D. I. Algın, Ö. Özdemir, Hayrettin Çürüksulu, Yasemin Tekşen
{"title":"The Impact of Iron Metabolism in the Pathogenesis of Multiple Sclerosis","authors":"D. I. Algın, Ö. Özdemir, Hayrettin Çürüksulu, Yasemin Tekşen","doi":"10.5336/NEURO.2014-41570","DOIUrl":"https://doi.org/10.5336/NEURO.2014-41570","url":null,"abstract":"Objective: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) leading to oligodendrocyte destruction, demyelination, remyelination, astrocytic scar formation, and neurodegeneration, all being associated with inflammation. Iron may contribute to the pathogenesis and progression of MS due to its accumulation in the human brain with age. It is unclear whether iron metabolism plays a role in the pathogenesis of MS. In this study, our aim was to investigate the possible role of dysfunctional iron metabolism in the pathogenesis of MS. Material and Methods: The study consisted of 32 patients with MS, and 30 age-matched healthy controls. Seven patients had relapsing remitting active (RRMS-A), 7 had relapsing-remitting stable (RRMSS), 10 had secondary progressive disease (SPMS) and 8 had progressive relapsing (PRMS) disease. We analyzed hemoglobin, iron, transferrin and soluble transferrin receptor (sTfR) levels in MS patients and compared with controls. Results: There was no significant difference in terms of age between patients with MS (mean age, 36.85±7.23 years, n=32) and control group (mean age, 34.26±6.85 years; n=30). The sTfR levels were significantly higher in MS patients compared to the control group (p<0.05). Conclusion: The increased serum sTfR levels in MS patients may reflect an increased iron turnover, due to inflammatory and oxidative stres. Iron chelating therapies for MS patients can therefore, based on our current knowledge, not be recommended. Nevertheless, blocking harmful downstream effects of iron liberation, such as oxidation of lipids and DNA, might be beneficial for MS patients.","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131109568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optic Neuritis After Influenza Vaccination: Case Report","authors":"B. Özkara, F. Budak","doi":"10.5336/NEURO.2016-53675","DOIUrl":"https://doi.org/10.5336/NEURO.2016-53675","url":null,"abstract":"Optic neuritis (ON) is an inflammatory demyelinating situation of the optic nerve. ON presents with subacute monocular visual loss associated with pain during eye movement. Visual loss usually develops during hours or days. ON is mostly idiopathic and infrequently occurs on the backgraund of autoimmune diseases, infectious diseases or vaccination. There are still many points that remain unclear in terms of the mechanism underlying the development of ON following influenza vaccination. Some authors suggested that anti phosphatidylcholine antibodies may be one of the causes of autoimmune vasculitis such as influenza vaccination-associated ON. We describe a patient presenting retrobulber pain and visual disturbance in the left eye three days after receiving the influenza vaccination.","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114256702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Balal, Turgay Demir, Gamze Tuğrul, H. Bozdemir
{"title":"Addison Hastalığı ve Polinöropati Birlikteliği","authors":"Mehmet Balal, Turgay Demir, Gamze Tuğrul, H. Bozdemir","doi":"10.5336/neuro.2015-47254","DOIUrl":"https://doi.org/10.5336/neuro.2015-47254","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114315705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eda Çoban, Nilüfer Kale Içen, Erkan Acar, A. Soysal
{"title":"Diplopi, Kemozis ve Pitozis ile Başvuran Hastada Bir Dışlama Tanısı; İdiyopatik Orbital İnflamasyon","authors":"Eda Çoban, Nilüfer Kale Içen, Erkan Acar, A. Soysal","doi":"10.5336/neuro.2014-40128","DOIUrl":"https://doi.org/10.5336/neuro.2014-40128","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116485095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Rıza Sonkaya, Abdullah Ilhan, A. Yalcin, Mustafa Ceylan
{"title":"VI. Kraniyal Sinir Felci Ayırıcı Tanısında Duane Sendromu","authors":"Ali Rıza Sonkaya, Abdullah Ilhan, A. Yalcin, Mustafa Ceylan","doi":"10.5336/neuro.2015-43670","DOIUrl":"https://doi.org/10.5336/neuro.2015-43670","url":null,"abstract":"","PeriodicalId":322260,"journal":{"name":"Turkiye Klinikleri Journal of Neurology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126484787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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