Jurnal Farmasi Galenika Galenika Journal of Pharmacy最新文献

Evaluation of High-Alert Drug Storage in The Central Pharmacy of RSUD Ratu Zalecha Martapura RSUD中心药房高度警戒药品储存评价

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-28 DOI: 10.22487/j24428744.2023.v9.i2.16523

Diah Aulia Rosanti, Sri Oktaviani Sari, Sindwi Rinanda Sari, Rachul Ridho Mahendra, Dita Ayulia Dwi Sandi, Okta Muthia Sari, Aditya Maulana Perdana Putra, Satrio Wibowo Rahmatullah, Rina Astiyani Jenah, Noor Hafizah

{"title":"Evaluation of High-Alert Drug Storage in The Central Pharmacy of RSUD Ratu Zalecha Martapura","authors":"Diah Aulia Rosanti, Sri Oktaviani Sari, Sindwi Rinanda Sari, Rachul Ridho Mahendra, Dita Ayulia Dwi Sandi, Okta Muthia Sari, Aditya Maulana Perdana Putra, Satrio Wibowo Rahmatullah, Rina Astiyani Jenah, Noor Hafizah","doi":"10.22487/j24428744.2023.v9.i2.16523","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16523","url":null,"abstract":"Background: High-alert drugs require special attention when used because they can cause adverse reactions. High-alert drugs are classified into 3, namely, concentrated electrolytes, LASA, and cytostatics. Objectives: This study aimed to determine the evaluation of High-alert drug storage at the central pharmacy of Ratu Zalecha Martapura Hospital. Material and Methods: The research was conducted using a descriptive method, with observational data collection using an observation checklist sheet. The population and study sample took data on all High-alert medicines at the central pharmacy of Ratu Zalecha Martapura Hospital. Results: High alert drug storage was based on SOP, placed in a central pharmacy using the FIFO and FEFO methods, was placed in a separate place based on cytotoxic drug groups, electrolyte concentrates, and others. High alert drug storage according to storage temperature requirements for each drug (cold temperature and room temperature), was labeled \"high alert\" and electrolyte concentrates were only available in pharmaceutical installations. Conclusions: The conclusion of this research was High-alert drug storage in the Pharmaceutical installation of Ratu Zalecha Martapura Hospital have been qualified seven (7) criteria based on Minister of Health Decision Nu. 1128 of 2022 and Minister of Health Regulation Nu. 72 of 2016. Good and correct drug storage is very important in order to maintain the quality and quality of drugs.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"50 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136233113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin 罗布斯塔咖啡种子乙醇提取物对链脲佐菌素诱导的雄性大鼠血糖、尿素和肌酐水平的影响

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-24 DOI: 10.22487/j24428744.2023.v9.i2.16352

Joni Tandi, Mimi Marsella, I Made Agus Suarsana, Niluh Puspita Dewi, Magfirah Magfirah, Tien Wahyu Handayani, Maria Kanan

{"title":"The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin","authors":"Joni Tandi, Mimi Marsella, I Made Agus Suarsana, Niluh Puspita Dewi, Magfirah Magfirah, Tien Wahyu Handayani, Maria Kanan","doi":"10.22487/j24428744.2023.v9.i2.16352","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16352","url":null,"abstract":"Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"44 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135315800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrative Review: Potential of Flavonoids from Moringa (Moringa oleifera Lam.) Leaves as Immunomodulators 辣木(Moringa oleifera Lam.)黄酮类化合物的研究进展叶子作为免疫调节剂

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-03 DOI: 10.22487/j24428744.2023.v9.i2.16265

Jesica Carine Poluan, Muhammad Sulaiman Zubair, Arba Pramundita Ramadani, Farida Hayati

{"title":"Narrative Review: Potential of Flavonoids from Moringa (Moringa oleifera Lam.) Leaves as Immunomodulators","authors":"Jesica Carine Poluan, Muhammad Sulaiman Zubair, Arba Pramundita Ramadani, Farida Hayati","doi":"10.22487/j24428744.2023.v9.i2.16265","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16265","url":null,"abstract":"Background: Moringa leaves (Moringa oleifera Lamk.) are plants from the Moringaceae family that have many properties and are often used empirically as traditional medicine. One of the benefits of M. oleifera leaves is immunomodulator, which functions to modulate the human immune system in both immunostimulants and immunosuppressants. Objectives: To provide information on the potential of flavonoids in M. oleifera leaves as immunomudulators developed as alternative therapies. Methods: Review of articles using original articles from national and international journals with the keywords \"immunomodulator,\" \"immunostimulant,\" \"immunosuppressant,\" \"Flavonoids,\" and \"Moringa oleifera leaf or leaves\". Results: Based on a search of various literature studies, M. oleifera leaf extract is proven as an immunomodulator with the most compounds found, namely flavonoids such as quercetin and kaempferol. This content can affect the immune response to trigger or inhibit the proliferation and activation of immune cells in the process of increasing or decreasing the immune system in the body. Conclusions: Moringa leaves have activity as immunomodulators that can help maintain the immune system in the body.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135739946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study 提高难水溶性药物溶解度的技术进展(BCS II和IV):综述

