Miznarodnij Endokrinologicnij Zurnal最新文献

{"title":"The relationships between variables of glycated hemoglobin and diabetes distress in patients with type 1 and type 2 diabetes mellitus","authors":"V.I. Pankiv, T.Yu. Yuzvenko","doi":"10.22141/2224-0721.19.6.2023.1310","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1310","url":null,"abstract":"Background. Diabetes distress is among potential barriers for people with diabetes mellitus (DM) to reach glycemic goals. Accumulating evidence suggests diabetes distress may be linked to individuals’ emotion regulation capacities. The purpose of this study was to explicate the relationships between variables of glyca­ted hemoglobin (HbA1c), diabetes distress, emotion regulation, and self-care variables through the analysis of cross-sectional data from individuals with type 1 and type 2 DM. Materials and methods. We used structural equation modeling to assess the cross-sectional relationships between variables of HbA1c, diabetes distress, emotion regulation, and self-care variables through the analysis of cross-sectional data from 132 individuals with type 1 and type 2 DM. After giving informed consent for their data to be used for research purposes without identifying them, study participants were examined by clinical psychologists with a structured clinical assessment and a series of other assessments relevant to DM. Results. While participants with type 2 DM differed from those with type 1 DM in terms of age, duration of DM, insulin dependence, and self-care, no significant diffe­rences were observed between the groups in sex, HbA1c levels, diabetes distress, emotion regulation-experience, or emotion regulation-skill scores. Study examined two potential explanatory models with one of them showing a more comprehensive view of the data revealing a total effect of poor emotional regulation on HbA1c levels. Diabetes distress in adults is linked to increased negative emotionality (emotion regulation-experience) and reduced skill at emotional regulation (emotion regulation-skill), both of which are associated with elevated HbA1c levels, and these relationships are stronger than those in diabetes self-care. Conclusions. This study suggests that in people with DM, elevated HbA1c levels and diabetes distress are linked to poor emotion regulation. These data emphasize that targeting difficulties in emotion regulation may hold promise for maximizing improvement in diabetes distress and HbA1c in individuals with DM.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135808847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of medullary carcinoma","authors":"O.Z. Lishchuk, Н.I. Suslyk, A.M. Urbanovych","doi":"10.22141/2224-0721.19.6.2023.1317","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1317","url":null,"abstract":"Medullary thyroid cancer (MTC) accounts for 5–10 % of all thyroid cancers. Most cases (75 %) are sporadic, but the proportion of patients with MTC and a familial predisposition syndrome is the highest among those with any hereditary cancer syndrome (about 25 %), and this possibility should be considered when examining a patient with MTC. Familial syndromes include multiple endocrine neoplasia (MEN) 2A, MEN 2B, and non-MEN familial MTC (familial MTC). Familial MTC syndromes occur in approximately one case per 30,000 of the population. Reduced penetrance and clinical variability are well-established features of many monogenic disorders, particularly phenotypes associated with the RET proto-oncogene. They require an individual assessment of the pathogenic effects and clinical significance of any identified new sequence of the RET va­riant as prerequisites for individual genetic counseling and planning of medical monitoring and treatment. Diagnostic criteria for the disease have been outlined, molecular and genetic aspects have been discussed, and the determination of treatment and further observation has been addressed. The article describes a clinical case of a rare variant of MTC. Treatment of this pathology with radical extrafascial thyroidectomy is under consideration. Given the ineffectiveness of radioiodine and chemotherapy, the main task in the treatment of MTC is early diagnosis, radical surgical intervention, and active monitoring aimed at early detection of disease recurrence. When planning prophylactic thyroidectomy, it is recommended to focus on the stratification of the level of RET gene mutations and the timing of prophylactic thyroidectomy proposed by the American Thyroid Association. The introduction of molecular genetic research into clinical practice for the purpose of diagnosing MTC allows for the objective assessment of the genetic lineage of the disease within a biological family. A timely diagnosis of MTC makes it possible to prescribe an adequate treatment at the stage of preclinical manifestations of the disease, which can significantly increase the quality and duration of life.