Eastern Ukrainian Medical Journal最新文献

{"title":"CORRECTION OF DIASTOLIC DYSFUNCTION AND LEFT VENTRICULAR REMODELING PROCESSES IN PATIENT WITH RHEUMATOID ARTHRITIS IN COMBINATION WITH ARTERIAL HYPERTENSION","authors":"N. G. Ryndina","doi":"10.21272/EUMJ.2019;7(1):60-65","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):60-65","url":null,"abstract":"Rheumatoid arthritis (RA) is recognized as an independent cardiovascular risk factor. The presence of arterial hypertension in patients with rheumatoid arthritis is associated with an unfavorable prognosis; the combination of diseases significantly interrelates to the course of each one. An important issue is the selection of complex therapy to correct diastolic dysfunction and left ventricular remodeling processes. The study involved 60 patients with RA in combination with hypertension, who were divided into two groups: group I and group II of 30 people each. All patients received basic therapy for RA, NSAIDs and GK. The control group III included 30 almost healthy people. Patients of group I additionally received ramipril 10 mg daily and amlodipine 5– 10 mg daily. All patients from group I also received atorvastatin 20 mg daily and metabolic therapy of Mildronate 5 ml 0.5 g/5 ml intravenous drip per 200 ml sodium chloride solution 0.9 % once a day for ten days, followed by a switch to capsules Mildronate 250 mg at a dose of 500 mg per day for 3 months. After repeated examination three months later, the patients of group I showed a decrease in myocardial mass index by 8.86 % (р < 0.05), decreased size of the left atrium by 5.52 % (p < 0.05), improved diastolic function: 13.33 % of patients showed normalization, and 6,67 % had type II diastolic dysfunction transition to type I (p < 0.05). Also in the patients of group I with fluid in the pericardial cavity there was a decrease in the final diastolic size of the circular rim of the fluid by 46.6 % (p < 0.05). Patients in group II showed an increase in myocardial mass index by 3.33 %, size of the left atrium by 8.68 % (p < 0.05) and the number of patients with diastolic dysfunction increased by 10 % (p < 0.05). The size of the circular rim of fluid in the patients of group II with fluid in the pericardial cavity increased by 6.67 % (p < 0.05). It can be concluded that such a scheme is relevant and can be recommended in order to select rational complex therapy in patients with RA in combination with hypertension.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116940524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Т786С POLYMORPHISM IN THE ENDOTHELIAL NO SYNTHASE GENE, VASCULAR ENDOTHELIAL GROWTH FACTOR-А IN MYOCARDIAL INFARCTION WITH ST SEGMENT ELEVATION","authors":"O. Petyunina, M. Kopytsya, L. L. Pietienova","doi":"10.21272/EUMJ.2019;7(1):48-59","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):48-59","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129099207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DENSITY OF THE ADHERENCE OF RESTORATIVE MATERIAL TO THE ENAMEL OF TEETH WITH DIFFERENT FORMATION OF CARIOUS CAVITY EDGE","authors":"Y. Smeyanov, Yu. V. Lakhtyn, A. Romanyuk, O. V. Belonozhko","doi":"10.21272/EUMJ.2019;7(1):20-27","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):20-27","url":null,"abstract":"Introduction. At present, the question of the influence of carious cavity edge design on the density of the adherence of restorative material to the enamel remains discursive; there is some confusion in the open access publications on this topic. \u0000Objectives. To study the density of the adherence of restorative material to the enamel of teeth depending on the design of the formation of carious cavity edge. \u0000Materials and methods. The research was carried out using 30 intact third molars extracted upon clinical indications. The samples were divided into three groups, 10 in each, depending on the formation of carious cavities of the 1st class according to Black classification. In group I a classical carious cavity with even, straight-edged walls without the formation of the bevel (folds) of the enamel was formed. In group II, the outer beveling of enamel was made at an angle of 45o to the enamel-dentine border. In group III, the cavity was formed with an internal beveling of enamel. Carious cavities were restored with micro-hybrid composite light cured material LATELUX (PE \"LATUS\", Kharkiv). One-time vertical mechanical load with a force of 98.07 N was performed on restoration, and treated with thermocycled in a mode of 200 cycles at a temperature from 5 °C to 55 °C with an exposure of 60 seconds at each temperature. The teeth were