynura procumbens in Alloxan-induced Diabetic Rats 四氧嘧啶诱导的糖尿病大鼠的联合降糖和降血脂作用

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.83785

Yani Mulyani, Nazarul Mastura, Salsha Rosilopya, Aris Suhardiman, Kania Fajarwati, Entris Sutrisno

{"title":"Combined Antidiabetic and Antidyslipidemic Activity of Ageratum conyzoides and Gynura procumbens in Alloxan-induced Diabetic Rats","authors":"Yani Mulyani, Nazarul Mastura, Salsha Rosilopya, Aris Suhardiman, Kania Fajarwati, Entris Sutrisno","doi":"10.22146/mot.83785","DOIUrl":"https://doi.org/10.22146/mot.83785","url":null,"abstract":"Unhealthy lifestyle habits greatly increase the risks of various degenerative illnesses, for example, diabetes mellitus as well as dyslipidemia. Recent studies have shown that the pharmaceutical drugs used for the treatment of these conditions have undesirable side effects. This indicates that it is necessary to find more effective and safe alternative treatment options, particularly in medicinal plants, such as Ageratum conyzoides and Gynura procumbens. Therefore, this research examined the combined antidiabetic and antidyslipidemic activity of Ageratum conyzoides and Gynura procumbens extracts in alloxan-induced diabetic rats. The insulin sensitivity of the test animals was assessed at the beginning of the experiment using the oral glucose tolerance test (OGTT) through the administration of 3 g/kgBW glucose. Pancreatic destruction was induced with the intraperitoneal injection of a single dose of 150 mg/kgBW alloxan, and the rats were treated with ethanol extract for 14 days. High-density lipoprotein cholesterol (HDL-C), Triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were measured using the enzymatic method. The results showed that the single extracts and their combination exhibited high antidiabetic and antidyslipidemic activity. This was indicated by a substantial reduction in fasting blood sugar, TG, TC, and LDL-C (p<0.05), and an insignificant increase in HDL-C. The activity of the combined extract was similar to the single extracts, but it was not better in decreasing TG levels. Based on these findings, 95% ethanol extract of Ageratum conyzoides, Gynura procumbens, and their combination exhibited high antidiabetic and antidyslipidemic activity in alloxan-induced rats.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cosmetic Serum Loaded Arabica Coffee (Coffea arabica) Extract: Formulation and Antioxidant Study 含有阿拉比卡咖啡精华液的化妆品:配方和抗氧化研究

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.83120

Harum Nadyanti Usman, Liza Pratiwi, Bambang Wijianto

{"title":"Cosmetic Serum Loaded Arabica Coffee (Coffea arabica) Extract: Formulation and Antioxidant Study","authors":"Harum Nadyanti Usman, Liza Pratiwi, Bambang Wijianto","doi":"10.22146/mot.83120","DOIUrl":"https://doi.org/10.22146/mot.83120","url":null,"abstract":"Arabica coffee (Coffea arabica) is a natural antioxidant that can be used in the prevention of skin aging. This study was conducted to determine the comparison of variations in the composition of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum, then to determine the physical properties of the preparation, as well as the IC50 value ofarabica coffee extract and arabica coffee serum in the DPPH test. Arabica coffee extract was obtained by maceration method using 70% ethanol. Determination of the optimum formula of arabica coffee serum using the Simplex Lattice Design method. The optimum formula of arabica coffee serum was evaluated for physical properties including organoleptic test, homogeneity test, pH test, spreadability test, and adhesion test. The antioxidant activity of arabica coffee extract and the optimum formula of arabica coffee serum was tested using the DPPH method. Data analysis used SPSS One sample T-test statistics. The results showed that the composition variation of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum using the Simplex Lattice Design method was 0.1%:0.8%:0.1%. The resulting predicted values are a pH value of 4.88 and a spreadability value of 7.95 cm. The optimum formula of arabica coffee serum has the physical properties of the preparation, namely brown color, coffee aroma, light texture, a cool sensation when applied to the skin, homogeneous, has a spreadability of 7.93 cm, stickiness of 1 second, and pH value of 4.9. The IC50 value of arabica coffee extract and the optimum formula of arabica coffee serum are 8.13 ppm and 250 ppm. The results of the SPSS One sample T-test statistical analysis showed that there was no significant difference between the prediction response and the results of the optimum formula evaluation.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Surfactant Concentration to Particle Size and Loading Dose of Immunity Jamu’s Ethanolic Extract SNEDDS (Self-Nano Emulsifying Drugs Delivery System) 表面活性剂浓度对免疫木参乙醇提取物粒径及载药剂量的影响