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"26 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Ki67 and CD68+ cells of red bone marrow monocyte sprout under triptorelin administration in the hypothalamic-pituitary-testis regulatory system: the experimental study","authors":"R.V. Martynenko, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, M.V. Rud, O.V. Vilkhova, R.A. Moskalenko, V.B. Martynenko","doi":"10.22141/2224-0721.19.6.2023.1308","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1308","url":null,"abstract":"Background. Red bone marrow (RBM) is the main organ of human haemopoiesis. Monocytopoiesis plays an important role in the formation of transitional states: from normal to pathology and in the transformation of pathological processes from one stage to another. In modern urological practice, the substance triptorelin is widely used for androgen deprivation therapy, according to the recommendations of the European Association of Urology. Ki67, a commercially available monoclonal antibody that reacts with a nuclear antigen detected only in proliferating cells, is used to assess immunohistochemical changes. CD68 is a valuable cytochemical marker for immunostaining of monocytes/macrophages during histochemical analysis of tissues in inflammation, cancer and other immunohistopathological purposes. The purpose of the study is to evaluate the proliferative activity and differentiation of progenitor cells through the expression of Ki67 and CD68+ monocyte sprouting of RBM under chemical castration of central origin in male rats caused by the administration of triptorelin solution with quercetin addition to the diet for one year. Materials and methods. The study was conducted on 60 adult male white rats. They were divided into 3 groups: group I — control (n = 10), group II (n = 25) — subcutaneous injection of triptorelin, group III (n = 25) — subcutaneous injection of triptorelin acetate and quercetin. Immunohistochemical analysis of biopsy specimens was conducted following a standard protocol at the Department of Pathological Anatomy in Sumy State University, under the supervision of the Head of the Department, Prof. Romaniuk A.M. Results. The study evaluated Ki67 expression on microsections of rat red bone marrow through immunohistochemistry, which exclusively reacted with nuclear antigen in the monocyte sprout’s proliferating cells. Irregular changes were revealed depending on the experimental groups and time periods. Immunohistochemical analysis of RBM tissue using anti-CD68 antibodies in the experimental groups revealed a strong positive cytoplasmic response in monocytes and resident macrophages located in the monocyte sprout and surrounding environment. The data of the two experimental groups of RBM had a noticeable proliferating compartment, as evidenced by the high content of mitotically active DNA in them. These data correspond to the results obtained in the experiment with triptorelin, where we found a marked positivity of Ki67, depending on the timing of the experiment and the addition of the flavonoid quercetin. This discrepancy suggests that bone marrow cells that grow and proliferate under normal conditions are guided by natural control mechanisms and may lose their Ki67 expression after leaving the progenitor compartment and entering the differentiation compartment. Conclusions. Triptorelin administration induces hormonal imbalance in the hypothalamus-pituitary-testis-RBM system, resulting in quantitative and qualitative alterations in the cel","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"26 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance and hyperuricemia in patients with type 1 diabetes mellitus: clinical and biochemical correlates","authors":"A.O. Cherniaieva","doi":"10.22141/2224-0721.19.6.2023.1307","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1307","url":null,"abstract":"Background. Some patients with type 1 diabetes mellitus (DM) have clinical symptoms that are characteristic of the type 2 DM: obesity, insulin resistance, hypertension, hyperuricemia (HU), dyslipidemia, or the metabolic syndrome, which has been called double diabetes. It is associated with an increased frequency of chronic micro- and macrovascular complications (nephropathy, arteriosclerosis obliterans and ischemic heart disease). The purpose of the study is quantitative assessment of insulin resistance severity using indirect (non-insulin) methods and determination of its correlation with serum uric