Sri Lankan Journal of Infectious Diseases最新文献

Serologic evidence of Zika virus, hepatitis B virus and rubella virus in pregnant women attending a south-west based Nigerian tertiary care centre An enzyme-linked immunosorbent assay based study 基于酶联免疫吸附试验的研究：在尼日利亚西南部一家三级医疗中心就诊的孕妇中发现的寨卡病毒、乙型肝炎病毒和风疹病毒血清学证据

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-07-18 DOI: 10.4038/sljid.v14i2.8618

HA DrAdekola, DI Fallatah, OA Oyesanya, AT Amusan, IB Onajobi, OJ Samson, OD Popoola, HO Egberongbe

{"title":"Serologic evidence of Zika virus, hepatitis B virus and rubella virus in pregnant women attending a south-west based Nigerian tertiary care centre An enzyme-linked immunosorbent assay based study","authors":"HA DrAdekola, DI Fallatah, OA Oyesanya, AT Amusan, IB Onajobi, OJ Samson, OD Popoola, HO Egberongbe","doi":"10.4038/sljid.v14i2.8618","DOIUrl":"https://doi.org/10.4038/sljid.v14i2.8618","url":null,"abstract":"This study investigated serological evidence for Zika, hepatitis B and rubella virus infection in 92 pregnant women attending a south-west based Nigerian tertiary care centre from January to May 2023. Of the 92 samples, 31 (33.7%), 14 (15.2%), and 90 (97.8%) exhibited seropositivity for Zika, hepatitis B, and rubella virus respectively. Cases of co-positives were also reported, with 28.3% seropositive for both Zika and rubella virus, 10.9% for hepatitis B and rubella virus, and 4.3% for all three viruses. The findings of this study underscore that a considerable portion of participants are susceptible to Zika and hepatitis B virus. Conversely, the majority of the participants appeared to be protected against rubella virus. This study strongly advocates initiation of public awareness campaigns and formulation of vaccination policies targeting women of reproductive age. Such measures are crucial for countering viral infections which could harm the developing foetus and give rise to pregnancy-related complications.","PeriodicalId":32303,"journal":{"name":"Sri Lankan Journal of Infectious Diseases","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and analysis of treatment outcome at one year of rhino-orbito-cerebral mucormycosis cases during the second wave of the Covid-19 pandemic (2nd wave); experiences from a tertiary care hospital in Kolkata, India Covid-19大流行第二波（第二波）期间鼻眶脑粘液瘤病例的临床特征和一年后的治疗结果分析；印度加尔各答一家三级医院的经验

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-07-18 DOI: 10.4038/sljid.v14i2.8661

Dr Dolan Champa, Modak, DC Modak, SK Guha, D. Majumdar

{"title":"Clinical characteristics and analysis of treatment outcome at one year of rhino-orbito-cerebral mucormycosis cases during the second wave of the Covid-19 pandemic (2nd wave); experiences from a tertiary care hospital in Kolkata, India","authors":"Dr Dolan Champa, Modak, DC Modak, SK Guha, D. Majumdar","doi":"10.4038/sljid.v14i2.8661","DOIUrl":"https://doi.org/10.4038/sljid.v14i2.8661","url":null,"abstract":"Literature published between December 2019 and March 2021 suggested that India had contributed to approximately 71% of the total global cases of mucormycosis in patients with COVID-19. This study aimed to analyse the clinical patterns and evaluate treatment outcomes at twelve months of rhino-orbital-cerebral mucormycosis (ROCM) diagnosed during the Covid -19 pandemic second wave.A prospective observational study was carried out at the School of Tropical Medicine, Kolkata between April 2021 and May 2021. Intravenous liposomal amphotericin B injection (10 mg/kg/day for 42 days in patients with cerebral involvement and 5mg/kg/day for 21 days in patients with non-cerebral involvement) was initiated followed by oral posaconazole (300 mg twice on the first day, followed by 300 mg daily for 6–12 months) (as per ICMR guidelines). Diabetes and other co-morbidities were adequately optimised.Seventeen patients were admitted with symptoms of ROCM with males outnumbering females. Four patients (23.5%) with extensive cerebral involvement died within the first week of initiation of treatment. Three (17.6%) patients had diabetic ketoacidosis. The survival rate of overall ROCM was 76.5%.The study shows that timely diagnosis and appropriate treatment reduces the mortality of ROCM except in cerebral involvement, where the outcome was guarded despite aggressive treatment. Six-month treatment was inadequate in most of the cases, and multiple surgical interventions along with antifungals accelerated the recovery.","PeriodicalId":32303,"journal":{"name":"Sri Lankan Journal of Infectious Diseases","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141826986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic allergy: Mislabels, Misinterpretation and Mismanagement 抗生素过敏：误标、误读和误治

