{"title":"The evolution of chemotherapeutic agents for the treatment of pediatric musculoskeletal malignancies.","authors":"M. Velez-Yanguas, R. Warrier","doi":"10.1097/01241398-199611000-00058","DOIUrl":"https://doi.org/10.1097/01241398-199611000-00058","url":null,"abstract":"The incorporation of antineoplastic agents in the treatment of pediatric musculoskeletal malignancies and their impact in the management and outcome of patients with these types of malignancies are briefly reviewed. The role of chemotherapy in the management of these tumors with special emphasis on osteosarcoma, Ewing's sarcoma family of tumors, and rhabdomyosarcoma and undifferentiated sarcomas is discussed. Also included are complications and side effects of the antineoplastic agents.","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126926278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric spinal infections.","authors":"P. Glazer, S. Hu","doi":"10.1097/01241398-199607000-00058","DOIUrl":"https://doi.org/10.1097/01241398-199607000-00058","url":null,"abstract":"A high index of suspicion for spinal infection and an appropriate and prompt diagnosis are essential for the treatment of pediatric spinal infections. A 3-week course of antibiotics and supportive therapy is effective in the majority of cases of discitis, the most common pediatric spinal infection. Patients who are not toxic may be treated with bracing, or with casting alone in many cases. Neurologic deficit or a failure to respond to early treatment requires more aggressive measures, including biopsy or surgical debridement. It is essential to diagnose rare but serious conditions such as epidural abscess, tuberculosis, or opportunistic infections in patients at risk. The authors stress that clinical evaluation and appropriate diagnosis are critical for prevention of permanent neurologic damage or late bony deformity.","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128973228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effects of drugs on laboratory tests.","authors":"R. Galen","doi":"10.1056/nejm197305242882122","DOIUrl":"https://doi.org/10.1056/nejm197305242882122","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133897391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peripheral nerve problems.","authors":"A. M. Moscony","doi":"10.1016/B978-0-323-09104-6.00024-9","DOIUrl":"https://doi.org/10.1016/B978-0-323-09104-6.00024-9","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114698515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Symposium on computed tomography.","authors":"","doi":"10.1148/132.3.780a","DOIUrl":"https://doi.org/10.1148/132.3.780a","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"16 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129874129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bacterial resistance.","authors":"L. Gentry","doi":"10.1007/bf03288033","DOIUrl":"https://doi.org/10.1007/bf03288033","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"1991 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130871492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Renal osteodystrophy.","authors":"K. L. Klein, M. Maxwell","doi":"10.1007/978-94-015-7961-2_8","DOIUrl":"https://doi.org/10.1007/978-94-015-7961-2_8","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125880971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac arrest.","authors":"M. Rosenberg, M. Goldberg, D. L. Bourke","doi":"10.1007/978-0-387-70715-0_10","DOIUrl":"https://doi.org/10.1007/978-0-387-70715-0_10","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117210757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amputation surgery and prostheses.","authors":"R. P. Rodriguez","doi":"10.1097/01241398-199611000-00024","DOIUrl":"https://doi.org/10.1097/01241398-199611000-00024","url":null,"abstract":"Wide surgical margins in surgery for a bone tumor can be accomplished either by local excision or by amputation surgery. Amputation surgery has less morbidity than limb salvage surgery. Prosthetic replacement in the lower-extremity amputation should provide an artificial limb that will be comfortable and stable for weight bearing. Retention of the anatomic knee joint is critical for better ambulation and less energy expenditure. Upper-extremity prosthesis should be functional and cosmetically acceptable.","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115695329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salvage or amputation after complex foot and ankle trauma.","authors":"S. Hansen","doi":"10.1016/S0030-5898(05)70201-7","DOIUrl":"https://doi.org/10.1016/S0030-5898(05)70201-7","url":null,"abstract":"","PeriodicalId":321658,"journal":{"name":"The Orthopedic clinics of North America","volume":"4 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117556135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}