acid (UA) levels in patients with type 1 DM. Materials and methods. One hundred and eighty-one patients with type 1 DM were examined, their average age was 42.5 ± 12.1 years. Anthropometric research was conducted. Indirect methods for quantitative assessment of insulin resistance were used. The analysis was conducted using non-parametric and parametric statistical methods. Results. In patients with HU, anthropometric indices were significantly higher than in those with normouricemia, which indicated an abdominal type of fat deposition. In HU, a more pronounced insulin resistance was observed compared to that in normouricemia. It was found that in type 1 DM, the serum UA level positively correlated with body mass index, waist circumference, waist-to-hip ratio, triglycerides/high-density lipoprotein cholesterol and negatively with the estimated rate of glucose utilization, sensitivity to insulin and the natural logarithm of the rate of glucose utilization. A group of variables with the greatest contribution to the variation of the serum UA level was selected by stepwise multifactorial regression analysis of models from the studied predicates. Conclusions. It has been shown that patients with type 1 DM and HU have a significantly more severe insulin resistance. There was a correlation between anthropometric and calculated indices, reflecting the severity of insulin resistance, with the serum level of UA. The group of predicates with the greatest contribution to the variance of the serum UA level in patients with type 1 DM was selected.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"26 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the monograph “Food, nutrition, and human diseases. Evolutionary and historical aspects” (author — H.F. Hendeleka, MD, PhD, Professor; Odesa: Polygraph, 2023. 496 p.)","authors":"No Authors","doi":"10.22141/2224-0721.19.6.2023.1319","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1319","url":null,"abstract":"No abstract","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"7 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in gut microbiota in patients with metabolic-associated fatty liver disease","authors":"O.Y. Komarytsia, O.M. Radchenko, K.A. Moskva, M.O. Borovets","doi":"10.22141/2224-0721.19.6.2023.1309","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1309","url":null,"abstract":"Background. Modern science considers changes in the gut microbiota as a pathogenetic factor in the development of many di­seases, including metabolic-associated fatty liver disease (MAFLD) and liver steatosis. Although dysbiosis is present at every stage of fatty liver disease, typical signs have not been identified separately for MAFLD that determines the relevance and expedien­cy of our research. This investigation purposed to evaluate the state of the gut microbiota in patients with MAFLD. Materials and methods. In total, 19 patients were observed. Among them, 14 had metabolic syndrome and MAFLD and 5 were without metabolic syndrome with intact liver. These two groups differed significantly only in body mass index, had similar gender-age distribution, blood pressure, parameters of lipid and carbohydrate metabolism. Metagenomic analysis of the intestinal microbiome was performed by polymerase chain reaction in a certified laboratory in addition to standard cli­nical and laboratory examinations. Patients were treated and exa­mined according to regulatory documents and the Declaration of Helsinki. Digital results were processed statistically, the level of significance was p < 0.05. Results. In patients with MAFLD, the changes in the gut microbiota began already at the stage of steatosis. They manifested by an increase in the total bacterial mass by a third, a lower number of obligate strains (Lactobacillus, Bifidobacterium, Bacteroides thetaiotaomicron, Akkermansia muciniphila) and an increased content of opportunistic pathogens (Сlostridium perfringens, Klebsiella pneumoniae, Klebsiella oxytoca, enterоpathogenic Escherichia coli, Shigella, Proteus, Salmonella) in contrast to patients with an intact liver. The bulk of bacterial DNA were DNA of Bacteroidetes (50.66 % compared to intact liver; Δ = +8.29 %) and Firmicutes (31.97 ± 3.19 %; Δ = –10.87 %) and Actinobacteria DNA (Δ = +40.41 %) made up 7.47 ± 2.69 %. Changes in the metagenomic status of the gut microbiota are associated with body weight, systemic blood circulation, lipid and carbohydrate metabolism. Conclusions. Alterations in the gut microbiota with an increase in total bacterial mass, a lower number of obligate and increased amount of opportunistic strains already at the stage of steatosis have been shown to correlate with the development and progression of fatty liver disease due to metabolic effects.