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.15969

Muhamad Reza Pahlevi, Iyan Sopyan, Dolih Gozali

{"title":"Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study","authors":"Muhamad Reza Pahlevi, Iyan Sopyan, Dolih Gozali","doi":"10.22487/j24428744.2023.v9.i2.15969","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.15969","url":null,"abstract":"Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal formation, and coamorphous can increase the solubility of API which has an impact on increasing bioavailability. The successful formation of solid dispersions, cocrystals and coamorphs can be confirmed by the characterization of PXRD, DSC and SEM. In conclusion, drug solubility is an important aspect of pharmacological effects. Drugs with high solubility can provide fast solubility rates and high bioavailability, reducing the dose administered. Solid dispersion, cocrystals, and coamorphous techniques, have succeeded in increasing the solubility of BCS class II and IV drugs.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Antidiabetic Pattern with Medication Adherence in Type 2 Diabetes Patients at Buleleng Hospital 布列冷医院2型糖尿病患者抗糖尿病模式与药物依从性的关系

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.15908

Pande Made Desy Ratnasari, I Gusti Ayu Indira Ardeliani, Agustina Nila Yuliawati, Putu Dian Marani Kurnianta

{"title":"Association Between Antidiabetic Pattern with Medication Adherence in Type 2 Diabetes Patients at Buleleng Hospital","authors":"Pande Made Desy Ratnasari, I Gusti Ayu Indira Ardeliani, Agustina Nila Yuliawati, Putu Dian Marani Kurnianta","doi":"10.22487/j24428744.2023.v9.i2.15908","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.15908","url":null,"abstract":"Background: Type 2 diabetes mellitus (DM) is a chronic disease which requires long-term therapy. Medication adherence plays an important role for therapeutic success in patients with T2DM. Antidiabetic usage pattern might involve with some problems related to medication adherence. Objectives: The aim of this study was to analyze the association between antidiabetic usage pattern with medication adherence. Material and Methods: This observational study was conducted cross-sectionally involving 90 participants of T2DM outpatient at Private Hospital in Buleleng Bali during July-September 2020. Patients were included if aged ≥18 years, received the same antidiabetic for three months before the study, signed informed consent, and provided with complete medical record data. Patients were excluded if appeared to be unwell, pregnant or breastfeeding. Demographic data and antidiabetic usage patterns were collected retrospectively based on the patient's medical records. Probabilistic Medication Adherence Scale (ProMAS) questionnaire was used to assess medication adherence. Data were analyzed with Kruskal-Wallis test. Results: The results showed that 55.6% patients were male, aged 46-65 years (61.1%), education predominantly by elementary school (37.8%), had suffered from DM for 5-10 years (46.7%), with comorbidities (50%), and without complications (77.8%). The antidiabetic usage pattern was dominated by a combination of two antidiabetics (53.3%). Most patients (42.2%) showed moderate-high medication adherence. There was no statistically significant association between antidiabetic usage pattern and medication adherence (p=0.275). Conclusions: A higher rate of medication adherence was found in patients taking combination of two antidiabetics compared to combination of three or four antidiabetics.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical and Antioxidant Activity Evaluation of Lime (Citrus aurantifolia) Juice Powder 酸橙(Citrus aurantifolia)果汁粉的植物化学和抗氧化活性评价

