{"title":"Clinical effectiveness of compounded topical medications in oral medicine: a meta-analysis","authors":"H. Margono, I. Sufiawati","doi":"10.20517/2573-0002.2019.18","DOIUrl":"https://doi.org/10.20517/2573-0002.2019.18","url":null,"abstract":"Aim: To assess the evidence of the efficacy and safety of compounded topical medications in oral medicine cases. Methods: Electronic databases were searched from inception to October 2019 for studies that evaluated compounded topical medications in oral medicine cases to assess their efficacy and safety. Search terms included drug compounding, topical administration, clinical efficacy, and oral lesions. Only randomized controlled trials (RCTs) or cross-over trials of compounded topical drug versus non-compounded drug or placebo or standard treatment were included. The exclusion criteria included compounded topical medications with herbal ingredients in the intervention group to compare with the non-compounded drug. The primary outcome measure was a clinical resolution of the oral lesions. The secondary outcome measure was pain resolution. Adverse events of interventions were discussed. The quality of RCTs was assessed using the Cochrane risk of bias tool (RoB 2.0). The data were synthesised in a fixed-effect model using RevMan 5. The evidence across studies for an outcome and decision of recommendations was assessed using GRADE criteria for the subgroup of included studies selected in","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131512603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trigeminal neuralgia: case report and literature review","authors":"M. Turton, Pieter Malan-Roux","doi":"10.20517/2573-0002.2019.08","DOIUrl":"https://doi.org/10.20517/2573-0002.2019.08","url":null,"abstract":"Trigeminal neuralgia (TN), also known as tic doloureaux, is a nerve disorder of the face and is considered to be one of the most painful human conditions. A 51-year-old male presented with severe intermittent pain on the left side of his face. Magnetic resonance image scan with contrast revealed a close association of the superior cerebella artery and the trigeminal nerve on the left side of the face. Oral medication is the first line of treatment for TN, because of its non-invasiveness, low cost and high effective rate. Surgical intervention for TN aims to relieve the pressure of the offending artery or vein that is compressing the trigeminal nerve or in other instances; surgery may stop the uncontrolled pain signals. An important criterion for clinical diagnosis is pain that cannot be attributed to another disorder and also the lack of evident neurologic disorder. TN is one of the most debilitating diseases an individual may suffer and an early astute diagnosis of TN will provide patients with relief from suffering, unnecessary dental and medical intervention. Appropriate and early diagnosis of TN is important to formulate an optimal management plan based on the patient’s age and general condition. The aim of this case report is to describe a case of Classical TN, and subsequent successful surgical management with microvascular decompression.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132910093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regenerative medicine approaches in large animal models for the temporomandibular joint meniscus","authors":"A. Almarza, W. Chung","doi":"10.20517/2573-0002.2019.02","DOIUrl":"https://doi.org/10.20517/2573-0002.2019.02","url":null,"abstract":"Several recent advancements have occurred regarding engineering replacements for tissues of the temporomandibular joint (TMJ). This review specifically summarizes the in vitro technological developments for TMJ meniscus tissue engineering followed by an in-depth look at in vivo studies for the regeneration of the TMJ meniscus, with a focus on large animal models. One recent study used mini-pigs to study implants placed into a partial thickness defects of the TMJ meniscus. The authors investigated the use of allogeneic costal chondrocytes in scaffold-free TMJ implants. Implants were found to be well integrated and the mechanical strength of the defects was more robust in the implanted meniscus than in untreated defects. Two recently published studies in a canine model showed that an extracellular matrix bioscaffold derived from porcine urinary bladder was an effective material for reconstruction of the TMJ meniscus. The composition and mechanical properties of the remodeled tissue were similar to that of the native meniscus. It is important to note that the half-life of these replaced meniscus is unknown, and that successful repair is dependent on identifying the cause for internal derangement. In the future, a large animal model that includes both healthy and pathogenic sites of implantation needs further investigation.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"155 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125905424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scientific evidence in surgery for the treatment of temporomandibular joint internal derangement","authors":"Ral Gonzlez-Garca","doi":"10.20517/2573-0002.2018.26","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.26","url":null,"abstract":"","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"21 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120844332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Generations of apex locators: which generation are we in?","authors":"Harpreet Singh, P. Kapoor","doi":"10.20517/2573-0002.2018.16","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.16","url":null,"abstract":"Endometrics is one of the key factors responsible for the success of endodontic therapy. Electronic determination of working length has gained enormous popularity, owing to its extreme accuracy and predictability. The literature is flooded with the self-proclaimed generations of the apex locators. This article is aimed at concise description of the actual scientific rationale behind the generations in order to diminish the related perplexity.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116148143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temporomandibular joint replacement devices - dark past to challenging future","authors":"L. Mercuri","doi":"10.20517/2573-0002.2018.25","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.25","url":null,"abstract":"Alfred Stille said, “Medicine, like all knowledge has a past as well as a present and a future...in that past is the soil out of which improvement must grow.” This original paper will review how past successes and failures have led to the development of improved temporomandibular joint replacement devices. Future considerations and challenges will be presented.