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-07-18 DOI: 10.4038/sljid.v14i2.8681

C. N. Badanasinghe

引用次数: 0

Comparison of broth microdilution and E-test for susceptibility of MRSA to vancomycin 肉汤微量稀释法和 E 测试法比较 MRSA 对万古霉素的敏感性

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-04-01 DOI: 10.4038/sljid.v14i1.8598

Dr N.P. Senanayake, FS Hiflan, H. Abeygoonawardena, RA Karawgoda, NS Chandrasiri, A. Balasuriya

{"title":"Comparison of broth microdilution and E-test for susceptibility of MRSA to vancomycin","authors":"Dr N.P. Senanayake, FS Hiflan, H. Abeygoonawardena, RA Karawgoda, NS Chandrasiri, A. Balasuriya","doi":"10.4038/sljid.v14i1.8598","DOIUrl":"https://doi.org/10.4038/sljid.v14i1.8598","url":null,"abstract":"Introduction: Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) developed soon after the introduction of methicillin. These bacteria have shown resistance to multiple drugs and therefore vancomycin became the antibiotic of choice for treatment of MRSA infections. Vancomycin is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. This study aimed to compare broth microdilution (BMD) and E-test in determining vancomycin minimum inhibitory concentration (MIC) against MRSA.Methods: A total of 30 clinical isolates of MRSA were acquired from Colombo South Teaching Hospital, Sri Lanka. These MRSA strains were identified by cefoxitin disk diffusion and the vancomycin MIC was determined through BMD and E-test. The Kruskal-Wallis test was applied to test if the samples originated from the same distribution with post hoc determination of the correlation between methods using the Mann-Whitney U test.Results: All 30 MRSA isolates were 100% vancomycin susceptible (≤2 μg/mL) irrespective of methodology, according to the Clinical and Laboratory Standards Institute (CLSI) established breakpoints. However, the E-test MIC values were 1 to 2 dilutions higher than those of BMD. A statistically significant difference between vancomycin MICs of BMD and E-test (p = <0.00001) was calculated which indicated a difference in accuracy.Conclusion: Due to cost, convenience, and the ability to detect vancomycin intermediate Staphylococcus aureus (VISA), exploring the possibility of using E-test as an alternative to BMD is worthwhile.","PeriodicalId":32303,"journal":{"name":"Sri Lankan Journal of Infectious Diseases","volume":"141 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of carbapenemase producing enterobacterales using the Modified Hodge Test from clinical isolates in Colombo South Teaching Hospital and Sri Jayewardenepura General Hospital, Sri Lanka in 2017 2017年在斯里兰卡科伦坡南部教学医院和斯里贾伊瓦德纳普拉综合医院使用改良霍奇试验从临床分离物中检测出产碳青霉烯酶的肠杆菌科细菌

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-04-01 DOI: 10.4038/sljid.v14i1.8584

S. H. Jayathilaka, A. H. Jayatissa, S. N. Chandrasiri, K. Jayatilleke, J. Kottahachchi

{"title":"Detection of carbapenemase producing enterobacterales using the Modified Hodge Test from clinical isolates in Colombo South Teaching Hospital and Sri Jayewardenepura General Hospital, Sri Lanka in 2017","authors":"S. H. Jayathilaka, A. H. Jayatissa, S. N. Chandrasiri, K. Jayatilleke, J. Kottahachchi","doi":"10.4038/sljid.v14i1.8584","DOIUrl":"https://doi.org/10.4038/sljid.v14i1.8584","url":null,"abstract":"Introduction: Enterobacterales is a large family of Gram-negative bacilli including many pathogens. Carbapenemase producing Enterobacterales (CPEs) have emerged as a global threat. This study was conducted to detect carbapenemase production by Enterobacterales isolates from clinical specimens and to correlate the occurrence of CPE with age, gender, and duration of hospital stay of the patients included in the study.Methods: A descriptive cross-sectional study was carried out using 120 consecutive, non-repetitive clinical isolates identified as Enterobacterales by the microbiology laboratories of Colombo South Teaching Hospital and Sri Jayewardenepura General Hospital. The demographic data of the patients was gathered and used to analyse the correlation with CPE occurrence. All isolates were identified up to species level using API 20E kits. Screening for detection of carbapenemase was carried out using meropenem, imipenem, and ertapenem disks. The Modified Hodge Test (MHT), which is one of the suggested procedures to determine carbapenemase production, was performed to identify carbapenemase producing isolates.Results: Of the120 isolates, 14 (11.7%) were resistant to at least one of the carbapenems tested. MHT detected carbapenemase production in ten (8.3%) isolates. The majority of these isolates were Klebsiella sp. (6; 60.0%). Of carbapenemase producing isolates, six were from urine specimens (60%). Eight (80.0%) of the CPE harbouring patients were males and eight (80.0%) were aged above 50 years. The mean duration of hospital stay of the patients was 7.2 days (±SD 5.65days).Conclusion: The proportion of CPE was 8.3% according to this study and emphasises the importance of conducting more studies on the prevalence of CPE in Sri Lanka.","PeriodicalId":32303,"journal":{"name":"Sri Lankan Journal of Infectious Diseases","volume":"114 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Imaging in Renal Infections: A Narrative Review 成像在肾脏感染中的作用：叙述性综述