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.83321

Dian Eka Ermawati, Samrotul Jannah

{"title":"The Effect of Surfactant Concentration to Particle Size and Loading Dose of Immunity Jamu’s Ethanolic Extract SNEDDS (Self-Nano Emulsifying Drugs Delivery System)","authors":"Dian Eka Ermawati, Samrotul Jannah","doi":"10.22146/mot.83321","DOIUrl":"https://doi.org/10.22146/mot.83321","url":null,"abstract":"Immunity jamu consists of ginger, turmeric, Centella, and cinnamon, that act as immunostimulant agents. However, the infusion is impractical and used a limited dose of the extract, so it is necessary to develop drug delivery to resolve that problem. The SNEDDS technique is expected to increase the solubility, drug release, and absorption of active substances in the body, especially for low solubility of an active substance. SNEDDS consists of oil, surfactant, and co-surfactant. A surfactant is a substance that can reduce surface tension so that emulsion globules form in nanoparticle size. Tween 80 can produce a more transparent solution for oil-in-water emulsions than surfactants with low HLB values. This study aimed to determine the effect of surfactant concentration on the physical properties of SNEDDS to obtain the most loading dose but the smallest particle size. The formula consists of tamanu oil tween 80-propylene glycol of 1:7:1; 1:8:1; and 1:9:1 that incorporated extracts were 75, 150, and 375 mg. The physical tests included transmittance percentage, emulsification time on AGF media, phase separation, and stability test using the cycling test method. SNEDDS, then followed by the Particle Size Analyzer test. The results showed that the greater surfactant concentration produced a better transmittance value, a faster emulsification time, and stability. Formula with oil: surfactant: co-surfactant of 1:8:1 is a system that meets the requirement for immunity jamu with an optimal loading dose and small particle size compared to another formula. The extract’s loading dose of 375 mg has a particle size of 27.17 nm and a polydispersity index of 0.25.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Antioxidant Activity Test of Rice Bran Extract Cream from Two Varieties of White Rice 两种白米米糠提取膏的配方及抗氧化活性试验

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.84715

Wira Noviana Suhery, Hayu Lestari, Armon Fernando, Fina Aryani, Gressy Novita

引用次数: 0

The Effectiveness of Sungkai Leaf (Peronema canescens Jack.) Extract Gel on the Collagen Density of Incision Wounds in Vivo 松开叶的药效研究(英文)提取凝胶对切口创面体内胶原蛋白密度的影响

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.80458

Clarissa Ester Diana Putri, Herlina Eka Shinta, Fatmaria Fatmaria, Elsa Trinovita

{"title":"The Effectiveness of Sungkai Leaf (Peronema canescens Jack.) Extract Gel on the Collagen Density of Incision Wounds in Vivo","authors":"Clarissa Ester Diana Putri, Herlina Eka Shinta, Fatmaria Fatmaria, Elsa Trinovita","doi":"10.22146/mot.80458","DOIUrl":"https://doi.org/10.22146/mot.80458","url":null,"abstract":"An incision is an open wound resulting in skin injury and underlying tissues. The wound-healing process involves a proliferative phase that produces collagen. Sungkai leaves (Peronema canescens Jack.) can be used as an alternative therapy for wound healing because it contains flavonoids, tannins, and saponins that stimulate fibroblasts to synthesize collagen. This study aimed to determine the effectiveness of sungkai leaf extract gel in healing incision wounds in vivo based on collagen density scoring. Twenty-five Wistar rats (Rattus norvegicus) were randomly divided into five groups, the negative control group (K1) was given a gelling agent CMC 1%, the positive control group (K2) was given bioplacenton gel 1%, the treatment group (K3, K4, K5) was given a gel sungkai leaf extract concentration of 5, 10, and 15. The treatment is given topically at the incision site of the incision site of 0.1 g once a day for 14 days. The rats were euthanized on the fifteenth day, and the incision area was excised for histopathological preparation. The data obtained were analyzed using Kruskal-Wallis with SPSS 26. The test results showed p=0.010, meaning there is a significant difference (p<0.05) between the entire treatment. Based on these results, the K4 group (Sungkai leaf extract gel concentration of 10%) showed the highest collagen density scoring results compared to other treatments. This study concludes that sungkai leaves effectively heal incision wounds in Wistar rats based on collagen density scoring parameter.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geographical Distribution, Chemical Constituents, and Activity Profile of Magnolia 木兰的地理分布、化学成分及活性特征

