Revista Medica del Hospital General de Mexico最新文献

{"title":"Morphology of leukaemias","authors":"W. Ladines-Castro ,&nbsp;G. Barragán-Ibañez ,&nbsp;M.A. Luna-Pérez ,&nbsp;A. Santoyo-Sánchez ,&nbsp;J. Collazo-Jaloma ,&nbsp;E. Mendoza-García ,&nbsp;C.O. Ramos-Peñafiel","doi":"10.1016/j.hgmx.2015.06.007","DOIUrl":"10.1016/j.hgmx.2015.06.007","url":null,"abstract":"<div><p>Acute leukaemias are characterised by uncontrolled proliferation of immature blood cells with lymphoid or myeloid lineage. Morphological classification is based on the identification of the leukaemia cell line and its stage of differentiation. The first microscopic descriptions dating from the 1930s pointed to 2 different types of leukaemia cells: lymphoid and myeloid. In 1976, the consensus that led to the French-American-British (FAB) classification was achieved. This includes criteria for identifying myeloid and lymphoid leukaemias, and gives a list of morphological subtypes, describing how these affect the patient's prognosis. Today, despite new classifications based on sophisticated studies, FAB classification is widely used by experts due to its technical simplicity, good diagnostic reliability and cost-effectiveness.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 107-113"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery and transfusion","authors":"C.O. Ramos-Peñafiel,&nbsp;C. Balderas-Delgado,&nbsp;Á. Cabrera-García","doi":"10.1016/j.hgmx.2015.09.003","DOIUrl":"10.1016/j.hgmx.2015.09.003","url":null,"abstract":"<div><p>Even though blood transfusion saves thousands of lives worldwide, it causes complications in some patients, and must therefore be correctly administered. As there is no universally accepted consensus on blood transfusion in surgical patients, we have reviewed the latest studies and gathered the best available evidence on blood management strategies. In this study, we discuss indicators for transfusion of erythrocytes and other blood products, haemostatic agents for cardiothoracic and orthopaedic interventions where it is imperative to regulate blood loss, and alternatives in specific situations such as Jehovah's Witnesses patients. Finally, we put forward an algorithm for the preoperative management of surgery patients with low haemoglobin levels.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 98-106"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, aetiological and therapeutic findings in Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, four years experience in a third-level Mexican hospital","authors":"V.L. Díaz-Molina,&nbsp;A. Tirado-Sánchez,&nbsp;R.M. Ponce-Olivera","doi":"10.1016/j.hgmx.2015.08.004","DOIUrl":"10.1016/j.hgmx.2015.08.004","url":null,"abstract":"<div><h3>Background</h3><p>Skin reactions are the most frequent adverse drug event, and manifest clinically in many ways, ranging from mild, self-limiting reactions, to severe and potentially fatal forms. DRESS syndrome is one of the most severe forms of drug-induced skin reaction, and can be life threatening. However, currently we have no internationally accepted guidelines for the correct characterisation and treatment of some drug-induced skin reactions, DRESS syndrome and other severe drug-induced skin reactions, in particular.</p></div><div><h3>Methods</h3><p>A retrolective and descriptive study. The sample was selected from the records of patients registered in the Dermatology Department. Twenty-seven cases were selected, and the suspected causative drug, clinical presentation, complications, treatment response and mortality were evaluated.</p></div><div><h3>Results</h3><p>The patients were aged between 17 and 99. DRESS syndrome was the second most common drug-induced skin reaction. Antibiotics were the most commonly associated group of drugs, followed by anticonvulsants. The drug exposure time and the onset of dermatosis were variable. All the patients responded well to treatment with a mortality of 0%.</p></div><div><h3>Conclusions</h3><p>For correct diagnosis and intervention it is essential to identify the different clinical patterns of drug-induced skin reactions; DRESS syndrome in particular, is a drug-induced skin reaction that can endanger a patient's life, and therefore it is important that it is correctly identified and managed.