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OECD Series on Adverse Outcome Pathways最新文献

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Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation 通过影响性腺分化，抑制芳香化酶导致性别比偏向男性的不良后果途径
OECD Series on Adverse Outcome Pathways Pub Date : 2023-12-12 DOI: 10.1787/6a069853-en
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引用次数: 0
Adverse Outcome Pathway on Androgen receptor agonism leading to male-biased sex ratio 雄激素受体激动导致性别比偏向男性的不良后果途径
OECD Series on Adverse Outcome Pathways Pub Date : 2023-12-12 DOI: 10.1787/6f60dce3-en
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引用次数: 0
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 物质与肺驻留细胞膜成分相互作用导致肺纤维化
OECD Series on Adverse Outcome Pathways Pub Date : 2023-12-12 DOI: 10.1787/10372cb8-en
{"title":"Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis","authors":"","doi":"10.1787/10372cb8-en","DOIUrl":"https://doi.org/10.1787/10372cb8-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"30 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 甲状腺过氧化物酶抑制通过减少前鳔膨胀导致死亡率增加
OECD Series on Adverse Outcome Pathways Pub Date : 2022-12-15 DOI: 10.1787/447c5cba-en
{"title":"Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation","authors":"","doi":"10.1787/447c5cba-en","DOIUrl":"https://doi.org/10.1787/447c5cba-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115434794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chitin synthase 1 inhibition leading to mortality 几丁质合成酶1抑制导致死亡
OECD Series on Adverse Outcome Pathways Pub Date : 2022-12-15 DOI: 10.1787/35cd5862-en
{"title":"Chitin synthase 1 inhibition leading to mortality","authors":"","doi":"10.1787/35cd5862-en","DOIUrl":"https://doi.org/10.1787/35cd5862-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130730719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory 在大脑发育过程中，亲电化学物质与SH(硫醇)蛋白和/或硒蛋白结合，参与防止氧化应激，导致学习和记忆受损
OECD Series on Adverse Outcome Pathways Pub Date : 2022-12-15 DOI: 10.1787/4df0e9e4-en
{"title":"Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory","authors":"","doi":"10.1787/4df0e9e4-en","DOIUrl":"https://doi.org/10.1787/4df0e9e4-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129506624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitor binding to topoisomerase II leading to infant leukaemia 结合拓扑异构酶II的抑制剂导致婴儿白血病
OECD Series on Adverse Outcome Pathways Pub Date : 2022-12-15 DOI: 10.1787/4782fbfc-en
{"title":"Inhibitor binding to topoisomerase II leading to infant leukaemia","authors":"","doi":"10.1787/4782fbfc-en","DOIUrl":"https://doi.org/10.1787/4782fbfc-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123173887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 脱碘酶1抑制通过减少前鳔膨胀导致死亡率增加
OECD Series on Adverse Outcome Pathways Pub Date : 2022-12-15 DOI: 10.1787/9f651c16-en
{"title":"Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation","authors":"","doi":"10.1787/9f651c16-en","DOIUrl":"https://doi.org/10.1787/9f651c16-en","url":null,"abstract":"","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"523 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132352625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response 抑制钙调磷酸酶活性导致t细胞依赖性抗体反应受损的不良后果途径
OECD Series on Adverse Outcome Pathways Pub Date : 2021-10-15 DOI: 10.1787/3c988dde-en
Hiroyuki Komatsu, Junichiro Sugimoto, Ken Goto, Kiyoshi Kushima, N. Tsutsui, S. Hisada, S. Ito, T. Kosaka, T. Ohishi, Y. Otsubo, Yoshihiro Takahashi
{"title":"Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response","authors":"Hiroyuki Komatsu, Junichiro Sugimoto, Ken Goto, Kiyoshi Kushima, N. Tsutsui, S. Hisada, S. Ito, T. Kosaka, T. Ohishi, Y. Otsubo, Yoshihiro Takahashi","doi":"10.1787/3c988dde-en","DOIUrl":"https://doi.org/10.1787/3c988dde-en","url":null,"abstract":"The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions and have been used in the medical domain to prevent hyper immune reactions. However, CNIs are reported to also induce immunosuppression-derived adverse effects such as increased frequency and/or severity of infections and increased tumor incidences. CNIs might affect several T-cell derived immune functions to induce compromised host. Among the affected immune functions, T-cell dependent antibody response (TDAR) is an important factor to resist infections and thought to be the useful endpoint on evaluating immunotoxicity of chemicals; therefore, this AOP describes the linkage between the inhibition of CN activity and impairment of TDAR.","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"22 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113941084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy 组蛋白去乙酰化酶抑制导致睾丸萎缩的不良后果途径
OECD Series on Adverse Outcome Pathways Pub Date : 2021-10-15 DOI: 10.1787/b9c4bdb2-en
Shihori Tanabe, A. Hirose, Takashi Yamada
{"title":"Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy","authors":"Shihori Tanabe, A. Hirose, Takashi Yamada","doi":"10.1787/b9c4bdb2-en","DOIUrl":"https://doi.org/10.1787/b9c4bdb2-en","url":null,"abstract":"The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are suggested as histone deacetylase (HDAC) inhibition as MIE, histone acetylation increase, disrupted cell cycle, apoptosis, and spermatocyte depletion as KEs. The adverse outcome has been defined as testicular atrophy. The HDIs inhibit deacetylation of the histone, leading to an increase in histone acetylation. The apoptosis induced by disrupted cell cycle leads to spermatocyte depletion and testis atrophy. Testicular toxicity is of interest for human health risk assessment especially in terms of reproductive and developmental toxicity, however, the testicular toxicity has not been fully elucidated. This AOP may be one of the pathways induced by HDIs, which suggests the pathway networks of protein hyperacetylations.","PeriodicalId":315932,"journal":{"name":"OECD Series on Adverse Outcome Pathways","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114424174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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