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135869909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging strategies for treating autoimmune disorders in patients with type 1 diabetes and multiple sclerosis","authors":"P.P. Kravchun, I.P. Dunaieva, I.V. Chernyavska, S.P. Oleynikova, O.V. Kryvoshapka","doi":"10.22141/2224-0721.19.6.2023.1316","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1316","url":null,"abstract":"In the world as a whole and in Ukraine in partmicular, the incidence of autoimmune pathologies continues to grow steadily. There is an increase in the number of type 1 diabetes mellitus (T1DM) and multiple sclerosis (MS) cases in the population. Both diseases have an autoimmune nature and several common features in terms of onset, diagnosis, lack of effective treatment and deve­lopment of complications that are potentially life-threatening. In addition, both diseases have genetic risk factors associated with human leukocyte antigen. There are also other genetic risk factors, such as T-cell alleles of interleukin-2 and protein tyrosine phosphatase, non-receptor type 22 in MS and T1DM, respectively. The environment also plays a significant role in the development of both diseases, with smoking and exposure to viruses increasing the risk of MS and T1DM. To date, the proposed methods of therapy for both diseases are not completely effective, and some of them even have serious side effects. The authors consider the possibility of using clemastine fumarate as a histamine H1 antagonist in the management of T1DM and MS. This histamine H1 antagonist penetrates the blood-brain barrier more easily and thus leads to a sedative effect. The efficacy of clemastine fumarate to enhance remyelination in MS was recently demonstrated in a double-blind crossover clinical trial. In addition, this compound was effective in the treatment of T1DM and its complications in a number of experimental studies. The currently available data allow us to recommend clemastine fumarate as the drug of choice in the comprehensive management of patients with MS. Attention is focused on the need for clinical studies to prove the effectiveness of clemastine fumarate in the treatment of patients with T1DM.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"26 20","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135808998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of diabetic macular edema: role of the glial factor (literature review and own data)","authors":"M.L. Kyryliuk, S.A. Suk","doi":"10.22141/2224-0721.19.6.2023.1312","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1312","url":null,"abstract":"The review presents modern data on the pathogenesis of diabetic macular edema. Today, a new understanding of the pathophysiology of diabetic retinal lesions includes structural dysfunction of the neurovascular unit (NVU) of the retina. NVU includes astrocytes and Müller cells, it is a physical and biochemical link between neurons, glia, vascular network in situ, acts as an interface between neurons and the vascular system, and is a key regulator of neuronal metabolism. The close interdependence of glial cells, pericytes and neurons contributes to the formation of a barrier between the blood and the retina, which controls the flow of fluid and hemotransmissive metabolites into the glial parenchyma of eye tissue. Glial components of NVU contribute to the survival of neuronal ganglion cells and photoreceptors, stabilization of the retinal structure, and modulation of inflammatory and immune reactions. It has been shown that intercellular interactions between blood vessels and neurons play a critical role in the formation of blood-retinal barrier whose activity is modulated by the state of retinal endothelial communications. In diabetes, the blood-retinal barrier breaks down already at the early stage of diabetic retino­pathy, changing the structure and function of most types of cells in the retina; however, the molecular mechanisms of this pathological process in diabetes are not sufficiently studied and require the search for new therapeutic strategies, in particular, with the participation of clusterin. Emphasis is placed on the significance of dysfunction in the neurovascular unit of the retina for the deve­lopment of complications in diabetes. Increased attention is paid to microglial activation, Müller cell dysfunction, damage to the blood-retinal barrier, as well as the role of clusterin and fractalkine in barrier cytoprotection.