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of cancer testis antigens in chronic myeloid leukemia","authors":"I. Mendoza-Salas ,&nbsp;I. Olarte-Carrillo ,&nbsp;E. Miranda-Peralta ,&nbsp;C. Ramos-Peñafiel ,&nbsp;A. García-Laguna ,&nbsp;R. Cerón-Maldonado ,&nbsp;A. De la Cruz-Rosas ,&nbsp;J. Collazo-Jaloma ,&nbsp;J. Kassac-Ipiña ,&nbsp;E. Mendoza-García ,&nbsp;E. Ramón-Gallegos ,&nbsp;A. Martínez-Tovar","doi":"10.1016/j.hgmx.2015.10.003","DOIUrl":"10.1016/j.hgmx.2015.10.003","url":null,"abstract":"<div><h3>Background</h3><p>Cancer testis antigens (CTA) are expressed in several types of cancer but not in normal adult tissue, with the exception of testicular germ cells, and for this reason are considered targets for immunotherapy.</p></div><div><h3>Objective</h3><p>The aim of this study was to determine the frequency and clinical significance of CTA expression in cells from patients with chronic myeloid leukaemia (CML).</p></div><div><h3>Materials and methods</h3><p>We analysed 8 genes of the CTA family (MAGE-A3, MAGE-A4, MAGE-B2 MAGE-C1, BAGE-1, GAGE-2, LAGE-1 and NY-ESO-1) in 10 peripheral blood samples from healthy donors and 65 bone marrow samples from CML patients using reverse transcriptase polymerase chain reaction (RT-PCR). Eleven samples from hematopoietic progenitor stem cells from patients receiving conventional treatment (hydroxyurea and INFα) and 21 samples from patients receiving tyrosine kinase inhibitors (Imatinib, Nilotinib, Dasatinib) were analysed.</p></div><div><h3>Results</h3><p>Frequency of CTA genes in CML patients was 32.3%, 63.0%, 1.5%, 3.0%, 6.1%, 20.0%, 13.8% and 36.9% for MAGE-A3, MAGE-A4, MAGE-B2, MAGE C1, BAGE, GAGE, LAGE and NY-ESO, respectively. The correlation between expression and clinical parameters showed statistical significance in the MAGE-A3 genes in sex (<em>p</em> <!-->=<!--> <!-->0.018), MAGE-C1 in leukocytes (<em>p</em> <!-->=<!--> <!-->0.014) in platelets (<em>p</em> <!-->=<!--> <!-->0.002), and finally LAGE-1, which was associated with platelets (<em>p</em> <!-->=<!--> <!-->0.001). The hematopoietic progenitor stem cells from patients in treatment showed a higher frequency of expression than <em>de novo</em> patients. In patients receiving conventional drugs (CD), frequency of MAGE-A3 expression was 50%, and 69.2% with TKI, MAGE-A4 frequency was 20% with CD and 53.8% with TKI. Finally, frequency of NY-ESO-1 was 20% with CD and 0% with TKI. The frequency of MAGE-A4 expression was highest, followed by MAGE-A3, NY-ESO-1, GAGE-2, LAGE-1, BAGE-1, MAGE-B2 and MAGE-C1.</p></div><div><h3>Conclusion</h3><p>Detection of CTA genes by molecular biology techniques is important due to their use as biomarkers in LMC, in the monitoring of disease progression and in patients who are resistant to chemotherapy. The frequency of CTA expression in treated and <em>de novo</em> differs significantly.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 46-54"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anaemia","authors":"G. Barragán-Ibañez ,&nbsp;A. Santoyo-Sánchez ,&nbsp;C.O. Ramos-Peñafiel","doi":"10.1016/j.hgmx.2015.06.008","DOIUrl":"10.1016/j.hgmx.2015.06.008","url":null,"abstract":"<div><p>Iron deficiency anaemia is a public health problem that affects all age groups. In Mexico, it is a common cause of morbidity, and accounts for 50% of cases of anaemia worldwide. It is more prevalent during the first 2 years of life, during adolescence and pregnancy. It is characterised by fatigue, weakness, pallor and koilonychia. Treatment is based on dietary recommendations and oral and intravenous iron supplements. In this review article, we summarise the characteristics of iron efficiency anaemia, its metabolism, epidemiology, symptoms and diagnosis, and explore different therapeutic approaches.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 88-97"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.06.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate recovery of neurological function in response to deep brain stimulation of the globus pallidus internus in a patient with idiopathic camptocormia","authors":"I. Madrazo ,&nbsp;E. Magallón ,&nbsp;C. Zamorano ,&nbsp;F. Jiménez ,&nbsp;A. Ysunza ,&nbsp;I. Grijalva ,&nbsp;R.E. Franco-Bourland ,&nbsp;G. Guízar-Sahagún","doi":"10.1016/j.hgmx.2015.11.002","DOIUrl":"10.1016/j.hgmx.2015.11.002","url":null,"abstract":"<div><p>Camptocormia is a major disabling abnormality characterized by severe forward flexion of the thoracolumbar spine. We report here on the effectiveness of deep brain stimulation (DBS) for the management of