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132302011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Open reduction and internal fixation in temporomandibular joint traumatology: current concepts and future perspectives","authors":"A. Neff","doi":"10.20517/2573-0002.2018.27","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.27","url":null,"abstract":"Since the turn of the century a paradigm shift has challenged the centuries old tradition of non-surgical treatment for condylar fractures. The advent of functionally stable osteosynthesis introduced into condylar traumatology in the 1980ies step by step widened out the indications for surgical treatment, paralleled also by improvement in computerized tomography diagnostics and more recently by continuous refinement of indication-specific osteosynthesis materials, with three-dimensional-plates for the condylar base and neck and resorbable materials for the condylar head being the latest developments. Over the last decades, a series of new approaches was introduced, too, to cope with the specific demands for open reduction and rigid internal fixation (ORIF) in the different fracture locations, which according to the recent consensus based Arbeitsgemeinschaft für Osteosynthese comprehensive injury automatic classifier (AOCOIAC) classification are now defined as fractures of the condylar base, condylar neck and condylar head. By now even fractures of the condylar head, treated surgically by Rasse already in 1992, have moved into the focus of surgical interest and ORIF by now is far from being “experimental”, as dubbed only a decade ago. According to recent consensus (International Bone Research Association, 2012) and based on improved evidence, ORIF may now be considered as the golden standard for both displaced or dislocated condylar base and neck fractures in adults. Endoscopic approaches should be considered for base fractures with lateral displacement. Meanwhile, there is a growing tendency to perform ORIF in condylar head fractures and severely displaced or dislocated fractures in younger children with mixed dentition.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114055628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Papillon-Lefèvre syndrome: from then until now","authors":"F. Hattab","doi":"10.20517/2573-0002.2018.22","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.22","url":null,"abstract":"Papillon-Lefévre syndrome (PLS) is a very rare autosomal recessive trait characterized by palmoplantar hyperkeratosis and severe generalized early-onset periodontitis leading to premature loss of both primary and permanent dentitions. The etiopathogenesis of the disorder is multifactorial with genetic, immunological, and microbial factors playing a major role. Other significant factors involved are environmental and reduced host defense mechanism. Consanguinity is a contributing factor because of its relevance to clinical genetics. The genetic defect underlying etiology of PLS is mutations of the gene 11q14-q21encoding for cathepsin C, an enzyme involved in a variety of inflammatory and immune processes. Virulent pathogens and their toxins in the subgingival plaque play a major factor in the initiation and progression of PLS periodontitis. Dysfunction of leukocytes is secondary causative factor. Variable clinical expression, late onset of symptoms, and frequent gene mutations reflect the complexity of the syndrome. Today, over 300 cases been reported in dental and medical literature with more cases discovered among Arabs, Indians, and Africans. About 20%-25% of patients with PLS have increased susceptibility to infections besides overwhelming destructive periodontitis. Management of the disorder directed toward halting periodontal destruction by eliminating the reservoir of causative organisms; using conventional periodontal treatment, oral hygiene instructions, antiseptic mouth rinses; and systemic antibiotic. Skin lesions usually treated with topical application of emollients, keratolytic agents, steroids, and oral retinoid. Any attempt to achieve and preserve healthy oral conditions will improve quality of life in patients with this intriguing syndrome.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123790829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiology and treatment alternatives in tooth agenesis: a comprehensive review","authors":"N. Bilgin, B. Kaya","doi":"10.20517/2573-0002.2018.11","DOIUrl":"https://doi.org/10.20517/2573-0002.2018.11","url":null,"abstract":"The purpose of this review article is to examine the etiology, clinical properties and treatment alternatives of tooth agenesis. A comprehensive literature review is realized by using widespread database sources. Disorders in early stages of dental formation may cause congenital or developmental absence of teeth. Both genetic and environmental factors are responsible for tooth agenesis. Skeletal and dental anomalies accompany absence of teeth most of the time. Management of tooth agenesis can be realized by either closing or opening the spaces of congenitally missing teeth and by correction of dentoskeletal problems with orthodontic mechanics. Restorative dentistry procedures accompany orthodontic treatment when filling the spaces of missing teeth or when reshaping the teeth substituting missing teeth. As a conclusion, treatment of problems related with mild or severe tooth agenesis requires multidisciplinary treatment approaches. Early diagnoses of congenitally missing teeth and comprehensive treatment planning have great importance in multidisciplinary approach to prevent or reduce complications which cause both aesthetic and functional disorders and decrease quality of life.","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123401226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filippos Thomopoulos, N. Nikitakis, A. Daskalopoulos, Evangelia Piperi, Nikolaos Kolomvos, A. Sklavounou
{"title":"Chronic sclerosing sialadenitis of the sublingual gland: case report and literature review","authors":"Filippos Thomopoulos, N. Nikitakis, A. Daskalopoulos, Evangelia Piperi, Nikolaos Kolomvos, A. Sklavounou","doi":"10.20517/2573-0002.2017.22","DOIUrl":"https://doi.org/10.20517/2573-0002.2017.22","url":null,"abstract":"","PeriodicalId":319131,"journal":{"name":"Stomatological Disease and Science","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130828168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}