Majalah Obat Tradisional Pub Date : 2023-07-31 DOI: 10.22146/mot.84275

Purabi Saha, Supriyo Saha, Amit Semwal, Prinsa Prinsa, Tarun Parashar, Vikash Jakhmola

{"title":"Geographical Distribution, Chemical Constituents, and Activity Profile of Magnolia","authors":"Purabi Saha, Supriyo Saha, Amit Semwal, Prinsa Prinsa, Tarun Parashar, Vikash Jakhmola","doi":"10.22146/mot.84275","DOIUrl":"https://doi.org/10.22146/mot.84275","url":null,"abstract":"Many Asian countries use the bark of the Magnolia for medicinal purposes. Magnolia has many medical uses, including regulating GI motility, treating cough and asthma, preventing cardiovascular disease, and treating mental illness and brain disorders. To date, 118 magnolia species have been discovered. However, the International Union for Conservation of Nature has designated 231 species as vulnerable and critically endangered. Magnolia leaves yielded 20 isolated chemicals, including 16 lignans with 6 distinct structural types, such as honokiol, veraguensin, sitosterol, and magliflonenone. Magnolia species show pharmacological activities like Neuroprotective, anti-cancer, Anti-microbial, Antiplatelets, Anti-asthmatic, Gastrointestinal, and Hormone regulation. Magnolia bark extracts such as honokiol 2',6-di-(5-propenyl)-1,1'-biphenyl-2,2'-diol, have been demonstrated to benefit health. In recent in vitro and preclinical research, honokiol was found to have anti-inflammatory, anti-angiogenic, anti-oxidative, and anti-cancer activities. Honokiol and magnolol prevented the thromboxane B2 synthesis in response to thrombin, arachidonic acid, and collagen. So, soon, if we cultivate and save the endangered magnolia species through biotechnological means, it will be a boon for mankind.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes 罗勒精油乳膏、软膏及乳状液对痤疮丙酸杆菌的抑菌活性

Majalah Obat Tradisional Pub Date : 2023-04-11 DOI: 10.22146/mot.80909

I. Irianto, I. Ismiyati, Enggar Witaningrum, Elly Nur Ayuningtyas, Meilana Maria Ulfah, P. Purwanto

{"title":"Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes","authors":"I. Irianto, I. Ismiyati, Enggar Witaningrum, Elly Nur Ayuningtyas, Meilana Maria Ulfah, P. Purwanto","doi":"10.22146/mot.80909","DOIUrl":"https://doi.org/10.22146/mot.80909","url":null,"abstract":"Propionibacterium acnes is bacteria that is commonly found on healthy human skin. However, unbalanced hormonal conditions can lead to excessive growth of P. acnes, a bacteria causing acne. Previous research reported that Ocimum basilicum L. essential oil (BEO) has activity against P. acnes. Therefore, this study aims to make BEO into cream, ointment, and emulgel forms to determine its properties and antibacterial activity on those topical drug delivery systems. The preparations consisted of variations in BEO concentrations of 5%; 10%; and 15%. The three preparations were evaluated based on organoleptic, homogeneity, pH value, adhesion, and spreadability. The antibacterial activity test of the three preparations against P. acnes was carried out by the good diffusion method with the observation of the diameter of the inhibition zone (in mm). The produced cream, ointment, and cream had a typical BEO aroma, yellowish white color, and homogeneous. Based on organoleptic consistency, the texture of the thicker and longer adhesion was ointment > emulgel > cream, respectively. The pH value of the topical preparation was 5-6 and easily leveled. Antibacterial activity against P. acnes from the strongest was ointment > cream > emulgel, with a value of 14,30 + 0,30 mm; 10,54 + 0,01 mm; 3,90 + 0,04 mm, respectively.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45106572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0