a case of untreatable idiopathic camptocormia. The patient, a 51-year-old male, with an 11-year-long history of radicular pain. Camptocormia symptomatology initiated 4 years ago. Preoperative muscle electrodiagnostic testing was within normal limits. Myopathy was ruled out. In the standing position myokymic discharges were recorded. Under local anesthesia and stereotactic control, electrodes for DBS were placed bilaterally in the globus pallidus internus. Patient's symptoms disappeared immediately following DBS. This response cannot be attributed to the surgical procedure itself. When stimulators were turned “off” accidentally, the patient returned immediately to his pre-surgery condition. Erect posture and walking were restored when stimulators were back “on”.</p></div><div><p>La Camptocormia es un trastorno incapacitante caracterizado por flexión anterior severa del tronco. Aquí presentamos un caso de camptocormia idiopática intratable donde la estimulación cerebral profunda (ECP) fue altamente eficaz. El paciente, un hombre de 51 años de edad, con historia de dolor radicular de 11 años y sintomatología de camptocormia de 4 años de evolución. Se descartó la presencia de miopatías. Las pruebas musculares preoperatorias mediante electrodiagnóstico resultaron normales, aunque en la posición de pie se registraron descargas mioquímicas. Para proveer la ECP se colocaron electrodos en el globo pálido interno bilateralmente, bajo anestesia local y control estereotáctico. Los síntomas de camptocormia desaparecieron inmediatamente después de la ECP. Esta respuesta no es atribuible a la intervención quirúrgica en sí, pues cuando el estimulador se apagó accidentalmente, el paciente regresó a su condición pretratamiento y la postura erecta se restauró al restablecer la estimulación.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 63-67"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current treatments in Parkinson's including the proposal of an innovative dopamine microimplant","authors":"M. Velázquez-Paniagua ,&nbsp;A.M. Vázquez-Álvarez ,&nbsp;G. Valverde-Aguilar ,&nbsp;P. Vergara-Aragón","doi":"10.1016/j.hgmx.2015.10.006","DOIUrl":"10.1016/j.hgmx.2015.10.006","url":null,"abstract":"<div><p>Parkinson's disease is a chronic, debilitating, progressive neurological disorder of multifactorial origin. It affects between 0.3% and 2% of the over-65 population worldwide, with a predilection for men, and is characterised by bradykinesia, muscular rigidity, resting tremor and postural instability. Parkinson's is caused by decreased dopamine levels due to the loss of dopaminergic neurons in the substantia nigra. Because dopamine is a highly oxidisable molecule, precursors such as levodopa, together with catechol-O-methyltransferase and monoamine oxidase inhibitors to prevent degradation, are used in the treatment of this disease. These therapies, however, are not without their adverse effects. Surgical treatments for Parkinson's include pallidotomy, therapy deep brain stimulation, and stem cells. A more recent development involves a titanium dioxide micro-implant containing nanopores that stabilise the dopamine for continuous release. When inserted into the caudate nucleus, this micro-implant was found to counteract 85% of symptoms in hemiparkinsonian rats, and is a promising therapy for patients with Parkinson's disease.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 2","pages":"Pages 79-87"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54293017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition is related to a higher frequency of serious complications in patients with cirrhosis","authors":"E. Pérez-Reyes ,&nbsp;J. Rivera-Sánchez ,&nbsp;A.I. Servín-Caamaño ,&nbsp;E. Pérez-Torres ,&nbsp;J.M. Abdo-Francis ,&nbsp;F. Higuera-de la Tijera","doi":"10.1016/j.hgmx.2015.04.003","DOIUrl":"10.1016/j.hgmx.2015.04.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Patients with cirrhosis are at risk of malnutrition and this has been recognized as a predictor of morbidity and mortality. The aim of this study was to compare the frequency of serious complications (variceal bleeding, ascites, hepatic encephalopathy and infections) between cirrhotic patients with and without malnutrition.</p></div><div><h3>Subjects and methods</h3><p>An observational, analytic, cross-sectional study. The nutritional status of cirrhotic patients was evaluated according to Subjective Global Assessment (SGA). Characteristics of cirrhotic patients with and without malnutrition were compared.