separated in a medio-distal direction through a center of restoration with diamond disks, placed in a column of a raster electron microscope with a low vacuum chamber REM 102, and the contact area of the restoration with solid tissues of the teeth was studied, the density of their adherence, and the present gaps were measured and expressed in micrometers (μm) \u0000Results. Electron diffraction pattern of the samples of group I showed that the density of the adherence of the restorative material to the enamel of the carious cavity was different throughout: sometimes thick, sometimes the space in the contact area was determined. Moreover, the space was formed between the adhesive layer of the material and enamel. The space size averaged 7.90 ± 0.73 μm (95% CI: 6.3: 9.5). Enamel prisms adjoined in the area of contact with the material partly linear, longitudinal along its axis or transversely, obliquely with a slanted body. \u0000In the samples of group II restorative material was evenly in contact with the layer of adhesive, adherence of which to the enamel edge of the carious cavity was dense almost throughout. But in some areas there was a violation of the contact of the enamel with the adhesive layer, there were cracks 2.76 ± 0.52 μm (95% CI: 1.6: 3.9). Enamel prisms in the area of contact with the material were located more transversely to their axis, obliquely with a slanted body. \u0000In the samples of group III, the adherence of the restorative material to the enamel of the carious cavity was not dense almost throughout. The restorative material had a uniform contact with the adhesive. At the same time, there was a breach of con","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132742667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYGIENIC ASPECTS OF EDUCATIONAL ACTIVITY OF SECONDARY SCHOOL CHILDREN AND ITS IMPACT ON HEALTH","authors":"M. Kindruk","doi":"10.21272/EUMJ.2019;7(1):1-10","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):1-10","url":null,"abstract":"process at school, providing the optimal training conditions. Conclusion. On the basis of the analysis of the literature, it was concluded that the educational institution has a significant influence on the development of the health of schoolchildren both emotional and behavioral. That is why it is necessary to help schoolchildren to form behavior that will increase the protective properties of the body; fight bad habits; attract pupils to various activities and rest, provide satisfactory nutrition, optimal motor activity, development of physical culture, tempering and compliance with the rules of personal hygiene.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130529362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some fibrinolytic parameters in coronary artery disease patients: focus on unstable angina subgroups","authors":"Y. Tyravska, O. Bondarchuk, N. Raksha, V. Lizogub, O. Savchuk","doi":"10.21272/EUMJ.2021;9(1):54-65","DOIUrl":"https://doi.org/10.21272/EUMJ.2021;9(1):54-65","url":null,"abstract":"Unstable angina is classified into new-onset, progressive, and angina at rest. Though hemostasis plays a crucial role in the pathogenesis of coronary artery disease, including unstable angina, limited data exist regarding peculiarities of fibrinolytic parameters in the above-mentioned types of unstable angina. Our study aims to investigate if there is a difference in the fibrinolytic state between the groups of patients with new-onset, progressive unstable angina in comparison with stable angina patients depending on medical history data, electrocardiographic and hemodynamic features. \u0000In our cross-sectional study, we recruited 93 coronary artery disease patients (mean age 62.32 (6.94) years, 41 males (44.1%)). They were divided into 3 groups: stable angina patients (n=22) (control), new-onset unstable angina patients (n=21), and progressive unstable angina patients (n=50). The groups were comparable by baseline characteristics. Blood samples were obtained before treatment onset. The concentrations of tissue plasminogen activator and inhibitor of plasminogen activator (type 1) were measured by the ELISA method. We registered 14 points at the admission department, particularly age, sex, body mass index, smoking, presence of the family history of cardiovascular disorders, ST-segment depression, T-wave variability, arrhythmias, left bundle branch blockage, heart rate, systolic and diastolic blood pressure, Sokolov-Lyon voltage criteria, and unstable angina type (new-onset or progressive). After comparison of fibrinolytic parameters’ concentrations among groups under investigation, we defined the main independent predictors among observed 14 parameters to create optimal regression models for assessment of fibrinolytic parameters concentrations.