D: Wet biomarkers最新文献_第2页

D03 Novel bioassays to detect soluble and aggregated isoforms of the huntingtin protein on three technology platforms D03在三个技术平台上检测亨廷顿蛋白可溶性和聚集型的新生物测定方法

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.59

C. Landles, Georgina F Osborne, Rebecca E Milton, Alexandre Jean, Stuart J McLarnon, Chuangchuang Zhang, W. Duan, G. Bates

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D11 miR-122 dysregulation IN siRNA-treated in vitro cell model of Huntington’s disease D11 miR-122失调IN sirna治疗体外亨廷顿舞蹈病细胞模型

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.67

N. E. Tunalı, Ezgi Keske

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D17 Extracellular vesicles biology in huntington disease D17亨廷顿病的细胞外囊泡生物学

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.73

A. Neueder, Philipp Nitzschner, Ronja Wagner, Julia Hummel, Franziska Hoschek, Maximilian Wagner, Alshaimaa Abdelmoez, B. Einem, S. Tabrizi, M. Orth

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D12 Faulty linear and back-splicing in Huntington’s disease: novel players in the pathologic process hint at innovative RNA biomarkers 亨廷顿氏病的线性和反向剪接错误:病理过程中的新参与者暗示了创新的RNA生物标志物

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.68

M. Pellegrini, Dilara Ayyildiz, G. Bergonzoni, A. Monziani, T. Tripathi, J. Döring, Giulia Cardamone, E. Kerschbamer, F. Di Leva, F. Perrone, MP Abruzzese, LC Busi, R. Asselta, E. Pennati, L. Donini, J. Zasso, L. Conti, V. Wheeler, C. Dieterich, Silvano Piazza, E. Dassi, F. Squitieri, M. Biagioli

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D08 Elevated GFAP and UCHL-1 in plasma and CSF in HD D08 HD患者血浆和脑脊液GFAP和UCHL-1升高

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.64

Fiona C Kinsella, L. Byrne, F. B. Rodrigues, E. Johnson, E. Vita, D. Alexander, G. Palermo, R. Scahill, A. Heslegrave, Henrik Zetterberg, E. Wild

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D21 Analysis of blood and CSF biomarkers in mouse models of Huntington’s disease D21亨廷顿氏病小鼠模型血液和脑脊液生物标志物分析

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.77

Marie K Bondulich, L. Byrne, Arzo Iqbal, Iulia M Nita, María Cañibano-Pico, Jemima M Phillips, E. Wild, G. Bates

引用次数: 1

D14 Plasma levels of 24S-hydroxycholesterol are reduced in Huntington disease subjects: preliminary results of a 2-year longitudinal study 亨廷顿病患者血浆24s -羟基胆固醇水平降低:一项为期2年的纵向研究的初步结果

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.70

M. Fichera, L. Nanetti, Monica Favagrossa, A. Castaldo, A. Nigri, A. Mongelli, Gloria Marchini, C. Gellera, M. Grisoli, Giulia Birolini, M. Valenza, R. Bagnati, A. Passoni, L. Colombo, E. Cattaneo, M. Salmona, C. Mariotti

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D13 Saliva biomarker discovery in Huntington’s disease 唾液生物标志物在亨廷顿氏病中的发现

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.69

F. Qvist, M. N. Hellem, J. E. Nielsen, M. Mann, N. Skotte

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D06 Influencing Huntington’s disease monitoring and therapeutic development with remote quantification of blood neurofilament light protein 血液神经丝轻蛋白远程定量对亨廷顿病监测和治疗发展的影响

D: Wet biomarkers Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.62

L. Byrne, J. Schultz, Sophie Field, Kate Fayer, Yara Y. Hassan, F. B. Rodrigues, Ellen van der Plas, D. Langbehn, S. Tabrizi, P. Nopoulos, E. Wild

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D04 Blood glucose and insulin levels following an oral glucose challenge are promising biomarkers in the zQ175 knock-in mouse model of huntington’s disease 在zQ175敲入亨廷顿病小鼠模型中，口服葡萄糖挑战后的血糖和胰岛素水平是有希望的生物标志物

D: Wet biomarkers Pub Date : 2021-09-01 DOI: 10.1136/jnnp-2021-ehdn.35

A. Tanghe, Lentel Pringels, Tom Vandooren, G. Griffioen

{"title":"D04 Blood glucose and insulin levels following an oral glucose challenge are promising biomarkers in the zQ175 knock-in mouse model of huntington’s disease","authors":"A. Tanghe, Lentel Pringels, Tom Vandooren, G. Griffioen","doi":"10.1136/jnnp-2021-ehdn.35","DOIUrl":"https://doi.org/10.1136/jnnp-2021-ehdn.35","url":null,"abstract":"Background The neurological impairments that typify Huntington’s disease (HD) are caused by neurotoxic effects of mutant Huntingtin in striatum and cerebral cortex. Huntington patients however also suffer from non-motor symptoms, including metabolic alterations. Interestingly, the latter symptoms typically set on several years before the motor symptoms. Dysfunction of the hypothalamus, the brain part that controls energy balance by integrating both central and peripheral signals, is postulated to be at least partly responsible for these non-motor symptoms, in mice and humans (Hult et al., 2011; Petersen and Bjorkvqvist, 2006). Aim We set out to explore the potential of metabolic parameters as biomarkers and surrogate endpoints for assessing the efficacy of experimental Huntington therapies in the zQ175 knock-in mouse model. Method The zQ175 model faithfully recapitulates many of the clinical phenotypes of HD in the absence of overexpression artefacts (Menalled et al., 2021). We subjected these mice to an oral glucose tolerance test (OGTT), entailing the measurement of blood glucose levels and insulin secretion levels at different time-points post oral glucose administration. Result When challenged with glucose in an OGTT, zQ175 mice show prolonged blood glucose levels and lower insulin secretion levels compared to wild type controls. In homozygous mice these deficits were observed at younger age than in heterozygous mice, in line with the more aggressive progression of pathology development. Deregulation of glucose metabolism is also manifest from the observation that the zQ175 mice drink more than control mice. Conclusion These metabolic parameters entail clinically compliant read-outs for diagnostic purposes of disease onset and progression in carriers with extended CAG repeat Huntingtin, as well as surrogate endpoints to assess therapies both in preclinical models and subsequently in patients aimed at countering neuronal toxicity of pathological Huntingtin.","PeriodicalId":318593,"journal":{"name":"D: Wet biomarkers","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132268800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0