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.16347

Nur Rahmiati, Retno Sari, Tutik Sri Wahyuni

{"title":"Phytochemical and Antioxidant Activity Evaluation of Lime (Citrus aurantifolia) Juice Powder","authors":"Nur Rahmiati, Retno Sari, Tutik Sri Wahyuni","doi":"10.22487/j24428744.2023.v9.i2.16347","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16347","url":null,"abstract":"Background: Many chronic diseases that occur in society can be caused by free radicals. Excessive free radicals in the body can contribute to oxidative stress. Therefore, the role of antioxidants in needed to inhibit the effects of free radicals. Lime (Citrus aurantifolia) is a plant that contains several active compounds. The lime juice was reported to contain flavonoids and ascorbic acid which have several bioactivities including antioxidants. Objectives: This study aims to evaluate the chemical compounds and determine antioxidant activity in the lime juice powder of lime fruit collected from Ujung Pangkah, Gresik. Material and Methods: Lime was squeezed and dried by a freeze-dryer to remove the water content. The phytochemical profile of lime juice powder was evaluated by thin layer chromatography (TLC) method and ascorbic acid content in lime juice powder was determined further. The antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) method. Results: The results of the study showed that lime juice powder contained flavonoids, saponins, terpenoids, and steroids. The ascorbic acid content was 0.38 mg/100mg. Antioxidant activities revealed strong antioxidant activity with an IC50 value of 32.59 mg/mL, while an IC50 value of ascorbic acid showed 8.57 mg/mL. Conclusions: Lime juice powder has potential as an antioxidant with an IC50 value of lime juice powder being categorized to possess very strong antioxidant activity.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnopharmacology Study of Traditional Herbs as Anti-dandruff and Anti-baldness in Amarasi District, Kupang Regency 古邦县阿马拉西地区去屑、去秃传统草药的民族药理学研究

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.16119

Muhamad Satria Mandala Pua Upa, Marce Inggritha Taku Bessi, Yulius Baki Korassa, Maria I.M. Indrawati

{"title":"Ethnopharmacology Study of Traditional Herbs as Anti-dandruff and Anti-baldness in Amarasi District, Kupang Regency","authors":"Muhamad Satria Mandala Pua Upa, Marce Inggritha Taku Bessi, Yulius Baki Korassa, Maria I.M. Indrawati","doi":"10.22487/j24428744.2023.v9.i2.16119","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16119","url":null,"abstract":"Backgrounds: Hot weather in Indonesia can cause problems with hair and scalp health, including dandruff (seborrheic) and cause hair roots to become weak, making it easier for hair loss or alopecia to occur. The Amarasi people still do hair and scalp treatments with traditional plants. Objectives: This study aims to determine the ethnopharmacology of herbs as anti-dandruff and anti-baldness in Amarasi sub-district, Kupang district, including plant names, plant properties, plant parts, processing methods, usage methods and usage rules. Methods: This research is a qualitative descriptive study with an exploratory observational design. The data was obtained in the form of a survey by interviewing respondents with the help of a questionnaire. The sample in this study was a traditional healer (Hatra) who understood the use and use of anti-dandruff and anti-baldness drugs. Sampling was carried out using a purposive sampling techniq namely Hatra who were over 20 years old and had experience as a hatred for more than 3 years and above. The sample in this study was 17 traditional healers (Hatra). Results: result research shows that there are 18 plants consisting of 8 single plants and 16 herbs that are used and efficacious as anti-dandruff and anti-baldness. The plant parts used are leaves, fruit, seeds, sap/mucus, tube and oots. the method of processing plants for hair and scalp care by burning, splitting, fryinsqueezing and g, mashing, then, how to use it is washed, smearing, washedmassagingsaged. Rules for using plants 1-2 times a week. Conclusion: The Amarasi community has traditional plants and herbs that can be used as a treatment for scalp problems, including anti-dandruff, preventing hair loss and nourishing hair (anti-baldness). These plants based on research literacy studies conducted by previous researchers proved to have potential in the treatment of anti-dandruff and antibody.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy Profile and Drug Use Analysis of Chronic Kidney Disease Patients Hospitalized at Dr. H. M. Ansari Saleh Hospital H. M. Ansari Saleh医院慢性肾病患者治疗概况及用药分析

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.16488

Okta Muthia Sari, Aditya Maulana Perdana Putra, Putri Nur Azizah, Sofia Sofia

{"title":"Therapy Profile and Drug Use Analysis of Chronic Kidney Disease Patients Hospitalized at Dr. H. M. Ansari Saleh Hospital","authors":"Okta Muthia Sari, Aditya Maulana Perdana Putra, Putri Nur Azizah, Sofia Sofia","doi":"10.22487/j24428744.2023.v9.i2.16488","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16488","url":null,"abstract":"Background: Therapy in chronic kidney disease aims to slow down the prognosis of the disease. Objectives: Describe the types of classes and names of most drugs in treating chronic kidney disease patients based on the stage of the disease. As well as analysing the use of renal risk drugs in patients with chronic kidney disease. Material and Methods: This descriptive research will be carried out in May-June 2023. The population of this study was the entire medical record of inpatient chronic kidney disease patients at Ansari Saleh Hospital. Data analysis was performed uni variat for the study of patient characteristics and therapy profiles, while the analysis of the use of renal risk medications refers to the 2019 renal handbook. Results: A total of 51 medical records were analysed. The top five drug classes based on stages 4 and 5 include diuretics, cephalosporin antibiotics, vitamins, trace elements, angiotensin II receptor blockers, and insulin. The top five drugs received by patients based on disease stages 4 and 5 consist of furosemide, ceftriaxone, aminefron®, candesartan, and insulin aspart. Renal risk drugs found in studies include drugs that need dose adjustment, are lisinopril, ramipril, cefixime, cefotaxime, meropenem, levofloxacin, ciprofloxacin, bisoprolol, diltiazem, and simvastatin. At the same time, renal-risk drugs that need to be avoided are hydrochlorothiazide and spironolactone. Conclusions: Furosemide diuretics are the most widely used therapy in stages 4 and 5. Hospitalised chronic kidney disease patients receive some renal risk drugs that, in the literature, need dose adjustment, and some need to be avoided.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135406699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Honey Bees Propolis Extract in The Treatment of Type 1 Diabetes Mellitus 蜂胶提取物治疗1型糖尿病的疗效观察