</p></div><div><h3>Results</h3><p>103 cirrhotic patients were included, 58 (56.3%) were women; the media of age was 55<!--> <!-->±<!--> <!-->12.2 years. According to SGA, 45 patients (43.7%) were classified as well-nourished, and 58 (56.3%) as malnourished. The development of serious complications was related to nutritional status. Malnourished patients had higher frequency of development of ascites (67.2% vs. 42.2%, <em>P</em> <!-->=<!--> <!-->0.01, OR<!--> <!-->=<!--> <!-->2.8; 95% CI: 1.3–6.3) and infections (21.4% vs. 6.7%, <em>P</em> <!-->=<!--> <!-->0.03, OR<!--> <!-->=<!--> <!-->4.5; 95% CI: 1.2–16.6).</p></div><div><h3>Conclusions</h3><p>The presence of serious complications, such as, ascites and development of bacterial and fungal infections, was more frequent between cirrhotic patients with malnutrition than in those well-nourished.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 1","pages":"Pages 11-16"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54291526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychomycosis in the elderly. A 2-year retrospective study of 138 cases","authors":"J. Araiza-Santibáñez,&nbsp;A. Tirado-Sánchez,&nbsp;A.L. González-Rodríguez,&nbsp;L. Vázquez-Escorcia,&nbsp;R.M. Ponce-Olivera,&nbsp;A. Bonifaz","doi":"10.1016/j.hgmx.2015.10.004","DOIUrl":"10.1016/j.hgmx.2015.10.004","url":null,"abstract":"<div><h3>Background</h3><p>As life expectancy increases worldwide, so does the incidence of age-related pathologies, among them onychomycosis (OM). This fungal infection of the nails may represent a potential risk of complications among elderly due to the presence of concomitant diseases that can complicate their treatment.</p></div><div><h3>Objective</h3><p>To determine the frequency of onychomycosis among elderly patients over a period of 2 years at the General Hospital of Mexico “Dr Eduardo Liceaga”.</p></div><div><h3>Methods</h3><p>Retrospective, observational, descriptive study.</p></div><div><h3>Results</h3><p>A total of 138 patients were diagnosed with onychomycosis. Of these, 43 (31.2%) reported no concomitant diseases. The most common comorbidities in the remaining patients was arterial hypertension in 50 patients (36.2%) and diabetes mellitus in 49 (35.5%); the most common clinical type of OM was total dystrophic (87 patients, 63%), with involvement of the hallux of both feet (48 patients, 34.8%). The average evolution was 12 years; 60 patients (42.3%) denied previous treatments, and 32 (22.5%) used OTC medicines. In 125 patients (90.6%), filaments, yeasts or arthroconidia were observed. On culture examination, <em>Candida</em> yeasts (24 patients, 46.2%), followed by <em>Trichophyton rubrum</em> (21 patients, 40.4%) were identified.</p></div><div><h3>Conclusions</h3><p>Approximately 9 out of 10 nail disorders in the elderly were onychomycosis; many of these patients may present with comorbidities such as hypertension or diabetes mellitus, which often complicate treatment outcomes, affecting quality of life. Elderly patients should receive adequate health education and monitoring. This will improve their quality of life.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 1","pages":"Pages 5-10"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult colloid milium. An underdiagnosed and difficult to treat entity","authors":"A.B. Zamora,&nbsp;M.P. Simón,&nbsp;A.T. Sánchez,&nbsp;R.M. Ponce Olivera","doi":"10.1016/j.hgmx.2015.10.002","DOIUrl":"10.1016/j.hgmx.2015.10.002","url":null,"abstract":"<div><p>Millium colloid is a rare cutaneous deposition disorder of unknown aetiology on light-exposed skin. It presents as flesh-coloured or yellow papules. A skin biopsy and light microscopy study is required for diagnosis, with findings of fissured eosinophilic colloid masses in the papillary dermis, with solar elastosis that is separated from the epidermis by a Grenz zone containing normal collagen. There is no single effective treatment. We present a case report of a 42-year-old man with papular lesions on the dorsum of both hands and a history of prolonged sun exposure.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"79 1","pages":"Pages 21-25"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2015.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54292781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}