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"26 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135809005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of leptin resistance in the development of thyroid neoplasia","authors":"O.S. Miroshnichenko","doi":"10.22141/2224-0721.19.6.2023.1313","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1313","url":null,"abstract":"Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator. Therefore, an increase in leptin stimulates thyrotropin-releasing hormone secretion, which leads to an increase of thyroid-stimula­ting hormone with normal or slightly elevated levels of thyroxine and triiodothyronine. Leptin imbalance leads to leptin resistance, which develops as a result of impaired sensitivity of hypothalamic receptors to leptin, its penetration through the blood-brain barrier, damage or dysfunction of these receptors, dysfunction of transport proteins accompanied by an increased content of inflammatory mediators that affect leptin receptors and, in turn, damage them. The purpose of the study was to reveal the relationship between hyperleptinemia and leptin resistance in people with different body weight and thyroid nodules. Materials and methods. One hundred and twenty-three patients were examined, who were divided into four groups depen­ding on the body mass index to determine the le­vels of leptin, insulin, and degree of insulin resistance: group 1 — excess body weight (n = 22); group 2 — class 1 obesity (n = 28); group 3 — class 2 obesity (n = 32); group 4 — class 3 obesity (n = 21). The control group consisted of persons with normal body weight (n = 20). Results. It was found that all examined patients had hyperleptinemia (34.5 ng/ml) simultaneously with hyperinsulinemia and insulin resistance (HOMA-IR was 8.3 units). Patients with thyroid neoplasia compared to individuals with normal body weight had significantly higher (by 1.3 times) serum leptin concentrations (p < 0.05; p < 0.001). The research proved that the level of leptine­mia is directly related to the body mass index, waist circumference (r = 0.54; p < 0.001) and hip circumference (r = 0.51; p < 0.001). Conclusions. Among patients with leptin resistance and insulin resistance against the background of obesity of various classes, thyroid neoplasms occur in 28 % of cases. Leptin resistance along with insulin resistance can be considered as independent risk factor for neoplasia. People with abdominal obesity need a mandatory exami­nation of the structural and functional state of the thyroid gland for early detection of nodular neoplasms.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into histopathological features of Warthin-like papillary thyroid carcinoma","authors":"V. Hoperia, O. Mostiuk, A. Dinets, S. Sheptukha, O. Hubar, M. Gorobeiko","doi":"10.22141/2224-0721.19.6.2023.1311","DOIUrl":"https://doi.org/10.22141/2224-0721.19.6.2023.1311","url":null,"abstract":"Background. The Warthin-like variant of papillary thyroid carcinoma (WLPTC) is a rare papillary thyroid carcinoma that is considered to be a subtype of the oncocytic variant. Purpose of the study: to present the diagnostic and clinical features, the oncological and surgical management of a patient with WLPTC as well as its discussion with other relevant studies. Materials and methods. We report a case of Warthin-like papillary thyroid carcinoma in a 31-year-old woman with Hashimoto thyroiditis. Results. The patient was admitted to the hospital with the presence of a node in the thyroid gland. Thyroid ultrasound showed a 24-mm nodule with oval shape and irregular contours in the left lobe. A fine-needle aspiration biopsy was performed, and a diagnosis of papillary thyroid carcinoma was made. The patient underwent thyroidectomy, bilateral modified and central neck dissection, lymphadenectomy. Histopathological examination suggested a WLPTC coexisting with chronic thyroiditis, metastases to the lymph nodes 2, 3, 4 on the left and 6 neck compartments. The patient underwent postoperative I131 ablation therapy. Conclusions. WLPTC is a recently described variant of papillary thyroid cancer that is frequently associated with lymphocytic thyroiditis. The correct cytological and histomorphological features are of utmost importance to render the diagnosis of WLPTC for better management. A surgical and postoperative treatment is identical to that in classic differentiated thyroid cancer, having a favorable outcome due to a low recurrence rate. A surgical management should be thyroidectomy and dissection of central neck compartment as well as lateral dissection in cases of suspicions for metastases in the lymph nodes or metastases confirmed preoperatively by a fine-needle aspiration biopsy.","PeriodicalId":31740,"journal":{"name":"Miznarodnij Endokrinologicnij Zurnal","volume":"379 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}