TIP Revista Especializada en Ciencias QuimicoBiologicas最新文献

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Modelo de propagación de ondas solitarias en el corazón 单波在心脏传播的模型
TIP Revista Especializada en Ciencias QuimicoBiologicas Pub Date : 2013-01-01 DOI: 10.1016/S1405-888X(13)72079-5
Ivonne Domínguez , Rafael A. Barrio , Carmen Varea , José Luis Aragón
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引用次数: 0
Transformación de la aflatoxina B1 de alimentos, en el cancerígeno humano, aducto AFB1-ADN 黄曲霉毒素B1转化为人类致癌物afb1 - dna加合物
TIP Revista Especializada en Ciencias QuimicoBiologicas Pub Date : 2013-01-01 DOI: 10.1016/S1405-888X(13)72082-5
Magda Carvajal
{"title":"Transformación de la aflatoxina B1 de alimentos, en el cancerígeno humano, aducto AFB1-ADN","authors":"Magda Carvajal","doi":"10.1016/S1405-888X(13)72082-5","DOIUrl":"10.1016/S1405-888X(13)72082-5","url":null,"abstract":"<div><p>Aflatoxins (AF) are secondary toxic metabolites formed mainly by the molds <em>Aspergillus flavus</em> and <em>A. parasiticus</em>; they are potent mutagens and carcinogens of foods, and human exposure to them is continuous. AF bind to DNA, RNA and proteins forming AFB<sub>1</sub>-DNA adducts that accumulate for years and damage from viruses to humans. To identify and quantify the chemical reactions and molecular biology of these adducts is of primary importance because they are long-term biomarkers validated as a source of mutagenicity and risk of cancer in animals and humans. The cytochrome P<sub>450</sub> activates AF as an unstable molecule called 8,9 AFB<sub>1</sub> epoxide, that binds mainly to the N<sup>7</sup> of the guanine nucleotide forming adducts that are the active carcinogens themselves and, as biomarkers, an objective measure of human exposure to environmental carcinogens. Adducts represent an integration of exposure, absorption, distribution, metabolism, DNA repair, and cell turnover. The different issues presented here are the formation of AFB<sub>1</sub>-DNA adducts, in vitro and <em>in vivo</em> studies, dietary AFB<sub>1</sub> exposure, effects, development of human cancer and mutations in the p53 tumor suppressor gene, the effect of diet, routes of exposure, vitamins, kinds of AFB<sub>1</sub>-DNA adducts, methodology used for their study and their control.<span></span></p></div>","PeriodicalId":31507,"journal":{"name":"TIP Revista Especializada en Ciencias QuimicoBiologicas","volume":"16 2","pages":"Pages 109-120"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1405-888X(13)72082-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74117954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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