\u0000The groups under investigation differ significantly in concentration of tissue plasminogen activator (P<0.001) and inhibitor of plasminogen activator (type 1) (P<0.001). The tissue plasminogen activator concentration correlated significantly with ST depression (r=0.344, P=0.001), T wave variability (r=-0.233, P=0.02), systolic blood pressure (r=-0.675, P<0.001), diastolic blood pressure (r=-0.655, P<0.001), heart rate (r=-0.568, P<0.001) and clinical unstable angina subgroups (r=-0.706, P<0.001) as well as plasminogen activator inhibitor (type 1) concentration associated with age (r=-0.560, P<0.001), body mass index (r=-0.249, P=0.049), ST-segment depression (r=0.542, P<0.001), arrhythmia (r=0.210, P=0.03), systolic blood pressure (r=0.310, P=0.04), and clinical unstable angina subgroups (r=-0.406, P<0.001). An optimal regression models for tissue plasminogen activator and its inhibitor assessment included systolic blood pressure, heart rate, unstable angina subgroup (R2adj. = 65.0%, P<0.001) and systolic blood pressure, unstable angina subgroup (R2adj. = 42.7%, P<0.001), respectively. Thus, fibrinolytic state among unstable angina clinical types differs significantly independently on observed baseline clinica","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121062509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FREQUENCY AND VARIANTS OF MENSTRUAL DISORDERS IN ADOLESCENTS WITH METABOLIC SYNDROME","authors":"Anna A. Sinkina, I. Nikitina, Svetlana A. Smiіan, T. V. Babar","doi":"10.21272/eumj.2022;10(2):188-195","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(2):188-195","url":null,"abstract":"The problem of the correlation between reproductive disorders and metabolic syndrome (MS) is well known, but data on the frequency and nature of these disorders among adolescents are extremely limited.\u0000 The aim of the study: is to determine and analyze the frequency and structure of menstrual disorders in adolescent girls on the background of metabolic syndrome, as well as to study the correlation of these disorders with possible reproductive health disorders in the future.\u0000 Materials and methods. To achieve this goal, a retrospective analysis of randomly selected 2,000 outpatient medical records (primary registration form № 025/o) of girls aged 10 to 18 years was performed at the Sumy Regional Clinical Perinatal Center from 2011 to 2021. The menstrual cycle was assessed according to the FIGO 2018 classification. Pathological menarche was defined as early (up to 10 years) or late (after 15 years) onset of menstrual function. Polycystic ovarian syndrome (РCOS) was diagnosed according to the Rotterdam criteria (2003): oligo‑ or anovulation (≤ 6 menstrual periods per year); clinical or laboratory hyperandrogenism (hirsutism/acne) and/or hyperandrogenemia (increased levels of free testosterone in the blood); polycystic ovaries during transvaginal ultrasound (≥ 15 follicles 2–9 mm in size in each ovary).\u0000Results. The results showed that in adolescent girls with overweight and MS, the frequency of menstrual dysfunction was observed in 71.1% of cases. Moreover, the most common variant of menstrual disorders in this category of patients was oligomenorrhea (60.0%), and the frequency of its manifestations was directly dependent on overweight degree. It was found that almost 82% of girls with confirmed MS had a high risk of developing polycystic ovarian syndrome (PCOS) in the future.\u0000 Conclusion. It was found that the incidence of obesity in children and adolescents in the population was 27.1%, and the incidence of menstrual syndrome among children and adolescents with obesity was 41.5%. A significant proportion of adolescents with menstrual syndrome had menstrual irregularities – 71.1%, which was significantly higher than in healthy girls – 19%. Among menstrual disorders in girls with menstrual syndrome and obesity, oligomenorrhea prevailed (60.0% and 52%, respectively). Moreover, the frequency of oligomenorrhea was significantly affected by the degree of obesity. Almost 82% of girls with confirmed menstrual syndrome had at least two of the three criteria, which put them at high risk for developing polycystic ovarian syndrome in the future.