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.16297

Khairun Nisa, Paula M Kustiawan

{"title":"Effectiveness of Honey Bees Propolis Extract in The Treatment of Type 1 Diabetes Mellitus","authors":"Khairun Nisa, Paula M Kustiawan","doi":"10.22487/j24428744.2023.v9.i2.16297","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16297","url":null,"abstract":"Background: Diabetes Mellitus (DM) is a health problem that affects more than 400 million people worldwide. Type 1 diabetes is an autoimmune disease characterized by damage of pancreatic cells followed by hyperglycemia and oxidative stress. Propolis is one of the natural ingredients of bee products. Propolis is known to have bioactive compounds that are rich in flavonoids, phenolic and antioxidant properties so that it has potential as an antidiabetic. Objectives: This writing aims to determine the activity of propolis in test animals of Type 1 DM model. Material and Methods: This research method uses a literature study using type 1 diabetic as inclusion criteria in journal screening. Keywords used include propolis, diabetes and hyperglycemia. Literature is obtained through an electronic data base, such as Google Scholar, PubMed, Scopus and Science Direct. Results: Based on the articles that have been collected, that Type 1 DM causes inflammation which is characterized by decreased immune function due to increased levels of IL-6, IL-1β and TNF-α. Propolis can reduce levels of pro-inflammatory cytokines, prevent the inflammatory process in diabetes and have hypoglycemic activity. Conclusions: The conclusion of the reviewed article that propolis from honey bee has effectiveness to improve the function of body cells and reduce diabetes complication.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135407191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate 含牛油果叶或山竹果皮乙醇提取物的防晒霜配方优化与甲氧基肉桂酸辛酯结合

Jurnal Farmasi Galenika Galenika Journal of Pharmacy Pub Date : 2023-10-01 DOI: 10.22487/j24428744.2023.v9.i2.16083

Vanessia Verda, William Leonardo, Deka Prismawan, Dion Notario

{"title":"Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate","authors":"Vanessia Verda, William Leonardo, Deka Prismawan, Dion Notario","doi":"10.22487/j24428744.2023.v9.i2.16083","DOIUrl":"https://doi.org/10.22487/j24428744.2023.v9.i2.16083","url":null,"abstract":"Background: Most sunscreens contain chemicals that can cause health and environmental problems. Natural actives can be an alternative to minimize the use of chemicals. Avocado leaves (Persea americana Mill.) and mangosteen peel (Garcinia mangostana L.) contain active compounds that have UV absorption. Objective: In this study, the optimal composition of a mixture of ethanol extracts of avocado leaves or mangosteen peel with octyl methoxycinnamate (OMC) was determined based on the Sun Protection Factor (SPF) and adhesive properties using Response Surface Methodology (RSM). Material and method: The optimal formula calculated with RSM was then made and underwent a series of tests, including a hedonic test with a scale of 0-9 on 30 respondents, a freeze-thaw stability test, and an accelerated stability test with the Arrhenius equation. Results: The RSM analysis showed that the optimal concentration of extract and OMC was 10% and 0.75% (avocado leaves) & 0.65% (mangosteen peel). The optimized formula resulted in adhesive properties and SPF of 7.41±0.03 and 16.52±0.16 (avocado leaves) & 7.43±0.04 and 15.84±0.15 (mangosteen peel) respectively. Both optimized formulations were physically stable against freeze-thaw and had a t90 of 29 minutes (avocado leaves) and 17 minutes (mangosteen peel). The average hedonic scale obtained was 7.8 (avocado leaves) and 7.9 (mangosteen peel), indicating that both optimized formulations were preferred by the respondents. Conclusions: The sunscreen formulation with an optimized combination of active ingredients from avocado leaf extract or mangosteen peel extract with OMC using RSM results in preparation with SPF value and physical properties that meet the requirements.","PeriodicalId":32345,"journal":{"name":"Jurnal Farmasi Galenika Galenika Journal of Pharmacy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0