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-02-28 DOI: 10.4038/sljid.v14i1.8602

Dr SR Siriwardana, C. Piyabani

{"title":"Role of Imaging in Renal Infections: A Narrative Review","authors":"Dr SR Siriwardana, C. Piyabani","doi":"10.4038/sljid.v14i1.8602","DOIUrl":"https://doi.org/10.4038/sljid.v14i1.8602","url":null,"abstract":"Urinary tract infections (UTIs) are among the most common bacterial infections in community and hospital settings. Infections of the urinary system can range from pyelonephritis to urethritis. Acute renal infections encompass entities such as acute pyelonephritis, acute focal bacterial nephritis, renal and perinephric abscesses, emphysematous pyelonephritis, and pyonephrosis, while xanthogranulomatous pyelonephritis is a chronic granulomatous inflammatory condition that affects the kidneys.The diagnosis of UTIs predominantly relies on clinical assessment and confirmation through abnormal laboratory results. Routine medical imaging is therefore typically reserved for complicated cases, aiming to identify contributing factors such as renal calculi, determine the type of infection, and evaluate the extent of the infection and its associated complications. Furthermore, imaging has become crucial for radiologists during interventional procedures in treating pyonephrosis and renal abscesses. Traditional imaging tools, like abdominal X-rays, are vital for identifying renal calculi and gas shadows in emphysematous pyelonephritis, while ultrasonography emerges as an excellent modality for assessing urinary infections in emergency scenarios, pregnancy, and paediatric cases. Contrast-enhanced computed tomography (CECT) or non-contrast computed tomography (NCCT) is the imaging method of choice in the most complex situations, allowing for precise assessment of the disease burden. Current magnetic resonance imaging (MRI) sequences yield promising results in specific scenarios such as pregnancy and paediatric subjects where minimising radiation exposure is a concern. This review focuses on elucidating the essential radiological modalities and their distinctive features in the context of renal infections, offering valuable guidance to microbiologists and physicians.","PeriodicalId":32303,"journal":{"name":"Sri Lankan Journal of Infectious Diseases","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Non Typhoidal Salmonella Infection of the Thyroglossal Duct Cyst in a Diabetic Patient - A Case Report 糖尿病患者甲状舌管囊肿复发性非伤寒沙门氏菌感染--病例报告

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-02-28 DOI: 10.4038/sljid.v14i1.8615

Dr Stephen Pradeep Moses, Tr Chinniah

引用次数: 0

Sphingomonas paucimobilis Meningitis in a Neonate First Case Report 新生儿鞘氨单胞菌脑膜炎首例报告

Sri Lankan Journal of Infectious Diseases Pub Date : 2024-02-28 DOI: 10.4038/sljid.v14i1.8607

D. R. Rangaswamy, N. Kamble, K. Kavatagi

引用次数: 0

A preliminary study on antibacterial activity of common antiseptic and herbal soaps in Sri Lanka against Staphylococcus aureus 斯里兰卡常见消毒皂和草药皂对金黄色葡萄球菌抗菌活性的初步研究

Sri Lankan Journal of Infectious Diseases Pub Date : 2023-12-20 DOI: 10.4038/sljid.v13i5.8652

G. Samaraweera, M. Perera, P. Opanayake, N. Wageesha, N. De Silva, P. Perera

引用次数: 0

Serotypes distribution and virulence factors of Streptococcus agalactiae isolates from pregnant women attending antenatal clinics in Western Province of Sri Lanka 从斯里兰卡西部省产前门诊孕妇分离的无乳链球菌血清型分布和毒力因素

Sri Lankan Journal of Infectious Diseases Pub Date : 2023-12-20 DOI: 10.4038/sljid.v13i5.8635

Prof. Jananie Kottahachchi, G. Dilrukshi, J. Kottahachchi, Dmbt Dissanayake, C. Surige, W. Suranimala, W. Perera, K. Kapuwalla, Ssn Fernando

引用次数: 0