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114510188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE RELATIONSHIP BETWEEN MANIFESTATIONS OF AUTONOMIC DYSFUNCTION AND HYPERTENSION SEVERITY","authors":"Yuriy O. Ataman, Lina Pryimenko","doi":"10.21272/eumj.2022;10(1):64-70","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):64-70","url":null,"abstract":"Introduction. Hypertension is one of the most common diseases of the cardiovascular system, which is observed in the majority of the working population of Ukraine and around the world. Autonomic dysfunction syndrome is one of the first manifestations and precursors of hypertension.\u0000Materials and Methods. The study included 81 patients with hypertension and autonomic dysfunction. Patients were divided into 3 groups depending on blood pressure. To assess the pathology data, blood pressure was measured according to the 2018 recommendation and patients were surveyed according to a standard questionnaire to identify autonomic disorders by Vein.\u0000Results. When assessing the prevalence of symptoms of autonomic dysfunction in the study groups, there was a weak dependence of their occurrence with the severity of hypertension, even in patients with mild hypertension there was a significant frequency of symptoms, which cannot but adversely affect patients' quality of life. Assessing the severity of symptoms of autonomic dysfunction, the prevalence of symptoms such as palpitations, sweating, periodic discoloration of the extremities and paroxysmal headaches in the first group (the most favorable course of high blood pressure). For the second group, the most severe were symptoms such as intermittent numbness of the fingers and shortness of breath. The rank correlation between the degree of hypertension and the severity of autonomic dysfunction was 0.103 (p = 0.302), which indicates a positive correlation between these parameters, but the relationship was weak and did not acquire statistical significance.\u0000Conclusion. In patients with a combination of hypertension and autonomic dysfunction, the symptoms of the latter are common at any severity of hypertension. The relationship between the severity of hypertension and autonomic dysfunction could not be established, among hemodynamic indicators, pulse blood pressure was most correlated with the index of autonomic dysfunction.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128247698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE CHARACTERISTICS OF DEXDOR AND DIPRIVAN FOR SEDATION IN UROLOGICAL OPERATIONS UNDER SPINAL ANESTHESIA","authors":"Sergiy Redko, Y. Shkatula, Yuliia A. Tkachenko, Diana A. Steblovskaya","doi":"10.21272/eumj.2022;10(1):50-56","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):50-56","url":null,"abstract":"Currently, anesthesiologists-resuscitators have a large number of sedatives (hypnotics, general anesthetics, anxiolytics), but many of them, in addition to the main action, give a number of side effects or do not provide optimal sedation. On the other hand, there are new modern drugs for sedation, thus, the need to correct existing regimens of sedative therapy is quite timely and necessary.\u0000The aim of the study was to examine the advantages and disadvantages of different sedation methods in patients with urological profile operated under spinal anesthesia.\u0000 80 patients (54 men and 26 women) who underwent urological surgery under balanced anesthesia (spinal anesthesia in combination with drug sedation) were examined. Patients were randomly divided into two groups. Group 1 (n = 40) – sedation with dexdor, group 2 (n = 40) – sedation with diprivan. The level of sedation was assessed using the RAMSEY scale, the degree of post-anesthesia recovery on the Bidway five-point scale, and anesthesia satisfaction was assessed using the Lowa Satisfaction with Anesthesia Scale (ISAS). The degree of hemodynamic disorders was determined by continuous monitoring of heart rate, blood pressure and ECG. The normality of the distribution was checked using the Shapiro–Wilk method. The Mann–Whitney test was used to assess the statistical significance of the difference between the two independent groups.\u0000 Results. The study showed that a deeper level of sedation during surgery was observed in the second group (sedation with diprivan). In this group, postoperative drowsiness was also higher both during the first 15 minutes and 30 minutes after surgery. Despite the fact that patients receiving dexdor had more superficial sedation, they generally showed significantly higher overall satisfaction with anesthesia. The study proved the effectiveness and safety of both drugs for sedation in urological patients under spinal anesthesia. However, a number of important advantages of dexdor were found as compared to diprivan. Dexdor, due to its ability to cause mild to moderate sedation, allows the patient to contact staff, almost does not suppress respiration, lets the patient feel comfortable and causes sufficient retrograde amnesia.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127736347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROSURGICAL TREATMENT OF INTRAMEDULLAR TUMOR OF CERVICAL LOCATION","authors":"Yevgeniy I. Slynko, O. O. Potapov, Y. Derkach, A. I. Pastushyn","doi":"10.21272/eumj.2022;10(1):88-97","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(1):88-97","url":null,"abstract":"Materials and methods. This report analyzes 47 patients who were operated on at Romodanov Neurosurgery Institute of the Academy of Medical Sciences of Ukraine in the period from 2010 to 2020 due to intramedullary tumors of the cervical spine.\u0000Results. All patients with intramedullary tumors of the cervical spine were operated. According to the volume of tumor removal, operations with total (17 observations), subtotal (14 observations), and partial (19 observations) removal were distinguished. The removal of at least 95% of the tumor volume was considered total, which was confirmed by examination of the operating field under a microscope at the end of the operation or by early postoperative MRI.\u0000Discussion. Total tumor removal is the gold standard in the surgical treatment of intramedullary spinal cord tumors. Ferrante L. et al reported that none of the patients who underwent total tumor resection had a recurrence, while 57.1% of patients with subtotal resection had a recurrence. The authors argue that the volume of the removed tumor is an important factor influencing the further prognosis. Total tumor resection can be recommended for most cases of intramedullary tumors of the cervical spinal cord. It is not possible to determine preoperatively whether total tumor removal is possible.\u0000Conclusions. Intramedullary tumors of the cervical spine can be completely removed. Surgery should be performed immediately after diagnosis without expecting an increase in neurological deficit.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129971288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF ALLOXAN-INDUCED HYPERGLYCEMIA ON THE RENAL CORTEX","authors":"S. Frolova, O. Gordienko, Olha Yarmolenko","doi":"10.21272/eumj.2022;10(3):268-273","DOIUrl":"https://doi.org/10.21272/eumj.2022;10(3):268-273","url":null,"abstract":"About 422 million people in the world suffer from diabetes mellitus. Among diseases, diabetes ranks third, and among endocrine disorders, it ranks first. Some issues concerning the pathogenesis of this disease are unclear. The main reason for diabetes damage is high blood glucose levels. Hyperglycaemia has a toxic effect on the vessels of the kidneys. The present study aims to investigate the impact of alloxan-induced diabetes mellitus on the remodeling of the renal cortex.\u0000Materials and methods. We divided twenty-four mature white male rats into the control and experimental groups. We administered alloxan to experimental animals intraperitoneally at a single dose of 40 mg/kg. Blood glucose levels were measured 2, 12, and 24 hours after injection of alloxan and then weekly. The average glucose level remained 11.0 ± 2.0 mmol/l. Animals were sacrificed on days 14, 21, and 45. We stained histological preparations of kidneys with hematoxylin and eosin. The selected dose of alloxan and the method of its administration caused persistent hyperglycemia in rats and did not lead to their death.\u0000Results. On the 14th day, the diseased kidney had a thickening of the glomerular capillary walls. Nephrons had a spherical shape with a slightly uneven surface. On the 21st day of the observation, it was more difficult to distinguish the cortex from the medulla. On the 45th day, the distal tubules lost their usual shape, became thinner, and were difficult to distinguish from other tubules by histological preparation. The cortex became spongy due to cystic dilation of the tubules.\u0000Conclusions. All components of the renal cortex underwent daily changes. At the early stages of the experiment, it looked much denser compared to the cortical layer of the kidneys of animals in the control group. The number of subcapsular nephrons visually increased, and the renal capsule thickened. In the later period of the experiment, dilatation and blood fullness of glomerular capillary with their leukocyte infiltration were observed. In addition, there was a cystic expansion of the tubules, due to which the cortical layer of the kidney looked like a sponge.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130461830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}